• Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A". The Journal of Biological Chemistry. (wikipedia.org)
  • Our latest finding signifies that phosphorylation of Hes-1 at Ser263 by c-Jun N-terminal kinase 1 (JNK1) stabilizes the Hes-1 proteins and enhances its suppressing influence on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidity receptor subunit GluR1 appearance [3]. (molecularcircuit.com)
  • Furthermore phosphorylation at proteins kinase C consensus LY2784544 (Gandotinib) sites (Ser37 Ser38) in the essential domains of Hes-1 inhibits the DNA-binding activity of Hes-1 during nerve development factor arousal of Computer12 cell differentiation [4]. (molecularcircuit.com)
  • Furthermore Hes-1 phosphorylation by calmodulin-dependent proteins kinase II delta transforms it from a repressor for an activator that's needed is for neuronal stem cell differentiation [5]. (molecularcircuit.com)
  • However, over the same period protein kinases have rapidly become one of the most significant classes of drug targets for the pharmaceutical industry, with the global market for kinase therapies being about US$15 billion per annum in 2010 and this value is predicted to double by 2020 (3). (ddw-online.com)
  • Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). (icr.ac.uk)
  • Though the multi kinase inhibitor sorafenib has not long ago been authorized for treatment method of advanced stage HCC, the overall efficacy still remains dissatisfying. (hdacassay.com)
  • This study evaluated the roles of PINK1 mitochondrial kinase, and Parkin E3 ubiquitin ligase in targeting depolarized mitochondria for degradation in vivo, using quantitative measurements of mitochondria in Drosophila nervous system. (sdbonline.org)
  • The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
  • Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
  • One group of molecular targeted agents, vascular endothelial growth factor receptor tyrosine kinase inhibitors, is a standard care for advanced RCC [ 8 ]. (oncotarget.com)
  • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
  • Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
  • In this report, we have explored the activity of the selective small molecule SUMOylation inhibitor subasumstat (TAK-981) in promoting antitumor innate immune responses. (bvsalud.org)
  • Three zinc-binding groups were considered including hydroxamic acid, imidazole and a precursor of a potent small molecule CSN5 inhibitor, CSN5i-3. (gla.ac.uk)
  • The SUMO E3 ligases after that transfer the SUMO molecule from UBC9 to particular substrate proteins [7]. (molecularcircuit.com)
  • Consequently, small-molecule drug discovery usually involves an iterative process of molecular design, chemical synthesis, biological assay and data analysis feeding directly into the next cycle, but this process always needs a chemical starting point. (ddw-online.com)
  • As an alternative approach to such conventional inhibitors, the first-in-class small molecule sEH degraders were recently developed by our group that promote the degradation of sEH within cells with superior cellular efficacy compared to sEH inhibitors. (einsteinmed.edu)
  • The long-term goal of this application is to show the proof-of-concept that small molecule induced degradation of sEH is a promising pharmacological approach for the treatment of diabetes. (einsteinmed.edu)
  • The central hypothesis is that small molecule sEH degrader has higher efficacy to reduce hepatic insulin resistance and BAT regression compared to sEH inhibitors. (einsteinmed.edu)
  • Normally, the conjugation of ubiquitin to other proteins involves the formation of an isopeptide bond between the α-carboxyl group of the C-terminal glycine of a ubiquitin molecule with an ε-amino group of a specific lysine residue within the target protein [2,3]. (123dok.net)
  • For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. (icr.ac.uk)
  • MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. (icr.ac.uk)
  • The level of protein within cells is determined by both the rate of synthesis and the rate of degradation. (amerigoscientific.com)
  • The difference in protein degradation rates is an important aspect of cell regulation. (amerigoscientific.com)
  • In eukaryotic cells, the ubiquitin/proteasome pathway and lysosomal proteolysis are the two main pathways of protein degradation. (amerigoscientific.com)
  • MSC represents a brand new variety of HIF inhibitor by enhancing the degradation, but not affecting the synthesis of HIF. (hdacassay.com)
  • Specifically we evaluate the effect of increased dietary protein intake and caloric restricted diets on gene expression in skeletal muscle, particularly focusing on biosynthesis, degradation and the expression of genes in the ubiquitin-proteosome (UPP) and mTOR signaling pathways, including MuRF-1, MAFbx/atrogin-1, mTORC1, and S6K1. (biomedcentral.com)
  • In the present study, we show that benzoic acid derivatives isolated from Bjerkandera adusta promote the activity of the two main protein degradation systems, namely the ubiquitin-proteasome (UPP) and especially the autophagy-lysosome pathway (ALP) in human foreskin fibroblasts. (mdpi.com)
  • Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. (cusabio.com)
  • Ubiquitin functions as a reversible post-translational modifier of proteins to regulate many different cellular processes such as DNA repair, chromatin dynamics, cell cycle regulation, membrane and protein trafficking, endocytosis, autophagy, but most notably proteasome-dependent protein degradation [2-4]. (123dok.net)
  • The Cullin-RING E3 ligase (CRL) family consists of over 200 enzymes that are responsible for the ubiquitylation and regulation of a huge variety of proteins involved in the immune response, cell cycle control and cell proliferation. (gla.ac.uk)
  • Proteins inhibitor of turned on STAT1 (PIAS1) is normally a SUMO E3 ligase is one of the PIAS proteins family that's well examined in the disease fighting capability [8 9 Through LY2784544 (Gandotinib) ligase activity-dependent or -unbiased system PIAS1 regulates the experience of distinctive proteins including transcription elements [10]. (molecularcircuit.com)
  • In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. (icr.ac.uk)
  • Ubiquitin binds reversibly to the target protein via an enzyme cascade including ubiquitin-activating enzyme E1, ubiquitin-conjugation enzyme E2, and ubiquitin-protein ligase E3. (amerigoscientific.com)
  • Finally, we showed that Bonus SUMOylation is mediated by the SUMO E3-ligase Su(var)2-10, revealing that although SUMOylation of TIF1 proteins is conserved between insects and mammals, both the mechanism and specific site of modification is different in the two taxa. (elifesciences.org)
  • EXPERIMENTAL DESIGN: In a first-of-its-kind phase 0 clinical trial, we explored the effects of an investigational stage SUMOylation-activating enzyme (SAE) inhibitor, subasumstat (TAK-981) in 12 patients with head and neck carcinoma (HNC). (bvsalud.org)
  • METHODS: Levels of sumoylation enzymes and sumoylated proteins were quantified in MCL cell lines and primary MCL patient samples by scRNA sequencing and immunoblotting. (bvsalud.org)
  • Immunoprecipitation and orbitrap mass spectrometry were used to identify proteins targeted by sumoylation in MCL cells. (bvsalud.org)
  • Furthermore Hes-1 SUMOylation stabilized the Hes-1 proteins and elevated the transcriptional suppressing activity of Hes-1 on development arrest and DNA damage-inducible proteins alpha (GADD45α) appearance. (molecularcircuit.com)
  • Furthermore Hes-1 SUMOylation was unbiased of Hes-1 phosphorylation and and (Hes-1) is normally a transcriptional repressor is one of the simple helix-loop-helix (bHLH) proteins family members and was proven to play a pivotal function in legislation of cell differentiation and proliferation in a variety of cell types during advancement [1]. (molecularcircuit.com)
  • SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
  • Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
  • SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
  • Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
  • Collectively, our results indicate that SENP2 binds to intracellular membranes where it interacts with membrane-associated protein and gets the potential to modify their sumoylation and membrane-associated features. (conferencedequebec.org)
  • To various other ubiquitin-like protein Likewise, sumoylation provides another Zolpidem known degree Zolpidem of legislation to proteins activity, balance, and localization. (conferencedequebec.org)
  • The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. (icr.ac.uk)
  • Substrates Related to Chromatin and to RNA-Dependent Processes Are Modified by Arabidopsis SUMO Isoforms That Differ in a Conserved Residue with Influence on Desumoylation. (mpg.de)
  • The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
  • The repression activity of Hes-1 SSI-1 could be controlled by proteins phosphorylation. (molecularcircuit.com)
  • L ike protein phosphorylation by kinases, protein ubiquitylation regulates many aspects of cell function and provides a wealth of drug target opportunities across many therapeutic areas including cancer, cardiovascular, metabolism, inflammation, neurodegeneration and infectious diseases. (ddw-online.com)
  • Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7. (salvesenlab.org)
  • In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. (icr.ac.uk)
  • Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
  • The ubiquitin/proteasome pathway that degrades ubiquitin-tagged cell target proteins through the proteasome is a common regulatory modification system involved in the regulation of cell cycle, signal transduction, DNA damage response, apoptosis, and immune response. (amerigoscientific.com)
  • Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)
  • Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)
  • In an endeavour to mimic the entire substrate of CSN5, the synthesis of NEDD8 was attempted but not successful. (gla.ac.uk)
  • MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. (icr.ac.uk)
  • Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. (salvesenlab.org)
  • Faulty or damaged proteins are recognized and rapidly degraded within the cells, thereby eliminating the consequences of errors in protein synthesis. (amerigoscientific.com)
  • Maintenance of fat free mass is dependent upon nutrient stimulation of protein synthesis via the mTOR complex, although during caloric restriction a decrease (atrophy) in skeletal muscle may be driven by a homeostatic shift favouring protein catabolism. (biomedcentral.com)
  • Emerging evidence suggests a high ratio of protein to carbohydrate in a low-fat, caloric restricted (CR) diet may mitigate FFM reductions during weight loss through increasing muscle protein synthesis and/or reducing protein catabolism, thereby improving net muscle protein balance[ 6 ]. (biomedcentral.com)
  • We conclude that ubiquitin might serve as a cis-acting molecular chaperone that assists in the folding and synthesis of the fused eL40 and eS31 ribosomal proteins. (123dok.net)
  • Metformin, a known inhibitor of mitochondrial OXPHOS, has been indicated to reduce NSCLC morbidity and mortality in clinical studies. (spandidos-publications.com)
  • Ubiquitin is an 8.5-kDa polypeptide that exists in all eukaryotic cells and acts as a tag in post-translational modification of proteins. (amerigoscientific.com)
  • Post-translational modification of proteins by SUMO in Arabidopsis thaliana. (mpg.de)
  • Subsequently, the ubiquitin-labeled target protein is recognized by the proteasome and eventually degraded into small peptides. (amerigoscientific.com)
  • This technique has frequently been applied to animal tissue slices for the purpose to map proteins, peptides , lipids, sugars or small metabolites to find disease specific bio-markers or to study drag metabolism. (go.jp)
  • Research on protein kinases is now reported to account for approximately 30% of the drug discovery programmes in the pharmaceutical industry and more than 50% of cancer research and development (3). (ddw-online.com)
  • CRLs are activated by covalent attachment to the C-terminus of the ubiquitin-like modifier NEDD8 by forming an isopeptide bond in a process called NEDDylation. (gla.ac.uk)
  • The C terminus of ubiquitin must be activated before it can form isopeptide bonds with other proteins. (amerigoscientific.com)
  • In most eukaryotes studied, ubiquitin is encoded by two classes of genes: (i) The first comprises genes coding for a single copy of ubiquitin fused to ribosomal proteins (r-proteins), most commonly eL40 and eS31. (123dok.net)
  • Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis. (mpg.de)
  • Ubiquitin is a highly conserved small eukaryotic protein. (123dok.net)
  • Ubiquitin is a small eukaryotic protein of 76 amino acids whose name (i.e., it occurs ubiquitously) results from its remarkable evolutionary conservation [1]. (123dok.net)
  • Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. (icr.ac.uk)
  • Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
  • 5 mg mL one and cells were incubated for 1 hour at 37 C. Digestion was stopped by washing the cells twice with Tris HCl containing 10% fetal calf serum and outer membrane proteins have been ready as described over. (hdacassay.com)
  • For outer membrane proteins that have been utilized for ac tivity assays, cells weren't handled with Proteinase K. SDS Web page Outer membrane isolates had been diluted with sam ple buffer containing 4% SDS, 0. (hdacassay.com)
  • Skach, W. R. Cellular mechanisms of membrane protein folding. (nature.com)
  • Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)
  • These data demonstrate that cell cell interaction c-Met inhibitor isn't sufficient to stimulate IDO induction in non Tat handled cells and propose that induction of IDO in MoDCs is rather mediated by a direct action of HIV one Tat protein following its action at cell membrane level. (statpathway.com)
  • Effect of Tat induced IDO on the Capability of Dendritic Cells to Stimulate T cell Proliferation The results presented above display that Tat protein, by acting in the cell membrane level, induced the production of IDO. (statpathway.com)
  • In keeping with membrane association, biotin id (BioID) revealed connections between SENP2 and endoplasmic reticulum, Golgi, and internal nuclear membrane-associated protein. (conferencedequebec.org)
  • SENP2I8D dropped association with multiple membrane proteins and obtained brand-new nucleoplasmic interactors. (conferencedequebec.org)
  • We also discovered a distinctive subset of membrane-associated protein that connect to SENP2, providing additional insights in to the potential jobs SUMO can play in regulating membrane-associated features. (conferencedequebec.org)
  • But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
  • Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
  • The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
  • Dynamic cellular events beyond genetic encodings, such as epigenetics, and intermolecular protein interaction, play critical roles in dictating cellular functions. (go.jp)
  • C3H10T1/2 MSCs cultured within extremely adipogenic medium communicate peroxisome proliferator-activated receptor gamma and also adiponectin mRNA along with health proteins, and accumulate intra cellular lipid. (microrna21.com)
  • These cellular changes c-Met Inhibitor were also detected in our animal type, which supports the event of cell death and indicates that the prominence of Bax expression could be accountable for the cell death observed in the conclusion of pregnancy. (pimpathway.com)
  • We have analyzed the phenotypic effects of a genomic ubi1∆ub-HA ubi2∆ mutant, which expresses a ubiquitin-free HA-tagged eL40A protein as the sole source of cellular eL40. (123dok.net)
  • A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
  • It is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a polyubiquitin precursor of head-to-tail monomers, or as a single N-terminal moiety to ribosomal proteins. (123dok.net)
  • It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
  • Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. (icr.ac.uk)
  • Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11. (salvesenlab.org)
  • This conclusion can also be in agreement with the incapacity of Tat conditioned medium selleck chemicals mTOR inhibitor to induce IDO in MoDCs. (statpathway.com)
  • We discovered MSA treatment method cause 786 0 tumor growth in hibition which correlated with reduced HIF two protein levels. (hdacassay.com)
  • Therefore, our data sup ports further evaluation of MSC being a HIF inhibitor in mixture with multikinas Background Hepatocellular carcinoma is definitely the most typical major tumor from the liver and represents an unmet health care want, becoming between probably the most frequent tumor diseases and causes of cancer linked deaths around the world and displaying a increasing incidence also in Western nations. (hdacassay.com)
  • Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
  • A marked increase in IFN-induced DR4 protein expression after tocilizumab treatment was observed by immunohistochemical staining in the tumor from the mice xenograft model. (oncotarget.com)
  • Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases. (en-journal.org)
  • Understanding the role of the ubiquitin fused to ribosomal proteins becomes relevant, as these proteins are practically invariably eS31 and eL40 in the different eukaryotes. (123dok.net)
  • The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)
  • Immunocytochemistry spot of STAT and PIAS To reveal the tissues accountable for the expression of STAT and PIAS proteins, immunocytochemistry experiments were carried out. (statpathway.com)
  • In sugar fed mosquitoes, although males presented STAT and PIAS immunolabeling in numerous physique elements, noticeably from the body fat physique, the two learn this here now proteins expression was weaker in sugar fed females. (statpathway.com)
  • Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. (icr.ac.uk)
  • During eucaloric conditions the continual breakdown of protein that occurs in the body's organs and vital tissues is replenished in the post-absorptive state via supply of amino acids derived primarily from the skeletal muscle component of FFM[ 7 ]. (biomedcentral.com)
  • These DHN proteins are all highly hydrophilic, but they differ significantly in size, ranging from 188 to 475 amino acids, and in biochemical properties, such as theoretical pI, aliphatic index, and instability index. (researchensemble.com)
  • Proteins synthesized at the ER are subject to covalent modifications that include N- and O-glycosylation, disulfide bond formation, and in some cases, proline and lysine hydroxylation. (stanford.edu)
  • Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. (en-journal.org)
  • RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. (icr.ac.uk)
  • Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. (icr.ac.uk)
  • ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
  • Invertebrates and Fungus exhibit one SUMO proteins, while vertebrates exhibit several useful paralogues, including SUMO-1, SUMO-2, and SUMO-3. (conferencedequebec.org)
  • Although first-generation soluble epoxide hydrolase (sEH) inhibitor entered clinical trials more than 10 years ago for the treatment of insulin resistance and diabetes, there are currently still no drugs on market targeting this promising therapeutic target for diabetes. (einsteinmed.edu)
  • However, vegetation use multiple mechanisms to increase their tolerance to freezing temps, such as accumulation of compatible osmolytes (soluble sugars, glycine betaine, and proline) and improved levels of antioxidants and soluble proteins in cell cytoplasm [2]C[3]. (researchensemble.com)
  • Recent reports based on proteomic studies have identified many SUMOylated substrates that play important roles in the development and progression of cancer. (frontiersin.org)
  • For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)
  • Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying genetic modifiers that influence PLIN2 expression and post-translational stability under different metabolic conditions and in different cell types. (stanford.edu)
  • There are primarily two types of lung cancer: Non-small cell lung cancer (NSCLC) and SCLC, and the former accounts for ~85% of all lung cancer cases ( 3 ). (spandidos-publications.com)
  • The present study explored the expression and potential role of TRIM13 in non-small-cell lung carcinoma (NSCLC). (cancerindex.org)
  • We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)
  • The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
  • Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)
  • Proteins that control the CELL DIVISION CYCLE. (lookformedical.com)
  • Proteins found in the nucleus of a cell. (lookformedical.com)
  • actin related protein 2 [Source:HGNC S. (gsea-msigdb.org)
  • Ubiquitin fusion to other r-proteins, such as P1 or P2, and even to non-ribosomal proteins such as actin, has been reported in diverse genera of rare single-celled algae as, for example, Bigelowiella [6]. (123dok.net)