So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikidoc.org)
MKP-1 −/− showed an aberrant regulation of several DUBs and increased expression of proteins and genes involved in IL-1/TLR signaling upstream of MAPK, including IL-1R1, IRAK1, TRAF6, phosphorylated TAK1, and an increased K63 polyubiquitination on TRAF6. (life-science-alliance.org)
MALT12
When T or B cells recognize a foreign substance, the CARD11 protein is turned on (activated) and attaches (binds) to two other proteins, BCL10 and MALT1, to form the CBM signalosome complex. (medlineplus.gov)
Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. (icr.ac.uk)
Kinase3
Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family. (wikipedia.org)
Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. (wikipedia.org)
Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. (affbiotech.com)
Adaptor1
SHP-2 can hamper the TRIF (TIR-domain-containing adapter-inducing interferon-β) adaptor protein-dependent TLR4 and TLR3 signal transduction with a consequent block of the pro-inflammatory cytokine production [ 7 ]. (biomedcentral.com)
CARD114
The CARD11 gene provides instructions for making a protein involved in the function of immune system cells called lymphocytes, particularly certain types called T cells and B cells. (medlineplus.gov)
The altered protein produced from the mutated copy of the gene interferes with the normal protein produced from the non-mutated copy of the gene (such mutations are described as "dominant-negative"), so the amount of functioning CARD11 protein in cells is reduced. (medlineplus.gov)
The mutations are described as "loss of function" because they lead to production of an abnormally short, nonfunctional CARD11 protein. (medlineplus.gov)
CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. (wikipedia.org)
Phosphorylation3
Tyrosine phosphorylation is a central mechanism in the control of key signaling proteins involved in innate immunity. (biomedcentral.com)
Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. (avivasysbio.com)
Ubiquitination and phosphorylation are reversible posttranslational protein modifications regulating physiological and pathological processes. (life-science-alliance.org)
Ubiquitin3
Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. (icr.ac.uk)
The ubiquitin-proteasome pathway: on protein death and cell life. (antikoerper-online.de)
Among abundant DUBs, ubiquitin-specific protease-13 (USP13), which cleaves polyubiquitin-chains on client proteins, was substantially enhanced in murine MKP-1-deficient BMDMs. (life-science-alliance.org)
BCL21
BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
Complexes1
This complex in turn activates other protein complexes called nuclear factor-kappa-B (NF-κB) and mTOR complex 1 (mTORC1), which are important for cellular signaling. (medlineplus.gov)
Antibody1
No antibody was detected against rat IgM or against non-immunoglobulin serum proteins. (srgroupchemical.com)
TRAF61
Bcl10 kann die K63-Polyubiquitinierung von NEMO stimulieren, und TRAF6 kann die Mono-Ubiquitinierung von NEMO oder die K63-Polyubiquitinierung von sich selbst katalysieren. (antikoerper-online.de)
Interactions1
It participates in signaling through highly specific protein-protein homophilic interactions. (wikipedia.org)
Macrophages2
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
Encodes2
Song et al identified a tumor suppressor gene that encodes the A-20 protein, which acts as an inhibitor to the NF-kappa-B pathway downstream from the tumor necrosis factor (TNF) receptor. (medscape.com)
The TEX101 gene is situated on individual chromosome 19q13.2 and encodes 249 proteins including a secretion indication peptide (1-25 proteins) in its N-terminus. (biospraysehatalami.com)
Accession1
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
PMID1
PMID:14996496, table 1 provides links to papers that describe subcellular location of many pro- and anti-apoptotic proteins. (geneontology.org)
Interaction2
This download is the types and cells led from a human assembly target content soccer methylated alongside the set of two interaction localizing enzyme proteins in New Zealand. (evakoch.com)
the interaction is inhibited by HTLV-1 protein Tax. (icr.ac.uk)
Expression2
Der gezielte Proteinabbau mit Hilfe der PROTAC-Technologie entwickelt sich zu einer neuartigen therapeutischen Methode, um Krankheiten wie Krebs zu bekämpfen, die durch die abnorme Expression eines krankheitsverursachenden Proteins verursacht werden. (antikoerper-online.de)
However prior studies in the distribution of TEX101 generally examined its mRNA level [11 14 15 To time systematic evaluation of TEX101 proteins expression has seldom been reported. (biospraysehatalami.com)
OMIM1
supplied by OMIM] CARD10 has been shown to interact with BCL10. (wikipedia.org)
Drugs1
Cermakova K, Hodges HC: "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation. (antikoerper-online.de)
Membrane2
loop kappa p21 D cell 4( ABCD4) is shown to reduce the CD127 performance of cobalamin( Cbl membrane parking B12) into the mitochondrion, interacting it ED for the composition of Cbl lives. (evakoch.com)
Bioinformatics evaluation implies that TEX101 is certainly a membrane GPI-anchored proteins using a conserved UPAR/Ly6 area indicating an identical protein framework as urokinase-type plasminogen activator receptor (uPAR) [1]. (biospraysehatalami.com)
Degradation1
Li X, Song Y: "Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy. (antikoerper-online.de)
Receptor2
ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
Here, we show that these characteristics of the Omicron spike protein are determined by its receptor-binding domain. (bvsalud.org)
Immune1
PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. (biomedcentral.com)
Cleavage2
Recent studies have revealed the unique virological characteristics of Omicron, particularly those of its spike protein, such as less cleavage efficacy in cells, reduced ACE2 binding affinity, and poor fusogenicity. (bvsalud.org)
Atmospheric pressure/matrix-assisted laser desorption ionization (AP/MALDI) mass spectra are reported and the data recorded, together with the introduction of a reduction/alkylation step, allows us to fully characterize the cleavage sites of the bovine insulin interacting with IDE. (cnr.it)
Mechanism1
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins. (opencampus.net)
Induction1
how to decide whether a protein is involved in '+ve reg of apoptosis or induction ([GO:0006917])?emily. (geneontology.org)
Target2
Tunable light and drug induced depletion of target proteins. (opencampus.net)
Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene. (wikipedia.org)
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. (wikipedia.org)
Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein. (opencampus.net)
Complex2
The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. (avivasysbio.com)
Cytochrome c then forms a multi-protein complex known as the 'apoptosome' and initiates activation of the caspase cascade through caspase 9. (geneontology.org)
Cells1
Conclusions Our data verified TEX101 to be always a testis protein that might be linked to the maturation procedure for man germ cells. (biospraysehatalami.com)
Factor1
The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. (opencampus.net)
Levels1
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). (affbiotech.com)
Production1
These mutations result in the production of an altered protein that does not function normally. (medlineplus.gov)
Type1
Following the indication peptide and its own C-terminus (223-249 proteins) are taken out TEX101 is changed into its mature type delivering a molecular fat of 21?kDa and an isoelectric stage of 4.7. (biospraysehatalami.com)