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  • peptides
  • Furthermore, perturbing ADAM10/SAP97 association in vivo by cell-permeable peptides impairs ADAM10 localization in postsynaptic membranes and consequently decreases the physiological amyloid precursor protein (APP) metabolism. (jneurosci.org)
  • furthermore, proteins are digested into peptides for MHC class I antigen presentation. (wikipedia.org)
  • functional
  • Structural and functional studies of ALS-associated proteins and their disease-linked variants have significantly contributed to our current understanding of the mechanisms of disease development and progression. (biomedcentral.com)
  • therapeutic
  • 11-13 Although NEP1-40 peptide seems to be a potential candidate for therapeutic intervention after CNS injury, for many years delivery of these therapeutic proteins into the brain parenchyma has been limited because of the obstacle of the blood-brain barrier (BBB). (asahq.org)
  • The ligand-regulated transactivation system was used to test the therapeutic efficiency of the tumor suppressor protein p53 in HepG2 (p53(+/+)) and SKBr3 (p53(-/-)/mutant-p53(+/+)) cells in culture and tumor xenografts in living mice. (nih.gov)
  • BMLF1
  • BMLF1 expression gave a heterogeneous protein pattern, with molecular sizes between 45 and 70 kDa, including a predominant 60-kDa protein detected in different B-cell lines. (uni-regensburg.de)
  • neuroprotective
  • 14 have demonstrated that systemic delivery of neuroprotective protein Bcl-xL does not lead to protection after focal cerebral ischemia. (asahq.org)
  • interaction
  • However, the precise mechanisms and outcomes of transactivator-TFIID interaction remain unclear. (pubmedcentralcanada.ca)
  • Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. (semanticscholar.org)
  • In fact, we report that synapse-associated protein-97 (SAP97), a protein involved in dynamic trafficking of proteins to the excitatory synapse, is responsible for driving ADAM10 (a disintegrin and metalloproteinase 10, the most accredited candidate for α-secretase) to the postsynaptic membrane, by a direct interaction through its Src homology 3 domain. (jneurosci.org)
  • membrane
  • The PSD is a highly organized biochemical organelle that segregates, in a highly ordered array, membrane receptors and signaling elements clustered through a family of linker proteins, i.e., the membrane associated guanylate kinase (MAGUK). (jneurosci.org)
  • Family
  • The basic region is involved in RNA (TAR, trans-activation response element) binding and Tat proteins thus belong to the family of arginine-rich motif (ARM) RNA binding proteins. (wikipedia.org)
  • indicate
  • Our data indicate that CREST and certain other ALS-linked proteins share several features implicated in ALS pathogenesis, namely the ability to aggregate, be recruited to stress granules and alter paraspeckle integrity. (biomedcentral.com)