Protein receptors laminin. Medical search. Frequent questions

A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)
Matriglycan is indeed a scaffold for multiple laminin-G (LG) domain-containing extracellular matrix proteins (e.g. laminin, agrin, and perlecan) and it has the remarkable capacity to be tuned during skeletal muscle development and regeneration. (enmc.org)
Affinity for these extracellular matrix proteins explains the striking ability of NP41 to highlight degenerated nerve "ghosts" months posttransection that are invisible to the unaided eye but retain hollow laminin-rich tubular structures. (dualsystems.com)

As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)
We studied human bone marrow cell adhesion to laminin-10/11 (alpha5beta1gamma1/alpha5beta2gamma1), laminin-8 (alpha4beta1gamma1), laminin-1 (alpha1beta1gamma1), and fibronectin. (ox.ac.uk)
About 35% to 40% of CD34(+) and CD34(+)CD38(-) stem and progenitor cells adhered to laminin-10/11, and 45% to 50% adhered to fibronectin, whereas they adhered less to laminin-8 and laminin-1. (ox.ac.uk)
Cell motility measurements by computer-assisted time-lapse videomicroscopy of the alpha 7-transfected cells revealed an 8-10-fold increase in motility on laminin-1 and its E8 fragment, but not on fibronectin. (uea.ac.uk)

Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. (rndsystems.com)
Transcriptional profiling by genechip analysis revealed that PAR1 expression promotes the expression of mesenchymal proteins such as vimentin, laminin, and integrin, and down-regulates epithelial proteins such as E-cadherin, claudin, zona occludens and cytokeratin. (tufts.edu)
Laminins are alphabetagamma heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. (ox.ac.uk)
Adhesion of CD34(+)CD38(-) cells to laminin-10/11 was maximal without integrin activation, whereas adhesion to other proteins was dependent on protein kinase C activation by 12-tetradecanoyl phorbol-13-acetate (TPA). (ox.ac.uk)
Integrin alpha6 and beta1 chains were involved in binding of both cell fractions to laminin-10/11 and laminin-8. (ox.ac.uk)
In functional assays, both laminin-8 and laminin-10/11 facilitated stromal-derived factor-1alpha (SDF-1alpha)-stimulated transmigration of CD34(+) cells, by an integrin alpha6 receptor-mediated mechanism. (ox.ac.uk)
mESCs lack major integrin receptors for collagens but express high levels of functional receptors for LM and FN. (biolamina.com)
These findings further support the notion that a3b1 and a6b1 integrin receptors expressed on the mES cell surface are involved in the specific binding to LM in general and to LM 511 and 521. (biolamina.com)
One of the major laminin receptors of myoblasts is the alpha 7 beta 1 integrin, which was first described in human MeWo melanoma cells and Rugli glioblastoma cells. (uea.ac.uk)
In order to investigate and directly test the role of the alpha 7 integrin in cell migration on laminin, we expressed the murine alpha 7B splice variant in human 293 kidney cells and 530 melanoma cells which cannot migrate on laminin and are devoid of endogenous alpha 7. (uea.ac.uk)
These findings prove that alpha 7 integrin expression confers a gain of function-motile phenotype to immobile cells and may be responsible for transduction of the laminin-induced cell motility. (uea.ac.uk)

Ribosomal protein SA is part of the small subunit. (medlineplus.gov)
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. (nih.gov)

10 −7 ) and minor enrichment of laminin-γ1 and collagens I and VI. (dualsystems.com)

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)

Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. (thermofisher.com)

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. (thermofisher.com)
The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. (thermofisher.com)
The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)
Dystroglycan is also required non-cell-autonomously to organize the planar polarity of basal actin in follicle cells, possibly by organizing the Laminin ECM. (lu.se)
article{5f173e96-c6fe-4b5f-8f37-b070076bc387, abstract = {{The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)
Dystroglycan is a core and essential component of the dystrophin-glycoprotein complex of muscle and brain, making vital links between the cytoskeleton and laminin in the extracellular matrix. (enmc.org)
Perturbations in the ability of dystroglycan to interact with laminin have severe implications for human disease. (enmc.org)
In rare, isolated instances they involve primary mutations of dystroglycan itself, but more frequently are associated with mutations in genes involved in the post-translational modification of dystroglycan: the secondary dystroglycanopathies, but also the so-called tertiary dystroglycanopathies arising from mutations in metabolic enzymes and other proteins that are involved more generally in multiple glycosylation pathways and cellular roles that in turn also impinge on dystroglycan function. (enmc.org)
Furthermore, detailed biochemical and cell biological analyses have finely mapped the biosynthetic pathways leading to the glycosylation of dystroglycan that enable it to bind to laminin. (enmc.org)
This wealth of information has led to a new understanding of how the defective interaction between of dystroglycan and laminin leads to disease. (enmc.org)
This allows dystroglycan to function as the predominant extracellular matrix receptor in skeletal muscle and brain. (enmc.org)
Moreover, in addition to our understanding of the glycosylation of dystroglycan, much insight has also been gained into the functional roles of dystroglycan, not only in the bran and muscle, but also in other cells types, and the implication that the defective processing of this protein has with respect to role in Lassa fever virus infections. (enmc.org)
A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments. (courtlab.cl)
the Beta-dystroglycan is a transmembrane protein that plays an important role in connecting the extracellular matrix to the cytoskeleton. (absoluteantibody.com)
It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. (absoluteantibody.com)

This antibody was used in combination with anti-laminin-2 antibody C3_Hu10 to generate a duobody called TBTI (US11254737). (absoluteantibody.com)

The signaling pathways involved in initiating the EMT seem to primarily involve the Smad-dependent pathway, whereby TGFbeta binding to specific high affinity cell surface receptors activates the receptor-Smad/Smad4 complex. (nih.gov)
2. The laminins forms networks that remain in close association with cells through interactions with cell surface receptors. (premiumbeautynews.com)

We make use of a highly flexible multi-step cloning strategy in order to allow for the rapid synthesis of new recombinant proteins that can introduce many different biofunctionalities. (frontiersin.org)

The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
Caspr2 is a cell adhesion molecule as well as a receptor. (antibodiesinc.com)
Regulation of adhesion of mouse bone marrow-derived mast cells to laminin. (aai.org)
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. (ox.ac.uk)
It acts as a cell adhesion receptor in both muscle and non-muscle tissues. (absoluteantibody.com)
The ECM composed of hundred proteins is a dynamic network controlling the proliferation, adhesion, migration, polarity, differentiation, and apoptosis of the cells. (premiumbeautynews.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Abcam: antibodies, proteins, kits. (abcam.com)
Adherence was inhibited by antibodies to laminin and laminin receptor and was calcium ion and temperature dependent. (aai.org)
EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)

They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)

The RPSA gene provides instructions for making a protein called ribosomal protein SA, which is one of approximately 80 different ribosomal proteins. (medlineplus.gov)
RPSA gene mutations are thought to reduce the amount of functional ribosomal protein SA. (medlineplus.gov)
Growth arrest - specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. (wikipedia.org)

We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
Sterile /Armadillo/Toll-Interleukin receptor homology domain protein (SARM1) can induce Wallerian degeneration. (bvsalud.org)

Laminin-421 and -211 were identified by proximity-based labeling using singlet oxygen and by an adapted version of TRICEPS-based ligand-receptor capture to identify glycoprotein receptors via ligand cross-linking. (dualsystems.com)
Glycoprotein receptor capture also identified laminin-α4 and -γ1. (dualsystems.com)

Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3. (wikipedia.org)
Treatment of cells with dibutyryl cAMP, which activates protein kinase A, inhibited both adherence and histamine release induced by Ag or calcium ionophore. (aai.org)
Treatment of cells with staurosporin, which inhibits protein kinase C, also inhibited adherence and histamine release induced by calcium ionophore, but was not significantly active against either adherence or histamine release induced by Ag. (aai.org)

Jan. 13, 2022, 10:40 AM by Bill Snyder Transmembrane receptors called integrins and proteins called laminins play important roles in the formation and function of tissues, including the ducts that collect urine from the filtering units of the kidneys. (vanderbilt.edu)

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. (medlineplus.gov)

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. (antibodiesinc.com)
In this study, we demonstrate that the cross-linking of cell surface high-affinity IgE-R on mast cells derived from mouse bone marrow cultured for 3 wk in the presence of WEHI-3-conditioned media acts as a highly sensitive physiologic stimulus for this attachment and that receptor activation is also induced by calcium ionophore A23187. (aai.org)
Hence, the high-affinity IgE-R on the mast cell functions not only in exocytosis but also facilitates the process of mast cell adherence to laminin. (aai.org)

PAR1 expression also induced a concerted shift in the expression of ErbB family of receptors and ligands, promoting the constitutive activity of EGFR/HER2 signaling. (tufts.edu)
This finding suggests that this receptor may have the ability to detect ligands from a broader spectrum of pathogens, not limited to fungal origins. (lu.se)

Physical adsorption isotherms were experimentally determined for these engineered proteins, allowing for direct calculation of the available ligand density present on coated surfaces. (frontiersin.org)
Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)

Laminin α1 reduces muscular dystrophy in dy2J mice. (lu.se)

Type F adenoviruses and the EKC-causing adenoviruses are substantially different in their cellular receptor homing, and thus tissue tropism, as well as their structure. (biospace.com)

The diversity of proteoglycans and their high interaction with growth factors and their receptors provides structural basis for a multitude of biological functions. (premiumbeautynews.com)

A wild type mouse with a working Crucio receptor and no pathogen exposure will be compared against a wild type mouse with a working Crucio receptor that has been exposed to the toxin and a mouse with a Crucio knockout and toxin exposure. (bartleby.com)

Netrins are a laminin-related family of matrix-binding secreted proteins containing an N-terminal laminin gamma-chain-related globular domain (domain VI), three laminin EGF-like repeats, and a C-terminal heparin-binding domain. (rndsystems.com)
Netrin-G1a and Netrin-G2a contain an N-terminal laminin globular domain (domain VI) followed by 3 laminin EGF-like repeats, and a C-domain with a hydrophobic signal for glycosylphosphatidylinositol (GPI) lipid linkage. (rndsystems.com)
Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. (antibodiesinc.com)

Abstract: Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor that is not expressed in normal breast epithelia, but is up-regulated in invasive breast carcinomas. (tufts.edu)

In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
The proteins produced from the affected genes form part of NADPH oxidase. (bartleby.com)

This type of metabolism indicates the different biochemical processes regarding the synthesis of proteins and amino acids, as well as breaking down proteins by catabolism. (stjohnslabs.com)

We have reported that mast cells adhere to laminin after activation with PMA. (aai.org)
NTHi utilizes a variety of proteins to adhere to and colonize the surface of epithelial cells, which is crucial for its invasion. (lu.se)

Our results indicate that the active factor is either a high molecular weight protein or protein complex and is not the respiratory protein hemocyanin. (nature.com)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)

Laminin-10/11 was highly adhesive to lineage-committed myelomonocytic and erythroid progenitor cells and most lymphoid and myeloid cell lines studied, whereas laminin-8 was less adhesive. (ox.ac.uk)
The C-Type Lectin receptor (CRL) is known as the major β-glucan receptor expressed in myeloid cells and is responsible for targeting respiratory fungal pathogens. (lu.se)

Laminins containing alpha4 and alpha5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. (ox.ac.uk)

Laminins colocalized with NP41 within nerve sheath, particularly perineurium, where laminin-421 is predominant. (dualsystems.com)

The cell-adhesive laminins affected migration of hematopoietic progenitors, suggesting a physiologic role for laminins during hematopoiesis. (ox.ac.uk)

All stem from dysfunctional N -glycosylation of proteins. (medscape.com)

3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)

Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. (joplink.net)
The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)
For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)
The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. (cshlpress.com)
In conclusion, we demonstrate laminin isoform-specific adhesive interactions with human bone marrow stem, progenitor, and more differentiated cells. (ox.ac.uk)

however, culture of mast cells with TGF-beta 1 was determined to enhance IgE-mediated adherence to laminin. (aai.org)
Su YC, Mattsson E, Singh B, Jalalvand F, Murphy TF, Riesbeck K. The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization. (lu.se)

Research suggests that ribosomal protein SA helps the ribosome control the production of certain proteins, many of which are likely important for development before birth. (medlineplus.gov)
The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma. (nih.gov)
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells. (nih.gov)

Evidence suggests that the protein plays a role in tumor invasion. (bvsalud.org)

Currently, our focus is to determine whether the interaction between NTHi surface proteins and CRL can trigger an immune response, as this information will be valuable in identifying potential vaccine candidates. (lu.se)

It is similar to the Protein S with the same domain organization and 43% amino acid identity. (wikipedia.org)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

Protein metabolism occurs in the liver and ammonia is the major end product. (stjohnslabs.com)

Laminin next to FN appears to be the major pro-adhesive ECM protein for mESCs. (biolamina.com)

Also functions as a cell surface receptor for laminin. (joplink.net)

Northern blotting of the transfected cells showed that the alpha 7 mRNA was expressed efficiently, and the protein was detected on the cell surface by immunofluorescence and fluorescence-activated cell sorter analysis. (uea.ac.uk)

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. (musc.edu)

Notably, the addition of hemolymph to laminin substrates accelerated growth cone migration rate over ten-fold. (nature.com)
By using protein fractionation and mass spectrometry analysis, we identified several novel candidates for EPC migration enhancing factor in PL-MSCs secretome that could be used to enhance neovascularization in the injured/ischemic tissues. (hindawi.com)
Moreover, the candidate EPC migration inducing factors presented in PL-MSCs secretome were identified using protein fractionation and mass spectrometry analysis. (hindawi.com)

Proteomics study identified 88 high stringent differentially expressed proteins comparing the three treatment groups with controls. (dovepress.com)

Previously we have shown that the locomotion of murine skeletal myoblasts is specifically and significantly enhanced on laminin but not on other matrix proteins. (uea.ac.uk)

Anatomy28

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Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes34

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Extracellular matrix p3

Fibronectin4

Collagen2

Integrin11

Subunit2

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Adhere2

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