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  • mRNA
  • It was found that central nesfatin-1 resulted in a marked suppression of hepatic PEPCK mRNA and protein levels in both standard diet (SD) and high fat diet (HFD) rats but failed to alter glucose 6-phosphatase (G-6-Pase) activity and protein expression. (wikipedia.org)
  • cerebrospinal fluid
  • While placebo-patients and non-antibody responders worsened, these antibody-responders showed a degree of stability in cognitive levels as assessed by the neuropsychological test battery (although not by other measures), and had lower levels of the protein tau in their cerebrospinal fluid. (wikipedia.org)
  • Synthesis
  • Different products of protein synthesis in isolated chloroplasts and mitochondria are obtained in the presence of redox reagents with different redox potentials. (wikipedia.org)
  • genes
  • This leads to the activation of different downstream substrates and regulatory proteins, inducing transcription of different target genes that function in differentiation, chemotaxis, proliferation, and activation of many immune cells. (wikipedia.org)
  • Most genes for proteins of chloroplasts and mitochondria are, however, now located on chromosomes in the nuclei of eukaryotic cells. (wikipedia.org)
  • receptor
  • In particular, similarities in post-translational processing have invited comparisons to the signaling role of the surface receptor protein Notch. (wikipedia.org)
  • The region between the fifth and sixth conserved cysteines houses the most divergent area of TGF-β proteins that is exposed at the surface of the protein and is implicated in receptor binding and specificity of TGF-β. (wikipedia.org)
  • inactive
  • Pro-sequences are areas in the protein that are essential for its correct folding, usually in the transition of a protein from an inactive to an active state. (wikipedia.org)
  • fibers
  • Two of these, the cerebrovascular amyloid deposits and the senile plaques have as their major component a unique protein designated ß protein (ßP) 1 and the fibers denoted as Aß. (springer.com)
  • Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. (wikipedia.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • complex
  • May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus. (uniprot.org)
  • Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. (uniprot.org)
  • This complex remains in the cell until it is bound by another protein called Latent TGF-β-Binding Protein (LTBP), forming a larger complex called Large Latent Complex (LLC). (wikipedia.org)
  • The OCA-S transcriptional coactivator complex contains GAPDH and lactate dehydrogenase, two proteins previously only thought to be involved in metabolism. (wikipedia.org)
  • binds
  • p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • cleaves
  • Although BACE cleaves the extracellular domains of several transmembrane proteins, its physiological function remains unknown. (wikipedia.org)
  • cell
  • Some protein precursors are secreted from the cell. (wikipedia.org)
  • p>This section provides information on the location and the topology of the mature protein in the cell. (uniprot.org)
  • Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages. (wikipedia.org)
  • TGF-β is secreted by many cell types, including macrophages, in a latent form in which it is complexed with two other polypeptides, latent TGF-beta binding protein (LTBP) and latency-associated peptide (LAP). (wikipedia.org)
  • The study demonstrated that GAPDH is S-nitrosylated by NO in response to cell stress, which causes it to bind to the protein SIAH1, a ubiquitin ligase. (wikipedia.org)