Protein superfamily channels. Medical search. Frequent questions

Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. (edu.sa)
The receptors belong to a superfamily that share a common CYSTEINE loop. (bvsalud.org)

We find that the electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily. (nih.gov)
Subunits share topology with all members of the cys-loop ligand-gated ion channel superfamily: a large extracellular N-terminal domain, four transmembrane domains (TM1-4), and a large intracellular loop between TM3 and TM4. (asahq.org)

The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. (wikipedia.org)
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. (thermofisher.com)
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. (thermofisher.com)
The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. (thermofisher.com)
The mRNA expression level of the ligand-gated cation channel 5-HTR 3 and the heptahelical 5-HTR 2A did not significantly change during maturation. (aai.org)

Avermectins interact with vertebrate and invertebrate GABA receptors and invertebrate glutamate-gated chloride channels. (nih.gov)
Though researchers' attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of the more unusual suspects, such as G-protein coupled receptors. (stanford.edu)
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. (thermofisher.com)
UT Southwestern researchers have identified the structure of a key member of a family of proteins called nicotinic acetylcholine receptors in three different shapes. (phys.org)
Nicotinic acetylcholine receptors are members of a broader super-family of proteins called Cys-loop receptors that function as ion channels on cell surfaces and are found in the membranes of many cell types. (phys.org)
When the right molecule settles on these receptors, it opens the gated channels, letting ions flood from the outside to the inside of cells to trigger other cellular processes. (phys.org)
Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)

CFTR belongs to the large ABC transporter superfamily, but is the only member known to function as an ion channel. (sorbonne-universite.fr)

SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

Voltage-gated sodium channels mediate a rapid and transient increase in Na + permeability in response to membrane depolarization, thereby contributing to the generation and conduction of action potentials. (jneurosci.org)
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction. (stanford.edu)
This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. (stanford.edu)
MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. (stanford.edu)
As the field continues to grow, so too will the list of proteins suspected to function as mechanosensors and the diversity of known MS membrane proteins. (stanford.edu)
The channels are important cellular switches which transduce changes in intracellular concentrations of cyclic nucleotides into changes of the membrane potential and the Ca2+ concentration. (cipsm.de)
Among these, the multidrug resistance-associated protein AtMRP5/AtABCC5 regulates stomatal aperture and controls plasma membrane anion channels of guard cells. (uea.ac.uk)
Further NOD1 Formulation modeling showed that the membrane binding region and the canonical switch I and II regions communicate across the protein by means of long-range side-chain interactions (21) in a conformational choice mechanism (22). (calcium-channel.com)
The most common type of albinism is caused by defects in a protein called OCA2, which is found in the membrane that surrounds melanosomes. (elifesciences.org)
propose that OCA2 is part of an ion channel that allows chloride ions to pass through the membrane, to make the melanosome less acidic and enable melanin to be produced. (elifesciences.org)
Ion channels are membrane proteins that regulate the concentration of key signaling ions to control a wide range of cellular functions. (elifesciences.org)
While plasma membrane ion channels have been extensively studied, much less is known about the identity and physiology of intracellular channels because they are less accessible to direct electrophysiological characterization. (elifesciences.org)
Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. (bvsalud.org)
Here we show by mass spectrometric analyses of enriched insoluble protein fractions that, unexpectedly, nucleus-encoded transporters are not inserted into the chromatophore inner envelope membrane. (frontiersin.org)
We hypothesize that these proteins are involved in modulating membrane permeability. (frontiersin.org)
12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)

TrkH belongs to a superfamily of K(+) transport proteins required for growth of bacteria in low external K(+) concentrations. (cornell.edu)

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. (nih.gov)
Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)

A C. elegans messenger RNA expressed in Xenopus oocytes encodes an avermectin-sensitive glutamate-gated chloride channel. (nih.gov)
To elucidate the structure and properties of this channel, we used Xenopus oocytes for expression cloning of two functional complementary DNAs encoding an avermectin-sensitive glutamate-gated chloride channel. (nih.gov)
Each receptor-channel complex consists of five homologous subunits arranged symmetrically around a gated chloride channel. (asahq.org)
Expression of OCA2 increases organelle pH, suggesting that the chloride channel might regulate melanin synthesis by modulating melanosome pH. (elifesciences.org)
Cystic fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein, altering chloride efflux in epithelial cells. (sorbonne-universite.fr)

It encodes contactin-associated protein 2 (CASPR2), a transmembrane protein from the neurexin superfamily, which is involved in neural-glia interactions and clustering of potassium channels in myelinated axons. (orpha.net)
The most common form of albinism is caused by mutations in oculocutaneous albinism II (OCA2), a melanosome-specific transmembrane protein with unknown function. (elifesciences.org)

The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. (edu.sa)
Kinact: a computational approach for predicting activating missense mutations in protein kinases. (lu.se)
Kin-Driver: a database of driver mutations in protein kinases. (lu.se)
wKinMut: an integrated tool for the analysis and interpretation of mutations in human protein kinases. (lu.se)

MAPKs are short for the mitogen-activated protein kinase family. (spandidos-publications.com)

Kv1.1 Potassium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)

The HVCN1 and Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of voltage gated ion channels. (wikipedia.org)
1. McKinnon D (1989) Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. (aspetjournals.org)

TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. (thermofisher.com)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. (cipsm.de)

In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. (edu.sa)
Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. (edu.sa)
In humans, CETN1, CETN2 and CETN3 genes code the protein. (prospecbio.com)
2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)

CYP2C9 is a gene that encodes the cytochrome P450, a superfamily of enzymes in the liver tasked with breaking down a wide range of medicines we commonly use to treat anything from inflammation to epilepsy. (sciencealert.com)

It imports hundreds of nucleus-encoded proteins, and diverse metabolites are continuously exchanged across the two chromatophore envelope membranes. (frontiersin.org)

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. (cathdb.info)

2012). Single-molecular artificial transmembrane water channels. (tcdb.org)
Probing molecular identity of native single potassium channels by overexpression of dominant negative subunits. (ucdenver.edu)
Major Conclusions: As(OH)3 and Sb(OH)3 behave as inorganic molecular mimics of glycerol a property that allows their passage through AQP channels. (techuniq.com)
Intracellular ion channels are essential regulators of organellar and cellular function, yet the molecular identity and physiological role of many of these channels remains elusive. (elifesciences.org)
Since most of the proteins inferred from genomic sequencing lack this structural information, the ab-initio prediction of disulfide bridges from protein sequences can be very useful in several molecular biology studies. (biomedcentral.com)
The molecular weight of the protein is 20 kDa. (prospecbio.com)
3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
Furthermore, by using refined sequence alignments and molecular dynamics simulations (now including advanced methods, such as metadynamics), we were able to understand the specific evolution of this member of the ABC transporter family towards a channel function, especially by highlighting the presence of cytoplasmic portals allowing ion flux from the cytosol. (sorbonne-universite.fr)

This graph shows the total number of publications written about "Kv1.1 Potassium Channel" by people in this website by year, and whether "Kv1.1 Potassium Channel" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Kv1.1 Potassium Channel" by people in Profiles. (ucdenver.edu)
Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits. (ucdenver.edu)
Primary sensory neurons express a Shaker-like potassium channel gene. (ucdenver.edu)
7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)

Furthermore, chromatophore-localized biosynthetic pathways as well as multiprotein complexes include proteins of dual genetic origin, suggesting that mechanisms evolved that coordinate gene expression levels between chromatophore and nucleus. (frontiersin.org)
Apparently these chromatophore-targeted proteins evolved convergently to plastid-targeted expression regulators and are likely involved in gene expression control in the chromatophore. (frontiersin.org)
9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)

For example, a negatively charged amino acid in a7's inner channel seems to draw in positively charged calcium from outside cells , explaining why a7 is so permeable to calcium. (phys.org)
The methods take advantage of two new decomposition kernels for measuring the similarity between protein sequences according to the amino acid environments around cysteines. (biomedcentral.com)
Classification of amino acid substitutions in mismatch repair proteins using PON-MMR2. (lu.se)
The Complementarity Between Protein-Specific and General Pathogenicity Predictors for Amino Acid Substitutions. (lu.se)

Many eukaryotic channels have four additional transmembrane helices (TM) (Pfam PF00520), related to or vestigial of voltage gating. (wikipedia.org)
Centrin is a type of protein that is essential for practically all eukaryotic cells. (prospecbio.com)

Cloned Kir channel cDNAs encode proteins of between ~370-500 residues, both N- and C-termini are thought to be cytoplasmic, and the N terminus lacks a signal sequence. (embl.de)
4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)

Contactin/F3, a cell adhesion molecule, has been shown to interact with and enhance surface expression of sodium channels Na v 1.2 and Na v 1.9. (jneurosci.org)
To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. (stanford.edu)
The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)
Homogeneous development of electrical excitability via heterogeneous ion channel expression. (ucdenver.edu)
Western blotting and immunohistochemistry demonstrated protein expression in both the UBSM and urothelium that was absent in TRPV4 −/− bladders. (aspetjournals.org)
These proteins show similar domain architectures as known organelle-targeted expression regulators of the octotrico peptide repeat type in algae and plants. (frontiersin.org)
Two critical factors during this dauntingly complex process appear to be the establishment of metabolic connectivity between the symbiotic partners, and the evolution of nuclear control over protein expression levels within the organelle. (frontiersin.org)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)

Persistent channel modulation was blocked by 320-fold excess etomidate but enhanced when 32-fold excess etomidate was present. (asahq.org)

structure of the mscl homologue from mycobacterium tuberculosis: a gated mechanosensitive channel. (berkeley.edu)

Although ion selectivity has been studied for decades, the mechanisms underlying this selectivity for trimeric channels, and particularly for the ENaC/DEG family, are still poorly understood. (surrey.ac.uk)
STAT3 Purity & Documentation Whereas these allosteric modes likely contribute to Ras partitioning and reorientation in vivo, direct functional consequences on Ras protein rotein interactions are poorly understood. (calcium-channel.com)
This suggests that ionic homeostasis plays an important role in melanin synthesis and storage, yet how ion channels might contribute to melanosome function and pigmentation remains poorly understood ( Bellono and Oancea, 2014 ). (elifesciences.org)
However, the structural features associated with this specific evolution remained for a long time poorly understood in absence of experimental 3D structure of the full-length protein. (sorbonne-universite.fr)

They are described as minimally having two transmembrane helices flanking a loop which determines the ion selectivity of the channel pore. (wikipedia.org)
The proteins with only two transmembrane helices (Pfam PF07885) are most commonly found in bacteria. (wikipedia.org)

This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification. (wikipedia.org)

There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. (wikipedia.org)
TrkH assembles with TrkA, a cytosolic protein comprising two RCK (regulate the conductance of K(+)) domains, which are found in certain K(+) channels and control their gating. (cornell.edu)

Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. (edu.au)
The protein appeared to have a high affinity for calcium and a much lower affinity for phosphorus and other mineral constituents of the cell. (prospecbio.com)

In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system. (cipsm.de)
Researchers had previously identified the structures of some members of the Cys-loop super-family, a significant step toward creating drugs that fit onto these ion channels to block or enhance their function. (phys.org)
Members of your Ras superfamily of little GTPases are widely deemed to be monomeric (23). (calcium-channel.com)
On the other hand, a number of members across the Ras GTPase subfamilies are now identified to dimerize (248), plus a class of tiny GTPases that use dimerization rather than GTPase activating proteins (GAPs) for GTPase activity has been identified (29). (calcium-channel.com)

Arabidopsis possesses a superfamily of ATP-binding cassette (ABC) transporters. (uea.ac.uk)
However, the limited set of chromatophore-encoded solute transporters appears insufficient for supporting metabolic connectivity or protein import. (frontiersin.org)

These proteins provide a selective conduction of ions across cellular membranes, which is crucial for cell survival. (surrey.ac.uk)

Prediction of disulfide bridges from protein sequences is useful for characterizing structural and functional properties of proteins. (biomedcentral.com)
Some interesting structural, functional, and evolutionary properties of proteins can be inferred from knowledge about the existence and the precise location of disulfide bridges. (biomedcentral.com)
Somatic variations in protein kinases with experimental evidence demonstrating their functional role. (lu.se)

Kv2 channels form delayed-rectifier potassium channels in situ. (ucdenver.edu)

In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)

Researchers found that it was essential in calcium channel metabolism. (prospecbio.com)

We introduce new methods for predicting disulfide bridges from protein sequences. (biomedcentral.com)

Moreover, we revealed that 5-HTR 1 and 5-HTR 2 receptor stimulation induced intracellular Ca 2+ mobilization via G i/o proteins in immature, but not mature, DC. (aai.org)

KinMutBase is a comprehensive knowledge base for human diseaserelated variations in protein kinase domains. (lu.se)

The transient receptor potential (TRP) vanilloid 4 (TRPV4) member of the TRP superfamily has recently been implicated in numerous physiological processes. (aspetjournals.org)

In the current study, we analysed the biophysical effects of Org 34167 on HCN channels in stably transfected human embryonic kidney 293 (HEK293) cells and mouse layer V neurons using patch-clamp electrophysiology, and we utilised three high-throughput screens for depressive-like behaviour to assess the activity of Org 34167 in mice. (frontiersin.org)
In this study we show that contactin coimmunoprecipitates with Na v 1.3 from postnatal day 0 rat brain where this channel is abundant, and from human embryonic kidney (HEK) 293 cells stably transfected with Na v 1.3 (HEK-Na v 1.3). (jneurosci.org)

Cav1.4 channels are unique among the high voltage-activated (HVA) Ca2+ channel family because they completely lack Ca2+-dependent inactivation (CDI) and display very slow voltage-dependent inactivation (VDI). (cipsm.de)
The aim of this exciting PhD is to investigate selectivity of sodium (Na+) within a specific channel family: the Epithelial Sodium Channel/Degenerin (ENaC/DEG) Family. (surrey.ac.uk)
The motif in the ENaC/DEG Family is (G/S)XS, where X is a non-conserved residue within this ion channel family. (surrey.ac.uk)
The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-selective channels that play diverse and important physiological roles in a wide variety of animal species. (surrey.ac.uk)
Furthermore, our mass spectrometric analysis revealed an expanded family of chromatophore-targeted helical repeat proteins. (frontiersin.org)

UTSW scientists have characterized three different conformations of alpha 7, a key cell-surface protein. (phys.org)
They plan to continue studying a7 in various cell types and how it interacts with other molecules and proteins. (phys.org)
It really is becoming progressively extra clear that the spatial arrangement of proteins within a cell, not just their chemical structure, is an critical aspect of their function. (calcium-channel.com)

However, the mechanisms behind their selectivity - e.g. how these proteins can perfectly discriminate between ions - is not entirely understood. (surrey.ac.uk)
I will mainly be focused on the selectivity filter of the channels, which is generally the narrowest part of the pore and where the channel can discriminate different ions, even those of identical charge, allowing only the right one to pass through (in this case Na+). (surrey.ac.uk)

Inserting the molecules into the lipid membranes of vesicles leads to the transport of water through the channels produced by single molecules, as supported by dynamic light scattering and cryo-SEM experiments. (tcdb.org)

Org 34167 is a broad-spectrum inhibitor of HCN channels, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation. (frontiersin.org)
The upregulation of voltage-gated sodium channel Na v 1.3 has been linked to hyperexcitability of axotomized dorsal root ganglion (DRG) neurons, which underlies neuropathic pain. (jneurosci.org)

The crystal structure of TrkH from Vibrio parahaemolyticus showed that TrkH resembles a K(+) channel and may have a gating mechanism substantially different from K(+) channels. (cornell.edu)

Thus, a melanosomal anion channel that requires OCA2 is essential for skin and eye pigmentation. (elifesciences.org)

In this study, we describe a small molecule TRPV4 channel activator, ( N -((1 S )-1-{[4-((2 S )-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), which we have used as a valuable tool in investigating the role of TRPV4 in the urinary bladder. (aspetjournals.org)

However, there is currently no peer-reviewed data supporting the use of a small molecule modulator of HCN channels in depression treatment. (frontiersin.org)

Anatomy23

Organisms15

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes48

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science6

Belong to a superfamily2

Ligand-gated ion channel s2

Cation channel5

Receptors7

Transporter Superfamily1

Structural Classifi2

Membrane16

Transport proteins1

Subunit5

Chloride5

Transmembrane protein2

Mutations4

Mitogen-activa1

MeSH1

Putative2

Subfamily2

Genes5

Encodes1

Metabolites1

Clusters1

Molecular8

Potassium channel6

Gene3

Amino Acid4

Eukaryotic2

CDNAs2

Expression8

Fold1

Mechanosensitive1

Poorly understood4

Helices2

Families1

Regulate2

High-affinity2

Members4

Transporters2

Conduction1

Functional3

Delayed-rectifier potassium1

Neuronal1

Calcium channel1

Sequences1

Intracellular1

Kinase1

Vanilloid1

Human embryonic kidney2

Family5

Cell3

Ions2

Molecules1

Voltage2

Mechanism1

Anion1

TrpV41

Small molecule1