• Protein phosphorylation is involved in many mechanisms that contribute to neuronal plasticity, i.e. in the modulation of the information processing and storage properties of nerve cells resulting, ultimately, in the ability of the nervous system to learn. (springer.com)
  • It is primarily a neuronal protein, but can also be found in the neuroglial cells. (biolegend.com)
  • SIRPα was also found to regulate the FS stress-induced tyrosine phosphorylation of other neuronal proteins. (jneurosci.org)
  • The neuronal pp100-110 are structurally and functionally related to the 100-110-kD component of the bovine brain assembly protein (AP), a protein complex that also contains 50-kD and 16.5-kD components and is characterized by its ability to promote the reassembly of clathrin coat structures under physiological conditions of pH and ionic strength (Zaremba, S. and J. H. Keen, 1983, J. Cell Biol. (rupress.org)
  • Although the brain AP50 is prominently phosphorylated by an endogenous protein kinase in isolated coated vesicle preparations, the neuronal AP50 was not detectably phosphorylated in intact cells as assessed by two-dimensional non-equilibrium pH gradient gel electrophoresis of labeled cells dissolved directly in SDS-containing buffers. (rupress.org)
  • Phosphorylation of Munc18-1 in neuronal cells ( 10 , 11 ) and Munc18-3 and syntaxin 4 in endothelial cells ( 12 ) promotes Munc18-syntaxin dissociation, thereby facilitating vesicular fusion. (jimmunol.org)
  • Proteomics approaches aimed at identifying synaptic proteins ( 11 - 16 ) and their post-translational modifications ( 8 , 17 , 18 ) have increased our knowledge of synaptic complexity. (mcponline.org)
  • Activity- dependent, dihydropyridine-sensitive as well as cAMP-dependent phosphorylation of myosin light chain was observed. (jneurosci.org)
  • Recent evidence (preprinted at BioRxiv) suggests widespread human protein phosphorylation on multiple non-canonical amino acids, including motifs containing phosphorylated histidine, aspartate, glutamate, arginine and lysine in HeLa cell extracts. (wikipedia.org)
  • In the early 1980, the amino-acid sequence of the first protein kinase was determined which helped geneticists understand the functions of regulatory genes. (wikipedia.org)
  • The NtrC transcription factor is a member of a family of homologous prokaryotic regulatory proteins that participate in the transduction of extracellular and nutritional signals. (asm.org)
  • We have investigated the site of phosphorylation of the Salmonella typhimurium NtrC protein and find that it is an aspartate residue (Asp-54) that is found within a sequence conserved in all of the members of the family of regulatory proteins. (asm.org)
  • This review focuses on the regulatory roles that phosphorylation of CPs has in the life cycle of viruses with RNA genomes. (dovepress.com)
  • Although the catalytic and regulatory subunits of DNA-PK remain to be characterized in this organism, DNA-dependent phosphorylation of histone during nucleosome assembly has been demonstrated in the oocytes (Kleinschimdt and Steinbeisser, 1991). (thefreelibrary.com)
  • Now, a new study by researchers at the University of California San Francisco and published on the preprint server bioRxiv * in June 2020 shows the effect of phosphorylation on the state and function of the N protein. (news-medical.net)
  • These collective findings indicate that phosphorylation induces unique secondary structural changes that may enhance the functional capacity of native phosphorylated amelogenins like LRAP to stabilize an ACP precursor phase during early stages of enamel mineral formation. (frontiersin.org)
  • None of these thylakoid proteins were completely phosphorylated in the steady state conditions of continuous light or completely dephosphorylated after a long dark adaptation. (diva-portal.org)
  • The development of analogous high throughput methods for directly monitoring protein levels, while increasingly desirable for biological investigations in the postgenome era ( 1 - 3 ), presents a formidable analytical challenge. (pnas.org)
  • Objectives To identify the major tyrosine-phosphorylated proteins in the normal artery and their changes after balloon injury. (bmj.com)
  • Individual protein bands were excised, destained, washed, and digested with modified trypsin (Boehringer Mannheim), and the resulting peptides were extracted with acetonitrile. (pnas.org)
  • Full phosphorylation of specific synthetic peptides confirmed that beads were successfully loaded with kinases. (rsc.org)
  • Whereas ubiquitin marks eukaryotic proteins for proteasomal degradation, a general tagging system for the equivalent bacterial Clp proteases is not known. (nature.com)
  • Although many links and effectors are still unknown, central components of this network include the mammalian target of rapamycin (mTOR) and its downstream effectors - the ribosomal protein S6 kinase (S6K) and the translational repressor eukaryotic initiation factor 4E-binding protein. (nih.gov)