Protein receptors rank ligand. Medical search. Frequent questions

The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. (nih.gov)
On the other hand, PQQ did not inhibit the signaling pathway from RANK/RANKL binding to NFATc1 activation, including NF-κB and mitogen-activated protein kinases (MAPKs). (nih.gov)
Systemic IL-6 levels were measured by enzyme-linked immunosorbent assay, and local synovial IL-1 and receptor activator of NF-kappaB ligand (RANKL) expression was analyzed using specific immunohistochemistry. (nih.gov)
RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)
The discovery of the receptor activator of nuclear factor κB (RANK) ligand (RANKL) pathway, a transmembrane protein belonging to the tumour necrosis factor (TNF) superfamily, and its inhibition by osteoprotogerin (OPG) has had important implications for bone physiology as well as inflammation research. (biomedcentral.com)
Interaction of RANKL with RANK on mature osteoclasts results in their activation and prolonged survival. (biomedcentral.com)
OPG blocks the interaction of RANKL with RANK and thus acts as a physiological regulator of bone turnover. (biomedcentral.com)
in the canonical pathway of osteoclastogenesis, these cells fuse and differentiate to form specialised bone-resorbing osteoclasts in the presence of receptor activator for nuclear factor kappa B ligand (RANKL). (ox.ac.uk)
Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. (joplink.net)
Osteoclasts and odontoclasts are multinucleated cells derived from hematogenous bone marrow, from the monocyte/macrophage cell lineage, and are formed by the fusion of these cells under the action of colony stimulating factor 1 (CSF-1), macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1) and RANKL (receptor activator of nuclear factor kappa-B ligand), which also have a role in chemotaxis and cell differentiation [1]. (oatext.com)
The differentiation of the osteoclast precursor into a mature osteoclast requires RANKL binding to its receptor RANK (receptor activator of nuclear factor kappa-B). However, OPG binding to RANKL will block RANKL binding to RANK, which will result in inhibition of osteoclastogenesis (Figure 1) [3]. (oatext.com)
The balance of the RANKL/RANK/OPG triad contributes to bone remodeling. (oatext.com)
As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
Conclusion: Our study suggests that the RANKL/RANK pathway contributes to the development and maintenance of the immunosuppressive tumor microenvironment and denosumab may be a promising adjuvant therapy targeting TAMs in cancer of apocrine origin. (iiarjournals.org)
Recently the osteoclast differentiation factor (ODF), better termed RANKL (receptor activator of NF-kappaB ligand), expressed by osteoblasts has been cloned as well as its cognate signaling receptor, receptor activator of NFkappaB (RANK), and a secreted decoy receptor osteoprotegerin (OPG) that limits RANKL's biological action. (ox.ac.uk)
We determined that the breast cancer cell lines MDA-MB-231, MCF-7, and T47D as well as primary breast cancers do not express RANKL but express OPG and RANK. (ox.ac.uk)
Schematic representation of the cellular and molecular mechanisms of the effects of OPG, RANK, and RANKL on skeletal metabolism.A variety of skeletal and non-skeletal cells can express several cell products [in brackets] that regulate the balance between osteoblastic bone formation (left) and osteoclastic bone resorption (right). (endotext.org)
and OPG (osteoprotegerin), a soluble "decoy" receptor for RANKL. (endotext.org)
In addition to OPG, the stimulation of osteoclastic bone resorption by RANKL is opposed by activation of the gamma interferon receptor (INFR) by gamma interferon (INF) production by activated lymphocytes and by the peptide hormone, calcitonin. (endotext.org)
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. (moviplans.com)
RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. (moviplans.com)
RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. (moviplans.com)
Tumor cells produce factors that increase the formation of osteoclasts through the RANK-RANKL (receptor activator of nuclear factor-κB ligand) system: IL-6 (interleukin-6), prostaglandin E2 (PGE2), tumor necrosis factor (TNF), macrophage colony-stimulating factor (M-CSF), and parathyroid hormone-related peptide (PTH-rP). (endocrinology-journals.org)
Simvastatin increases the oestrogen receptor (ER) expression in order to regulate the OPG/RANKL/RANK signalling pathway and thus it inhibits osteoclasto- genesis. (syksignaling.com)
Osteoprotegeryna uniemożliwia wiązanie RANKL z jego receptorem - RANK, zlokalizowanym na powierzchni komórek linii dojrzewających osteoklastów, wpływając na ich różnicowanie i aktywność. (osteoporoza.pl)

OPG (osteoprotegerin) is a soluble TNF receptor-like molecule and the natural inhibitor of osteoclastogenesis [3]. (oatext.com)
For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
Can bind this type of bone resorption by osteoprotegerin, a L Soluble protein, RANK L prevents its interaction with the receptor RANK balanced. (srcsignaling.com)
RÉSUMÉ L'objectif de l'étude était d'évaler l'importance clinique du ligand de CD40 soluble (sCD40L) chez des patients atteints d'un carcinome hépatocellulaire (CHC) associé au virus de l'hépatite C (VHC). (who.int)

Its differentiation and function are mainly regulated by macrophage colony-stimulating factor (M- CSF), receptor activator of nuclear factor kappa B(RANK) ( 7 ). (frontiersin.org)

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the Tumor Necrosis Factor (TNF) family of proteins. (cellgs.com)
Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. (medlineplus.gov)

Cancer cells expressing these genes secrete normal bone ECM protein products, abnormally altering the bone matrix and activity of osteoblasts and osteoclasts in the local microenvironment. (wikipedia.org)
Denosumab is a fully human monoclonal antibody that binds to RANK Ligand, a protein essential for the formation, function and survival of osteoclasts (the cells that break down bone). (oncozine.com)
Denosumab prevents RANK Ligand from activating its receptor, RANK, on the surface of osteoclasts, thereby decreasing bone destruction and halting release of growth factors, making the environment less conducive to tumor growth. (oncozine.com)
During bone resorption, osteoclasts release transforming growth factor-β (TGF-β), insulin-like growth factors (IGFs), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and bone morphogenetic proteins (BMPs), which increase the production of parathyroid hormone-related peptide by tumor cells, as well as growth factors that increase tumor growth. (endocrinology-journals.org)
Another treatment that is competing with bisphosphonates in this patient population RANKligand denosumab.15 inhibitor L RANK is usually by osteoblasts and acts by binding to receptors on the surface Surface of osteoclasts RANK is synthesized. (srcsignaling.com)
The ligand-receptor interaction then causes the activation of the survival pathways and proliferation of osteoclasts foreign St bone resorption. (srcsignaling.com)

A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
Identification from the molecular mechanisms that determine specificity of coupling interactions between gastrin-releasing peptide receptors (GRPrs) and their cognate heterotrimeric GTP-binding proteins is a fundamental step in understanding the signal transduction cascade initiated by receptor-ligand interaction. (biopaqc.com)
In addition, we provide tutorials on model validation (evaluation of target gene and ligand activity), model construction and parameter optimization such that users can benchmark their methods against NicheNet and construct their own models (for example, with their own data sources to include more cell type specificity). (nature.com)
The ubiquitous expression and the broader ligand specificity suggest that BLT2 may mediate distinct biological and pathophysiological roles from BLT1. (hindawi.com)

A longstanding effort to do so is by exploiting protein structures to predict new reagents and therapeutic leads (structure-based ligand discovery). (ucsf.edu)
The company offers the optimized combination of either module to address problems related to target characterization of structure-based ligand optimization, and has agreements or contracts with different biotech and pharma companies. (pharmacelera.com)

This interacts with its cognate receptor RANK, which is expressed on osteoclast precursors and promotes osteoclast differentiation. (biomedcentral.com)

Applying these to G-Protein Coupled Receptors (GPCRs), which are the single largest family of signaling receptors in human cells. (ucsf.edu)
Initially focused on G protein-coupled receptors (GPCRs), the company has recently evolved the GPCR-Modsim web server, a one-stop shop for the 3D modeling and molecular dynamics (MD) simulations of GPCRs, into a generic membrane protein modeling and simulation package optimized for HPC. (pharmacelera.com)
LTs exert their biological effects by activating specific receptors belonging to the superfamily of G protein-coupled receptors (GPCRs) [ 22 - 24 ]. (hindawi.com)

PICK1 (protein interacting with C kinase 1) contains a single PDZ domain known to mediate interaction with the C termini of several receptors, transporters, ion channels, and kinases. (huji.ac.il)
Molecular Docking and Interaction Evaluation AutoDock Vina 1.1.two in PyRx 0.8 computer software (ver.0.eight, Scripps Study, La Jolla, CA, USA) was applied to predict the protein-ligand interactions on the triazole compounds against the SARS-CoV-2 principal protease protein. (nrtisinhibitor.com)
The follow-up detailed analysis of amino acid and ligand interaction was performed with BIOVIA Discovery Studio Visualizer (BIOVIA, San Diego, CA, USA). (nrtisinhibitor.com)
Although low-affinity ligands induced phosphorylation of the Cd3 chains of the T cell receptor and the interaction of Cd3 with the Zap70 kinase as strongly as high-affinity ligands, they failed to activate Zap70 to the same extent. (nature.com)
We defined quantitative signatures of ligand affinity based on protein phosphorylation and protein-protein interaction (PPI) stoichiometry for critical molecular events associated with TCR signaling. (nature.com)

We applied NicheNet to tumor and immune cell microenvironment data and demonstrate that NicheNet can infer active ligands and their gene regulatory effects on interacting cells. (nature.com)
In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)

Membranes prepared from murine LM (tk-) fibroblasts stably transfected with this clone were shown to bind [3H]5-HT in a saturable manner and displayed an apparently homogeneous population of high affinity (Kd = 3.6 nM, Bmax = 275 fmol/mg of protein) [3H]5-HT binding sites. (aspetjournals.org)
High affinity [3H] 5-HT binding was unchanged using assay conditions [1 microM (+/- )-pindolol and 1 microM (R)-(+/- )-SCH 23390) to pharmacologically mask 5-HT1A, 5-HT1B, and 5-HT1C receptors. (aspetjournals.org)
As a result, formation of the signalosome of the Lat adaptor was severely impaired with low- compared with high-affinity ligands, whereas formation of the signalosome of the Cd6 receptor was affected only partially. (nature.com)

For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
Immunotherapy with programmed cell death protein-1 (PD-1) inhibitors had previously shown efficacy as monotherapy in second- or later-line therapy for women with cervical cancer, but KEYNOTE 826 was the first study to show a benefit to promoting immunotherapy to the front ranks. (medscape.com)

PQQ augmented the expression of type I interferon receptor (IFNAR) and enhanced the IFN-β-mediated janus kinase (JAK1) and signal transducer and activator of transcription (STAT1) expression. (nih.gov)
Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
100-fold higher affinity than the type I sequences presented by protein kinase Cα (-QSAV) and the β 2 -adrenergic receptor (-DSLL), respectively. (huji.ac.il)
Src kinase family is a family of non-receptor tyrosine kinases. (srcsignaling.com)

Expression and pharmacological characterization of a canine 5-hydroxytryptamine1D receptor subtype. (aspetjournals.org)
The EC50 for GRP was 3.5 nM which correlates well with the reported (1994) 46 235 The apparent receptor reconstitution method will allow molecular characterization of G protein coupling to other heptahelical receptors. (biopaqc.com)
Yet, characterization of the emergence of differences in signaling events triggered by ligands with different affinities along the TCR signaling cascade remains incomplete. (nature.com)

M-CSF binds to the M-CSF receptor, which is promote the proliferation and differentiation of OC and the continuous expression of RANK. (frontiersin.org)
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. (joplink.net)
BLT2 is a pharmacologically distinct receptor, which is ubiquitously expressed and displays low affinity for LTB4 and also binds other eicosanoids [ 26 , 27 ]. (hindawi.com)
Sequestration of infected erythrocytes in the placenta is mediated by VAR2CSA, the P. falciparum erythrocyte membrane protein 1 variant that binds to chondroitin sulfate A (CSA) on the syncytiotrophoblast ( 11 , 12 ). (cdc.gov)

These methods AM 694 have allowed the examination of G protein selectivity using purified G protein subunits as well as extended our knowledge of the molecular pharmacology of the GRPr. (biopaqc.com)

Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
Immunohistochemical staining of MMP1 and MMP25 as well as chemokine (C-C motif) ligand (CCL) 5 in the lesional skin from five patients with PCAC showed a substantial number of MMP1-bearing cells and MMP25-bearing cells, as well as CCL5-producing cells, that were distributed in the lesional skin. (iiarjournals.org)

The post-translational modifications of these SMAD proteins in the linker domain regulate their function and these can be triggered by inflammation through the activation of kinases or phosphatases. (bvsalud.org)
Our analysis indicated that ligand affinity differentially affected signaling pathways associated with specific kinases and biological processes. (nature.com)

For example, TAMs suppress effector T-cells through immune checkpoint molecules, such as those of the programmed cell death 1 (PD-1) ( 7 ) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) ( 8 , 9 ) pathways. (iiarjournals.org)
In particular, it is unclear whether ligand affinity uniformly affects the different signaling pathways involved in T cell activation. (nature.com)

Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity- based enrichment. (genomicglossaries.com)
The active sites on the receptor compounds have been chosen and had been enclosed within a three-dimensional affinity grid box. (nrtisinhibitor.com)
Which early molecular events are affected by ligand affinity, and how, has not been fully resolved. (nature.com)
T cells have the ability to sense and discriminate a wide range of antigenic peptides bound to major histocompatibility complex (pMHC) molecules according to their affinity for the T cell receptor (TCR). (nature.com)
Hence, how ligand affinity converts into signaling potency (that is, magnitude of T cell responses) remains unresolved. (nature.com)

Dulbecco's modified Eagle's medium (DMEM) fetal bovine serum and aminoglycoside G-418 were from BRL-Life Technologies (Gaithersburg MD). Protein gel electrophoresis equipment and gels for SDS/PAGE were from NOVEX (San Diego). (biopaqc.com)
Serum therapy worked, no doubt, but also gave rise to various side effects related to the presence of a complex foreign protein substance (e.g. animal serum in a human body), a condition known as 'serum sickness', accompanied by fever, chills, joint pain, allergy, and in extreme cases, anaphylaxis. (inscientioveritas.org)
This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
Conse- demonstrated that this protein signature provided an added value quently, using minute amounts of nonfractionated serum (14) and compared with conventional clinical parameters. (lu.se)

Serotonergic ligands displaced specific [3H]5-HT binding with a rank order of potency expected of a 5-HT1D receptor subtype, 5-carboxyamidotryptamine greater than 5-HT greater than yohimbine greater than 8-hydroxy-2-(di-n-propylamino)tetralin greater than ketanserin = spiperone greater than zacopride. (aspetjournals.org)
Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
This approach also estimates the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process. (mdpi.com)
The results define the structural basis for the unusual binding pattern of the PICK1 PDZ domain by substantiating the critical role of the αB1 position (Lys 83 ) and of discrete side chain differences in position P(0) of the ligands. (huji.ac.il)
neuromedin B. Reconstitution of urea extracted membranes with a purified Gαq showed that receptor-catalyzed binding of GTPγS was dependent on agonist (GRP) and Gβγ subunits. (biopaqc.com)
The ultimate pellet was resuspended in remedy A supplemented with 12% (wt/vol) sucrose and aliquots had been frozen and kept at ?80°C. Ligand Binding. (biopaqc.com)
GRPr ligand binding sites in the membrane. (biopaqc.com)
The achievable ligand- αvβ3 Antagonist Gene ID binding pockets that have been solvent accessible, have been ranked based on region and volume [37]. (nrtisinhibitor.com)
The binding pocket ranked initially was chosen (predicted from CASTp). (nrtisinhibitor.com)
The binding energies of nine docked conformations of each and every ligand against the protein have been recorded utilizing Microsoft Excel (Workplace Version, Microsoft Corporation, Redmond, Washington, USA). (nrtisinhibitor.com)
According to the kinetic proofreading model, antigen discrimination properties could be explained by the gradual amplification of small differences in binding affinities as the signal is transduced downstream of the T cell receptor. (nature.com)
Small differences in binding kinetics between TCR ligands lead to marked differences in T cell effector function and differentiation. (nature.com)
The kinetic proofreading model postulates that TCR ligand discrimination is due to several signaling steps that introduce a delay between ligand binding and T cell activation. (nature.com)
MELD-Bracket ranks binding affinities of diverse sets of ligands. (ucsf.edu)
Influenza virus neuraminidase (NA) can act as a receptor-binding protein, a role commonly attributed to hemagglutinin (HA). (cdc.gov)
Taken together, our findings provide new insights into the molecular mechanisms underlying the ability of NA to function as a binding protein. (cdc.gov)

Databases used to create the NicheNet model are mentioned and referred to in the Methods section Collection of ligand-receptor, intracellular signaling and gene regulatory interactions , in Supplementary Table 1 and in the Supplementary Notes . (nature.com)

These genes include osteocalcin, osteopontin, bone sialoprotein, osteonectin, RANK ligand (NF-κB receptor activator) and parathyroid hormone related peptide (PTHrP). (wikipedia.org)

The divergence between signals induced by ligands with different affinities occurred early in the canonical TCR signaling cascade. (nature.com)

Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. (cellgs.com)

Upon activation, the IL-1 receptor antagonist (IL-1Ra)/IL-1β ratio was higher in AAT than in SM cultures. (bmj.com)
In contrast, enhancing PDC recruitment and activation to arthritic joints by topical application of the Toll-like receptor 7 (TLR-7) agonist imiquimod significantly ameliorated arthritis in various mouse models. (cnrs.fr)
An endogenous substance or a drug that can interact with a receptor and initiate a physiological or a pharmacological response characteristic of that receptor (contraction, relaxation, secretion, enzyme activation, etc. (genomicglossaries.com)
Activation of PLC by Bn receptors can be more developed (24). (biopaqc.com)
This implies that the pMHC ligand dwell time on the TCR determines the probability of completing a series of signaling events leading to T cell activation 5 . (nature.com)
This is consistent with reports that the slow phosphorylation of tyrosine residues of the Lat adaptor associates with recruitment and activation of the phospholipase Plcγ1, thereby constituting an important kinetic bottleneck for ligand discrimination 11 . (nature.com)
The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)

Ligand and G-protein selectivity in the κ-opioid receptor. (ucsf.edu)

T cell expression of RANK Ligand promotes dendritic cell maturation. (cellgs.com)

135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)

Using a combined receptor- and ligand-based approach, we tested 98 of the top 0.1% ranked compounds, revealing novel chemotypes as compared to the ~1.45 million known ligands in the ChEMBL database. (advion.com)
Through this collaborative platform the two companies will be able to combine the expertise in virtual screening with the Free Energy Perturbation (FEP) technology for both performing in silico mutagenesis in proteins and ranking ligands, to find and prioritize compounds within chemical series and ultimately facilitate the identification of pre-clinical development candidates. (pharmacelera.com)
Pharmacelera has established one of the strongest ligand-based computational pipelines to screen millions of compounds virtually and filter large chemical libraries. (pharmacelera.com)
Water compounds and attached ligands were eliminated from the protein structure prior to the docking experiments. (nrtisinhibitor.com)

It expresses a range of cell surface molecules involved in adaptive and innate immunity, as well as crucial sentinel molecules, including toll-like receptors (TLRs), which are pivotal in early cellular defense against virus infection. (molvis.org)

However, VAR2CSA-based vaccine research is challenged by the size and polymorphism of this protein and requires identification of smaller functional domains that combine an ability to induce strain-transcending antibody responses with a facility of production in a recombinant protein form. (cdc.gov)

Target and Ligand Preparation The crystal structure of SARS-CoV-2 most important protease in complicated with an inhibitor 11b (PDB-ID: 6M0K at resolution 1.80 R-Value Totally free: 0.193, R-Value Operate: 0.179 and R-Value Observed: 0.180) was retrieved from RCSB PDB database (http://www.rcsb/pdb, accessed on 27 February 2021) and employed in the present study. (nrtisinhibitor.com)
The PRMT3 Inhibitor Purity & Documentation search space included the whole 3D structure chain A. Protein-ligand docking was initially visualized and analyzed by Chimera 1.15. (nrtisinhibitor.com)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

RDC4 is an intronless gene encoding a protein of 377 amino acids, which exhibits greatest sequence identity (43%) to the 5-HT1A receptor and lower overall homology to other serotonergic and catecholaminergic receptors. (aspetjournals.org)
The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. (frontiersin.org)

Developing new computational methods for ligand discovery and 2. (ucsf.edu)
Developing computational methods to relate receptors by the similarity of their ligands, rather than by protein sequence or structure. (ucsf.edu)
Unfortunately, the design of drugs with multiple activities on a selected handful of different protein structures remains a significant experimental and computational challenge ( Konc, 2019 ). (frontiersin.org)

Hence, increased bone resorption due to increased RANK Ligand expression appears to augment bone metastasis. (oncozine.com)
CD64 protein expression and localization was evaluated using immunohistochemistry and immunofluorescence and quantified using flow cytometry. (bvsalud.org)
Furthermore, we observed that synovial CD64 protein levels in source tissue for OAS-CM significantly associated with the OAS-CM-induced expression of MMP1, MMP3 and especially ADAMTS4 in cultured fibroblasts, but not chondrocytes. (bvsalud.org)
We present NicheNet ( https://github.com/saeyslab/nichenetr ), a method that predicts ligand-target links between interacting cells by combining their expression data with prior knowledge on signaling and gene regulatory networks. (nature.com)
The data source networks, NicheNet's ligand-target matrix and the processed ligand treatment and case study expression datasets are available on Zenodo ( https://doi.org/10.5281/zenodo.3260758 ) 59 . (nature.com)
ligand-to-target signaling path visualization and assessment of how well prioritized ligands explain changes in gene expression in the receiver cell. (nature.com)

We have isolated the corresponding genomic clone for RDC4, have expressed this clone in murine LM (tk-) fibroblasts, and have determined that it encodes a serotonin 5-hydroxytryptamine1D (5-HT1D) receptor. (aspetjournals.org)

Here, we used time-resolved high-throughput proteomic analyses to identify and quantify the phosphorylation events and protein-protein interactions encoding T cell ligand discrimination in antigen-experienced T cells. (nature.com)

Structural basis of BAM-mediated outer membrane β-barrel protein assembly. (ucsf.edu)
Tissue sequestration is primarily mediated by members of the parasite variant antigen family of P. falciparum erythrocyte membrane protein 1, which is expressed on the membrane of infected erythrocytes. (cdc.gov)

This changes pharmacological relationships dramatically-targets that would normally be considered sequence neighbors are pushed far apart (because their ligands are dissimilar), whereas other targets that supposedly have nothing to do with one another become neighbors (because their ligands are very similar). (ucsf.edu)

Anatomy9

Diseases6

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes12

Information Science2

RANKL26

Soluble4

Macrophage colony1

Activator of nuclear factor2

Osteoclasts6

Specificity4

Structure-based ligand2

Cognate1

GPCRs3

Interaction5

Tumor2

High affinity3

Inhibitors2

Kinase4

Characterization3

Binds4

Pharmacology1

Chemokine2

Kinases2

Pathways2

Affinity5

Serum4

Binding16

Intracellular1

Parathyroid1

Affinities1

SCD40L1

Osteoclast differentiation1

Activation7

Selectivity1

Dendritic1

Antibodies1

Compounds4

Molecules1

Recombinant1

Inhibitor3

Amino2

Computational3

Expression6

Murine1

Interactions1

Membrane2

Pharmacological1