Protein protein snap proteins n ethylmaleimide sensitive proteins. Medical search. Frequent questions

This gene encodes soluble NSF attachment protein gamma. (antibodies-online.com)
The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. (antibodies-online.com)
is compatible with a role in regulating Ca 2+ channel activity or SNARE [soluble N -ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complex function in vesicle fusion. (jneurosci.org)
The essential membrane fusion apparatus in mammalian cells, the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consists of four alpha-helices formed by three proteins: SNAP-25, syntaxin 1, and synaptobrevin 2. (nih.gov)
Martin HG, Henley JM, Meyer G. ( 2006 ) Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX. (neurotree.org)
Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e. (uchicago.edu)
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) make up the core machinery that mediates membrane fusion. (bvsalud.org)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
In this model, the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins syntaxin-1, SNAP-25, and synaptobrevin form tight complexes that bring the membranes together and are crucial for membrane fusion. (elsevierpure.com)
The complex process by which tick salivary gland proteins exit the glands and enter the host has been extensively studied, in what is called the SNARE hypothesis, soluble N-ethylmaleimide-sensitive factor attachment proteins (SNAPs) and their receptor proteins (SNAREs) interact to move vesicles rich in tick salivary gland proteins out of the salivary gland cells. (usm.edu)
Consistent with this, dynamin and a-SNAP (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I on VAMP2 sorting. (uninsubria.it)
Proteins of the SNARE family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are necessary to bring the membranes of a small vesicle and a cell membrane into close contact to promote fusion. (uni-goettingen.de)
An abundance of soluble N-ethylmaleimide-sensitive factor adaptor protein receptors. (kegg.jp)

During this process, SNARE proteins on two joining membranes (usually a vesicle and a target membrane such as the plasma membrane) form a complex, with the α-helical domains of the SNAREs coiling around each other and forming a very stable four-helix bundle. (wikipedia.org)
SNAREs, syntaxin, synaptosome-associated protein (SNAP), and synaptobrevin form a tight SNARE complex that brings the vesicle and plasma membranes together and is essential for membrane fusion. (bvsalud.org)
The specificity of vesicle trafficking: coat proteins and SNAREs. (kegg.jp)

The M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (TSHD7A), and neural epidermal growth factor-like 1 protein (NELL-1) are major autoantigens against podocyte antigens in idiopathic membranous nephropathy (IMN) [ 1 ]. (biomedcentral.com)
Using this framework to analyze the SM (Sec1/Munc18)-SNARE ( N -ethylmaleimide-sensitive factor activating protein receptor) system in exocytic membrane fusion in yeast and neurons, we find that the SM-SNARE network motifs of yeast and neurons show distinct dynamical behaviors. (biomedcentral.com)

SNARE Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "SNARE Proteins" by people in this website by year, and whether "SNARE Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "SNARE Proteins" by people in Profiles. (uchicago.edu)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
In this study, we tested the hypothesis that VTI family of SNARE proteins, VTI1A and VTI1B, are required for the salivary vesicle transport and success of tick to gain an uninterrupted access to blood-meal for several days. (usm.edu)

Orthologous to human NAPA (NSF attachment protein alpha). (nih.gov)

NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. (antibodies-online.com)
2007 ) GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors. (neurotree.org)

Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. (nih.gov)
The cDNAs of SNAP-25, VAMP2, and Syntaxin 1A from Bombyx mori were inserted into a plasmid, transformed into Escherichia coli, and purified. (bvsalud.org)
We then produced antibodies against the SNAP-25, VAMP2, and Syntaxin 1A of Bombyx mori of rabbits and rats, which were used for immunohistochemistry. (bvsalud.org)
VAMP2 co-localized with SNAP-25 in the CX, and with Syntaxin 1A in the PI and DL. (bvsalud.org)
VAMP2, SNAP-25, and Syntaxin 1A are present in the CA. Bombyxin-immunohistochemical reactivities (IRs) of brain and CA overlapped with VAMP2-, SNAP-25, and Syntaxin 1A-IRs. (bvsalud.org)
NSF and SNAPs disassemble SNARE complexes and ensure that fusion occurs through an exquisitely regulated pathway that starts with Munc18-1 bound to a closed conformation of syntaxin-1. (elsevierpure.com)
VAMP (Vesicle-associated membrane protein), SNAP-25 (Synaptosome associated protein of 25 kDa) and Syntaxin constitute the basic SNARE complex. (biomedcentral.com)
In this study the tension-dependency of fusion using model membranes equipped with a minimal fusion machinery consisting of syntaxin 1, Synaptobrevin and SNAP 25 is addressed. (uni-goettingen.de)

Previous studies suggest that the vesicular cysteine-string protein (CSP) may modulate presynaptic Ca 2+ channel activity in fast neurotransmitter release. (jneurosci.org)
Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. (elsevierpure.com)
ATP-sensitive potassium (K ATP ) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death. (biomedcentral.com)

Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body. (psyclopeptide.com)
These bacteria or yeast secrete their proteolytic enzymes in due course to release peptides from the proteins. (psyclopeptide.com)

Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene. (wikipedia.org)
they identified NSF after observing that a cytoplasmic factor, required for membrane fusions, was inactivated by treatment with N-ethylmaleimide. (wikipedia.org)
Biochemical and molecular dynamic simulation experiments revealed that the two substitutions do not regulate secretion by affecting the property of SNARE complex itself, but rather make the SNAP-25b-containing SNARE complex more available for the interaction with accessory factor(s). (nih.gov)
Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). (uchicago.edu)
Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)

Protein-protein interaction is not sufficient for the control of VAMP2 sorting, which is mediated by the C-terminal domain of synaptophysin I. Synaptophysin I directs the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. (uninsubria.it)

Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)

Protein is hydrolyzed by culturing bacteria or yeast on the protein substrates. (psyclopeptide.com)
The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)

2012 ) SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming Neuron . (neurotree.org)
2010 ) SNARE protein recycling by Î±SNAP and Î²SNAP supports synaptic vesicle priming. (neurotree.org)
In the present study, we have addressed the targeting of synaptobrevin 2/VAMP2 (vesicle-associated membrane protein 2), a critical component of the synaptic vesicle--fusion machinery, in a heterotypic context where its sorting is not confounded by the presence of other neuron-specific molecules. (uninsubria.it)
These results indicate that the sorting determinants of synaptic vesicle proteins can operate independently of a neuronal context and implicate the association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis. (uninsubria.it)

2003 ) A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. (neurotree.org)

Thus, conditional temperature-sensitive mutations in the Drosophila melanogaster gene for NSF lead to a comatose behaviour at the restrictive temperature (and hence the gene is called comatose), presumably because neuronal functions are blocked. (wikipedia.org)
60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
Mutations of a gene sequence can modify the interfaces or domains of its protein product and lead to the emergence of new or loss of existing protein interaction patterns [ 11 ]. (biomedcentral.com)

N-ethylmaleimide sensitive fusion protein has been shown to interact with NAPA. (wikipedia.org)
A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. (uchicago.edu)
These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
It is proposed that membrane fusion is induced by, the formation of SNARE complexes, at the active zones in the plasma membrane that are composed many of different lipids and proteins. (uni-goettingen.de)
In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster . (rupress.org)
As for many essential biological processes, intracellular membrane fusion is mediated by interactions among a series of evolutionarily conserved proteins. (biomedcentral.com)

It is alternatively spliced into two forms, SNAP-25a and SNAP-25b, differing by nine amino acids substitutions. (nih.gov)

The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)
Integrating the dynamics across species is particularly important in modeling cellular processes through protein interaction networks. (biomedcentral.com)
Many of the biological processes mediated by protein interaction networks are highly evolutionarily conserved or related across species. (biomedcentral.com)

Find NAPG Proteins for a variety of species such as anti-Human NAPG, anti-Arabidopsis thaliana NAPG, anti-Mouse NAPG. (antibodies-online.com)

SNAP-25 contributes two helices to the complex and is targeted to the plasma membrane by palmitoylation of four cysteines in the linker region. (nih.gov)
More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)

Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)

sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)

α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility. (nih.gov)
Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)
Seeking ovarian cancer related SNAP proteins may help to reveal new mechanisms of invasion and metastasis of ovarian cancer, and provide new ideas for clinical diagnosis and treatment. (biomedcentral.com)

These two proteins appear to play different roles in vesicular trafficking and exhibit distinct localization. (usm.edu)

SNAP-25 was restricted to neurons in the PI and the CX of the brain. (bvsalud.org)
Cell-attached and cell-free recordings of K ATP currents in large DRG neurons from control rats (sham surgery, SS) revealed activation of K ATP channels by NO exogenously released by the NO donor SNAP, through decreased sensitivity to [ATP]i. (biomedcentral.com)
Neurons generate their polarity by directing membrane traffic to growing neurites and growth cones, and by sorting proteins differentially between the axon and dendrites. (sdbonline.org)
This protein is required for many aspects of membrane traffic within neurons, including the elaboration of neurites, but the release of neurotransmitter at the synapse is independent of this exocyst component (Murthy, 2003). (sdbonline.org)
Within neurons, multiple pathways are known to transport proteins and transmitters to the cell surface. (sdbonline.org)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)

Understanding the basic mechanisms of VTI protein family in salivary glands may lead to better ways to prevent tick and tick-borne diseases. (usm.edu)
By capturing the evolutionary dynamics of target biological systems, the comparative modeling framework is empowered to (i) identify the functional roles of poorly characterized proteins and interactions and (ii) further decipher the underlying regulatory mechanisms of complicated cellular processes. (biomedcentral.com)

Ectopically expressed synaptophysin I interacts with VAMP2 and alters its default surface targeting to a prominent vesicular distribution, with no effect on the targeting of other membrane proteins. (uninsubria.it)

Intracellular bacteria encode inhibitory SNARE-like proteins. (uchicago.edu)

We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)

A pure form of proteolytic enzyme is used to hydrolyze the protein to produce short peptide sequences. (psyclopeptide.com)

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)

When expressed in chromaffin cells from SNAP-25 null mice, the isoforms support different levels of secretion. (nih.gov)
Although the members of these protein families are widely distributed among various types of somatic cells [10,11] , it is not known whether related proteins function in the acrosome reaction. (ommegaonline.org)
Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)

Failure to block the NO-mediated amplification of K ATP currents with specific inhibitors of sGC and PKG indicated that the classical sGC/cGMP/PKG signaling pathway was not involved in the activation by SNAP. (biomedcentral.com)

We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)

Immunohistochemistry and immunofluorescence was used to evaluate relative proteins expression. (biomedcentral.com)

K ATP channels, widely represented in metabolically active tissues, are hetero-octamers composed of four regulatory SUR subunits (SUR1, SUR2A, or SUR2B) and four ATP-sensitive pore-forming inwardly rectifying potassium channel (Kir6.x) subunits (Kir6.1 or Kir6.2) [ 20 ]. (biomedcentral.com)

Our results demonstrate an important role of VTI protein family in uninterrupted prolonged tick feeding on the host. (usm.edu)
Therefore this study provides a new method to solve the discrepancies and to generalize the functional role of SM proteins. (biomedcentral.com)

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes3

Information Science2

Soluble13

SNAREs3

Receptor2

SNARE Proteins6

Attachment1

Receptors2

Syntaxin8

Neurotransmitter release3

Peptides2

Exocytosis1

Factor5

Vesicles1

Intracellular protein transport1

Yeast2

Synaptic4

Cysteine-string1

Gene3

Fusion7

Amino acids1

Interaction3

Arabidopsis1

Complex2

Lipid1

Drosophila1

Ovarian3

Localization1

Neurons5

Molecular1

Mechanisms2

Vesicular1

Encode1

Mutants1

Peptide1

Regulates1

Cells3

Signaling pathway1

Humans1

Evaluate1

Subunits1

Role2