• Cyclic GMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Harvard Catalyst Profiles by year, and whether "Cyclic GMP-Dependent Protein Kinases" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Profiles. (harvard.edu)
  • We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. (biomedcentral.com)
  • The new features significantly enhance the ability of Predikin to analyse protein kinases and their substrates. (biomedcentral.com)
  • Protein kinases, the enzymes responsible for protein phosphorylation, make up almost 2% of protein-encoding genes in the human genome [ 1 ] and an estimated 30-50% of human proteins are phosphorylated [ 2 ]. (biomedcentral.com)
  • Protein kinases and their substrates regulate essentially all cellular processes through complex regulatory networks, in which phosphorylated proteins act as switches that tune the response of the cell to environmental stimuli. (biomedcentral.com)
  • Defects in these networks result in a variety of disease states making protein kinases important targets for drug design [ 3 ]. (biomedcentral.com)
  • The relative contribution of substrate recruitment and peptide specificity to protein kinase substrate specificity varies between protein kinases. (biomedcentral.com)
  • The prediction of peptide specificity is therefore the basis for most of the available computational methods aimed at predicting substrates of protein kinases. (biomedcentral.com)
  • Protein phosphorylation is a reversible and dynamic post-translational modification that is governed by the opposing activities of protein phosphatases and kinases. (rndsystems.com)
  • We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)
  • This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
  • This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit. (bvsalud.org)
  • Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
  • Briefly, PI 3-kinase activity will be assessed by immunoprecipitating tissue lysates with a polyclonal IRS antibody coupled to protein A-sepharose beads and assessing the incorporation of 32 P into PI. (umassmed.edu)
  • The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
  • Protein kinase C (PKC)-mediated phosphorylation of SERT occurs on the plasma membrane during the initial phase of rapid transporter inhibition, and later, the phosphorylated SERT enters the intracellular pool. (aspetjournals.org)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. (rochester.edu)
  • The following is a list of 14 human genes encoding SR proteins involved in splicing: SR proteins are characterized by an RS domain and at least one RNA recognition motif (RRM). (wikipedia.org)
  • RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
  • Sequencing studies are identifying CHD candidate genes at a brisk rate including MINK1 , a serine/threonine kinase. (xenbase.org)
  • Blasticidin is a peptidyl nucleoside antibiotic isolated from Streptomyces griseochromogenes that inhibits protein synthesis by interfering with the peptide-bond formation in the ribosomal machinery. (invivogen.com)
  • Protein kinase C-mediated phosphorylation of the Serine at 41 within this site inhibits this interaction. (neuromics.com)
  • B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
  • Stevenson NJ, Ryan EJ, Keogh CA, Lloyd AT, Cormican P, Hegarty JE, O'Farrelly C. , Hepatitis C virus (HCV) regulates signal transducer and activator of transcription (STAT) protein expression to escape interferon-alpha (IFN-alpha) responses. (tcd.ie)
  • However, the mechanism through which phosphorylation regulates the activity of PIF7 is unclear. (elifesciences.org)
  • MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. (nih.gov)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • On Western blots, the full-length ATM protein was detected in eight of 18 AT cases, albeit at 1-32% of the normal levels, whereas a truncated ATM protein was detected in a single case, despite the prevalence among cases of truncation mutations. (nih.gov)
  • Altogether, our study shows that AT and A(-T) cases bearing truncation mutations of the ATM gene can produce modest amounts of full-length (and only rarely truncated) ATM protein. (nih.gov)
  • Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
  • this suppression is caused by an accumulation of mutations in the Zika virus genome that increase the number of phosphorylation sites on virus proteins that compete with host proteins for phosphorylation. (cdc.gov)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Treatment with PKC inhibitor GF109203X or PKCα siRNA reduced phosphorylation at 15 min but not 30 min, whilst rottlerin, a selective PKCδ inhibitor and PKCδ siRNA reduced the response at both time points. (strath.ac.uk)
  • Treatment of cells with the MAPK kinase inhibitor, PD 98059, prevented both T4-induced nuclear MAPK-TR co-immuno-precipitation and serine phosphorylation of TR. (tmu.edu.tw)
  • NF-kB activity is normally regulated via the inhibitor kB protein. (medscape.com)
  • Tumor necrosis factor receptor activation results in phosphorylation and inactivation of inhibitor kB by IKK, thus resulting in activation of NF-kB. (medscape.com)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
  • Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation. (harvard.edu)
  • cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. (harvard.edu)
  • PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. (harvard.edu)
  • Controlled by sequential serine-phosphorylation, ubiquitination and degradation. (lu.se)
  • Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca 2+ -permeable channel activated by the agonists of G q -protein-coupled heptahelical receptors. (mdpi.com)
  • In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)
  • Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
  • In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
  • SR proteins were discovered independently through the use of two different monoclonal antibodies. (wikipedia.org)
  • These were tested for antibodies against the SARS-CoV-2 spike protein and nucleocapsid, including neutralising capacity. (bvsalud.org)
  • Taken together these data indicate dependency for Gq/11 in early phosphorylation of p65 NFκB and this subsequently affects initial NFκB-dependent gene transcriptional activity, however later regulation of p65 is unaffected. (strath.ac.uk)
  • Overall these novel data demonstrate an IKK2-dependent, predominantly G-protein-independent pathway involved in PAR-2 regulation of NFκB phosphorylation in keratinocytes. (strath.ac.uk)
  • Furthermore, we found that the Ca 2+ effector enzyme protein kinase C (PKC) is essential for the Ca 2+ -dependent regulation of Rho GTPases during the transduction of guidance signals. (jneurosci.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Transfection into CV-1 cells of TR gene constructs in which one or both zinc fingers in the TR DNA-binding domain were replaced with those from the glucocorticoid receptor localized the site of TR phosphorylation by T4-activated MAPK to a serine in the second zinc finger of the TR DNA-binding domain. (tmu.edu.tw)
  • Perichromatin fibrils are areas of gene transcription and where SR proteins associate with RNA polymerase II for co-transcriptional splicing. (wikipedia.org)
  • Huntington's disease is a genetic neurological disorder caused by a repeated expansion of the CAG trinucleotide, causing instability in the N-terminal of the gene coding for the Huntingtin protein. (benthamscience.com)
  • This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. (origene.com)
  • The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. (origene.com)
  • What does this gene/protein do? (cancerindex.org)
  • these proteins are also important in regulating gene transcription. (biomedcentral.com)
  • The GJB2 gene provides instructions for making a protein called gap junction beta 2, more commonly known as connexin 26. (medlineplus.gov)
  • The MT-TS1 gene mutation that causes palmoplantar keratoderma with deafness leads to reduced levels of tRNA Ser(UCN) to assemble proteins within mitochondria. (medlineplus.gov)
  • Testis-specific serine kinase 3 (Tssk3) is a conserved gene, but TSSK3 kinase functions and phosphorylation substrates of TSSK3 are not known. (cdc.gov)
  • SWCNT induced a significant activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB), and the effect was inhibited by mitogen-activated protein kinase (MAPK) inhibitors. (cdc.gov)
  • 3 Pro-apoptotic proteins, such as cytochrome c and second mitochondria-derived activator of caspase (SMAC), are released from mitochondria into the cytosol where they participate in the activation of execution caspases. (nature.com)
  • Enables kinase binding activity and protein serine/threonine kinase activator activity. (nih.gov)
  • We characterized the ATM protein expression in immortalized cells from AT and AT-variant patients, and heterozygotes and correlated it with two ATM-dependent radiation responses, G1 checkpoint arrest and p53-Ser 15 phosphorylation. (nih.gov)
  • However, this limited expression of ATM protein provides no benefit regarding the ATM-dependent responses related to G1 arrest and p53-ser15 phosphorylation. (nih.gov)
  • Inhibition of Gi or G12/13 pathways by pertussis toxin pre-treatment or over-expression of the RGS mutant Lsc, also did not effect NFκB phosphorylation. (strath.ac.uk)
  • Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
  • Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency. (harvard.edu)
  • Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
  • STAT3 protein expression and tyrosine phosphorylation will be measured using phospho-specific STAT3 (Tyr705) polyclonal antibody. (umassmed.edu)
  • GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
  • These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)
  • Furthermore, stimulation of cells through a novel PAR-2 mutant PAR-234-43, delayed p65 phosphorylation but was without effect on the kinetics of ERK activation. (strath.ac.uk)
  • Activated nongenomically by L-thyroxine (T4), mitogen-activated protein kinase (MAPK) complexed in 19-20 min with endogenous nuclear thyroid hormone receptor (TRβ1 or TR) in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. (tmu.edu.tw)
  • Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). (cdc.gov)
  • We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Among these cell-signaling proteins, activation of p53 is important in cells with UV radiation-induced DNA damage ( 4 , 7 ). (spandidos-publications.com)
  • In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
  • Connexin proteins form channels called gap junctions that permit the transport of nutrients, charged atoms (ions), and signaling molecules between neighboring cells that are in contact with each other. (medlineplus.gov)
  • The altered protein probably disrupts the function of normal connexin 26 in cells, and may interfere with the function of other connexin proteins. (medlineplus.gov)
  • Non-muscle cofilin (n-cofilin) is a member of the ADF/cofilin family of actin depolymerizing proteins. (nature.com)
  • The interaction between the adaptor protein APS and Enigma is involved in actin organisation. (genscript.com)
  • By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
  • and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)
  • Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
  • Based on sequence analysis, SR proteins are suspected to be intrinsically disordered proteins resulting in an unstructured RS domain. (wikipedia.org)
  • Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)
  • SR proteins are important in constitutive and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. (wikipedia.org)
  • SR proteins alternatively splice pre-mRNA by preferentially selecting different splice sites on the pre-mRNA strands to create multiple mRNA transcripts from one pre-mRNA transcript. (wikipedia.org)
  • Once splicing is complete the SR protein may or may not remain attached to help shuttle the mRNA strand out of the nucleus. (wikipedia.org)
  • As RNA Polymerase II is transcribing DNA into RNA, SR proteins attach to newly made pre-mRNA to prevent the pre-mRNA from binding to the coding DNA strand to increase genome stabilization. (wikipedia.org)
  • SR proteins can control the concentrations of specific mRNA that is successfully translated into protein by selecting for nonsense-mediated decay codons during alternative splicing. (wikipedia.org)
  • SR proteins can alternatively splice NMD codons into its own mRNA transcript to auto-regulate the concentration of SR proteins. (wikipedia.org)
  • Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation of mRNA. (wikipedia.org)
  • Interchromatin granule clusters are for the storage and reassembly of pre-mRNA splicing proteins. (wikipedia.org)
  • Homo sapiens protein phosphatase 5 catalytic subunit (PPP5C), transcript variant 1, mRNA. (origene.com)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • Rattus norvegicus SH2B adaptor protein 2 (Sh2b2), mRNA. (genscript.com)
  • Conserved region 2 (CR2) is a serine-rich region that functions as a hinge on the molecule. (news-medical.net)
  • The RRM domain mediates the RNA interactions of the SR proteins by binding to exon splicing enhancer sequences. (wikipedia.org)
  • These sequences represent the protein coding region of the Sh2b2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
  • The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
  • Outer mitochondrial membrane permeabilization and cytochrome c release are typically achieved by pro-apoptotic Bcl-2 proteins, such as Bax and Bak. (nature.com)
  • I hypothesized that this pattern of rapid suppression of liver mitochondrial metabolism with gradual reversal, was related to changes in the phosphorylation state of Ictidomys tridecemlineatus ' mitochondrial proteins in different stages of torpor bouts. (uwo.ca)
  • Changes in protein phosphorylation among hibernation-specific metabolic stages do not correlate with mitochondrial respiration. (uwo.ca)
  • Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. (genscript.com)
  • The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)
  • Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
  • Our study additionally shows that the majority of AT heterozygotes express almost halved levels of ATM protein, sufficient in most cases to normally regulate the ATM-dependent DNA damage-response pathway. (nih.gov)
  • RS domains regulate protein-protein interactions of SR proteins. (wikipedia.org)
  • Das D, Chen SY and Arur S *. ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers. (mdanderson.org)
  • Tyrosine-phosphorylation could only lead to dissociation from NF-kappa-B. (lu.se)
  • The results in this dissertation also demonstrate that the protein phosphatase type 2A (PP2A) can directly and independently decrease the phosphorylation levels of both p38 and caspase 3. (lu.se)
  • SR proteins were discovered in the 1990s in Northern Ireland, Belfast in amphibian oocytes, and later in humans. (wikipedia.org)
  • Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
  • Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)
  • In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. (diabetesjournals.org)
  • Tissue samples will be obtained at the end of clamp studies to measure in vivo activities of the following insulin/inflammatory signaling proteins: 1) tyrosine/serine phosphorylation of IRS, 2) PI-3 kinase, 3) Akt/PKB, 4) PKC isoforms, 5) STAT3 and 6) IKK. (umassmed.edu)
  • In general, a protein kinase acts on a discrete set of substrates to ensure that signalling fidelity is maintained. (biomedcentral.com)
  • Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)
  • The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it is also stimulated by environmental stress conditions, such as starvation, oxidative stress, and the accumulation of misfolded proteins. (mdpi.com)
  • This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. (rochester.edu)
  • In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
  • Together, they conduct experiments that include injecting zebrafish embryos with alpha-synuclein DNA and manipulating the protein at different sites. (lclark.edu)
  • Haversat J, Woglar A, Klatt K, Akerib CC, Roberts V, Chen SY, Arur S , Villeneuve AM and Kim Y. Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex. (mdanderson.org)
  • A) Schematic of Xenopus tropicalis Mink1 protein domains, site of kinase-dead (KD) mutation, and Crispr target sites (yellow). (xenbase.org)
  • Rat GAP-43 is a 226 amino acid (aa) protein that contains an N-terminal lipid binding motif, an 11 aa IQ domain (IQ:Ile-Gln-X-Ser-etc) (aa 38 - 48), and a C-terminus with four potential serine phosphorylation sites. (neuromics.com)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control. (uci.edu)
  • We detected phosphorylation on S155 and identified S155 as a functionally important site for lipid metabolism. (uci.edu)
  • How a particular protein kinase recognises its substrate protein(s) is therefore a key question. (biomedcentral.com)
  • Two major factors determine the formation of a protein kinase-substrate complex [ 4 ]. (biomedcentral.com)
  • The first, termed substrate recruitment, encompasses any process that increases the effective concentration of the protein kinase substrate. (biomedcentral.com)
  • APS was identified as a novel substrate for protein kinase B/Akt. (genscript.com)
  • In the current study we found that trypsin and the selective PAR-2 activating peptide, 2f-LIGKV-OH, stimulated large and sustained increases in the serine 536 phosphorylation of p65/RelA in a transfected skin epithelial cell line and primary keratinocytes. (strath.ac.uk)
  • Parallel experiments showed that in both cell types, p65 NFκB phosphorylation is mediated through the selective activation of IKK2. (strath.ac.uk)
  • These studies demonstrate a phosphorylation-dependent translocation of PIF7 when plants are in shade and a novel mechanism involving 14-3-3 proteins, mediated by the retention of PIF7 in the cytoplasm that suppresses the shade response. (elifesciences.org)
  • When phosphorylated by an active IkB kinase (IKK) complex, IkB proteins are degraded by proteasomes, resulting in the release and nuclear translocation of active NFkB. (rndsystems.com)
  • It phosphorylates a specific sequence on protein targets. (news-medical.net)
  • The proposed method is novel because it works independently of protein sequence databases and without any prior knowledge about modifica- tions. (lu.se)
  • PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Reyes-Castro R, Chen SY, Seemann J, Arur S . ERK-dependent DICER1 phosphorylation promotes open chromatin state and lineage plasticity to mediate tumor progression. (mdanderson.org)
  • These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
  • Furthermore, Ca 2+ -induced GTPase activity correlated with activation of protein kinase C and required a basal activity of Ca 2+ /calmodulin-dependent protein kinase II. (jneurosci.org)
  • The initial serine phosphorylation corresponded to the first phase of rapid inhibition mediated by changes in intrinsic activity and/or silencing of SERT. (aspetjournals.org)
  • This activity is strongly conserved and probably represents a primordial function of these proteins. (biomedcentral.com)
  • Using two different methods it was possible to detect constitutive activity of p38 mitogen-activated protein kinase (p38) in newly isolated neutrophils. (lu.se)
  • In Arabidopsis , the shade-induced de-phosphorylation of the transcription factor PIF7 (PHYTOCHROME-INTERACTING FACTOR 7) is the key event linking light perception to stem elongation. (elifesciences.org)
  • A number of successful drugs have been developed that target protein phosphatases. (rndsystems.com)