Protein structures membrane protein. Medical search. Frequent questions

To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
Diffusion is the process by which molecules migrate over the cell membrane from areas of higher concentration to areas of lower concentration. (wikibooks.org)
Vitamin- E, superoxide-dismutase (SOD), P240, or piperaquine was added to assess their ability to protect against quartz induced cell membrane damage. (cdc.gov)
Quartz disrupted the cell membrane. (cdc.gov)
I will present our recent structural studies, using solid-state NMR spectroscopy, of three membrane proteins that give insights into the mechanisms of virus-cell membrane fusion and virus budding. (lu.se)

Solid-state NMR (ssNMR) is a versatile technique that can provide high-resolution (sub-angstrom) structural data for integral membrane proteins embedded in native and model membrane environments. (nih.gov)
This review describes the spectroscopic experiments and data analysis methods (including assignment) used to generate high-resolution structural data for membrane proteins. (nih.gov)
A structural fit to the experimental solid-state NMR data results in a three-dimensional structure with precision equivalent to an RMSD of 0.4 A. Vpu(2-30+) exists mainly as an oligomer on PFO-PAGE and forms ion-channels, a most frequent conductance of 96(+/- 6) pS in lipid bilayers. (rcsb.org)
The structural features of the trans-membrane domain are determinants of the ion-channel activity that may be associated with the protein's role in facilitating the budding of new virus particles from infected cells. (rcsb.org)
Herein is described procedures implemented in the Caffrey Membrane Structural and Functional Biology Group to harvest and cryo-cool membrane protein crystals grown in lipidic cubic and sponge phases for use in structure determination using macromolecular X-ray crystallography. (jove.com)
Nuclear magnetic resonance (NMR) structural analysis showed that the first membrane-spanning segment (amino acids 69 to 93) consists of two helices separated by a "helix breaker. (rcsb.org)
The method thereby opens up the possibility of observing structural changes of proteins associated with specific diseases. (mpg.de)
Small membrane proteins are difficult targets for structural characterization. (cornell.edu)
This strategy gives rise to 14 new structures of five vertebrate proteins from distinct functional families, bringing a substantial expansion to the structural database of small membrane proteins. (cornell.edu)
Now Rubén Fernández-Busnadiego from the Department of Molecular Structural Biology at the MPI of Biochemistry and Stefan Kochanek, head of the Department of Gene Therapy at the University Hospital Ulm, have succeeded in decoding the molecular, three-dimensional structure of the huntingtin protein. (mpg.de)
Structural and biophysical data show that ASTN-2 (but not ASTN-1) binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. (ox.ac.uk)
Structural insights into SARS coronavirus proteins. (iucr.org)
These structural proteins encapsulate the virus. (getjar.com)

Protein targeting to the endoplasmic reticulum. (manchester.ac.uk)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

Cell membranes need to change their shapes during many cellular processeslike protein trafficking, cytokinesis and membrane homeostasis. (kth.se)
Ion channels and membrane transporters are in the business of moving ions and small molecules across cellular membranes. (scifivoice.com)
Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential. (hindawi.com)
Curcumin modulates cellular activity through interacting with membrane-bound proteins and modulating signaling cascade activity by altering the fluidity of the membrane bilayer [ 17 ]. (hindawi.com)
This makes cancer cells inherently more dependent on the most important cellular garbage disposal unit, the proteasome , which degrades defective proteins and removes them from circulation. (analytica-world.com)
In order to understand how cellular machines such as the proteasome work, it is essential to determine their three-dimensional structure in detail. (analytica-world.com)
Stanford University researchers have identified a protein that helps these organisms form a protective, lipid-linked cellular membrane - a key to withstanding extremely highly acidic habitats. (stanford.edu)
This compartmental organisation demands that newly synthesised proteins are accurately and efficiently targeted to their appropriate sub-cellular locations. (manchester.ac.uk)
The thread was lodged in the perforated part, and consequently left in contact with the cellular membrane . (dictionary.com)
These sessions, providing diverse perspectives using different systems, are "Protein machines and disorder," "Organelles, mechanisms and phase properties of cellular quality control," and "Cell signaling - new tools and emerging concepts. (asbmb.org)
It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
Objectives: To investigate the potential role of a commercially available preparation of micronized Amniotic Membrane Allograft (AMA) (Amniofix, MiMedx, USA) in the biological augmentation of an in vitro model of rotator cuff repair with respect to cellular pro- liferation, collagen content and mechanical properties of the bone- tendon interface. (researchgate.net)
Precisely how the changes in cellular structure due to storage translates into adverse effects on cell function remains enigmatic. (medscape.com)

To obtain information about BIN1's interaction with themembrane in near native environments, we used artificial lipid systems suchas liposomes and lipids nanotubes.First, we have shown that electrostatic interactions are more important forBIN1 when binding to membranes with low curvature. (kth.se)
The formation ofinvaginations (or tubules) is regulated by the composition of negativecharged lipids in membrane bilayer or electrostatic residues on the BARdomain. (kth.se)
These lipids influence the biophysical properties of membranes and thereby modulate G protein binding to bilayers. (unisa.it)
Finding preserved membrane lipids, for example, could suggest when an organism evolved and how that may have been the circumstance of its environment. (stanford.edu)

Bin/Amphiphysin/Rvs (BAR) proteins are peripheralmembrane proteins (PMP) and play an important role in sculpturingmembranes and in the regulation of actin dynamics. (kth.se)
and consequently membrane deformation.Second, we clarified BIN1's role in actin dynamics. (kth.se)
Chandler EL, Smith AL , Burden LM, Kasianowicz JJ, Burden DL , " Membrane surface dynamics of DNA-threaded nanopores revealed by simultaneous single-molecule optical and ensemble electrical recording. (wheaton.edu)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
Critical biomolecules of the cell are identified, engineered and harnessed for myriad applications in sessions on "Frontiers in carbohydrate synthesis and recognition," "Lipid dynamics and signals in membrane and protein structure," and "Regulation of RNA. (asbmb.org)

Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present throughout all cell types. (hindawi.com)
Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present in all cell types that transfers electrons from intracellular substrates to extracellular acceptors maintaining redox homeostasis for a successful cell physiology [ 1 ]. (hindawi.com)
These results demonstrate that co/post-translational G protein lipid modifications regulate the membrane lipid structure and that they influence the physico-chemical properties of membranes, which in part explains why G protein subunits sort to different plasma membrane domains. (unisa.it)
Osmotic balance is maintained between the extracellular fluid and the cytoplasm by movement of water through the plasma membrane when the total concentration of particles on one side is not equal to that on the other. (britannica.com)
When the inside of the plasma membrane has a negative charge compared to the outside, the neuron is said to be polarized. (britannica.com)
The plasma membrane of the neuron is highly permeable to K + , and in fact the recorded membrane potential of most neurons (−60 to −75 mV) is close to that predicted by the Nernst equation for K + . However, it is not exactly the same, because K + is not the only ion affecting the membrane potential. (britannica.com)
The discussion above demonstrates that the electrical potential existing in neurons is based on the distribution of ions across the plasma membrane and that this distribution comes about through permeation of the membrane. (britannica.com)
In fact, ions are almost always hydrated in the form of ion-water complexes, which have great difficulty in penetrating the hydrophobic lipid bilayer of the plasma membrane. (britannica.com)
and plasma membrane. (nih.gov)
In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. (jneurosci.org)

Both these classes of membrane proteins are extremely important for our health," observes Nieng Yan, the Shirley M. Tilghman Professor at Princeton's Department of Molecular Biology. (scifivoice.com)

The NS1 structures reveal distinct domains for membrane association of the dimer and interactions with the immune system and are a basis for elucidating the molecular mechanism of NS1 function. (nih.gov)
Our ~2.7 Å structure of alcohol dehydrogenase (82 kDa) proves that bound ligands can be resolved with high fidelity to enable investigation of drug-target interactions. (nature.com)
long range interactions within the protein molecule. (flashcardmachine.com)
2015. Interactions of the Metalloregulatory Protein SloR from Streptococcus mutans with its Metal Ion Effectors and DNA Binding Site. (middlebury.edu)
The MIPs are produced by various polymerization methods but in all cases specifi c interactions, molecular partitioning and polymer structure are key properties that we focus on. (lu.se)

For this, the protein must always be in the same conformation. (mpg.de)
The β-sheet conformation causes negative Gaussian curvature and membrane dehydration, which are required for membrane merger, while the α-helical conformation resides in low-curvature lamellar membranes and forms three-helix bundles. (lu.se)
We find that this domain is trimerized in the lipid membrane with a helix-turn-helix conformation, suggesting that this domain stabilizes the trimer structure of gp41 and promotes membrane curvature during the fusion process. (lu.se)

Around 30% of all proteins in eukaryotic organisms have recently been shown to belong to intrinsically disordered proteins (IDPs) involved in many central biological processes and diseases. (lu.se)
Expected announcement of the position is spring 2023, and the project will focus on liquid-liquid phase separation mediated by phosphorylated intrinsically disordered proteins utilizing computer simulations in combination with SAXS. (lu.se)
To reveal static and dynamic properties of intrinsically disordered proteins (IDPs) to provide a deeper understanding of the mechanism of action and the static as well as dynamic structure-function relationship. (lu.se)

ssNMR data may be used to annotate and refine existing structures in regions of the protein not fully resolved by crystallography (including ligand-binding sites and mobile solvent accessible loop regions). (nih.gov)
Three poster prizes sponsored by the IUCr, the RCSB PDB and CrSJ were awarded to young scientists: There was also a pre-meeting satellite on Theoretical Crystallography and Materials Science organized by The IUCr MaThCryst commission in cooperation with the IUCr Commission on Inorganic and Mineral Structures. (iucr.org)

Determining high-resolution structures of biological macromolecules amassing less than 100 kilodaltons (kDa) has been a longstanding goal of the cryo-electron microscopy (cryo-EM) community. (nature.com)
Structure of biological macromolecules. (uu.se)
In the first term, topics will include the structure and chemical properties of biological macromolecules, molecular biology methods, and biological catalysis. (caltech.edu)

The methodologies for a priori structure determination have for the most part been developed using samples with crystalline and fibrous morphologies. (nih.gov)
In the frame of granted ANR (French National Research Agency) project the candidate would work on the structure determination of partners of T9 secretion system using single particle cryoEM. (cnrs.fr)
This resolution regime has also expanded the potential of cryo-EM SPA for structure-based drug design, particularly for targets that are less amenable to other structure determination techniques due to limited sample quantity or recalcitrance to crystallization. (nature.com)
Despite these advances, the radiation sensitivity of ice-embedded proteins and the low signal-to-noise ratio (SNR) of cryo-EM images nonetheless impede routine structure determination for all samples, and specimen size remains a considerable limiting factor in cryo-EM SPA. (nature.com)
Termini restraining of small membrane proteins enables structure determination at near-atomic resolution. (cornell.edu)
The reassembled GFP provides a versatile scaffold for membrane protein crystallization, enables diffraction to atomic resolution, and facilitates crystal identification, phase determination, and density modification. (cornell.edu)
Overall, termini restraining proves exceptionally effective for stabilization and structure determination of small membrane proteins. (cornell.edu)
The data represent the first direct determination of the cholesterol-binding structure of a membrane protein in lipid bilayers, and moreover indicate a specific mechanism by which cholesterol concentration gradients in the membrane drive the M2 protein to the neck of the budding virus to conduct membrane scission. (lu.se)

noscale control of internal inhomogeneity enhances water transport in desalination membranes, Science (2020). (phys.org)

Permeation actually occurs through protein structures embedded in the lipid bilayer and spanning the membrane from cytoplasm to extracellular fluid. (britannica.com)

Protein translocation into and across the ER membrane. (manchester.ac.uk)
Protein translocation across membranes. (lu.se)

By contrast, both myristate and palmitate increased the Gαi1 preference for lamellar membranes. (unisa.it)

Our model is that this organism evolved the ability to make these membranes because it lives in an environment where the acidity changes," said co-author Paula Welander, an assistant professor of Earth system science at Stanford's School of Earth, Energy & Environmental Sciences (Stanford Earth). (stanford.edu)
That mutated organism was able to grow at high temperatures but withered in a highly acidic environment, suggesting that the protein is necessary to both make the unusual membrane and withstand acidity. (stanford.edu)
The ability to form an outer membrane around the organism that separates it from the external world. (dictionary.com)
Topics will include the derivation of protein structure from the information inherent in a genome, biological catalysis, and the intermediary metabolism that provides energy to an organism. (caltech.edu)

The successful candidate will join our group at the institute of Chimie et Biology des Membranes et Nano-objets (Pessac, Bordeaux) which aims at deciphering the molecular mechanisms of active transport across biological membranes, using biochemical, biophysical and cryoEM approaches. (cnrs.fr)

Here, we employed transmission electronmicroscopy and other biophysical methods to elucidate how BAR domainproteins steer processes at the membrane.In this work we studied the BAR protein bridging integrator 1 (BIN1), whichhas an established role in cancer, Alzheimer's disease and skeletalmyopathies. (kth.se)
A group of scientists led by Ashwin Chari at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and Gleb Bourenkov at EMBL have now managed to determine the three-dimensional structure of the human proteasome at an unprecedented resolution of 1.8 Ångström - enabling them to pinpoint the position of single atoms in the garbage disposal unit. (analytica-world.com)

GSH is a hydrophilic antioxidant with nucleophilic thiol group and has been reported to participate in regulation of gene expression, protein synthesis, cell proliferation, signal transduction, cytokine production, apoptosis, immune response, and protein glutathionylation [ 11 ]. (hindawi.com)
We are also interested in the general problem of the over-expression and synthesis of membrane proteins. (caltech.edu)
Asbestos has the most suppressive effect on macrophage protein synthesis. (cdc.gov)

Welander became interested in studying this microbe because of its rare chemistry, including its unusual lipid membranes. (stanford.edu)

However, the techniques are now being applied to large, polytopic membrane proteins including receptors, ion channels, and porins. (nih.gov)

Continuous protein pathways are composed of carrier proteins , channels and pumps . (wikibooks.org)
The first two systems, Sec and Tat, are pathways for proteins to be translocated across membranes. (caltech.edu)

The flavivirus nonstructural protein 1 (NS1) functions in genome replication as an intracellular dimer and in immune system evasion as a secreted hexamer. (nih.gov)
There exists an exchange of molecules and ions in and out of the cell wall, as well as in and out of membrane-bounded intracellular compartments such as the nucleus, ER, and mitrochondria. (wikibooks.org)
Cytoskeletal proteins appear to be involved in the control of intracellular signaling. (jneurosci.org)

However, the biochemical basis for the combined enzyme deficiency is a loss of a protective protein that interacts with both enzymes to produce catalytic activity. (medscape.com)
To understand how cholesterol interacts with M2 to generate membrane curvature, we have determined the cholesterol-binding site of M2 by measuring protein-cholesterol distances and cholesterol orientation in the membrane. (lu.se)
Interacts with the snare proteins SNAP-23 and VAMP. (lu.se)

The three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer samples. (rcsb.org)
Palmitoylation reinforced the binding of the monomer to PC membranes and myristoylation decreased its binding to PE-enriched bilayer. (unisa.it)
The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
The availability of free energy is one of the factors that determine if a molecule will move across a membrane, the other being the permeability of the molecule in the lipid bilayer. (wikibooks.org)
The virus contains host-derived elementary membrane (lipid bilayer). (getjar.com)

The OmpX structure shows that the membrane-spanning part of the protein is much better conserved than the extracellular loops. (wikipedia.org)
Proposed functions of PMRS include maintenance of redox state in proteins, stimulation of cell growth, reduction of lipid hydroperoxides, recycling of α -tocopherol, reduction of ferric ion prior to iron uptake by a transferring-independent pathway, and the maintenance of the extracellular concentration of ascorbic acid [ 2 - 6 ]. (hindawi.com)

Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a disorder of the nervous system. (medlineplus.gov)
Dogu O, Krebs CE, Kaleagasi H, Demirtas Z, Oksuz N, Walker RH, Paisan-Ruiz C. Rapid disease progression in adult-onset mitochondrial membrane protein-associated neurodegeneration. (medlineplus.gov)
Hartig M, Prokisch H, Meitinger T, Klopstock T. Mitochondrial membrane protein-associated neurodegeneration (MPAN). (medlineplus.gov)

Given the concentrations of all three ions on each side of the membrane and the relative permeability of the membrane to each ion, researchers can calculate the combined effect of K + , Na + , and Cl − on the membrane potential by using the so-called constant-field equation. (britannica.com)
Water will move from an area with a higher concentration of water to the other side of the membrane with a lower concentration of water. (wikibooks.org)

Filmtec, now a part of DuPont Water Solutions, which makes numerous desalination products, partnered with the researchers and funded the project because their in-house scientists found that thicker membranes were actually proving to be more permeable. (phys.org)
This equation, by including relative permeability as an important factor, takes into account the phenomenon that the more permeable a membrane is to a particular ion, the greater is the influence of that ion on the membrane potential. (britannica.com)
Osmosis is the diffusion of water through a semi-permeable membrane. (wikibooks.org)
Membranes are usually made of layers of phospholipids containing suspended protein molecules and are permeable to water and fat-soluble substances. (dictionary.com)

Together our data identified promising targets to be genetically engineered to modulate seed storage protein accumulation that have a growing role in health and nutritional issues. (nature.com)

Although we have known for some time that the mutation of the huntingtin gene has severe consequences, we still know relatively little about the function and tasks of the healthy protein,' explains Kochanek. (mpg.de)

This understanding could increase membrane efficiency by 30% to 40%, according to the researchers, resulting in more water filtered with less energy-a potential cost-saving update to current desalination processes. (phys.org)
While more efficient than non- membrane desalination processes, this still takes an immense amount of energy, the researchers said, but improving the efficiency of the membranes could reduce that burden. (phys.org)
The aim of this unit is to examine the molecular mechanisms of protein sorting in eukaryotes, and will review recent data demonstrating that some of these processes are fundamental to all living cells. (manchester.ac.uk)
We are currently focused on three processes involved in protein secretion. (caltech.edu)
Lectures and recitation introducing the molecular basis of life processes, with emphasis on the structure and function of proteins. (caltech.edu)
Membrane curvature generation and membrane remodeling underlie many biological processes such as virus entry into cells and virus budding. (lu.se)

Although OmpX has the same beta-sheet topology as the structurally related outer membrane protein A (OmpA) InterPro: IPR000498, their barrels differ with respect to the shear numbers and internal hydrogen-bonding networks. (wikipedia.org)
Here we report the first topology model of flavivirus NS2A on the ER membrane. (rcsb.org)

OspA and OspB share 53% amino acid identity and likely have a similar antiparallel "free-standing" β sheet protein structure associated with the outer membrane surface via a lipidated NH2-terminal cysteine residue. (wikipedia.org)
The structure shows two girdles of aromatic amino acid residues and a ribbon of nonpolar residues that attach to the membrane interior. (wikipedia.org)
Here, we stabilize their folding by restraining their amino and carboxyl termini with associable protein entities, exemplified by the two halves of a superfolder GFP. (cornell.edu)

Thenovel NT* tag is derived from a spider silk protein and was reported to be apromising fusion tag for protein purification. (kth.se)
experience with membrane protein expression, and purification is preferred. (cnrs.fr)
The termini-restrained proteins are functional and show improved stability during overexpression and purification. (cornell.edu)

Maternal sera were dialyzed in vitro across individual or combined fetal membranes to elucidate the functions of the membranes in protein transport. (researchgate.net)

Transport of small molecules across membranes. (lu.se)

Thus, endomembrane-modifying proteins within the endomembrane system will have an influence on the final grain quality/yield and recombinant protein production. (nature.com)
The same phenomenon was observed with membranes from Sf9 cells, expressing a recombinant PLCβ 1 cascade. (jneurosci.org)

As stated above, the Nernst potential is the potential difference that exists across a membrane when a particular ion , having reached equilibrium between the tendency to diffuse down its concentration gradient and the tendency to be drawn back by other ions, is in a state of no net flux. (britannica.com)
There is also a tendency for Cl − to permeate the membrane, since that ion is at higher concentration outside the neuron than inside. (britannica.com)
When ΔG is positive the transport is active, an input of energy is needed to move a molecule up a concentration gradient, contrary to ΔG being negative the transport is passive, which means that such molecules will pass through a membrane down their own gradient, simple diffusion. (wikibooks.org)
Concentration of individual proteins in the dialyzates obtained, closely resembled the composition of amniotic fluid. (researchgate.net)

At such low temperatures, the signals of fluorescent proteins can be localized more precisely. (mpg.de)
The method thereby opens up the possibility low temperatures, the signals of fluorescent proteins can be localized more precisely. (mpg.de)

Vahid Sandoghdar and his colleagues have been working on alternative methods to increase the performance of high-resolution fluorescence microscopy for several years now − with considerable success, as the Erlangen physicist reports: "Our new approach allows us to display structures that are separated by a distance of less than five angstroms, i.e. half a nanometre. (mpg.de)
We previously demonstrated that a transmission electron microscope (TEM) operating at 200 keV equipped with a K2 Summit direct electron detector (DED) could be used to resolve a ~150 kDa protein complex to ~2.6 Å using conventional defocus-based SPA methods 12 . (nature.com)
An improved understanding of the structure and the function of the huntingtin protein could contribute to the development of new treatment methods in the future. (mpg.de)

The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)

Studying a protein's structure lets scientists get a better handle on its mechanisms of action, but the structures of ion channels and membrane transporters have long been shrouded in mystery. (scifivoice.com)
Shape changes are thought to be central to the operation of membrane transporters, but how most proteins change shape to execute their function is still unknown. (scifivoice.com)

NPC1 is a membrane protein found in late endosomes and lysosomes that functions to transport cholesterol across the membrane. (scifivoice.com)
Snare that acts to regulate protein transport between late endosomes and the trans-golgi network. (lu.se)

Nearly all of the resonances in the two-dimensional 1H/15N HSQC spectrum of uniformly 15N labeled Vpu(2-30+) in micelles are superimposable on those from the corresponding residues in the spectrum of full-length Vpu, which indicates that the structure of the trans-membrane domain is not strongly affected by the presence of the cytoplasmic domain at its C terminus. (rcsb.org)
The analysis of the PISA wheels and Dipolar Waves obtained from both weakly and completely aligned samples show that Vpu(2-30+) has a trans-membrane alpha-helix spanning residues 8-25 with an average tilt of 13 degrees. (rcsb.org)
The area includes projects focused on the study of respiratory chain NADH:quinone oxidoreductase ( Complex I ), aquaporin membrane water channels and a technology platform for monitoring trans-membrane proton flux . (lu.se)

The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)
Most of the circulating testosterone is bound to carrier proteins (SHBG = sex hormone-binding globulin). (cdc.gov)

Virulence-related outer membrane proteins, or outer surface proteins (Osp) in some contexts, are expressed in the outer membrane of gram-negative bacteria and are essential to bacterial survival within macrophages and for eukaryotic cell invasion. (wikipedia.org)
Borrelia burgdorferi (responsible for Lyme disease) outer surface proteins play a role in persistence within ticks (OspA, OspB, OspD), mammalian host transmission (OspC, BBA64), host cell adhesion (OspF, BBK32, DbpA, DbpB), and in evasion of the host immune system (VlsE). (wikipedia.org)
The virus' surface proteins, hemagglutinin (HA) and neuraminidase (NA), were highlighted in light and dark blue, respectively. (cdc.gov)
Three of these RNP segments encode the virus' surface proteins, i.e., the HA, NA and M proteins. (cdc.gov)

This protective membrane is made from thin sheets of chitin, a natural, fibrous material that is similar in makeup to the group s hydrogel nanofibers. (nanotech-now.com)
Being able to show how this protective membrane is created could help researchers understand other molecular fossils in the future, offering new evidence about the evolution of life on Earth. (stanford.edu)

The vertebrate-specific proteins astrotactin-1 and 2 (ASTN-1 and ASTN-2) are integral membrane perforin-like proteins known to play critical roles in neurodevelopment, while ASTN-2 has been linked to the planar cell polarity pathway in hair cells. (ox.ac.uk)

Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)

This family consists of several bacterial and phage Ail/Lom-like proteins. (wikipedia.org)
Lom is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera. (wikipedia.org)
Members of this group include: PagC, required by Salmonella typhimurium for survival in macrophages and for virulence in mice Rck outer membrane protein of the S. typhimurium and S. enteritidis virulence plasmid Ail, a product of the Yersinia enterocolitica chromosome capable of mediating bacterial adherence to and invasion of epithelial cell lines OmpX from Escherichia coli that promotes adhesion to and entry into mammalian cells. (wikipedia.org)
This protein disappears from the bacterial surface around 2 weeks after infection. (wikipedia.org)
They are also examining how to develop the best membranes for specific materials, such as sustainable yet tough membranes that can prevent the formation of bacterial growth. (phys.org)
The damage which they do to the mucous membrane favors bacterial invasion. (dictionary.com)

In vitro Studies of Protein Transfer Across Human Fetal Membranes. (researchgate.net)

The platform may be used for functional investigations of important membrane proteins, as well as investigating lipid bilayers of different composition. (lu.se)
This ubiquitination enabled the formation of MST2 homodimer and enhanced its kinase activity, ultimately resulting in the functional inactivation of yes-associated protein (YAP) and inhibition of an epithelial-mesenchymal transition (EMT) feature. (bvsalud.org)

The results are expected to constitute a significant step towards deciphering the structure-function relationship of IDPs, which is vital for developing the next generations of pharmaceuticals, such as antibiotics, i.e., antimicrobial peptides. (lu.se)

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. (ox.ac.uk)

To study this, Yan's postdocs tried to visualize the channel bound to different toxins, but couldn't purify enough protein to get good images of the bound toxins. (scifivoice.com)
In a next step, the researchers solved the structure of the proteasome bound to four different inhibitors that are either already used in the clinic or are currently undergoing clinical trials. (analytica-world.com)

notably, integration of proteomics data with in situ subcellular microscopic analyses showed a high abundance of cytoskeleton proteins associated with acidified PBs at the early development stages. (nature.com)

View of a protein: Max Planck researchers have used the COLD method to visualize the four binding sites of biotin (labelled by red dye molecules) in the protein streptavidin, whose structure is already known. (mpg.de)
Researchers from Penn State, The University of Texas at Austin, Iowa State University, Dow Chemical Company and DuPont Water Solutions published a key finding in understanding how membranes actually filter minerals from water, online today (Dec. 31) in Science . (phys.org)
Although its function is unknown, researchers suggest that the C19orf12 protein plays a role in the maintenance of fat (lipid) molecules, a process known as lipid homeostasis. (medlineplus.gov)
However, recent improvements in cryogenic electron microscopy (cryo-EM) have enabled researchers, including Yan, to begin solving this problem for various membrane proteins. (scifivoice.com)
With the help of cryo-electron microscopy, the recently awarded Nobel Prize winning method, researchers have now decoded the three-dimensional, molecular structure of the healthy human huntingtin protein. (mpg.de)
To get a clear picture, the researchers in the Kochanek lab have been looking for other proteins that interact with huntingtin and stabilize it. (mpg.de)
A team of researchers from Göttingen and Hamburg have now succeeded in determining the 3D structure of the human proteasome in unprecedented detail and have deciphered the exact mechanism by which inhibitors block the proteasome. (analytica-world.com)

Proteins in this family are predicted to consist of eight transmembrane beta-sheets and four cell surface-exposed loops. (wikipedia.org)
Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). (nih.gov)
For the PIV5 fusion protein, the fusion peptide (FP) and the transmembrane domain (TMD) show striking membrane-dependent conformations. (lu.se)

The NS1 hexamer in crystal structures is similar to a solution hexamer visualized by single-particle electron microscopy. (nih.gov)
Co-led by Manish Kumar, associate professor in the Department of Civil, Architectural and Environmental Engineering at UT Austin, the team used multimodal electron microscopy, which combines the atomic-scale detailed imaging with techniques that reveal chemical composition, to determine that desalination membranes are inconsistent in density and mass. (phys.org)
This enabled the scientists to deduce their three-dimensional structure using cryo-electron microscopy. (mpg.de)
Fernández-Busnadiego, an expert in cryo-electron microscopy, mentions two main factors: 'First of all, cryo-electron microscopy has only been optimized in recent years to look at protein structures with almost molecular resolution. (mpg.de)

It also has a role in the resistance against attack by the human complement system a Bacteriophage lambda outer membrane protein, Lom OspA/B are lipoproteins from Borrelia burgdorferi. (wikipedia.org)
OspA from Borrelia burgdorferi is an unusual outer surface protein, it has two globular domains which are connected with a single-layer β-sheet. (wikipedia.org)
Unlike plants and fungi, archaeal organisms do not produce protective outer walls of cellulose and their membranes do not contain the same chemicals as bacteria. (stanford.edu)

He will develop method for stabilizing these complexes in membrane mimetic system, for optimizing cryoem grids, collect high resolution data and use image processing software to determine 3D reconstruction. (cnrs.fr)
Syroegin, E. A. , Aleksandrova, E. V. , and Polikanov, Y. S. (2022) Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes . (cornell.edu)
The mode of action of enzymes and macromolecular complexes as protein machines will be investigated. (manchester.ac.uk)

The aim of this study was to evaluate the sealing capability and tissue interaction of mussel-mimetic tissue adhesive (mussel glue) in comparison to fibrin glue on punctured fetal membranes in vivo. (researchgate.net)

Thisimplies that BIN1 rather bundles actin than decorates single filaments.Third, we explored a strategy to purify an aggregation prone BAR protein.Aggregation is a property common in Peripheral Membrane Proteins. (kth.se)

This protein is highly soluble, contains a large number of Lys and Glu residues. (wikipedia.org)

Based on proteome annotation and a homology search, 94 proteins associated with the endomembrane system were identified that exhibited significant changes in abundance during grain development. (nature.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

We report crystal structures for full-length, glycosylated NS1 from West Nile and dengue viruses. (nih.gov)

Tailored parallel X-rays perfectly matching the dimensions of the protein crystals enabled the scientists to determine the proteasome structure in unprecedented detail (top right). (analytica-world.com)

Anatomy31

Organisms8

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes71

Disciplines and Occupations5

Technology, Industry, Agriculture7

Information Science21

Health Care7

Cell Membrane5

Structural13

Endoplasmic reticulum2

Cellular13

Lipids4

Dynamics5

Plasma membrane10

Classes of membrane proteins1

Interactions5

Conformation3

Intrinsically disordered proteins3

Crystallography2

Macromolecules3

Determination8

20201

Embedded in the lipid1

Translocation2

Lamellar membranes1

Organism4

Biological membranes1

Biophysical2

Synthesis3

Lipid Membranes1

Receptors1

Pathways2

Intracellular3

Interacts3

Bilayer5

Extracellular2

Mitochondrial3

Side of the membrane2

Permeable4

Modulate1

Mutation1

Processes6

Topology2

Amino3

Purification3

Elucidate1

Small molecules1

Recombinant2

Concentration4

Signals2

Methods3

Subunits1

Transporters2

Late endosomes2

Trans-membrane3

Carrier proteins2

Surface proteins4

Protective membrane2

Integral1

Regulate1

Bacterial6

Vitro studies1

Functional2

IDPs1

Neuronal1

Bound2

Subcellular1

Researchers7

Transmembrane3

Electron microscopy4

Outer3

Complexes3

Mimetic1

Actin1

Residues1

Homology2

Dengue1

Crystals1