• Second, several different human diseases, such as Duchenne muscular dystrophy, can be linked to loss of protein function resulting from a change in just a single amino acid in the primary sequence. (wikipedia.org)
  • Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. (uchicago.edu)
  • Also, ionic bonds called salt bridges form between positively- and negatively-charged side-chains of amino acids, further stabilizing the tertiary structure. (pediaa.com)
  • A pronounced absorption band in the near-UV CD region, arising from immobilized aromatic side-chains, showed that the artificial protein is folded in solution. (caltech.edu)
  • Universalities in Protein Tertiary Structures: Some New Concepts, in Biomolecular Forms and Functions, 210-219. (jbsdonline.com)
  • Proteins (including their lipoprotein and glycoprotein forms) also constitute 10 percent of the weight of the blood plasma of living organisms, carrying various nutrients throughout the body and acting as signals to coordinate bodily functions between the different organs. (encyclopedia.com)
  • Knowledge-based functions are formed with statistical models capturing aspects of the properties of native protein conformations. (wikipedia.org)
  • It is quite apparent that efforts in tertiary structure prediction have saturated to a level where there is an immediate need for methodological innovations - beyond templates of folds to avoid falling into a trap of Lamarckism in protein folding. (jbsdonline.com)
  • H spin diffusion with MAS NMR is demonstrated for a helical transmembrane model protein complex. (figshare.com)
  • A Stoichiometry driven universal spatial organization of backbones of folded proteins: Are there Chargaff's rules for protein folding? (jbsdonline.com)