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  • mammalian
  • For example, a study of SDH which used diverse methods such as protein sequence alignments , structural comparisons, energy calculations, gel filtration experiments and enzyme kinetics experiments, could reveal an important hydrogen bonding network which stabilizes the tetrameric quaternary structure in mammalian SDH. (wikipedia.org)
  • amino acid
  • Proteins ( / ˈ p r oʊ ˌ t iː n z / or / ˈ p r oʊ t i . ɪ n z / ) are large biomolecules , or macromolecules , consisting of one or more long chains of amino acid residues . (wikipedia.org)
  • The sequence of amino acid residues in a protein is defined by the sequence of a gene , which is encoded in the genetic code . (wikipedia.org)
  • The amino acids produced by catabolism may be directly recycled to form new proteins, converted into different amino acids, or can undergo amino acid catabolism to be converted to other compounds via the Krebs cycle . (wikipedia.org)
  • SMC proteins are 1,000-1,500 amino-acid long. (wikipedia.org)
  • What would happen if there were a mutation in the gene for this protein, such that one of the charged amino acids is replaced by a neutral amino acid? (indiana.edu)
  • Synonyms
  • The free text search will scan for complete and partial matches to gene names, gene synonyms, gene descriptions, external ( UniProt , Ensembl , NCBI Entrez Gene) gene and protein identifiers, protein classes , Gene Ontology identifiers and descriptions, antibody identifiers and image annotations. (proteinatlas.org)
  • functional
  • Since it is usually the protein, rather than the mRNA, that has the functional role in cell response, a novel approach was needed. (wikipedia.org)
  • The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded [ 3 ] Failure to fold into the intended shape usually produces inactive proteins with different properties including toxic prions . (princeton.edu)
  • Microorganisms
  • Researchers at MSU have discovered that protein nanowire-expressing microorganisms are highly effective at precipitating and immobilizing heavy metal elements, including uranium, without compromising the organism's viability. (technologypublisher.com)
  • Nuclear
  • Methods commonly used to study protein structure and function include immunohistochemistry , site-directed mutagenesis , X-ray crystallography , nuclear magnetic resonance and mass spectrometry . (wikipedia.org)
  • L2 proteins contain two nuclear localisation signals (NLSs), one at the N-terminal (nNLS) and the other at the C-terminal (cNLS). (wikipedia.org)
  • Molecule
  • It is thought that the cycle of ATP binding and hydrolysis modulates the cycle of closing and opening of the V-shaped molecule, but the detailed mechanisms of action of SMC proteins remain to be determined. (wikipedia.org)
  • residues
  • Modifying these residues or nucleotides has a large effect on the communication pathways in the protein:RNA complex consistent with kinetic data. (pnas.org)
  • This study demonstrates that nucleotides in the tRNA as well as residues within the aaRS are essential for information transduction in the protein:RNA complex. (pnas.org)
  • targets
  • particularly DNA polymerase for PCR , reverse transcriptase for RNA analysis, restriction endonucleases for cloning, and to make proteins that are screened in drug discovery as biological targets or as potential drugs themselves. (wikipedia.org)
  • large
  • Its main advantage lies in the fact that large numbers of proteins can be tracked in parallel. (wikipedia.org)
  • In the most common type of protein array, robots place large numbers of proteins or their ligands onto a coated solid support in a pre-defined pattern. (wikipedia.org)
  • The ribosome of E. coli has about 22 proteins in the small subunit (labelled S1 to S22) and 33 proteins in the large subunit (somewhat counter-intuitively called L1 to L36). (wikipedia.org)
  • When a protein needs to be available on short notice or in large quantities, a protein precursor is produced. (princeton.edu)
  • immune
  • Other proteins are important in cell signaling , immune responses , cell adhesion , and the cell cycle . (wikipedia.org)
  • Your muscles , your organs, and your immune system are made up mostly of protein . (kidshealth.org)
  • This means that the protein contents of the food are split into tiny bits which ensures that the dog's immune system barely recognizes an allergic threat. (wikipedia.org)
  • Gene
  • Protein microarrays were developed due to the limitations of using DNA microarrays for determining gene expression levels in proteomics . (wikipedia.org)
  • cellular
  • The 1992 Nobel Prize in Physiology or Medicine to Edwin G. Krebs and Edmond H. Fischer for describing how reversible phosphorylation works as a switch to activate proteins , and to regulate various cellular processes including glycogenolysis . (wikipedia.org)
  • certain protein
  • Hydrolyzed Protein is also used in the manufacturing process of certain specially formulated Hypoallergenic Dog Foods for dogs and puppies that suffer from allergies caused by certain protein and carbohydrate types in standard commercial dog food brands. (wikipedia.org)
  • pathways
  • The contribution of each residue or node to the characteristic path length (CPL), defined as an average of the shortest path length between all pairs of nodes in the network, provides an estimate of the effect of node connectivity on communication pathways in a protein. (pnas.org)
  • Malfunction of GPCR [G Protein-Coupled Receptor] signaling pathways are involved in many diseases, such as diabetes , blindness, allergies, depression, cardiovascular defects, and certain forms of cancer . (wikipedia.org)
  • Folding
  • For each one, we'll consider 3 different alleles: non-mutant, a mutation such as that mentioned above with only 10% of normal activity, and a mutation that interferes with protein folding so much that the enzyme has no activity at all. (indiana.edu)
  • process
  • Once formed, proteins only exist for a certain period of time and are then degraded and recycled by the cell's machinery through the process of protein turnover . (wikipedia.org)
  • Protein production is the biotechnological process of generating a specific protein . (wikipedia.org)
  • When biopharmaceuticals are produced with one of these systems, process-related impurities termed host cell proteins also arrive in the final product in trace amounts. (wikipedia.org)
  • bound
  • The chip consists of a support surface such as a glass slide, nitrocellulose membrane, bead, or microtitre plate , to which an array of capture proteins is bound. (wikipedia.org)
  • reactions
  • We describe C (sp 3 )-C (sp 3 ) bond-forming reactions on proteins under biocompatible conditions, which exploit unusual carbon free radical chemistry, and use them to form Cβ-Cγ bonds with altered side chains. (sciencemag.org)
  • catalytic
  • Upon binding, the tRNA induces conformational changes throughout the protein:tRNA interface and within the catalytic site ( 2 ). (pnas.org)
  • Cell
  • The G protein activates a cascade of further signaling events that finally results in a change in cell function. (wikipedia.org)