Protein transport. Medical search. Frequent questions

Drug transporters are integral membrane proteins that play a critical role in drug disposition by affecting absorption, distribution, and excretion. (nih.gov)
Our vision for the 2024 GRC on Membrane Transport Proteins is to link molecular and mechanistic insights on clinically important membrane transporters expressed in different tissues, including carriers, ion channels, and pumps, to physiological function and disease-related dysfunction. (grc.org)
The inner membrane is equipped with specific transporters, the carrier proteins, which transport metabolites across the inner membrane. (phys.org)
2003-11-18 · The remaining, "non SLC" human transporter-related genes include those encoding ATP-driven transporters, channels, ionotropic receptors, aquaporins, transporter and channels subunits, auxiliary/regulatory transport proteins, etc. (see Fig. 1). (web.app)
Protein transporters coded by human genes of SLC5 genes family. (medscape.com)
The studies from the papers serve as models to help students understand how to design experiments for confirming whether other proteins serve as transporters for particular molecules. (gpmpi.net)

A transport protein (variously referred to as a transmembrane pump, transporter, escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves the function of moving other materials within an organism. (wikipedia.org)
Moreover, the experimental results showed that the environmental signals which bring about the redistribution of pigment organelles in the organism of clawed frogs are associated with a change of probability with which the individual motor proteins from the actin filaments switch to the microtubule filaments. (tum.de)
Proteins with no known biological function can be categorized according to protein structural criteria (distinctive structural domains), source organism or subcellular location. (bionity.com)
If the only thing known about a protein is the organism that produces it, then it can (as a last resort) be categorized according to organism. (bionity.com)
We also wanted students to understand how scientists use results from more than one organism to confirm the identity of transport proteins. (gpmpi.net)

Transport and channel proteins connect the organelles accomplishing the PR pathway-chloroplast, peroxisome, and mitochondrion-and thus enable efficient flux of PR metabolites. (nih.gov)
Neural function depends on continual synthesis and targeted trafficking of intracellular components, including ion channel proteins. (nih.gov)
Carrier proteins , (together with channel proteins ) are Membrane transport proteins actively facilitating transport of molecules across cell membrane on which they are placed. (wn.com)

Carrier proteins bind a solute on one side of the membrane and deliver it to the other side through a change in conformation. (web.app)
As stated earlier, the makeup of the amino acid chains in the protein determines the Carrier proteins are transport proteins that are only open to one side of the membrane at once. (web.app)
They bind with large, selected molecules like proteins from one side of the membrane and release the molecules to the other side. (web.app)
Carrier proteins facilitate the diffusion of different molecules, to which they have specificity, one molecule at the time is allowed to bind to carrier protein and is released on the other side of the membrane. (wn.com)

In mice, for example, scientists found an adapter protein that regulates this redirection. (tum.de)

The students will also be trained advanced optical imaging techniques to track cellular and intracellular transport in live cells. (ibecbarcelona.eu)
Since in the pancreatic exocrine cell synthesis and intracellular transport of secretory proteins can be uncoupled (1), it is possible to examine separately the metabolic requirements of the latter process. (rupress.org)
To monitor the intracellular transport dynamics of AtGRP7-DRONPA-s, we set up a single-molecule sensitive confocal fluorescence microscope. (uni-bielefeld.de)

abstract = "We have analyzed how the signal sequence of prepro-alpha-factor is recognized during the first step of posttranslational protein transport into the yeast endoplasmic reticulum. (edu.au)

Genetic analysis shows that Wim, Polaris and the IFT motor protein Kif3a are required for Hedgehog signalling at a step downstream of Patched1 (the Hedgehog receptor) and upstream of direct targets of Hedgehog signalling. (nih.gov)
The increased unfolded protein response in rock1 plants and suppression of phenotypes caused by the defective brassinosteroid receptor bri1-9 strongly suggest that the ROCK1 activity is an important part of the ER quality control system, which determines the fate of aberrant proteins in the secretory pathway. (ru.nl)
Here we show that adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr −/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively. (nature.com)
Mrx15 contacts mitochondrial translation products during their synthesis and plays, together with the ribosome receptor Mba1, an overlapping role in cotranslational protein insertion. (molbiolcell.org)

Carrier proteins are proteins involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane. (wikipedia.org)
These mechanisms of movement are known as carrier-mediated transport. (wikipedia.org)
Each carrier protein is designed to recognize only one substance or one group of very similar substances. (wikipedia.org)
Research suggests that potassium, calcium and sodium channels can function as oxygen sensors in mammals and plants, and has correlated defects in specific carrier proteins with specific diseases. (wikipedia.org)
A membrane transport protein (or simply transporter) is a membrane protein that acts as such a carrier. (wikipedia.org)
Porin/VDAC acts as coupling factor to stimulate the import of carrier proteins into the inner mitochondrial membrane. (phys.org)
The import of carrier proteins is particularly important for mitochondrial metabolism. (phys.org)
How the single transport steps of the carrier import pathway are connected to each other was not previously known. (phys.org)
Dr. Lars Ellerieder from Thomas Becker`s research lab showed that porin/VDAC stimulates the import of carrier proteins into the inner membrane . (phys.org)
The proteins binds to carrier precursors in the intermembrane space, to the TOM complex and the carrier translocase. (phys.org)
Thus, porin/VDAC spatially links the single transport steps, and thereby stimulate import of carrier proteins. (phys.org)
The researchers demonstrate that mitochondrial metabolite and protein transport are connected: "The role of porin/VDAC in protein transport could represent an elegant mechanism to fine-tune import of carrier proteins and therefore eventually metabolite transport to meet the requirements of the cell," explains Becker. (phys.org)
Carrier proteins use a process called carrier mediated transport to assist molecules across the cell membrane. (web.app)
Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) Carrier proteins required for faciliated transport and active transport. (web.app)
Press & media - en kunskapsbas om Carrier Transport Välkommen till Carriers sidor med pressinformation, kontaktvägar och bilder för redaktionell användning. (web.app)
Hydrophobic inner mitochondrial membrane proteins with internal targeting signals, such as the metabolite carriers, use the carrier translocase (TIM22 complex) for transport into the inner membrane. (web.app)
Carrier proteins are the other type of transport molecules found in the cell membrane. (web.app)
The binding of the molecule to the carrier protein changes the conformation of the latter. (web.app)
A carrier protein is a transport protein that is specific for an ion, molecule, or group of substances. (web.app)
Carrier proteins are proteins that carry substances from one side of a biological membrane to the other. (web.app)
Many carrier proteins are found in a cell 's membrane, though they may also be found in the membranes of internal organelles such as the mitochondria, chloroplasts, nucleolus, and others. (web.app)
Hepatic carrier-mediated membrane transport of the compounds. (web.app)
av S Cherukuri · 2005 · Citerat av 151 - The essential role of ferroportin in iron transport from enterocytes, as well as but it likely involves oxidation to ferric ion to increase binding to its carrier protein, Global variability analysis of mRNA and protein concentrations across and within Coexistence of passive and carrier-mediated processes in drug transport. (web.app)
808, 2378, _AQGEPVAGHES(ph)PK_, D6REX3, Protein transport protein Sec31A _ASPGTPLS(ph)PGSLR_, E1P5H9, Solute carrier organic anion transporter Title of thesis: Functional and structural study of Solute Carrier (SLC) proteins use ofMemStar has facilitated struc- tural studies of several transport proteins. (web.app)
Chapter 15: Intracellular Compartments and Protein Transport av MG till startsidan Sök - sjukdom som orsakas av en förändring i hemoglobin (Hb), det protein som ger Dessutom sker en onormal aktivering av transportkanaler i Americas GS1 Data matrix is a machine-readable, 2-dimensional data carrier. (web.app)
23 May 2020 Carrier proteins are also used in active transport for the movement of molecules with the expense of energy. (web.app)
Research has correlated defects in specific carrier proteins with specific diseases. (wn.com)
In the 1970s, mitochondrial pyruvate carrier (MPC) proteins were predicted to import pyruvate from the cytoplasm into mitochondria for cellular respiration. (gpmpi.net)
Fluorescence recovery after selective photoswitching experiments revealed that AtGRP7-DRONPA-s reaches the nucleus by carrier-mediated transport. (uni-bielefeld.de)

A List of types of proteins is part of on-going attempts to manage the large amounts of information concerning genes and proteins . (bionity.com)

Here, by employing a systematic mass spectrometry-based approach, we discovered the previously uncharacterized membrane protein Mrx15 that interacts via a soluble C-terminal domain with the large ribosomal subunit. (molbiolcell.org)

an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. (jove.com)
The cell's ability to selectively transport molecules across its membranes is critical for its survival. (gpmpi.net)

These proteins recognize specific nucleotide sequences or stem-loop structures formed by the mRNA and can bind different types of mRNA with similar binding features. (jove.com)
Nucleotide Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Nucleotide Transport Proteins" by people in this website by year, and whether "Nucleotide Transport Proteins" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Nucleotide Transport Proteins" by people in Profiles. (rush.edu)

Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. (nih.gov)
Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. (elifesciences.org)
Membrane Association and Remodeling by Intraflagellar Transport Protein IFT172. (nih.gov)

Szent-Gyorgyi's theory of cancer was based on his idea that the electron transport (charge transfer) essential to biological energy processes occurred via the structural proteins in cells. (nih.gov)

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. (bionity.com)
Second, we designed our lesson so that students would learn how scientists identify the proteins that are responsible for transport of a molecule using biochemical and genetic experiments. (gpmpi.net)

Fish and amphibians also have a protein corresponding to the mammalian adapter. (tum.de)
Aster proteins facilitate nonvesicular plasma to ER cholesterol transport in mammalian cells. (nih.gov)

TRO-sulfate (TS), the major TRO metabolite, inhibited TCA transport in plasma membrane vesicles overexpressing the efflux protein multidrug resistance-associated protein 4 (MRP4). (unc.edu)
ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. (ox.ac.uk)

As an excursion, the physiological contribution of transport proteins that are involved in C 4 metabolism is discussed. (nih.gov)
A detailed modeling & simulation program for in vitro metabolism & transport studies. (simulations-plus.com)

Here the motor proteins which move the pigments organelles are subject to different regulatory mechanisms, and there is no interaction between the different cytoskeleton networks", says Ökten. (tum.de)
However, they may have additional roles on the regulation of organelle transport by their interaction with motor proteins on the microtubules. (go.jp)

See the Integral membrane proteins category of wikipedia. (bionity.com)

Mitochondria further depend on the import of about 1,000 types of protein from the cytosol. (phys.org)
Researchers at the University of Freiburg discovered an unexpected function of the metabolite channel porin/VDAC in protein import into mitochondria. (phys.org)
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. (phys.org)
Taken together, our data reveal how these ribosome receptors organize membrane protein biogenesis in mitochondria. (molbiolcell.org)

The proteins may assist in the movement of substances by facilitated diffusion (i.e., passive transport) or active transport. (wikipedia.org)
The transport proteins that carry those molecules across the membrane via facilitated diffusion are specific for those molecules. (gpmpi.net)
While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division students' understanding of the proteins that mediate these forms of transport. (gpmpi.net)
Thus, life science students need a broad understanding of transport mechanisms such as diffusion, facilitated diffusion, and active transport, as well as the proteins that mediate these mechanisms. (gpmpi.net)

As a second set of experiments, we investigated the effects of modulating cAMP dependent protein kinase pathway on organelle transports in primary sensory neurons, where high-molecular-weight tau protein is the major MAP. (go.jp)
Amyloid-beta and Tau proteins are associated with Alzheimer's, and in all these cases, the critical element in the pathology is how these molecules are transported across neurons and the blood-brain barrier (BBB). (ibecbarcelona.eu)

In each case, the effect on transport was assessed by measuring the amount of labeled secretory proteins found in zymogen granule fractions isolated from the corresponding slices. (rupress.org)
This assay is actually a measure of the efficiency of transport of secretory proteins from the cisternae of the rough endoplasmic reticulum (RER) to the condensing vacuoles of the Golgi complex which are recovered in the zymogen granule fraction (16). (rupress.org)

Specifically, we want to understand the very early changes in insulin signalling and glucose transport in mature adipocytes, and how this is related to cell size. (lu.se)
Faciliated Transport Passage of molecules such as glucose and amino acids across the plasma membrane, even though they are not lipid soluble. (web.app)
Glucose transport proteins only carry glucose in and amino acid transport proteins only carry amino acid in. (gpmpi.net)

This Funding Opportunity Announcement (FOA) issued by t he National Heart, Lung, and Blood Institute , National Institutes of Health (NIH), solicits research grant applications to delineate t he protein interactions and pathways governing membrane trafficking pathways operative in pulmonary health and disease and develop novel therapeutic interventions. (nih.gov)
The National Heart, Lung, and Blood Institute invites research grant applications to delineate the protein interactions and pathways governing membrane trafficking pathways operative in pulmonary health and disease and develop novel therapeutic interventions. (nih.gov)
Local activation of protein kinase pathways in the axon might play an important role on the segregation of microtubules serving for either organelle transport or cytoskeletal architecture. (go.jp)

The Membrane Transport Proteins GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. (grc.org)
In addition, a Gordon Research Seminar (GRS) on Membrane Transport Proteins will be held immediately prior to the conference. (grc.org)
This GRC will be held in conjunction with the "Membrane Transport Proteins" Gordon Research Seminar (GRS). (grc.org)
av N Petri · 2005 · Citerat av 2 - Involvement of Membrane Transport proteins in Intestinal Absorption and. (web.app)
The Transporter Classification Database (or TCDB ) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins , including ion channels . (wikipedia.org)
This role-play case study teaches students about plasma membrane transport and the functions of transport proteins in the phospholipid bilayer. (gpmpi.net)
Lessons exist for helping introductory biology students understand the basics of membrane transport. (gpmpi.net)
We wanted students in our upper-division Cell Biology course to use their basic understanding of membrane transport concepts to gain a deeper understanding of the mechanisms involved. (gpmpi.net)

The first part is about the blood-brain barrier, or BBB in short, to peptides and proteins with a discussion of flow-independent influx transport systems. (hstalks.com)
The second part addresses influx transport of neurotrophic peptides and proteins. (hstalks.com)

A vesicular transport protein is a transmembrane or membrane associated protein. (wikipedia.org)
The transmembrane domain 6 of vacuolar H(+)-pyrophosphatase mediates protein targeting and proton transport. (genscript.com)
Cross-linking studies indicate that the signal sequence interacts in a Kar2p- and ATP-independent reaction with Sec61p, the multispanning membrane component of the protein-conducting channel, by intercalation into transmembrane domains 2 and 7. (edu.au)

The PINOID gene was recently cloned and found to encode a protein-serine/threonine kinase. (biologists.com)
Here we show that the PINOID gene is inducible by auxin and that the protein kinase is present in the primordia of cotyledons, leaves and floral organs and in vascular tissue in developing organs or proximal to meristems. (biologists.com)

Proteins are large, complex molecules that play many critical roles in the body. (medlineplus.gov)

Meanwhile, mutations at L307 and N318 completely abolished the targeting of the enzyme, causing broad cytosolic localization and implicating a possible role of these residues in protein translocation. (genscript.com)

For example, mRNA is exported through the nuclear pore complexes with the help of an exporter protein, which is a heterodimer of nuclear export factor 1 and nuclear export transporter 1. (jove.com)
In this Lesson, students will use their background knowledge of transport mechanisms to analyze data from those papers to determine which of the predicted MPC proteins are actually part of the mitochondrial pyruvate transporter. (gpmpi.net)

His lab uses such mice to understand how cholesterol transport works. (nih.gov)
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. (nature.com)

All cells of higher organisms are permeated by a cytoskeleton that essentially consists of actin filaments and small protein tubes called microtubules. (tum.de)
For this purpose they are actively transported by molecular motors on the microtubules and actin filaments. (tum.de)
Myosin transports its freight via the actin network, but the adapter protein also interacts with the microtubules and can redirect the transport on this network. (tum.de)
The scientists found out that the mouse adapter protein as well as the clawed frog adapter protein has a specific domain which enables the switching between the transport of actin and microtubules. (tum.de)

The mitochondrial ribosomes (mitoribosomes) synthesize, almost exclusively, membrane proteins that are subunits of oxidative phosphorylation complexes. (molbiolcell.org)

The structures have provided valuable insight into the structural basis of transport. (nih.gov)
The trans -acting elements include mRNA binding proteins that recognize specific sequences or structures formed by the mRNA and, together with RNA, form heterogeneous nuclear ribonucleoprotein particles. (jove.com)
Often, this is triggered by the accumulation of misfolded proteins that aggregate into structures that induce inflammation and ultimately degeneration. (ibecbarcelona.eu)
Yet these natural protein structures carry an evolutionary legacy of complexity and fragility that encumbers protein reengineering efforts and obfuscates the underlying design rules for light-driven charge separation. (nature.com)
Cells use bubblelike structures called vesicles (yellow) to import, transport and export cargo and in cellular communication. (nih.gov)
Some of the toughest challenges in treating disease are presented by "undruggable" proteins whose structures and roles in disease are known but are seemingly unable to be targeted by drugs that will bind to them. (phys.org)
Students act out the parts of molecules and structures in a fantastical cellular world where the unionized transport proteins have called for a work stoppage. (gpmpi.net)

This review presents a timely state of knowledge with regard to metabolite channeling in PR and the participating proteins. (nih.gov)
The research labs of Dr. Thomas Becker and Dr. Nikolaus Pfanner from the Institute for Biochemistry and Molecular Biology at the University of Freiburg have reported a function of the metabolite channel of the mitochondrial outer membrane in protein transport. (phys.org)
2019): Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to inner membrane. (phys.org)

In this work, molecular dynamics simulations used to understand the interactions of SYT with phospholipid bilayers and SNARE proteins in an effort to elucidate the process of membrane fusion at the atomic level. (aiche.org)
The potential of mean force (PMF) between SYT and phospholipid bilayers is calculated using the adaptive biasing technique [7] and shows that Ca 2+ binding to SYT is required creates favorable protein bilayer interactions that lead to the insertion of SYT. (aiche.org)
ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites? (nih.gov)

mRNA in these particles is then exported through nuclear pore complexes with the help of exporter proteins that associate with both the mRNA and the nuclear pore complexes. (jove.com)
Natural photosynthetic protein complexes capture sunlight to power the energetic catalysis that supports life on Earth. (nature.com)

The transport of mRNAs from the nucleus to specific locations in the cytoplasm is a highly regulated process aided by a variety of cis- and trans -acting elements. (jove.com)
Nucleus-specific proteins detach from the mRNA before it is exported to the cytoplasm while exporter proteins leave the mRNA in the cytoplasm and return to the nucleus for further mRNA export. (jove.com)
DRONPA-s fused to the RNA-binding protein AtGRP7 (Arabidopsis thaliana glycine-rich RNA-binding protein 7) under control of the endogenous AtGRP7 promoter localizes to cytoplasm, nucleoplasm and nucleolus of transgenic Arabidopsis plants. (uni-bielefeld.de)

The PDR1-3 gain-of-function mutant was then used to overproduce Yor1p up to 10% of the total plasma membrane proteins. (ox.ac.uk)

Recombinant mouse ATPase, Na+/K+ transporting, beta 3 polypeptide with N-terminal Fc fusion tag was expressed in E. coli. (creativebiomart.net)
These results suggest a general mechanism by which the signal sequence could open the channel for polypeptide transport. (edu.au)

Free ribosomes bind to mRNA and start the process of the translation to produce proteins. (jove.com)
Various proteins bind to the pre-mRNA during these modifications. (jove.com)
These proteins bind and carry atoms and small molecules within cells and throughout the body. (medlineplus.gov)

Transport-mediated translocation of molecules across membranes. (nih.gov)
Therefore, metabolites have to be transported across the two surrounding membranes. (phys.org)
Proteins involved in the transport of nucleobases such as PYRIMIDINES and PURINES across membranes. (ucdenver.edu)
Proteins involved in the transport of NUCLEOTIDES across cellular membranes. (rush.edu)
Whether transport of molecules occurs across the cell membrane or the membranes of organelles, regulation of molecular gradients is important for proper cellular function. (gpmpi.net)

The translocase of the outer membrane, also termed TOM complex, forms the entry gate for the precursor proteins. (phys.org)
The University of California at Los Angeles professor presented recent research that could explain how high-density lipoprotein (HDL), also known as good cholesterol, is transported from a cell's outer membrane into specialized areas within the cell. (nih.gov)

Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)

The synthetic protein, DRONPA-s, shows photochemical properties and switching behavior comparable to that of the original DRONPA from Pectiniidae both in vitro and in vivo. (uni-bielefeld.de)

Such research on the basics of cholesterol transport in animal models could lend insight into potential therapies for humans with high cholesterol and other lipid disorders. (nih.gov)
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. (nih.gov)
The binding site is located at the interface of the protein channel and the lipid bilayer. (edu.au)

As stated earlier, the makeup of the amino acid Passive and Active Cell Transport Word Wall Cards (Diffusion and Osmosis etc. (web.app)
Proteins are made up of hundreds or thousands of smaller units called amino acids, which are attached to one another in long chains. (medlineplus.gov)
There are 20 different types of amino acids that can be combined to make a protein. (medlineplus.gov)

that is, they exist within and span the membrane across which they transport substances. (wikipedia.org)
They are often designed this way because they transport substances against their concentration gradient. (web.app)

In this sense, phosphorylation of MAPs can be a good candidate for the molecular switch to regulate the organelle transport. (go.jp)
Synaptotagmin (SYT) and SNAREs have been identified as critical proteins that regulate membrane fusion in concert with Ca 2+ [1, 2]. (aiche.org)
Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments. (nih.gov)

The results indicate that transport is insensitive to glycolytic inhibitors (fluoride, iodoacetate) but is blocked by respiratory inhibitors (N 2 , cyanide, Antimycin A) and by inhibitors of oxidative phosphorylation (dinitrophenol, oligomycin). (rupress.org)

The textbook Molecular Biology of the Cell (4th edition, 2002), from the NCBI Bookshelf, offers a detailed introduction to protein function . (medlineplus.gov)

In this study we use the yeast two-hybrid assay and co-immunoprecipitation to show that tTG interacts with the nuclear transport protein importin-alpha3. (nih.gov)

Although the pathway and the enzymes catalyzing the biochemical reactions have been the focus of research for the last several decades, the knowledge about transport proteins involved in PR is still limited. (nih.gov)
Defects in this transport pathway have been associated with neurodegenerative disorders. (web.app)

If the synthesized protein is a cell surface or secreted protein, its target peptide sequence will be recognized, and the whole complex of the mRNA, ribosome, and newly synthesized peptide will be transferred to the surface of the endoplasmic reticulum for further synthesis. (jove.com)
Experiments with radio-labelled derivatives of indole-3-acetic acid (IAA), the predominant naturally occurring auxin, indicated that IAA is transported downward from its main site of synthesis, the shoot tip, to the root. (biologists.com)

Some mRNAs are transported to a specific location as directed by their zip-code sequences before starting protein production and remain translationally inactive until they reach their target location. (jove.com)

These data suggest that importin-alpha3 could mediate active nuclear transport of tTG which may be important for the regulation of critical cellular processes. (nih.gov)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (wakehealth.edu)

Anatomy37

Organisms18

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes56

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science3

Health Care1

Transporters6

Organism5

Channel proteins3

Side of the membrane4

Regulates1

Intracellular transport3

Abstract1

Receptor4

Carrier29

Genes1

Previously uncharacterized1

Selectively2

Nucleotide4

Intraflagellar transport3

Structural proteins1

Molecule2

Mammalian2

Multidrug2

Metabolism2

Motor proteins2

Integral1

Mitochondria4

Facilitated diffusion4

Neurons2

Secretory2

Glucose3

Pathways3

Membrane Transport8

Peptides2

Transmembrane3

Kinase2

Molecules that play1

Residues in protein1

Transporter2

Mice2

Actin4

Subunits1

Structures7

Metabolite3

Phospholipid3

Complexes2

Cytoplasm3

Plasma membrane1

Polypeptide2

Bind3

Membranes5

Outer membrane2

Genetic1

VIVO1

Lipid3

Amino3

Substances2

Regulate3

Oxidative phosphorylation1

Molecular Biology1

Interacts1

Pathway2

Synthesis2

Sequences1

Regulation1

Vesicular1