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  • kinase
  • Downstream of epidermal growth factor receptor (EGFR) and other receptors, SHP2 is activated by binding to phosphotyrosine-containing receptors and adapter proteins, is required for complete extracellular regulated kinase 1/2 (ERK) pathway activity, which promotes cellular proliferation and survival, and regulates other signaling processes. (upenn.edu)
  • regulation
  • We next developed computational models and associated quantitative experimental data sets to gain quantitative understanding of the regulation of protein complexes containing SHP2 and GRB2-associated binder 1 (GAB1), the primary phosphorylated adapter with which SHP2 associates following EGFR activation. (upenn.edu)
  • negatively
  • They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. (nih.gov)
  • Organism
  • AMPK signaling pathway, organism-specific biosystem AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. (nih.gov)
  • apoptosis
  • Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. (acris-antibodies.com)
  • Induction of apoptosis in an osteoscarcoma cell line that conditionally expresses a dominant negative mutant of E2F-1 (ER-dnE2F-1) by treatment with 4-hydroxytamoxifen (4-OHT) led to a significant increase in levels of PTP-1B, SHP-2, and PTEN mRNA expression in comparison to untreated cells. (aacrjournals.org)
  • transcription
  • Glucose is the major regulator of β-cell function, stimulating the transcription, translation, and secretion of insulin ( 1 , 2 ). (diabetesjournals.org)
  • Evidence is emerging that glucose-regulated transcription of other β-cell proteins, such as glucokinase, may also be mediated in part by insulin signaling ( 3 ). (diabetesjournals.org)
  • regulate
  • We investigated factors that regulate IA-2 and phogrin expression and their relationship to maturation of insulin secretory responses that occur after birth. (diabetesjournals.org)
  • anion
  • Reactive oxygen species (ROS), ubiquitous reactive derivatives of O 2 metabolism that include superoxide anion (·O 2 − ) and hydrogen peroxide (H 2 O 2 ), are produced primarily by nonphagocytic NAD(P)H oxidase (Nox) in the vasculature. (ahajournals.org)
  • interaction
  • Both IA-2 and phogrin associate with the cytoskeleton, and direct interaction with the cytoskeletal-associated proteins βIV spectrin and β2-syntrophin has been demonstrated for IA-2 ( 10 , 11 ). (diabetesjournals.org)
  • cells
  • Human PTP4A2 Protein (raised in Insect Cells) purified by multi-step, protein-specific process to ensure crystallization grade. (antibodies-online.com)
  • Knockdown of SHP-2, PTEN, or PTP-1B using siRNA increased cell viability and decreased cell death in 4-OHT-treated ER-dnE2F-1 cells compared to control. (aacrjournals.org)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • tumor
  • Furthermore, our findings suggest PTP-1B, SHP-2, and PTEN can contribute to tumor suppression through an Rb/E2F-associated mechanism. (aacrjournals.org)