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  • metabolism
  • In later developmental stages the capacity for matrix organic acid metabolism was evident, accompanied by the appearance of proteins for TCA cycle components, and coordination of electron transport chain assembly through components encoded in both mitochondrial and nuclear genomes. (deepdyve.com)
  • molecular
  • Hussein Naim is a Lebanese-Swiss biochemist and molecular virologist, known for his research in cell biology (membrane protein sorting and internalization) and virology (measles, SARS, HIV and Influenza). (wikipedia.org)
  • The unmodified protein is predicted to have a molecular weight of 53,835.05 Daltons and an isoelectric point of 6.673. (wikipedia.org)
  • The TMEM106A protein has a molecular weight of 28.9 kdal. (wikipedia.org)
  • substrate
  • A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate. (wikipedia.org)
  • E3 ligases interact with both the target protein and the E2 enzyme, and so impart substrate specificity to the E2. (wikipedia.org)
  • The E3, which may be a multi-protein complex, is, in general, responsible for targeting ubiquitination to specific substrate proteins. (wikipedia.org)
  • F-box proteins contain an F-box, which binds the rest of the SCF complex, and a substrate binding domain, which gives the E3 its substrate specificity. (wikipedia.org)
  • E3 ubiquitin ligases catalyze polyubiquitination events much in the same way as the single ubiquitylation mechanism, using instead a lysine residue from a ubiquitin molecule currently attached to substrate protein to attack the C-terminus of a new ubiquitin molecule. (wikipedia.org)
  • cell surface
  • For example, secreted proteins and plasma membrane proteins are easily accessible by drug molecules due to their localization in the extracellular space or on the cell surface. (wikipedia.org)
  • Bacterial cell surface and secreted proteins are also of interest for their potential as vaccine candidates or as diagnostic targets. (wikipedia.org)
  • His research was instrumental towards understanding the intracellular mechanisms of viral and membrane protein sorting in epithelial cells and the cell-surface assembly of several RNA viruses. (wikipedia.org)
  • Targeting
  • The aim is to build tools that can accurately predict the outcome of protein targeting in cells. (wikipedia.org)
  • We analyzed the mitochondria-targeting signal of rat Tom20 (rTom20) in COS-7 cells, using green fluorescent protein (GFP) as the reporter by systematically introducing deletions or mutations into the TMD or the flanking regions. (nih.gov)
  • The genomic context may not necessarily infer function, but Morn1 has been predicted to contain a second peroxisomal targeting signal using PSORTII at residues 451: RLPPAFKHL, which may suggest interaction with PEX10 (see genomic context above). (wikipedia.org)
  • Arabidopsis
  • The high similarities of gene structure, protein sequences and 3D models among ZmCHC1 , and Arabidopsis AtCHC1 and AtCHC2 suggest their similar functions in CME. (mdpi.com)
  • We developed CORNET (for CORrelation NETworks) as an access point to transcriptome, protein interactome, and localization data and functional information on Arabidopsis ( Arabidopsis thaliana ). (plantphysiol.org)
  • Expression in Arabidopsis cells of cDNAs encoding each of these KATs fused to green fluorescent protein (GFP) at their C-termini showed that three are targeted to peroxisomes while the fourth is apparently cytosolic. (deepdyve.com)
  • recognition
  • The signal recognition particle (SRP)-induced translation arrest and photo-cross-linking demonstrated that SRP recognized the TMD of rTom20-GFP, but with reduced affinity, while the positive charge at the COOH-terminal flanking segment inhibited the translation arrest. (nih.gov)
  • interact
  • DCAF11 is a protein that is known to interact with COP9 and has several alternative transcripts. (wikipedia.org)
  • This predicted structure indicates there are two main parts, and it is possible they interact depending on the state of the protein (e.g. whether or not it's phosphorylated). (wikipedia.org)