Protein phosphatase cyclin dependent kinase regulatory. Medical search. Frequent questions

Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
The potential role of serine/threonine phosphatases can be concluded from inhibitor studies based on okadaic acid or endothall. (bibbase.org)
Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) has become the first-line treatment for advanced renal cell carcinoma, despite the lack of prognostic biomarkers. (e-crt.org)
Recently, clinical trials of immune checkpoint inhibitor plus vascular endothelial growth factor receptor-tyrosine kinase inhibitor (TKI) for mRCC have exhibited outstanding efficacies [ 3 - 5 ]. (e-crt.org)
Inhibitor of protein-phosphatase 1. (t3db.ca)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
Furthermore, we validated the previously reported longevity locus cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1). (uni-kiel.de)
Pope PA, Bhaduri S, Pryciak PM. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. (umassmed.edu)
Mechanistically, overexpression of BCRC-3 induced the expression of cyclin-dependent kinase inhibitor 1B (p27). (biomedcentral.com)

The Cdc25A dual-specificity phosphatase promotes cell cycle progression by dephosphorylating and activating the cyclin-dependent kinases. (pitt.edu)
The catalytic domain of this dual-specificity phosphatase has recently been mapped to the 180 most C-terminal amino acids. (embl.de)

This switch in aMT dynamics, important for proper spindle orientation, specifically requires the degradation of the mitotic cyclin Clb4 by the Anaphase Promoting Complex bound to its activator subunit Cdc20 (APC/CCdc20). (bvsalud.org)
The Saccharomyces cerevisiae kinase/adenosine triphosphatase Rio1 regulates rDNA transcription and segregation, pre-rRNA processing and small ribosomal subunit maturation. (bvsalud.org)
Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. (kegg.jp)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) in Tissue homogenates, cell lysates and other biological fluids. (hiv-pharmacogenomics.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hiv-pharmacogenomics.org)
Description: A sandwich ELISA kit for detection of Protein Phosphatase 1, Regulatory Subunit 15A from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hiv-pharmacogenomics.org)
How could a small bit of the large RNA polymerase subunit ever be part of the RNA polymerase protein complex? (blogspot.com)
Genes that encode the B-regulatory subunit (Cdc55) and the three catalytic subunits (Pph21, Pph22, and Pph3) of phosphatase 2A (PP2A) were isolated. (fsu.edu)

DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)
Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
Phosphorylation assays also revealed that at least three kinase complexes (Cdc2Ms A/B, D and F) were successively active in G2/M cells after synchronization. (bibbase.org)
however tyrosine phosphorylation was indicated in the case of Cdc2Ms A kinase and the p13suc1-bound kinase activity was increased by treatment of this complex with recombinant Drosophila Cdc25. (bibbase.org)
article{meszaros_multiple_2000, title = {Multiple cyclin-dependent kinase complexes and phosphatases control {G2}/{M} progression in alfalfa cells}, volume = {43}, issn = {1573-5028}, url = {https://doi.org/10.1023/A:1006412413671}, doi = {10/cb64mn}, abstract = {Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
SMAD phosphorylation by active receptors, and constitutive SMAD dephosphorylation by nuclear phosphatases, are coupled through nucleocytoplasmic shuttling of SMADs. (nature.com)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. (embl.de)
Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. (embl.de)
During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. (affbiotech.com)
The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone (PTH) and dopamine. (duke.edu)
Reversible phosphorylation of nuclear proteins is required for both DNA replication and entry into mitosis. (duke.edu)
Inhibition of Cdk5 by olomoucine enhanced phosphorylation of kinesin, suggesting that the effect was mediated by negative regulation of other kinases. (frontiersin.org)
Repetto MV, Winters MJ, Bush A, Reiter W, Hollenstein DM, Ammerer G, Pryciak PM, Colman-Lerner A. CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. (umassmed.edu)
Bhaduri S, Valk E, Winters MJ, Gruessner B, Loog M, Pryciak PM. A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry. (umassmed.edu)

The kinase(s) responsible for phosphorylating these serine residues remain to be identified, although Cdk2 could be one prime candidate. (pitt.edu)
STP, serine/threonine protein phosphatase. (rupress.org)
Cdk5 is named after its structural similarity to members of the serine/threonine cyclin-dependent kinase family. (frontiersin.org)

and 3) to explore the mechanism by which Cdk2 kinase activity regulates Cdc25A protein turnover. (pitt.edu)
The results of our studies revealed that Cdc25A protein half-life in non-stressed interphase cells is regulated, in part, by Cdk2 kinase activity, and that Cdk2 does not regulate Cdc25A turnover by affecting several known signal transduction pathways that control Cdc25A protein stability. (pitt.edu)
While initial reports of the interactions between Cdc25A and Cdk2 focused on an auto-amplification feedback loop that results in increased catalytic activity of both proteins, it now appears that Cdk2 also regulates Cdc25A stability and plays an important role in regulating Cdc25A protein levels during interphase progression. (pitt.edu)
Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. (nih.gov)
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. (duke.edu)

The cdc25 gene product is a tyrosine phosphatase that acts as an initiator of M-phase in eukaryotic cell cycles by activating p34 cdc2 . (biologists.com)

Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)
In the high CDK5 subgroup, CD8 + T cells revealed a dysfunction phenotype with decreased granzyme B, and more regulatory T cells were identified. (e-crt.org)
GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration. (frontiersin.org)
So far, both kinases have mostly been examined in isolation, leading to a schism of the research field into defenders of the GSK3β-versus the Cdk5 hypotheses of AD. (frontiersin.org)
using cultured neurons: Their investigations to determine a regulatory pathway for kinesin-driven motility in axons revealed that Cdk5 is neccessary for kinesin-driven motility within the axon but cannot directly phosphorylate kinesin. (frontiersin.org)

A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
It makes no sense that conserved genes would be producing alternative protein variants that are species specific. (blogspot.com)
He is firmly convinced that most human genes express a number of different protein products that are produced as the result of alternatively spliced mRNA precursors. (blogspot.com)
185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)
Despite the importance of the PAP reaction, identification of the genes responsible for encoding PAP enzymes remained elusive until 2006 when the yeast PAP was identified and was shown to be an orthologue of a family of three mammalian proteins called lipins [reviewed in 1]. (aocs.org)
In conclusion, we identified 2 new potential candidate longevity genes, FN3KRP and PGP which may influence the phenotype through their role in metabolic processes, that is, the reverse glycation of proteins (FN3KRP) and the control of glycerol-3-phosphate levels (PGP). (uni-kiel.de)
A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
In the past decade, yeast have been frequently employed to study the molecular mechanisms of human neurodegenerative diseases, generally by means of heterologous expression of genes encoding the relevant hallmark proteins. (microbialcell.com)
In this respect, although obviously lacking a brain with a multicellular neuronal network, simple unicellular yeast are of great value to investigate the effects of overexpression and single point-mutations in genes encoding key proteins on cell physiology and on the function of conserved signaling cascades. (microbialcell.com)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)

This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously . (pp1a.com)
Among them, cyclin-dependent kinases (CDK)s with their modulatory partners, cyclins, represent the major players acting with switch-like behavior to turn on cell growth, through the control of chromatin replication and condensation, gene transcription, assembly of the mitotic spindle, and proper cytodieresis. (mdpi.com)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
The life of a gene product, from transcription to degradation, is controlled by a series of regulatory decisions. (biomedcentral.com)
elife-70588-supp1.xlsx (3.1M) GUID:?49F0120F-77B9-4447-8EB0-9A65C3C07153 Supplementary document 2: Outcomes of gene ontology analysis of proteins with significant adjustments in abundances from prophase We arrest towards the 1st embryonic cleavage. (gasyblog.com)
elife-70588-supp3.xlsx (2.5M) GUID:?6DFF4791-F5A6-48AA-A312-9D8FD1772A2F Supplementary document 4: Outcomes of gene ontology analysis of proteins suffering from emetine treatment. (gasyblog.com)
The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)
In a single-variant analysis, we observed an exome-wide significant association between rs1046896 in the gene fructosamine-3-kinase-related-protein (FN3KRP) and longevity. (uni-kiel.de)
A gene-based analysis, in which potential cumulative effects of common and rare variants were considered, yielded the gene phosphoglycolate phosphatase (PGP) as another potential longevity gene, though no single variant in PGP reached the discovery p-value (1 × 10E-04). (uni-kiel.de)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)

In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. (kegg.jp)
The purpose of this thesis was to examine the physiological regulation of Cdc25A protein levels in human tumor cells. (pitt.edu)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
INTRODUCTION: Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. (duke.edu)

Eukaryotic RNA polymerase is a complex protein machine consisting of ten different subunits. (blogspot.com)
Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. (duke.edu)

Interaction between alfalfa mitotic cyclin (Medsa;CycB2;1) and a kinase partner has been reported previously. (bibbase.org)
These data highlight a unique role for mitotic cyclin Clb4 in controlling aMT regulating factors, of which Kip2 is a prime candidate, provide a framework to understand aMT regulation in vertebrates, and uncover mechanistic principles of how the APC/CCdc20 choreographs the timing of late mitotic events by sequentially impacting on the three classes of spindle microtubules. (bvsalud.org)

Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)

Functional diversity between PTPases is endowed by regulatory domains and subunits. (embl.de)
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. (umassmed.edu)

Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase CCNDBP1 NM_012142 May negatively regulate cell cycle progression CCNG1 NM_004060 May play a role in growth regulation CCNH NM_001239 Involved in cell cycle control and in RNA transcription by RNA polymerase II. (wikipedia.org)
Increasing numbers of sequence and biochemical data show the involvement of cyclin-dependent kinases (CDKs) and cyclins in regulation of the cell cycle progression in higher plants. (bibbase.org)
Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
While Cdc25A downregulation in response to genotoxic stress occurs through defined signal transduction pathways, regulation of Cdc25A protein levels in non-stressed cells is poorly understood. (pitt.edu)
Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)

The proper development and homeostasis of tissues and organs at the cellular level are ensured by a finely and timely regulated progression of the cell division cycle, which requires the perfectly harmonized activity of numerous protein kinases/phosphatases and regulatory proteins. (mdpi.com)
Mammalian Cdc25 phosphatase is responsible for the dephosphorylation of Cdc2 and other cyclin-dependent kinases at Thr14 and Tyr15, thus activating the kinase and allowing cell cycle progression. (embl.de)
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. (umassmed.edu)
However, it has become evident that substantial posttranslational modifications of many of these proteins are required for the development and progression of potentially disease relevant changes. (microbialcell.com)
Thus, further exploration of genetic regulatory networks involved in BC progression and development of precise strategies are worthy and important. (biomedcentral.com)
In general, the circRNA-miRNA-mRNA axis may function as an extensive regulatory network in progression of some diseases. (biomedcentral.com)

The enzyme that catalyzes dephosphorylation of phosphatidate is called phosphatidate phosphatase (PAP), or lipin, and this is an important branch point in glycerolipid biosynthesis. (aocs.org)

After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)
Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. (duke.edu)

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)
The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. (affbiotech.com)
Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. (fsu.edu)

This is exemplified by the neuronal tau proteins, which are critically involved in a class of neurodegenerative diseases collectively called tauopathies and which includes Alzheimer's disease (AD) as its most common representative. (microbialcell.com)

Low expression of CDK6 protein in ZR-75-1, Neuro-2a, and INS-1 cells is consistent with the predicted expression pattern. (cellsignal.com)
Immunoprecipitation of CDK6 protein from Jurkat cell extracts. (cellsignal.com)

A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain. (embl.de)

adenosine kinase [Sourc. (gsea-msigdb.org)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility. (pp1a.com)

A subset of cyclins may also function as transcriptional regulators. (umassmed.edu)

F-box protein specificity for g1 cyclins is dictated by subcellular localization. (umassmed.edu)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

The complexity represented by different types of CDKs and cyclins in a single species such as alfalfa, indicates that multicomponent regulatory pathways control G2/M transition. (bibbase.org)

In budding yeast Saccharomyces cerevisiae, Cdc5 kinase is a component of mitotic exit network (MEN), which inactivates cyclin-dependent kinase (CDK) after chromosome segregation. (fsu.edu)

Alterations to physiologic Cdc25A regulatory mechanisms could be sufficient to result in oncogenic overexpression of this cell cycle regulatory protein. (pitt.edu)

Note that this locus is complex: it appears to produce several proteins with no sequence overlap. (blogspot.com)

Dopamine and cyclic-AMP activated Mr32kDa phosphoprotein (DARPP-32) is a central signaling proteins in neurotransmission. (pp1a.com)

At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
In neutrophils, IL-8 binding to CXCR1 triggers G protein-coupled signalling and formation of second messengers that mediate cellular migration, exocytosis of effectors and a respiratory burst to facilitate oxygen-dependent killing of phagocytosed microorganisms [ 2 ]. (biomedcentral.com)

The p53 protein, to exert its function, binds in a sequence-specific manner to the DNA-binding sites by forming a tetramer, via four self-assembling p53 molecules, which are stabilized by protein-protein and base-stacking interactions [ 3 ] . (encyclopedia.pub)

Label-free quantitative proteomic analyses using liquid chromatography in conjunction with a tandem mass spectrometry (LC-MS/MS) system showed significant alteration of mitochondrial, cytosolic, nuclear and cytoskeletal proteins in fetal brains exposed prenatally to alcohol [ 17 ]. (biomedcentral.com)
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. (duke.edu)

ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. (kegg.jp)
The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway was involved in this ubiquitin-proteasome-mediated degradation of PDCD4. (plos.org)

Regulated by MITF) HMGB1 High mobility group box binds DNA ILF2 Homo sapiens interleukin enhancer binding factor 2, 45kDa (ILF2), mRNA IER2 formerly ETR101 Immediate Early Protein? (wikipedia.org)
Homo sapiens BUB3 mitotic checkpoint protein (BUB3), transcript variant 2, mRNA. (dbcls.jp)
Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA. (dbcls.jp)
The remaining 2 mRNA variants (1 spliced, 1 unspliced) appear not to encode good proteins. (blogspot.com)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)

Lipins are cytosolic phosphatidate phosphatases (PAPs) involved in the glycerolipid biosynthesis pathway. (aocs.org)

Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)

Endothall elevated the kinase activity of p13suc1-bound fractions in G2-phase alfalfa cells. (bibbase.org)
A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model. (biomedcentral.com)
Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. (nature.com)

Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
In this review, we highlight that many of the key regulatory pathways of the cell are recruited by motifs and that the ease of motif acquisition has resulted in large networks of co-regulated biomolecules. (biomedcentral.com)

Signal duration and signal magnitude are crucial determinants of the outcome of TGFβ superfamily signalling, in particular in early embryonic patterning, in which TGFβ superfamily ligands act as morphogens that elicit distinct responses in a dose-dependent fashion. (nature.com)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)

Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin. (duke.edu)

Cyclins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

Anatomy17

Organisms6

Chemicals and Drugs163

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Inhibitor9

Dual-specificity phosphatase2

Subunit8

Phosphorylation20

Serine3

Cdk25

Tyrosine phosphatase1

Cdk55

Genes11

Gene14

Tumor4

Eukaryotic2

Mitotic cyclin2

Inhibitors1

Subunits2

Regulation5

Progression6

Dephosphorylation1

Complexes2

Regulates3

Neuronal1

CDK62

Cdc251

Adenosine1

MRNAs1

Prognostic1

Transcriptional regulators1

Subcellular1

Transcription1

Serum3

CDKs1

Saccharomyces1

Cell cycle1

Locus1

Dopamine1

Cellular2

Sequence1

Nuclear2

Degradation2

MRNA6

Cytosolic1

Homeobox1

Activity3

Pathways2

Outcome2

GTPase1

MeSH1