Protein septins. Medical search. Frequent questions

As filament forming proteins, septins can be considered part of the cytoskeleton. (wikipedia.org)
Each appressorium builds a powerful type of hydrostatic force called turgor pressure that drives a kind of "infection peg" through the plant's cuticle aided by a ring-shaped structure built from septins, a class of cytoskeleton proteins. (stuttgartdailyleader.com)
The cytoskeleton is a dynamic network of protein filaments and tubes that helps cells maintain their shape and internal organization. (stuttgartdailyleader.com)
Egan has built on Talbot's septin ring findings, revealing how cytoskeleton filaments called F-actin are recruited to the edge of the fungi's attacking septin ring to remodel it for plant invasion. (stuttgartdailyleader.com)
Egan says that despite progress made since the septins were discovered in budding yeast cells about 50 years ago, the proteins "remain poorly understood" compared to other major cytoskeleton proteins involved in the framework of the organisms even though they play important roles. (stuttgartdailyleader.com)
Actin Binding Proteins allow the actin cytoskeleton to respond rapidly to cellular and extracellular signals and are integral to cytoskeletal involvement in many cellular processes. (cytoskeleton.com)
Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. (labome.cn)
The highly homologous ERM (ezrin/radixin/moesin) proteins, molecular cross-linkers which connect the cell membrane with the underlying cytoskeleton, have molecular weights of 81, 80 and 78 kDa respectively. (embl-heidelberg.de)
Second, homologues of signature eukaryotic proteins, such as actin and tubulin that form the core of the cytoskeleton or the ubiquitin system, have been detected in diverse archaea. (catsboard.com)
Septins are part of the cytoskeleton and serve as a key structural element similar to a modular scaffold that can be flexibly put together and taken apart. (researchaether.com)
Turgor is applied as an enormous invasive force by septin-mediated reorganization of the cytoskeleton and actin-dependent protrusion of a rigid penetration hypha3. (uea.ac.uk)

GTpase activity has been verified in all of these recombinants, which shows that these proteins are present in native form and that additional molecules are not needed for this activity. (usp.br)
Septin 2 is a filament-forming cytoskeletal GTPase. (labome.cn)
In addition, overexpression of the ENTH domain of Ent2 (ENTH2) was shown to play a role in cell division by interacting with the septin organizing, Cdc42 GTPase activating protein, Bem3, leading to increased cytokinesis failure. (purdue.edu)
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. (nih.gov)
This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. (nih.gov)
Bub2's GTPase-activating protein (GAP) activity was needed for its removal from the mother-bound SPB. (rupress.org)
Rho1 is normally a little GTPase protein, which enhances the enzyme activity of Fks2 and Fks1 [17]. (bakingandbakingscience.com)

We show, first, that for septin-septin interactions, this method yields a robust signal whose strength reflects the known spacing between the subunits in septin filaments and thus serves as a "molecular ruler. (escholarship.org)
Apart from forming non-polar filaments, septins associate with cell membranes, the cell cortex, actin filaments and microtubules. (wikipedia.org)
These proteins found in fungi and animals, but not in plants present, as their main characteristics, a conserved guanine nucleotide-binding domain (GTP) and they also form homo and hetero-oligomeric filaments that are highly organized structures. (usp.br)
Measurements of fluorescence emissions have indicated that the SEPT 7, SEPT 7G and SEPT 9G form structures of amyloid-like filaments found in many septins. (usp.br)
To determine whether a protein binds to filaments or monomers of actin. (cytoskeleton.com)
F-actin binding proteins will co-sediment with actin filaments and form a pellet at the bottom of the centrifugation tube. (cytoskeleton.com)

During cytokinesis, the septin cortex splits into a double ring which eventually disappears. (wikipedia.org)
These protein complexes are involved in cytokinesis, chitin deposition, cell polarity, spore formation, in the morphogenesis checkpoint, spindle alignment checkpoint and bud site selection. (wikipedia.org)
Budding yeast cytokinesis is driven through two septin dependent, redundant processes: recruitment and contraction of the actomyosin ring and formation of the septum by vesicle fusion with the plasma membrane. (wikipedia.org)
In contrast to septin mutants, disruption of one single pathway only leads to a delay in cytokinesis, not complete failure of cell division. (wikipedia.org)
Both chromosome segregation and cytokinesis rely, in part, on intricate microtubule (MT)-based structures, which are organized by MT associated proteins (MAPs), molecular motors, and other regulatory elements. (nih.gov)
Septins assemble into various structures on cell membrane by binding membrane phosphatidylinositol phosphates (PIPs) to specialize cell shape widely needed for many essential eukaryotic cellular processes, ranging from cytokinesis, mitosis, exocytosis, neuronal spine morphogenesis, spermiogenesis, and T-cell motility, to the formation of infection structures in pathogenic fungi including Magnaporthe oryzae , the causal agent of devastating rice blast disease. (nature.com)
Furthermore, in the absence of Bni4p, a scaffold protein involved in the targeting of the chitin synthase III complex to the bud neck, Crh2p was not longer found at the neck in large-budded cells undergoing cytokinesis. (silverchair.com)
Septins are a family of filament-forming GTP-binding proteins involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics. (molcells.org)

Three surface proteins (small, middle and large) are produced from the pre-S1/pre-S2/S ORF (hereafter called the HBsAg gene). (medscape.com)
The SEPTIN9 gene provides instructions for making a protein called septin-9, which is part of a group of proteins called septins. (medlineplus.gov)
Approximately 15 slightly different versions (isoforms) of the septin-9 protein may be produced from this gene. (medlineplus.gov)
Changes in these signal transduction pathways can lead to differential gene regulation with subsequent changes in protein expression, which can affect the development and function of the nervous system. (nih.gov)
4. Expression profiling the human septin gene family. (nih.gov)
8. The pathobiology of the septin gene family. (nih.gov)
14. MLL-SEPTIN gene fusions in hematological malignancies. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Using this simple screen, we identify Rgs1, a regulator of G-protein signaling (RGS) protein that is necessary for appressorium development, as a novel transcriptional regulator of effector gene expression, which acts prior to plant infection. (exeter.ac.uk)
In one type of disease that affects both skeletal and cardiac muscle, a gene mutation alters the shape of a protein called dysferlin, which normally binds annexin proteins that, as noted in the video, play a vital role in patching holes. (nih.gov)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Also, the genome-wide mass-spectrometry evaluation showed decreased proteins degree of chitin synthases in cells treated basic medications, but this lower was not due to the alternation of gene transcription. (bakingandbakingscience.com)
This gene belongs to the septin family of GTPases. (nih.gov)

Septins tune lipid kinase activity and PI(4,5)P turnover during G-protein-coupled PLC signalling in vivo. (ncbs.res.in)
Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. (ncbs.res.in)
As a membrane protein and non-kinase client of Hsp90-Cdc37, this work shows the remarkable plasticity of Cdc37 to interact with a broad array of clients with significant sequence variation. (bvsalud.org)
To investigate the role of the liver kinase (LK) B1 protein, an activator of AMP-activated protein kinase (AMPK), in AMPK signaling suppression when exposed to vesicant, a kind of chemical warfare agent. (bvsalud.org)
The ankyrin repeat-rich membrane spanning (ARMS) scaffold protein, also known as kinase D-interacting substrate of 220 kDa (Kidins 220), has been previously identified as a prominent downstream target of neurotrophin and ephrin receptors. (molcells.org)
Sln1 acts in parallel with the protein kinase C cell-integrity pathway as a regulator of cAMP-dependent signalling by protein kinase A. Pkc1 phosphorylates the NADPH oxidase regulator NoxR and, collectively, these signalling pathways modulate appressorium turgor and trigger the generation of invasive force to cause blast disease. (uea.ac.uk)

Septins have been implicated in the localization of cellular processes at the site of cell division, and at the cell membrane at sites where specialized structures like cilia or flagella are attached to the cell body. (wikipedia.org)
Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. (nature.com)
However, both methods rely on isobaric tandem mass tag (TMT) labeling for quantifying subcellular protein localization, and they require extensive off-line peptide fractionation and consequently lengthy liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis time to achieve the desired depth on the proteome, thus minimizing throughput. (nature.com)
FEO localization at the cytokinetic furrow in telophase also recruits midbody proteins necessary for proper cell abscission. (nih.gov)
HN - 2011 MH - 5-Lipoxygenase-Activating Proteins UI - D058927 MN - D12.644.360.24.32 MN - D12.776.476.24.34 MN - D12.776.543.19 MS - Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASES. (nih.gov)
Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers. (wustl.edu)
The localization of Chs3 adjustments through the cell routine, which is controlled by extra chitin synthesis-related proteins, Chs4-7. (bakingandbakingscience.com)

2. Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. (nih.gov)
Here we report the biochemical and immunocytochemical characterization of a recently identified mammalian septin, SEPT12. (molcells.org)

The virus encodes four main proteins including the core, polymerase, surface and X proteins. (medscape.com)
Mycobacterium tuberculosis encodes two chaperonin proteins, MtbCpn60.1 and MtbCpn60.2, that share substantial sequence similarity with the Escherichia coli chaperonin, GroEL. (bvsalud.org)
Finally, Crh2p was not properly localised in cells deleted in CHS5 , which encodes a protein involved in the transport of Chs3p, and was completely mislocalised in sbe2/sbe22 mutants,suggesting that the transport systems for Chs3p and Crh2p are to a certain extent coincident. (silverchair.com)

Septins are found in fungi, animals, and some eukaryotic algae but are not found in plants. (wikipedia.org)

The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)

The phosphorylation of EphA2 is closely regulated by the human cytoplasmic protein tyrosine phosphatase (HCPTP), which is also overexpressed in cancers overexpressing EphA2. (purdue.edu)
Since ERM proteins can exist in dormant or active conformations corresponding to their phosphorylation state, we propose that the partitioning of ERM proteins between subcellular compartments may depend on their activation status. (embl-heidelberg.de)
Focusing on LKB1, heat shock protein (HSP) 90, and cell division cycle (CDC) 37 proteins, the protein expression, phosphorylation, and interaction were examined with western blot, immunofluorescence staining, and/or immunoprecipitation. (bvsalud.org)

Septins are highly conserved between different eukaryotic species. (wikipedia.org)
They are composed of a variable-length proline rich N-terminus with a basic phosphoinositide binding motif important for membrane association, a GTP-binding domain, a highly conserved Septin Unique Element domain, and a C-terminal extension including a coiled coil domain of varying length. (wikipedia.org)
These proteins contain a highly conserved Epsin N-terminal homology (ENTH) domain that is essential for cell viability. (purdue.edu)

A recombinant fusion protein containing a sequence corresponding to amino acids 202-298 of human Septin 2. (labome.cn)

There are seven different septins in Saccharomyces cerevisiae. (wikipedia.org)
Here,the specificity of the mechanisms that regulate the temporal and spatial localisation of cell wall proteins to sites of polarised growth in Saccharomyces cerevisiae is investigated. (silverchair.com)

Septins are a group of GTP-binding proteins expressed in all eukaryotic cells except plants. (wikipedia.org)
These results indicate that an overexpression of dephosphorylated HCPTP-A plays a key role in cell transformation and the future development of anti-cancer therapeutics should be targets towards HCPTP-A. Epsins are eukaryotic, endocytic adaptor proteins primarily involved in the early steps of clathrin mediated endocytosis. (purdue.edu)
In eukaryotic cells, proteins, nucleic acids and small molecules are distributed by specific trafficking mechanismsrather than by free diffusion as is largely the case in bacteria and archaea. (catsboard.com)

Tubular carriers contribute to the flux of membrane lipids and proteins to acceptor organelles, but how lipids and proteins impose a tubular geometry on the carriers is incompletely understood. (researchgate.net)
However, it remains largely unknown how membrane lipids regulate septin organization for cell shape specialization. (nature.com)

A recently described tripartite split-GFP system has the potential to report by direct visualization via a fluorescence signal the intimate association of minimally tagged proteins expressed at their endogenous level in their native cellular milieu and can capture transient or weak interactions. (escholarship.org)
Here we document the utility of this tripartite split-GFP system to assess in living cells protein-protein interactions in a dynamic cytoskeletal structure-the septin collar at the yeast bud neck. (escholarship.org)
These mutations may also change the distribution of septin-9 isoforms and their interactions with other septin proteins in some of the body's tissues. (medlineplus.gov)
3. Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol. (nih.gov)

In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. (abcam.com)
The sporulating septins (Spr3, Spr28) localize together with Cdc3 and Cdc11 to the edges of prospore membranes. (wikipedia.org)
Septins are among a few proteins that associate with membranes to regulate cell shape differentiation. (nature.com)
In summary, our study discovers a novel mechanism in which VLCFAs regulate PIPs-mediated septin ring formation by recruiting septins to curved plasma membranes to assemble into a septin ring for initiating the formation of a penetration peg. (nature.com)
Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)

Finally, we investigate the spatio-temporal stress signaling, revealing cellular relocation of ribosomal proteins in response to hypertonicity and muscle contraction. (nature.com)
Cellular distributions of the ERM proteins in MDCK epithelial cells: regulation by growth and cytoskeletal integrity. (embl-heidelberg.de)
It was found that 1.0, not 0.5 mM CEES also decreased the CDC37 protein, proteasome activity, and cellular ATP content that modulates HSP90 protein conformation. (bvsalud.org)
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Researchers at the National Cancer Institute (NCI) have developed mouse lines with fluorescently labelled membrane proteins regulating cellular motility and membrane trafficking. (nih.gov)
NCI is seeking licensees for mouse lines with fluorescently labeled membrane proteins regulating cellular motility and cancer progression. (nih.gov)
The section consists of five research groups located in two different laboratory environments: Protein Chemistry Laboratory and Laboratory of Cellular Ageing. (au.dk)

Different septins form protein complexes with each other. (wikipedia.org)
Septins form into hetero-oligomeric complexes that are comprised of several distinct septin subunits. (bvsalud.org)

In this work, with the goal of obtaining structural and biochemical information of human septins 7 and 9, the recombinants SEPT 7, SEPT 7G and SEPT 9G were expressed in E. coli. (usp.br)

Finally, we demonstrate the capacity of this approach to uncover additional new information by examining whether three other proteins reported to localize to the bud neck (Nis1, Bud4, and Hof1) are able to interact physically with any of the subunits in the septin collar and, if so, with which ones. (escholarship.org)

Structural organization of RDGB (retinal degeneration B), a multi-domain lipid transfer protein: a molecular modelling and simulation based approach. (ncbs.res.in)

As you'll learn by watching this video, Gladfelter's work has implications far beyond the world of fungi because the filamentous proteins called septins, which act to define territory within Ashbya cells, are very similar to certain proteins found in human cells. (nih.gov)

Structural changes require a destabilization of the septin cortex (fluid state) induced by dephosphorylation prior to bud emergence, ring splitting and cell separation. (wikipedia.org)
9. Structural and expression changes of septins in myeloid neoplasia. (nih.gov)

6. Septins: Active GTPases or just GTP-binding proteins? (nih.gov)

Taken together, our study reveals a novel mechanism by which ARMS/Kidins220 scaffold protein regulates tumor cell proliferation. (molcells.org)
Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)

Second, the method yields little or no spurious signal even with highly abundant cytosolic proteins readily accessible to the bud neck (including molecular chaperone Hsp82 and glycolytic enzyme Pgk1). (escholarship.org)
12. Cell and molecular biology of septins. (nih.gov)
Phylogenetic and molecular studies in humans have identified 14 septins which are divided into 4 subfamilies (groups I, II, III and IV). (usp.br)
Protein stability studies under different pH and temperature conditions show that the raise of the latter produces a greater molecular aggregation. (usp.br)
We present data which shows significant variation in the molecular weight and presence of multiple forms of ERM proteins in different cell lines, such that specific antibodies to each protein are essential for unambiguous detection. (embl-heidelberg.de)

Septin and actin contributions to endothelial cell-cell junctions and monolayer integrity. (wustl.edu)

Research in human cells suggests that septins build cages around pathogenic bacteria, that immobilize and prevent them from invading other cells. (wikipedia.org)
1. Conquering the complex world of human septins: implications for health and disease. (nih.gov)
The SNAP-tag is a small protein based on human O 6 -alkylguanine-DNA-alkyltransferase (hAGT), a DNA repair protein. (neb.com)
Human immunization against parasite proteins through transmission blocking vaccines (TBVs) [ 6 ] is one such strategy. (biomedcentral.com)
While such proteins are normally very flexible, they can morph into toxic, solid states in certain human disorders, including Alzheimer's disease and Huntington's disease. (nih.gov)

17. Septin roles in tumorigenesis. (nih.gov)

Assembled as such, septins function in cells by localizing other proteins, either by providing a scaffold to which proteins can attach, or by forming a barrier preventing the diffusion of molecules from one compartment of the cell to another, or in the cell cortex as a barrier to the diffusion of membrane-bound proteins. (wikipedia.org)
Septins form a specialised region in the cell cortex known as the septin cortex. (wikipedia.org)

By immunocytochemistry, it was shown that podocalyxin and the actin binding protein ezrin are co-expressed in podocytes and co-localize along the apical plasma membrane, where they form a co-immunoprecipitable complex. (embl-heidelberg.de)

VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity. (nature.com)
Pharmaceutic or genetic inhibition of PIPs biosynthesis compromises septin ring formation and pathogenicity of M. oryzae , indicating the importance of PIPs in septin-dependent host penetration. (nature.com)
We further discovered that a class of chemical herbicides targeting VLCFA biosynthesis is effective for inhibiting pathogenicity of M. oryzae through preventing septin-dependent penetration in both chamber test and field-trial. (nature.com)

5. The Mammalian Septin Interactome. (nih.gov)
This mechanism advances our understanding in fungal infection structure formation and may also contribute to other studies on septin/VLCFA-dependent cell morphogenesis in mammalian cells. (nature.com)

10. The anillin-related region of Bud4 is the major functional determinant for Bud4's function in septin organization during bud growth and axial bud site selection in budding yeast. (nih.gov)
16. Here come the septins: novel polymers that coordinate intracellular functions and organization. (nih.gov)

Analyses both in SDS-Page electroforesis and in native gel suggest that these proteins were purified successfully for they are soluble and homogeneous. (usp.br)

SNAP- and CLIP-tag protein labeling systems enable the specific, covalent attachment of virtually any molecule to a protein of interest. (neb.com)

Finally, either 0.5 or 1.0 mM CEES activated HSP70 and autophagy, and the application of an HSP70 inhibitor blocked autophagy and autophagic degradation of the LKB1 protein. (bvsalud.org)
This effect is mediated by the upregulation of a CDK inhibitor p21, which causes the decrease in cyclin D1 and CDK4 protein levels and subsequent reduction of pRb hyperphosphorylation. (molcells.org)
The job of the inhibitor proteins is to prevent the activity of the cutting proteins, to stop them from causing the unwanted death of cells. (frontiersin.org)
When a signal happens inside the cell signaling that the cell is meant for destruction, the caspases will increase until they outnumber the inhibitor proteins. (frontiersin.org)

Yet at the same time, septins can also encapsulate bacteria that have already penetrated and induce their liquidation, so they have an ambivalent function in infections. (researchaether.com)
This showed that binding via LecA was enough to induce septin accumulation. (researchaether.com)

The protein purity of the tubulin used for labeling is determined by scanning densitometry of Coomassie Blue stained protein on a 4-20% polyacrylamide gel. (cytoskeleton.com)

Septins provide microenvironment sensing and cortical actomyosin partitioning in motile amoeboid T lymphocytes. (nih.gov)

Better understanding of these proteins could aid in finding points of attack for drugs designed to prevent infection by antibiotic resistant bacteria. (researchaether.com)

A Δsln1 mutant generates excess intracellular appressorium turgor, produces hyper-melanized non-functional appressoria and does not organize the septins and polarity determinants that are required for leaf infection. (uea.ac.uk)

A long-chain biotin derivative was selected for this procedure because it allows the biotin molecules to be spaced far enough away from the tubulin protein so as not to interfere with its activity, e.g., ligand binding to SPA beads or other streptavidin based reagents. (cytoskeleton.com)

Consistently, the degradation of the LKB1 protein and its less interaction with the HSP90/CDC37 complex was confirmed. (bvsalud.org)
In conclusion, we reported here that AMPK signaling inactivation by CEES was a result of LKB1 protein loss via less protein complex formation and enhanced degradation. (bvsalud.org)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)

Mass spectrometry-based proteomics in combination with subcellular fractionation can provide comprehensive maps of spatio-temporal regulation of protein networks in cells, but involves laborious workflows that does not cover the phospho-proteome level. (nature.com)
Protein function is tightly controlled in cells through multiple mechanisms. (nature.com)
Proteins belonging to the septin family were originally discovered in 1971 through genetic studies of mutant cells. (usp.br)
When used in conjunction with SNAP-tag, CLIP-tag enables the orthogonal and complementary labeling of two proteins simultaneously in the same cells. (neb.com)
Septin molecules inside the cells (magenta) accumulate on contact with the bacteria. (researchaether.com)
In healthy cells there is a balanced system of proteins, some of which activate the normal death mechanism, and some of which inhibit this process. (frontiersin.org)
Researchers have found that cancer cells lack a protein, called ARTS, which is crucial for activating the cells' death mechanism. (frontiersin.org)

This polarity of the septin network allows concentration of some proteins primarily to the mother side of the neck, some to the center and others to the bud site. (wikipedia.org)
Cell proliferation is tightly controlled by the cell-cycle regulatory proteins, primarily by cyclins and cyclin-dependent kinases (CDKs) in the G 1 phase. (molcells.org)

The large surface and HBx proteins play important roles in hepatocellular carcinogenesis. (medscape.com)
Of these proteins, 4 from the cerebellum and 47 from the hippocampus, identifiable by mass spectrometry, were found to have roles in mitochondrial energy metabolism, oxidative stress, apoptosis, calcium signaling, and growth of the nervous system. (nih.gov)
There is therefore a need for development of animal models for studying the roles of these proteins in cancer and their responses to drug treatment in vivo. (nih.gov)

Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. (nature.com)

One critical MAP, Fascetto (FEO), crosslinks MTs in anaphase to form the central spindle and localizes key proteins such as the Chromosomal Passenger Complex for anaphase progression. (nih.gov)
Chs3 forms a complicated with Chs4/Skt5, and Bni4 EPHB2 proteins localizes this complicated towards the septin band on the bud throat. (bakingandbakingscience.com)

M. oryzae depends on assembly of a septin ring to form an infection structure called penetration peg from the base of appressorium for rupturing host cuticle. (nature.com)
Using PIPs biosensors, we revealed that a pool of PIPs colocalized with septin protein Sep3 in the appressorium. (nature.com)

Mitotic septins (Cdc3, Cdc10, Cdc11, Cdc12, Shs1) form a ring structure at the bud neck during cell division. (wikipedia.org)
Mitotic exit relies on a G-protein called Tem1, which activates the destruction of mitotic cyclins. (rupress.org)

Anatomy3

Organisms3

Chemicals and Drugs13

Phenomena and Processes1

Cytoskeleton11

GTPase7

Filaments6

Cytokinesis8

Gene13

Kinase6

Localization7

Characterization2

Encodes3

Found in fungi1

Binds1

Phosphorylation3

Highly conserved3

Amino acids1

Saccharomyces2

Eukaryotic3

Membrane lipids2

Interactions4

Membranes5

Cellular7

Complexes2

Biochemical1

Subunits1

Lipid1

Fungi1

Structural2

GTPases1

Regulates2

Molecular5

Endothelial1

HUMAN5

Tumorigenesis1

Cell cortex2

Localize1

Biosynthesis3

Mammalian2

Organization2

Soluble1

Covalent attachment1

Inhibitor4

Induce2

Purity1

Actomyosin1

Drugs1

Intracellular1

Tubulin1

Degradation3

Cells7

Primarily2

Roles3

Mediate1

Localizes2

Appressorium2

Mitotic2