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  • residues
  • Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. (ebi.ac.uk)
  • Autophosphorylated on serine and threonine residues. (abcam.com)
  • It is a homodimer composed of a catalytic kinase domain (residues76-338) located at the amino or N-terminus of the protein, a coiled-coil region(residues 425-1100) containing the Rho-binding domain, and a pleckstrin-homology domain(residues 1118-1317) with a cysteine-rich domain. (wikipedia.org)
  • enzyme
  • In enzymology, a receptor protein serine/threonine kinase (EC 2.7.11.30) is an enzyme that catalyzes the chemical reaction ATP + [receptor-protein] ⇌ {\displaystyle \rightleftharpoons } ADP + [receptor-protein] phosphate Thus, the two substrates of this enzyme are ATP and receptor protein, whereas its two products are ADP and receptor protein phosphate. (wikipedia.org)
  • This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups protein-serine/threonine kinases. (wikipedia.org)
  • The systematic name of this enzyme class is ATP:[receptor-protein] phosphotransferase. (wikipedia.org)
  • The systematic name of this enzyme class is ATP:protein phosphotransferase (non-specific) . (wikipedia.org)
  • PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. (wikipedia.org)
  • The involvement of this enzyme in a variety of pathways, protein-protein interactions, and nuclear transport suggests its potential to perform multiple nonglycolytic functions with diverse implications, although multidimensional role of this protein is as yet not fully explored. (wikipedia.org)
  • PKM2 is a cytosolic enzyme that is associated with other glycolytic enzymes, i.e., hexokinase, glyceraldehyde 3-P dehydrogenase, phosphoglycerate kinase, phosphoglyceromutase, enolase, and lactate dehydrogenase within a so-called glycolytic enzyme complex. (wikipedia.org)
  • Enzyme activity of ROCK1 is inhibited when the pleckstrin-homology and Rho-binding domains in the C-terminus independently bind to the N-terminus kinase domain. (wikipedia.org)
  • cytosolic
  • TGF beta receptor 1 has been shown to interact with: Caveolin 1, Endoglin, FKBP1A, FNTA, Heat shock protein 90kDa alpha (cytosolic), member A1 Mothers against decapentaplegic homolog 7, PPP2R2A, STRAP, TGF beta 1, and TGF beta receptor 2. (wikipedia.org)
  • tumor
  • When PKM2 is mainly in the less active dimeric form, which is the case in tumor cells, all glycolytic intermediates above pyruvate kinase accumulate and are channelled into synthetic processes, which branch off from glycolytic intermediates such as nucleic acid-, phospholipid-, and amino acid synthesis. (wikipedia.org)
  • activity
  • Controls sodium and chloride ion transport by inhibiting the activity of WNK4 , by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1 . (rcsb.org)
  • G-protein RhoE binds to the N-terminus of ROCK1 and inhibits its activity by preventing RhoA binding. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • mammalian
  • The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. (springer.com)
  • It is composed of ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3 related (ATR), DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Pyruvate kinase catalyzes the last step within glycolysis, the dephosphorylation of phosphoenolpyruvate to pyruvate, and is responsible for net ATP production within the glycolytic sequence. (wikipedia.org)
  • In fact, sequence homology searches have shown that two other Pim-1-like kinases, Pim-2 and Pim-3, are structurally and functionally similar. (wikipedia.org)