SarcomaTumoursLymphomaAnticancerMononuclear cellsVitro and in vivoGenesCompoundsAlterationCytotoxicResistanceUptakeReactive oxygenReceptorsMethotrexateMediatesApoptosisInduceModulationBiological activityGeneCancersCytoplasmSurvivalMetabolismChemicalHomeostasisCancerShownDiseaseDrugHumanSpecificMechanismInductionDeathActivationTreatmentRoleHostStudy
Sarcoma1
- Furthermore, in tumour necrosis factor alpha (TNFa)-stimulated Ewing's sarcoma (ES) cells, NF-jB is reported to prevent activation of an apoptotic cascade through inhibition of c-Jun N-terminal kinase (JNK) [23] and upregulation of anti-oxidant enzymes [24]. (lsd1receptor.com)
Tumours3
- Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
- The inhibition of P-gp and other ABC transporters can increase because the tumours have metastasized and/or have become resistant the intracellular concentration of cytotoxic drugs. (gotomydoctor.com)
- Consistent with this hypothesis, NF-jB is constitutively acti-vated in a wide variety of tumours permitting cells to evade apoptosis [16-19,21,22]. (lsd1receptor.com)
Lymphoma2
- Peripheral blood mononuclear cells of healthy donors and post-transplant lymphoma patients were stimulated with or without lunasin in the presence of IL-12 or IL-2. (weeksmd.com)
- The combination of lunasin and cytokines (IL-12 plus IL-2) was capable of restoring IFNγ production by NK cells from post-transplant lymphoma patients. (weeksmd.com)
Anticancer1
- Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
Mononuclear cells1
- an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
Vitro and in vivo4
- NK activation was evaluated, and its tumoricidal activity was assessed using in vitro and in vivo tumor models. (weeksmd.com)
- In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
- in vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil. (liverpool.ac.uk)
- 5-(2-fluoroethyl)-2'-deoxyuridine (fedu), its 2'-fluoroarabinofuranosyl analog (fefau) and the 2'-fluoroarabinofuranosyl analog (cefau) of the potent anti-herpesvirus compound 5-(2-chloroethyl)-2'-deoxyuridine (cedu) were evaluated for activity against herpes simplex virus type 1 (hsv-1) and hsv-2 in vitro and in vivo. (liverpool.ac.uk)
Genes2
- Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
- consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Compounds3
- This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
- In this study, we investigated the effects of Accepted 14 September 2009 nine naturally occurring compounds isolated from Citrus jambhiri Lush and Citrus pyriformis Hassk Available online 24 September 2009 (Rutaceae) for their potential to modulate the activity of P-gp in the multidrug-resistant human leukaemiacell line CEM/ADR5000. (gotomydoctor.com)
- Treatment of drug-resistant Caco-2 cells with the most active C. jambhiri and C. pyriformis compounds increased their sensitivity to doxorubicin and completely reversed doxorubicin resistance, which agrees with a decreased P- gp activity. (gotomydoctor.com)
Alteration1
- Hutchison and Sirotnak found that resistance to amethopterin in L1210 leukemia cells was due to an alteration in drug uptake and postulated the existence of specific drug transporters. (wikipedia.org)
Cytotoxic1
- One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
Resistance4
- Her research centered on agents effective against leukemia and on treatments to circumvent drug resistance that inevitably developed. (wikipedia.org)
- This finding in turn contributed to the concept of multi-drug resistance being mediated by specific transport proteins. (wikipedia.org)
- Over-expression of multidrug resistance-proteins has been shown to cause cross-resistance to doxorubicin, Cancer is one of the most important diseases in the world, killing topotecan, mitoxantrone, methotrexate and many other chemother- about every fifth or sixth person in western countries. (gotomydoctor.com)
- an ATP-binding ), coumarins () and terpenoids cassette (ABC) transporter (150-170 kDa), which pumps out lipo- have been reported as philic agents from cells that have entered them by free diffusion agents for overcoming multidrug resistance, and could be used aloneat very low concentrations or in combination to reverse multidrugresistance in vitro. (gotomydoctor.com)
Uptake2
- Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
- Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
Reactive oxygen1
- This was independent of the increase in reactive oxygen species, p38MAPK phos-phorylation and expression of NF-jB target proteins. (lsd1receptor.com)
Receptors1
- The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)
Methotrexate1
- These studies eventually led to the discovery that dihydrofolate reductase was amplified in methotrexate resistant cells. (wikipedia.org)
Mediates1
- it was reported that glycoprotein c of hsv-1 (gc-1) mediates the binding of c3b-coated erythrocytes to infected cells and has regulatory (decay-accelerating) activity for the alternative pathway c3 convertase of human complement. (liverpool.ac.uk)
Apoptosis2
- More recently, fenretinide-induced apoptosis has been reported to be dependent on phosphorylation of nuclear factor-kappa B (NF-jB) in SH-SY5Y neuroblastoma cells [13]. (lsd1receptor.com)
- The NF-jB family of transcription factors are involved in the regulation of several physiological processes such as inflammation, cell cycle regulation and apoptosis. (lsd1receptor.com)
Induce1
- NF-jB knockdown did not induce death under normal growth conditions, but did reduce TNFa-dependent cell survival. (lsd1receptor.com)
Modulation2
- ROS-modulation in normal vs. cancer cell. (degruyter.com)
- The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
Biological activity5
- The affinity and spectrum of biological activity is associated with the diverse triterpene skeleton structure and connected substituents. (encyclopedia.pub)
- Chemistry of RNA and DNA base methylation The addition of the methyl-group to DNA and RNA bases (Fig.?2) is catalyzed by DNA- and RNA-methyltransferases that use DNMTs, which methylate canonical dC bases.26 In contrast, DNMT1 maintains the methylation status Actinomycin D biological activity during cell division. (thebiotechdictionary.com)
- DNMT1 operates on hemi-methylated DNA during replication, where the template strand is already methylated, but the newly synthesized strand is usually lacking methylation.27 As such, Actinomycin D biological activity DNMT1 converts the methylation of dC into an inheritable adjustment that may be transferred during duplication.28,29 Open up in another window Body 2. (thebiotechdictionary.com)
- SAM as nature's methyl iodide is usually hence reactive enough to methylate even poor nucleophilic centers such Actinomycin D biological activity as the exocyclic amino groups of A, which feature, as an sp2-hybridized N-atom only a very poor nucleophilic lone pair at the system. (thebiotechdictionary.com)
- Functional research are needed to Ezetimibe biological activity confirm biological relevance of the obtained relationships. (thebiotechdictionary.com)
Gene1
- Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
Cancers2
- Fenretinide (N-(4-hydroxyphenyl)retinamide) is a synthetic vitamin A analogue with chemopreven-tive and therapeutic activity against a wide range of cancers [1]. (lsd1receptor.com)
- The pioneer researcher in the role of iron in immunity believed that an excess of dietary iron contributed to the development of leukemia and lymphatic cancers. (raypeatforum.com)
Cytoplasm2
- High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
- In most cell types, NF-jB is sequestered in the cytoplasm by association with IjBa [20]. (lsd1receptor.com)
Survival3
- Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
- This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
- Around the same time, research began to show that the regulation of iron is a central function of the immune system, and that this seems to have evolved because iron is a basic requirement for the survival and growth of cells of all types, including bacteria, parasites, and cancer. (raypeatforum.com)
Metabolism1
- It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
Chemical1
- Bilirubin is a chemical that is produced when old red blood cells break down. (webmd.com)
Homeostasis1
- Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
Cancer3
- Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
- This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
- It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. (lookformedical.com)
Shown1
- this protein has previously been shown to be a delayed early herpes simplex virus type-2 specific protein. (liverpool.ac.uk)
Disease1
- The key role in the pathogenesis of sarcoidosis is played by proinflammatory cytokines and chemokines, molecules crucially involved in the activation of immune and inflammatory cells and their trafficking to the site of disease [4]. (thebiotechdictionary.com)
Drug1
- The drug is used in the therapy of acute leukemia. (lookformedical.com)
Human1
- infection of human epidermoid carcinoma no. 2 cells with herpes simplex virus type 1 (hsv-1) leads to a reorganization of antigens associated with both the small and heterogeneous nuclear ribonucleoprotein complexes (snrnp and hnrnp). (liverpool.ac.uk)
Specific3
- specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral dna. (liverpool.ac.uk)
- dna binding of a 38,000-dalton herpes-simplex-virus-2-specific protein. (liverpool.ac.uk)
- the system is designed to identify and type hsv from direct lesion smears (ds) and from cell culture smears (cs) infected with a swab from the patient's lesion by means of an indirect fluorescence assay (ifa) using hsv type-common and hsv-2 type-specific monoclonal antibodies. (liverpool.ac.uk)
Mechanism1
- BAY 11-7082-induced cell death through an NF-jB-independent mechanism and enhanced cell death when combined with fenretinide. (lsd1receptor.com)
Induction1
- Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
Death2
- of cell death [7]. (lsd1receptor.com)
- In this study we have investigated the role of NF-jB in fenretinide-induced cell death and the importance of NF-jB in ESFT. (lsd1receptor.com)
Activation1
- Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. (lookformedical.com)
Treatment1
- It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (lookformedical.com)
Role1
- They frequently play an anti-apopto-tic role [14-16], but may also be pro-apoptotic in some cell types and conditions [16-19]. (lsd1receptor.com)
Host1
- the hnrnp core protein antigens remain associated with the host chromatin, which appears to collapse into internal aggregates and along the nuclear envelope. (liverpool.ac.uk)
Study1
- this study compared conventional viral isolation (vi) in cell cultures with a commercial product--virgo antigen detection system--for the identification and typing of herpes simplex virus (hsv). (liverpool.ac.uk)