Protein release factors. Medical search. Frequent questions

This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
However, new research shows that the decision is made collectively by an entire network of genes and proteins. (sciencedaily.com)
mRNA expression of genes and proteins related to disease pathology were. (lu.se)

Histamine Releasing Factor (HRF) also known as Translationally Controlled Tumor Protein (TCTP) is a ubiquitous, novel protein that has both intracellular and extracellular functions. (benthamopen.com)
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. (thermofisher.com)

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. (nih.gov)

Although the molecular mechanisms responsible for the selective vulnerability of these cells are not well understood, activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway has been implicated in neuroprotective responses to excitotoxicity in other neuronal populations. (jneurosci.org)
Along these lines, accumulating evidence shows that the p42/44 mitogen-activated protein kinase (MAPK) pathway plays an important role in neuronal cell survival. (jneurosci.org)

Termination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. (wikipedia.org)

Granulocyte macrophage-colony-stimulating factor (GM-CSF), released from alveolar macrophages (AM), is an important regulator of eosinophil, T cell, and macrophage function and survival. (nih.gov)
Conversely, when stem cells were exposed to granulocyte--macrophage colony-stimulating factor, which stimulates white blood cell formation, those that were highest in Sca-1 were the most likely to become white cells. (sciencedaily.com)

Some cancers release proteins called cytokines that can make you feel fatigued. (medlineplus.gov)
The release of cytokines and other inflammatory mediators at the site of injury has a systemic effect once the burn reaches 30% of total body surface area. (bmj.com)
It's packed with antibodies, growth factors, and cytokines. (webmd.com)

We determined the mechanisms of GM-CSF regulation in AM from normal volunteers activated by lipopolysaccharide (LPS) by examining the role of nuclear factor-kappaB (NF-kappaB), and of p38 mitogen-activated protein (MAP) kinase and MAP kinase kinase (MKK-1). (nih.gov)
GM-CSF expression and release in AM is controlled by NF-kappaB activation, and this is modulated by phosphorylation of MKK-1 and p38 MAP kinase acting on histone acetylation. (nih.gov)
One of protein kinase. (sciencedaily.com)
Our data reveal that the vulnerable cells express high levels of striatal-enriched protein tyrosine phosphatase (STEP), which is a key regulator of the extracellular signal-regulated kinase (ERK) pathway. (jneurosci.org)
The research group has focused on the protein Feronia, a receptor kinase protein found in plant cells. (isaaa.org)

abstract = "Purpose: GnRH-based chimeric proteins have been shown to specifically target and kill adenocarcinomas both in vitro and in vivo. (huji.ac.il)

The pattern of cellular growth has long been known, but it is the Italian developmental biologist Rita Levi-Montalcini and the American biochemist Stanley Cohen with their discovery of nerve growth factor (NGF) and epidermal growth factor (EGF), respectively, who could show how the growth and differentiation of a cell is regulated. (nobelprize.org)

This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
In the neurons to which information is input, MAPK(1) activates transcription factor CREB(2) by training with an interval, and expresses c-fos(3). (sciencedaily.com)
c-fos is also a transcription factor, which is activated by MAPK and expresses CREB. (sciencedaily.com)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. (jax.org)

Pg is different from other bacteria in that it gets inside cells and relies on proteins as an energy source instead of sugars or carbohydrates. (medscape.com)
For example, sodium, proteins and carbohydrates all impact water weight substantially. (dietbites.com)
When carbohydrates are reduced in the diet, water is readily released from the body. (dietbites.com)
Studies show that in young people eating carbohydrates increases protein synthesis beyond what happens with amino acids alone. (ironmanmagazine.com)
Ratio of carbohydrates to protein. (ironmanmagazine.com)
Standard nutrition recommendations are to take in 3.5 grams of carbohydrates for every gram of protein. (ironmanmagazine.com)
Research from Gabriel's lab at the University of Illinois, however, has demonstrated that lowering it to 1.5 grams of carb results in improved insulin sensitivity, fat loss and greater increases in muscle during training.9,10 Thus, we recommend eating no more than one to 1 1/2 grams of carbohydrates per gram of protein at a meal. (ironmanmagazine.com)

Here, we report that high levels of the striatal-enriched protein tyrosine phosphatase (STEP), a key regulator of ERK/MAPK signaling, are found in vulnerable somatostatin-immunoreactive hilar interneurons. (jneurosci.org)

While sodium is known for water retention issues, proteins have the opposite effect. (dietbites.com)
Significant ECF fluid losses also cause release of vasopressin , causing water retention by the kidneys, which can maintain or worsen hyponatremia. (msdmanuals.com)

Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)

Termination of translation: interplay of mRNA, rRNAs and release factors? (wikipedia.org)

In pre-clinical studies, E10030 demonstrated the potential to regress neovascularization when used in combination with a vascular endothelial growth factor (VEGF) inhibitor. (pipelinereview.com)
And then we have what's called the VEGF, which is the vascular endothelial growth factor, which is responsible for formation of blood vessels, and then bFGF. (chiroeco.com)

Eukaryotic translation termination factor 1 (eRF1), also known as TB3-1, is a protein that in humans is encoded by the ETF1 gene. (wikipedia.org)

The purpose of this study is to construct a new GnRH-based chimeric protein for the treatment of adenocarcinomas in humans. (huji.ac.il)
Conclusions: Because GnRH-DFF40 is a whole human-based chimeric protein when applied to humans, the nonspecific toxicity and immunogenicity seen with bacterial/ plant-based chimeric proteins should be avoided. (huji.ac.il)
Their analysis identified TGF beta 2 as one of the proteins upregulated in exercise in humans and mice. (newswise.com)

NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)

Such is the case with two proteins identified by scientists at The University of Texas MD Anderson Cancer Center that fit on to the same binding site on an important cellular growth factor receptor called FGFR2 with starkly different results. (mdanderson.org)
Ladbury is senior author of a paper published Sunday online at Nature Structural & Molecular Biology that describes the competition, identifies Plγcl's role and its relationship to the metastasis-blocking growth factor receptor bound protein 2 (Grb2). (mdanderson.org)
These interactions occur outside normal activation of FGFR2 by growth factors, so the protein with the highest concentration levels in the cell wins the contest to bind to FGFR, or fibroblast growth factor receptor 2, Ladbury said. (mdanderson.org)

Does glutamine methylation affect the intrinsic conformation of the universally conserved GGQ motif in ribosomal release factors? (wikipedia.org)

TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
We found that this chimeric protein can target and kill adenocarcinoma cells. (huji.ac.il)
They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
Blood stem cells with low levels of Sca-1 differentiated into red blood cell progenitors seven times more often than cells high in Sca-1 when exposed to erythropoietin, a growth factor that promotes red blood cell production. (sciencedaily.com)
Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
It's known that fat cells secrete proteins called adipokines, and that many adipokines increase with obesity, having harmful effects on metabolism and health. (newswise.com)
But scientists think cancer cells release an enzyme called nagalase that blocks the making of GcMAF to protect themselves against attack. (webmd.com)
The release of this protein facilitates healing of existing nerve cells while stimulating the production of new ones. (naturalnews.com)
These compounds stabilize protein channels that would otherwise "leak" calcium from muscle cells during strenuous exercise. (technologyreview.com)
The regenerative medicine is the combination of cells, material engineering, and biochemical factors to improve or replace the biological functions attempting to promote the medicine advancement. (bvsalud.org)

The overall process of termination is similar in bacteria, but in the latter 2 separate codon-recognizing release factors exist, RF1 and RF2. (wikipedia.org)
The bacteria release proteases called gingipains that "chop up" proteins into fragments that provide the energy, said Detke. (medscape.com)
Although we don't know all the things that stimulate the release of Zonulin, we do know that certain bacteria and gluten can do it. (newsmax.com)

Hypoxia increased the expression of Tenascin-C, whereas both hypoxia and TGF-β1 stimuli increased the release of VEGF, IL-6, IL-8 and MCP-1 in BEAS-2B. (lu.se)

As the bacterial pathogen tries to trick the plant, the Feronia protein sees through the ploy and counteracts the pathogen. (isaaa.org)

Myocardial contractility is decreased, possibly due to release of tumour necrosis factor α. (bmj.com)
Since this outgrowth did not require direct contact between the tumour and the chick embryo, Rita Levi-Montalcini concluded that the tumour released a nerve growth-promoting factor which had a selective action on certain types of nerves. (nobelprize.org)

H37Rv-infected murine bone marrow-derived macrophages (BMDMs) displayed both lysosomal leakage, with release of CTSB into the cytosol, as well as increased levels of mature IL-1β. (frontiersin.org)
Our bodies make the protein GcMAF to activate macrophages. (webmd.com)

The regeneration process itself relies highly on two factors: 1) the nutrients taken in following exercise and 2) the body's anabolic response to those nutrients. (ironmanmagazine.com)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

Systemic blockade of corticotropin-releasing factor (CRF) type 1 receptors (CRFR1s) reduces stress-induced thermal hyperalgesia. (nature.com)

Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)

The fact that insulin impairs protein synthesis in older muscles has spurred scientists to suggest that aging people need a higher protein-to-carbohydrate ratio. (ironmanmagazine.com)

In contrast to the negative effects of many adipokines, our study identified transforming growth factor beta 2 (TGF-beta 2) as an adipokine released from adipose tissue (fat) in response to exercise that actually improves glucose tolerance," says Laurie J. Goodyear, PhD, Head of Joslin's Section on Integrative Physiology and Metabolism and study co-author. (newswise.com)

The other protein inhibits the opportunity for this to occur," said John Ladbury, Ph.D., professor of Biochemistry and Molecular Biology. (mdanderson.org)

Research in the field of protein therapeutics has exploded over the past decade and continues to grow in both academia and in industry. (purdue.edu)
This research provides a basis from which researchers can create better controlled release formulations for future protein therapeutics. (purdue.edu)

These compounds promote nerve growth factor formation. (naturalnews.com)
The discovery of nerve growth factor (NGF) in the beginning of the 1950's is a fascinating example of how a skilled observer can create a concept out of apparent chaos. (nobelprize.org)

The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. (nih.gov)
This forms a ruthenium labeled intrinsic factor-vitamin B12 biotin complex. (cdc.gov)
The screening used a genetically modified sequence type (ST)-41/44 clonal complex (cc) strain lacking LPS sialylation, polysaccharide capsule, the factor H binding protein (fHbp) and MutS, a protein of the DNA repair mechanism. (uni-wuerzburg.de)
Predicted to act upstream of or within regulation of protein-containing complex assembly. (jax.org)
Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
Really excited today to talk about breakthrough in stem cell activation through an oral protein complex. (chiroeco.com)
And then it's going to be followed by epidemiology and pathology, followed by the actual overview of how this protein complex works, so the osteoinductive protein complex. (chiroeco.com)
So the complex itself is composed of what's called bone morphogenetic proteins. (chiroeco.com)
So these are the components that make up this protein complex, this oral protein complex known as Cyplexinol. (chiroeco.com)
They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. (bvsalud.org)

So we're going to go through its inflammatory modulating effects of what's called BMPs, which I'm going to refer to pretty frequently throughout the presentation, that's called bone morphogenetic proteins. (chiroeco.com)

Complejos proteicos multiméricos que se forman en el CITOSOL e intervienen en la activación de la APOPTOSIS. (bvsalud.org)
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. (bvsalud.org)

The Elecsys Vitamin B12 assay employs a competitive test principle using intrinsic factor specific for vitamin B12. (cdc.gov)
Neisseria meningitidis employs polysaccharides and outer membrane proteins to cope with human serum complement attack. (uni-wuerzburg.de)

The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. (nih.gov)

These observations suggest that during Mtb infection, lysosomal release of activated CTSB and possibly other cathepsins inhibitable by CA07-Me is critical for the induction of inflammasome-mediated IL-1β processing by regulating NLRP3-inflammasome assembly in the cytosol. (frontiersin.org)

10 microM), also prevented GM-CSF expression and release induced by LPS, indicating that GM-CSF release is NF-kappaB-dependent. (nih.gov)

These data will be used to estimate deficiencies and toxicities of specific nutrients in the population and subgroups, to provide population reference data, and to estimate the contribution of diet, supplements, and other factors to serum levels of nutrients. (cdc.gov)
The effect of vibration on back discomfort and serum levels of von Willebrand factor antigen: a preliminary communication. (cdc.gov)

Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)

During the 3rd incubation, streptavidin-coated microparticles and vitamin B12 labeled with biotin are added and the still-vacant sites of the ruthenium labeled intrinsic factor become occupied. (cdc.gov)

TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. (thermofisher.com)
Calcium is needed for muscle contraction and this "leaking" effect weakens the contractions and is a causal factor in muscle fatigue. (technologyreview.com)

Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome. (nih.gov)

An additional factor is the release of the hormone insulin. (ironmanmagazine.com)
That doesn't happen, though, unless insulin is released from the pancreas, binds to the muscle and signals it to increase the uptake of glucose. (ironmanmagazine.com)
So TGF-β, which is the transforming growth factor, IGF, which is insulin growth factor, which we know is related to growth hormone. (chiroeco.com)

These same factors are also shown to influence growth factor release from the bioinks. (nature.com)
Alginate is also commonly used for drug/growth factor delivery, where the degradation rate of the alginate can be tuned by altering the MW of the alginate 14 , 15 , which can in turn vary the release rate of the drug/growth factor encapsulated. (nature.com)
In a 2012 paper in the journal Cell, Ladbury and colleagues showed that Grb2 binds to FGFR2 and holds it in check, ready to be activated by a growth factor to signal other proteins. (mdanderson.org)
Eyetech, Inc., has entered into an agreement with Ophthotech Corporation to divest its anti-platelet derived growth factor (PDGF) aptamer program. (pipelinereview.com)
2) during 24 h, with or without transforming growth factor (TGF)-β1. (lu.se)

There is genetic determinants, there's hormonal determinants, also also environmental and nutritional factors. (chiroeco.com)

TSA (10 ng/ml), an inhibitor of histone deacetylase (HDAC), reversed the inhibitory effect of PD 098059, SB 203580, SN 50 and AS602868 on GM-CSF release. (nih.gov)

He noted that 22 of the last 25 genetic risk factors identified for AD relate to immune system function. (medscape.com)

There are mutations that occurred in the part of the viral genome that codes the viral envelope protein and the ends of the viral genome that are called 'untranslated regions. (eurekalert.org)

This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)

The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)

Results: In this study, we constructed and characterized a new chimeric protein, GnRH-DFF40, composed of a new human killing moiety: the apoptotic DNase-DFF40 (DNA fragmentation factor), known also as caspase-activated DNase (CAD). (huji.ac.il)

Thus, stressors must induce the release of an endogenous ligand within the CNS that signals via TLR2 and TLR4 to mediate neuroinflammatory sensitization produced by stressors. (jneurosci.org)

Initially it was believed that hormones were only produced in specialized glands such as the pituitary, from which hormones such as growth hormone, were released into the blood stream. (nobelprize.org)

Anatomy3

Organisms2

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes12

Technology, Industry, Agriculture2

Information Science3

Health Care5

Genes3

Translationally Controlled Tumor Protein2

Guanine nucleotide1

Mitogen activa2

Polypeptide chain1

Granulocyte-Macrop2

Cytokines3

Kinase5

Abstract1

Epidermal growth1

Transcription factor5

Carbohydrates7

MAPK1

Water retention2

Subunit1

MRNA1

Vascular2

Eukaryotic1

Humans3

Homo1

Receptor3

Ribosomal1

Cells10

Bacteria3

VEGF1

Bacterial1

Tumour2

Macrophages2

Relies1

SCOPe1

Systemic1

Nomenclature1

Scientists1

Metabolism1

Biochemistry1

Therapeutics2

Nerve growth2

Complex10

Inflammatory1

Apoptosis2

Employs2

Nuclear1

Cytosol1

Expression1

Serum levels2

Stress-induced1

Intrinsic1

Calcium2

Sodium1

Insulin3

Growth factor5

Nutritional1

Inhibitor1

Function1

Viral1

Obesity1

Cellular1

Human1

Signals1

Hormone1