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  • transcript
  • Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified. (wikipedia.org)
  • activation
  • Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1 /ERK2, MAPK3 /ERK1 and MAPK8 /JNK1. (rcsb.org)
  • Experiments using temperature-sensitive v-src and v-fps mutants indicate that Shc tyrosine phosphorylation is rapidly induced upon activation of the v-Src or v-Fps tyrosine kinases. (pnas.org)
  • Over the last decade, major advances have been made in the elucidation of mechanisms involved in leukemogenesis, and this is particularly true with regard to deregulated protein tyrosine kinase (PTK) activation. (haematologica.org)
  • We show that thrombin and collagen activation of platelets causes an induction of tyrosine phosphorylation of pp125FAK and that pp125FAK molecules isolated from activated platelets display enhanced levels of phosphorylation in immune-complex kinase assays. (rupress.org)
  • The induction of tyrosine phosphorylation of pp125FAK was inhibited in thrombin- and collagen-treated platelets preincubated with cytochalasin D, which prevents actin polymerization following activation. (rupress.org)
  • Signalling through IL-4/IL-13 complexes is thought to occur through IL-4Rα-chain, which is responsible for activation of JAK-1 and Tyk2 kinases. (wikipedia.org)
  • Allosteric activation by glucose 6 phosphate, which acts as an effector, stimulates glycogen synthase, and glucose 6 phosphate may inhibit the phosphorylation of glycogen synthase by cyclic AMP-stimulated protein kinase. (wikipedia.org)
  • ErbB3 binding causes the allosteric activation of p110[disambiguation needed], the lipid kinase subunit of PI3K, a function not found in either EGFR or ErbB2. (wikipedia.org)
  • Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. (wikipedia.org)