• Pathways for water and plasma proteins across the endothelial barrier that may be regulated by ANP. (jci.org)
  • A ) Pathways for plasma protein transport across the endothelial permeability barrier that ANP may modulate, including water and plasma transport through the interendothelial cleft at sites where there are infrequent breaks in the junctional strand (see refs. (jci.org)
  • In conclusion, the bidirectional transport of glutamine, glutamate, and aspartate by SLC38A10, and the immunostaining detected in neurons and astrocytes, suggest that SLC38A10 plays a role in pathways involved in neurotransmission. (diva-portal.org)
  • In addition to Cu acquisition, SPL7 triggers the expression of various microRNAs, denoted Cu-microRNAs, which promote the degradation of the transcripts encoding for dispensable Cu-utilizing proteins, including cytosolic Cu/Zn-SOD ( CSD1 ), chloroplast stroma Cu/Zn-SOD ( CSD2 ), several laccases, and plantacyanin [ 9 , 14 - 16 ]. (hindawi.com)
  • Thereby, Xdj1 promotes the transfer of precursory proteins from the cytosolic chaperones to the TOM complex to initiate their import into the mitochondria . (phys.org)
  • Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis, Cell Reports (2018). (phys.org)
  • You can select a given mouse superfamily member and download (or forward to NCBI BLAST) FASTA formatted protein sequences of that mouse gene and its mouse, human and rat homologs, as defined in the corresponding HomoloGene Class. (jax.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • One of these polypeptides, termed Erv14p (ER-vesicle protein of 14 kD), corresponds to an open reading frame on yeast chromosome VII that is predicted to encode an integral membrane protein and shares sequence identity with the Drosophila cornichon gene product. (psu.edu)
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • 4 Circadian clock proteins interact with E-box response elements in target gene promoters to affect transcriptional regulation. (ahajournals.org)
  • This gene encodes a member of the WD repeat protein family. (antibodies-online.com)
  • Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
  • These two configurations are known as the T or tense structure where the protein has a low affinity for oxygen and the R or relaxed structure where oxygen binds with higher affinity. (kenyon.edu)
  • The closed BBSome complex (green) binds the intraflagellar transport machinery (IFT, blue) at the base of the cilium and starts travelling towards the tip of the cilium along a structure called the axoneme (grey), which is formed by microtubules. (elifesciences.org)
  • Once near the tip, the complex binds ARL6, becoming activated, and it can take ciliary membrane proteins (red) as cargo and transport them to the base of the cilium. (elifesciences.org)
  • In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)
  • Half a century later this idea has turned into one of the most studied of all transporter proteins (SGLT1), the sodium-glucose cotransporter. (wikidoc.org)
  • The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. (sigmaaldrich.com)
  • The lipid A-core moiety and the O-antigen repeat units are synthesized at the cytoplasmic face of the IM and are separately exported via two independent transport systems, namely, the O-antigen transporter Wzx ( 13 , 17 ) and the ATP binding cassette (ABC) transporter MsbA that flips the lipid A-core moiety from the inner leaflet to the outer leaflet of the IM ( 12 , 28 , 45 ). (asm.org)
  • It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
  • Transport of proteins into and out of the nucleus occurs through nuclear pore complexes (NPC). (nih.gov)
  • Two additional proteins, the GTPase Ran and p10, are required to translocate the docked NLS protein into the nucleus. (nih.gov)
  • The retina projects proteins into more than 30 different areas of the central nervous system, but for the study, her team chose to evaluate the two major targets: the superior colliculus (which analyzes motion in the visual field and controls goal-directed head and eye movements), and the lateral geniculate nucleus (which analyzes the shape of objects we see and sends that information to a higher brain area, the visual cortex). (innovations-report.com)
  • These are proteins that are usually in the nucleus of a cell, but we found them far, far away from the nucleus, participating in some form of communication. (innovations-report.com)
  • Transport of maize streak virus (MSV) DNA into the nucleus of host cells is essential for virus replication and the presence of virus particles in the nuclei of infected cells implies that coat protein (CP) must enter the nucleus. (apsnet.org)
  • Both ss and ds DNA moved into the nucleus when co-injected with the CP but not with E. coli proteins alone. (apsnet.org)
  • These results suggest that, in addition to entering the nucleus where it is required for encapsidation of the viral ss DNA, the MSV CP facilitates the rapid transport of viral (ss or ds) DNA into the nucleus. (apsnet.org)
  • Although some of these nucleus-bound cargoes are essential for life, others cause disease, and researchers have been looking for ways to disrupt the transport chain that can fuel infection and cancer alike. (jefferson.edu)
  • Most importins, like the importin a1, tow upwards of 500-600 different proteins into the nucleus. (jefferson.edu)
  • ASK1 will be transported to the nucleus when UV-irradiation is used to treat the cell. (wikipedia.org)
  • A related system operates in bacteria, apparently for the export of redox cofactor-containing proteins. (asknature.org)
  • A heterodimeric protein complex, composed of karyopherin alpha and beta (or importin alpha and beta) functions to target proteins containing a nuclear localization sequence (NLS) to the NPCs. (nih.gov)
  • The number of protein sequences returned does not always match the numbers of homologs shown, because the same protein sequence can be associated with multiple homologs. (jax.org)
  • For mouse superfamily members not included in any HomoloGene Class, only the mouse protein sequence is returned. (jax.org)
  • View conserved domains detected in this protein sequence using CD-search. (nih.gov)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Despite exceptional sequence diversity, S-layer proteins (SLPs) share important characteristics such as their ability to form crystalline sheets punctuated with nano-scale pores, and their propensity for charged amino acids, leading to acidic or basic isoelectric points. (nature.com)
  • In response to Cu limitation, Arabidopsis master Cu homeostasis regulator SPL7 (SQUAMOSA promoter-binding protein-like 7), similar to Chlamydomonas reinhardtii Crr1 transcription factor [ 8 ], activates the expression of multiple genes that contain within their promoter repetitive Cu-responsive elements (CuREs) with a GTAC motif as the essential core sequence [ 9 - 11 ]. (hindawi.com)
  • The [ 3 H]LTC 4 -labeled 190-kilodalton protein was immunoprecipitated by an antiserum against the COOH-terminal sequence of multidrug resistance-associated protein. (aacrjournals.org)
  • Researchers reveal that the protein RCC1's overall structure, not its distinct amino acid sequence, determines whether it's fast-tracked into nuclei. (jefferson.edu)
  • Retention within the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible for preventing secretion of proteins from the lumen of the ER in eukaryotic cells. (wikipedia.org)
  • In this project, the first goal is to design a plan to extend already successful in vitro biophysical research on copper transport proteins to (1) zinc and manganese transport proteins, for which less is known, and to (2) in vivo conditions exploring diseases related to problems with metal transport. (stias.ac.za)
  • Thylakoids require the coordinated expression of both nuclear- and plastid-encoded proteins to allow rapid response to changing environmental conditions. (springer.com)
  • and proteins that play a direct role in the transport of karyopherin complexes through the nuclear pore complex. (harvard.edu)
  • Mutagenesis of a potential nuclear localization signal in the CP resulted in cytoplasmic accumulation of the mutant protein. (apsnet.org)
  • To investigate if CP might also be involved in viral DNA nuclear transport, Escherichia coli -expressed CP, together with TOTO-1-labeled viral ss or ds DNA, was microinjected into maize and tobacco epidermal cells. (apsnet.org)
  • The importin a3 molecule, or "car," is one of a family of importin proteins that help ferry other proteins across the nuclear membrane where they can alter the course of DNA transcription. (jefferson.edu)
  • Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. (wikipedia.org)
  • In vitro and in vivo measurement of defined cargoes and motors indicated that opposing motors are simultaneously engaged on cargoes that undergo bidirectional transport and suggest a potential for regulation during activation by controlling motor type and number. (jneurosci.org)
  • It could be proposed therefore that directed ZBP1 transport is carried out by and requires a fine-tuned regulation of multiple microtubule and actin motors. (jneurosci.org)
  • A potential role for guanine nucleotide-binding protein in the regulation of endosomal proton transport. (jci.org)
  • The current study aimed to investigate radiation-induced regulation of iron proteins including ferritin subunits in rats. (hindawi.com)
  • They also show that the BC3H-1 myocyte is not a good model for studying regulation of glucose transport in skeletal muscle. (osti.gov)
  • The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. (ahajournals.org)
  • These data support a role for the circadian clock protein Per1 in the coordinate regulation of genes involved in renal sodium reabsorption. (ahajournals.org)
  • The SemiSWEETs, among the smallest known transport proteins, assemble in pairs, thereby creating a structure that looks like their bigger plant and human SWEET homologs. (eurekalert.org)
  • Scientists at the University of Groningen studied the structure of a transport system that allows bacteria to pick up aspartate, a building block for proteins, from their environment. (rug.nl)
  • The structure of a transport complex used by bacteria to import aspartate has been mapped in unique detail by University of Groningen scientists. (rug.nl)
  • We have identified sister of open brain ( sopb ), a null allele of mouse Intraflagellar transport protein 122 ( Ift122 ). (pnas.org)
  • The researchers tested three Amt proteins that are present in the bacteria and also determined the speed with which they allow ammonium to pass through the membrane. (innovations-report.com)
  • Based on the preliminary analysis of the ABC transport systems of the bacteria we chose, we hypothesized that it would have different affinities for different carbohydrates", says Dr. Kanaujia. (indiatimes.com)
  • Nanowerk News ) A Kansas State University-led study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery. (nanowerk.com)
  • The membrane protein TonB plays an indispensable role in the uptake of iron by Gram-negative bacteria -- a classification of bacteria that is more resistant to antibiotics because of a nearly impenetrable cell wall. (nanowerk.com)
  • A team of scientists led by Prof. Dr. Susana Andrade from the Institute of Biochemistry of the University of Freiburg and the Cluster of Excellence BIOSS Centre for Biological Signalling Studies has now determined the transport properties of Amt proteins with great precision on the basis of electrophysiology tests on artificial lipid systems. (innovations-report.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • The team recently published a study ( 'Controlled delivery of hollow corn protein nanoparticles via non-toxic crosslinking: in vivo and drug loading study' ) detailing the performance of a custom nanoparticle made from zein, a corn-based protein whose biological properties make it an appealing vehicle for delivering therapeutic drugs throughout the body. (nanowerk.com)
  • Copper (Cu) is an essential micronutrient for all eukaryotes because it participates as a redox active cofactor in multiple biological processes, including mitochondrial respiration, photosynthesis, oxidative stress protection, and iron (Fe) transport. (hindawi.com)
  • Alcock F, Baker MA, Greene NP, Palmer T, Wallace MI, Berks BC (2013) Live cell imaging shows reversible assembly of the TatA component of the twin-arginine protein transport system. (springer.com)
  • A new study from Scripps Research , which appears this month in Cell Reports , examines these proteins in unprecedented detail--providing surprising new insights into how visual signals are distributed to different regions of the brain. (innovations-report.com)
  • Because this type of neuronal protein exists in other parts of the body, it may play a role in other nerve-cell communication disorders such as Charcot-Marie-Tooth disease. (innovations-report.com)
  • Live cell imaging of mCherryZBP1 in neurons expressing GTD showed an increase in the number of motile particles, run length, and stimulated anterograde moving ZBP1 particles, suggesting that MyoVa controls availability of ZBP1 for microtubule-dependent transport. (jneurosci.org)
  • Aspartate is picked up from the environment, transported through the cell membrane and released on the inside of the cell. (rug.nl)
  • Homologous sequences are present in several other localized mRNAs, suggesting that the RTS represents a general transport signal in a variety of different cell types. (rupress.org)
  • In order to function properly, mitochondria are dependent on roughly 1,000 kinds of proteins, which are imported from the cytosol, the fluid inside the cell. (phys.org)
  • In this study, Dr. Cingolani's "cargo" was the RCC1 protein, which has a multitude of functions in the cell, and without which, the cell dies. (jefferson.edu)
  • Phospholipase C from Clostridium perfringens (PLC-Cp), which generates diacylglycerol from membrane phospholipids, and 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) induced increases in glucose transport activity (assessed using 3-O-methylglucose transport) that were approximately 80 and approximately 20% as great, respectively, as that induced by a maximal insulin stimulus. (osti.gov)
  • Neither the submaximal nor maximal effects of PLC-Cp and insulin on glucose transport were additive, suggesting that PLC-Cp interferes with insulin action. (osti.gov)
  • In contrast, there was no additive effect on glucose transport with the combination of AICAR plus contraction. (diabetesjournals.org)