• The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity. (uniprot.org)
  • Malignant brain tumor (MBT) domain chromatin reader proteins bind to methylated histone lysine residues and associate with chromatin remodeling complexes. (jax.org)
  • Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. (genecards.org)
  • The green fluorescent protein ( GFP ) is a protein composed of 238 amino acid residues (26.9 kDa ) that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. (wikipedia.org)
  • Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. (nih.gov)
  • 5. The polypeptide analog according to claims 1, 2, 3, or 4 comprising, except for the cysteine replacement at either position 132 or 135, from 176 to 199 of the amino terminal residues of bactericidal/permeability- increasing protein. (google.es)
  • 6. The polypeptide analog according to claim 5 comprising the initial 193 amino terminal amino acid residues of bactericidal/permeability- increasing protein. (google.es)
  • 8. The DNA of claim 7 encoding the thirty-one amino acid leader sequence and the first 193 N-terminal residues of bacterial/permeability- increasing protein and having a stop codon immediately following the codon for the leucine residue at position 193. (google.es)
  • It occurs on the nitrogen side-chains in arginine and lysine residues and the carboxy-termini of a few different proteins. (wikipedia.org)
  • Methylations on the C-terminus can increase a protein´s chemical repertoire and are known to have a major effect on the functions of a protein Protein methylation is the addition a methyl group to proteins, typically on the arginine or lysine amino acid residues in the protein sequence. (wikipedia.org)
  • Methylation of arginine residues is catalyzed by at least two different classes of protein arginine methyltransferases (PRMTs): Arginine can be methylated once (monomethylated arginine) or twice. (wikipedia.org)
  • Although the histones are the prime target of lysine methyltransferases, other cellular proteins carry N-methyllysine residues including elongation factor 1A and the calcium sensing protein calmodulin. (wikipedia.org)
  • Epigenetics, or the study of the physiological mechanisms that silence or activate genes, encompasses processes which alter gene function without changing the sequence of nucleotide base pairs in our DNA. (oneradionetwork.com)
  • In total, we identified the protein products of 810 genes (13.1% of the genome's coding capacity). (apsnet.org)
  • A total of 27 putative nodulespecific proteins and 35 nutrient-stress-specific proteins were identified and used as a basis to define genes and describe processes occurring in S. meliloti cells in nodules and under stress. (apsnet.org)
  • DNA sequences are replicated by the cell prior to cell division and may include genes, intergenic spacers, and regions that bind to regulatory proteins. (thefreedictionary.com)
  • The majority of the proteins made are for secretion into the extracellular space, for export to the plasma membrane, or for membranes and internal compartments that constitute the vacuolar system. (springer.com)
  • Klausner RD. Architectural editing: determining the fate of newly synthesized membrane proteins. (springer.com)
  • Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the. (biomedsearch.com)
  • Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. (genecards.org)
  • It is a membrane protein which manufactures surfactant. (wikipedia.org)
  • Explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane. (muni.cz)
  • The most intriguing observation is that translocation of the TMAO reductase across the cytoplasmic membrane is independent of the SecY, SecE, SecA and SecB proteins. (embopress.org)
  • The minimal set of proteins constituting a functional translocase complex comprises SecA, SecY, SecE and SecG, which mediate the ATP‐ and proton motive force‐dependent translocation across the membrane ( Schatz and Dobberstein, 1996 ). (embopress.org)
  • However, both Sec‐dependent and Sec‐independent protein insertion into the E.coli cytoplasmic membrane have been reported. (embopress.org)
  • Mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c and other apoptogenic factors into the cytosol, is controlled by interactions between proteins of the Bcl-2 family [ 3 , 4 , 5 ]. (mdpi.com)
  • Proteins with up to seven transmembrane domains were identified in membrane preparations. (apsnet.org)
  • Many of these proteins participate in cell signaling, and they utilize prenylcysteine methylation to concentrate them on the cytosolic surface of the plasma membrane where they are functional. (wikipedia.org)
  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. (hmdb.ca)
  • Three murine mammary tumor virus (MuMTV)-producing epithelial cell lines derived from murine mammary tumors were examined in order to identify the MuMTV-specific cell surface antigens and their distribution on the cell surface, to study the kinetics of the MuMTV envelope precursor processing, virus assembly, and release, and to characterize the soluble MuMTV antigens that are shed into culture medium. (biomedsearch.com)
  • The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. (genecards.org)
  • The activation and translocation of the TMAO reductase precursor are post‐translational processes, and activation is dissociable from translocation. (embopress.org)
  • Consequently, it is necessary to maintain precursor proteins in an export‐competent conformation prior to the interaction with the translocase. (embopress.org)
  • It was first reported that precursor maltose‐binding protein is competent for transport into the periplasm only before it has achieved its final, stably folded, conformation. (embopress.org)
  • and two mature virion glycoproteins, GP-1 (40 to 46 kDa) and GP-2 (35 kDa), that are derived by posttranslational cleavage of a precursor polypeptide, GP-C (75 kDa) ( 47 , 55 , 57 ). (asm.org)
  • AMPK is a heterotrimeric protein composed of one catalytic subunit α (existing in two isoforms, α1, and α2) and two regulatory subunits, β (β1 and β2) and γ (γ1, γ2, and γ3) ( 8 ). (frontiersin.org)
  • F-actin-capping proteins bind in a Ca 2+ -independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. (uniprot.org)
  • Jaenicke R. Protein folding: local structures, domains, subunits and assemblies. (springer.com)
  • A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. (genecards.org)
  • Humans, animals, and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. (wikipedia.org)
  • Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. (nih.gov)
  • One such protein, L3MBTL2, functions in early embryonic development and methylated histone-binding, and is an essential component of an atypical Polycomb complex (termed polycomb repressive complex 1.6 or PRC1.6). (jax.org)
  • The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. (cancerindex.org)
  • We find that the mycobacterial histone-like protein HupB is required for the formation of these subpopulations. (sciencemag.org)
  • Protein methylation has been most studied in the histones, where the transfer of methyl groups from S-adenosyl methionine is catalyzed by histone methyltransferases. (wikipedia.org)
  • they contain the green fluorescent protein (GFP) fused to a constitutively active degradation signal (Ub G76V ). (jax.org)
  • however no GFP protein expression is detected due to the G76V substitution which leads to its ubiquitination and proteasomal degradation. (jax.org)
  • The Ub G76V -GFP transgene was designed with a chicken beta-actin promoter (and cytomegalovirus (CMV) immediate early enhancer) upstream of a green fluorescent protein (GFP) fused to a mutant ubiquitin moiety (Ub G76V ), a constitutively active proteasome degradation signal. (jax.org)
  • FAT10 is an ubiquitin-like modifier that targets proteins to proteasomal degradation. (nature.com)
  • Profile of secreted hydrolases, associated proteins, and SlpA in Thermoanaerobacterium saccharolyticum during the degradation of hemicellulose. (semanticscholar.org)
  • Ubiquitination of Mcl-1, that targets it for proteasomal degradation, allows for rapid elimination of the protein and triggering of cell death, in response to various cellular events. (mdpi.com)
  • 1. A polypeptide analog of bactericidal/permeability-increasing protein or biologically-active fragment thereof wherein a cysteine residue at position 132 or at position 135 is replaced by a different amino acid. (google.es)
  • 14. A method for producing polypeptide analogs of bactericidal/permeability increasing protein and biologically active fragments thereof comprising growing a host cell according to claim 11 in a suitable culture medium and isolating said analog from said host cell or said culture medium. (google.es)
  • 15. A hybrid fusion protein comprising, at its amino terminal, an analog polypeptide according to claim 1 and, at its carboxyl terminal, at least one constant domain of an immunoglobulin heavy chain or an allelic variation thereof. (google.es)
  • In this study we show that overexpression of an apparent Arabidopsis ortholog of Rop1Ps , Rop1At , induces isotropic cell growth in fission yeast ( Schizosaccharomyces pombe ) and that green fluorescence protein-tagged Rop1At displays polar localization to the site of growth in yeast. (plantphysiol.org)
  • These results strongly suggest that the translocation of the molybdoenzyme TMAO reductase into the periplasm uses a mechanism fundamentally different from general protein translocation. (embopress.org)
  • citation needed] Most lysine methyltransferases contain an evolutionarily conserved SET domain, which possess S-adenosylmethionine-dependent methyltransferase activity, but are structurally distinct from other S-adenosylmethionine binding proteins. (wikipedia.org)
  • Lysine methylation plays a central part how histones interact with proteins. (wikipedia.org)
  • In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemical pathways in cells. (muni.cz)
  • The results showed that berberine significantly attenuated TER decrease and paracellular permeability increase in Caco-2 monolayers treated with IFN-γ and TNF-α.Berberine also dramatically alleviated IFN-γ and TNF-α-induced morphological alteration of tight junction proteins ZO-1, occluding, and claudin-1.Additionally, berberine suppressed the activation of HIF-1α, but not NF-κB. (nih.gov)