Protein negatively regulates cellular. Medical search. Frequent questions

Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. (elifesciences.org)
it still remains to be determined if there are more proteins that can regulate the RPs-MDM2-p53 pathway. (elifesciences.org)
The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. (oregonstate.edu)
Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
This has led to an improved understanding of the multilayered mechanisms of this pathway transduction proceeds as well as the molecular mechanism regulating this pathway ( 28 ). (frontiersin.org)
Also, other proteins which involved in the same pathway with IL17RD were listed below. (creativebiomart.net)
The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. (sdbonline.org)
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. (nih.gov)
The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. (nih.gov)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
We offer evidence that negatively regulates the activation from the JAK\STAT signaling cytokine and pathway receptors in Rabbit Polyclonal to VAV3 (phospho-Tyr173) T\ALL. (thetechnoant.info)
Several recent studies reported that TERT mRNA expression in TPM cancers is supported by mitogen activated protein kinase (MAPK) signaling through the Ras pathway (Vallarelli et al. (uab.edu)
Organic dust augments nucleotide-binding oligomerization domain expression via an NF-kB pathway to negatively regulate inflammatory responses. (cdc.gov)
ODE induced significant NOD2 mRNA and protein expression at 24 and 48 h, respectively, which was mediated via a NF-KB signaling pathway as opposed to a TNF-a autocrine/paracrine mechanism. (cdc.gov)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. (thermofisher.com)
ZEB1 regulates a cohort of genes involved in cell differentiation and migration, including Neurod1 and Pard6b. (stanford.edu)
Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). (avivasysbio.com)
STRING database and Cytoscape software were used to construct protein interaction networks of differentially expressed genes, and MCODE and cytohubba plug-ins were used to screen out the most significant modules and key genes involved in lupus nephritis. (shsmu.edu.cn)
Results ·The GSE32591 data set was analyzed through the limma package, and 367 differentially expressed genes were obtained, including 253 up-regulated genes and 114 down-regulated genes. (shsmu.edu.cn)
A protein interaction network of differentially expressed genes was constructed by STRING and Cytoscape, and 10 pivotal genes related to LN were identified. (shsmu.edu.cn)
red nodes represent up-regulated genes, and blue nodes represent down-regulated genes. (shsmu.edu.cn)
Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. (hindawi.com)
2015). Importantly, the long isoform, GABP b 1L, regulates a restricted subset of genes, and in a mouse xenograft model of glioblastoma regulates expression from mutant TERT promoters (Mancini et al. (uab.edu)
MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to ʻseed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences' may compromise or enhance miRNA/mRNA interaction leading to either ʻloss‑of‑function' or ʻgain‑of‑function' effects. (spandidos-publications.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. (nih.gov)
The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)
LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)
Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. (nih.gov)
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis. (nih.gov)
Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. (oncotarget.com)
Protein tyrosine kinase 6 (PTK6, also called BRK) is a SRC-related intracellular tyrosine kinase expressed in normal epithelia and cancer. (oncotarget.com)
L.S. Huang, H. K. Doherty, and I. Herskowitz (2005) The Smk1p MAP kinase negatively regulates Gsc2p, a 1, 3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. (umb.edu)
Through biochemical purification of the MAP kinase Smk1, her lab identified several proteins that physically interact with Smk1, including Gsc2, a subunit of beta-glucan synthase, which plays an important role in spore wall synthesis. (umb.edu)
Parkin is phosphorylated and activated by the cellular energy sensor AMP-activated protein kinase (AMPK). (elsevierpure.com)
29, 30, 37] FNIP1 then interacts with 5'-AMP (activated protein kinase), which interacts with mammalian target of rapamycin (mTOR) that is involved in cellular energy, cytokinesis, cell motility, cellular adhesion, and nutrient sensing. (medscape.com)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)

Additionally, transfection with 50 nM miR‑125b mimics markedly reduced the mRNA and protein expression levels of TP53 in the cultured lens epithelial cells, and miR‑125b significantly induced apoptosis in the epithelial cells compared with negative control cells. (spandidos-publications.com)
Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. (biomedcentral.com)
In the cytosol, Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. (biomedcentral.com)
The effector caspases cleave their cellular specific substrates and generate the typical morphology of apoptosis. (biomedcentral.com)
This protein family is comprised by X-linked inhibitor of apoptosis (XIAP), cellular IAP-1 (c-IAP1), cellular IAP-2 (c-IAP2), Testis specific IAP (Ts-IAP), survivin, livin and BRUCE/Apollon [ 8 ]. (biomedcentral.com)
Smac (Second mitochondria-derived activator of caspase) protein, also known as DIABLO (Direct Inhibitor of Apoptosis-Binding protein with LOw pI), is codified by a nuclear gene. (biomedcentral.com)

This LA-dependent increase in Akt phosphorylation was accompanied by inhibition of LPS-induced NF-kappaB DNA binding activity and up-regulation of TNFalpha and monocyte chemoattractant protein 1. (oregonstate.edu)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)

Cytokine-induced expression of transcriptional regulators including cebpb, Ets2, Bcl3, c-Myc, Jun, and Fosl2 are differentially regulated in Socs3-deficient cells. (nih.gov)
E.M. Davison, A.M. Saffer, L.S. Huang, J. DeModena, P.W. Sternberg, and H.R. Horvitz (2011) The LIN-15A and LIN56 transcriptional regulators interact to negatively regulate EGF/RAS signaling in Caenorhabditis elegans vulval cell-fate determination. (umb.edu)
Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. (abcam.com)

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

We detected PTK6 mRNA and protein expression in the immortalized normal MCF-10A human mammary gland epithelial cell line, and examined PTK6 expression and activation in a normal human breast tissue microarray, as well as in human breast tumors. (oncotarget.com)

Gaur et al suggest FLCN acts as a tumor suppressor by negatively regulating rRNA synthesis. (medscape.com)

Messenger RNA (mRNA) regulates cell proliferation. (biosyn.com)

[ 4 ] Glucocorticoids are involved in almost every cellular, molecular, and physiologic network of the organism and play a pivotal role in critical biologic processes, such as growth, reproduction, intermediary metabolism, immune and inflammatory reactions, and central nervous system and cardiovascular functions. (medscape.com)
Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. (nih.gov)
The Huang Lab uses genetics, cell biology, molecular biology, and biochemistry to study the signal transduction processes that govern spore morphogenesis, with a long term goal of understanding how cellular architecture is regulated. (umb.edu)
Sirtuins have also been implicated in regulating the molecular mechanisms of aging. (biomedcentral.com)

Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. (wikipedia.org)
see MIM 603726) are secreted proteins involved in cellular proliferation, migration, differentiation, and survival. (creativebiomart.net)
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). (avivasysbio.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. (thermofisher.com)
In recent studies, renal and pulmonary tumors in Birt-Hogg-Dubé syndrome appear to follow the two-hit tumorigenesis theory relating to the interaction of folliculin with the FLCN-interacting protein 1 (FNIP1) and FLCN-interacting protein 2 (FNIP2). (medscape.com)

The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
4E-binding proteins (4E-BPs) block the interaction of eIF4E with eIF4G to negatively regulate the formation of the eIF4F complex. (biosyn.com)
42] Another study by Nahorski et al demonstrated tumor suppression by the interaction of p0071 (plakophilin-4, a potential novel folliculin-interacting protein) and the regulation of RhoA. (medscape.com)

Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. (csic.es)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
In order to determine which elements of cellular responses to cytokines require Socs3, we have examined the differentiative and proliferative capacity of hematopoietic progenitor cells stimulated by G-CSF and IL-6. (nih.gov)

RANK signals from CD4 + 3 − inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. (nature.com)
Cataracts are the leading cause of blindness worldwide and are characterized by progressive aggregation and precipitation of lens proteins, and the development of age‑related cataracts is associated with dysregulated cellular activities of lens epithelial cells. (spandidos-publications.com)
Our previous cell and animal experiments confirmed that zinc supplementation could activate Nrf2 and up-regulate its downstream antioxidant factors, thus reducing oxidative damage to renal tubular epithelial cells and kidney tissues [ 11 ]. (nature.com)
The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)

DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7. (cancerindex.org)

Histone deacetylases (HDACs) are a family of epigenetic enzymes that suppress gene transcription by removing acetyl groups from histone proteins ( Kouzarides, 2007 ). (jneurosci.org)
Here, we report that expression is epigenetically regulated by DNA methyltransferase\3A\mediated DNA methylation and methyl CpG binding protein\2\mediated histone deacetylation. (thetechnoant.info)
Here, we report that is epigenetically regulated by DNA methylation and histone deacetylation. (thetechnoant.info)
Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)

Here we show that VCAM1, a transmembrane protein previously found in quiescent adult NSCs, is expressed by a subpopulation of embryonic RGCs, in a temporal and region-specific manner. (stanford.edu)

Granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) play key roles in regulating emergency granulopoiesis and inflammation, and are both negatively regulated by the inducible intracellular protein suppressor of cytokine signaling-3 (Socs3). (nih.gov)
Here we find that Parkin (also known as PARK2), an E3 ubiquitin ligase implicated in Parkinson's disease and as a tumour suppressor, regulates necroptosis and inflammation by regulating necrosome formation. (elsevierpure.com)
Here we find that Parkin (also known as PARK2), an E3 ubiquitin ligase implicated in Parkinson{\textquoteright}s disease and as a tumour suppressor, regulates necroptosis and inflammation by regulating necrosome formation. (elsevierpure.com)

This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. (thermofisher.com)
Mechanistically, silencing induces activation of JAK\STAT signaling, and negatively regulates interleukin\7 and interleukin\4 receptors. (thetechnoant.info)
This in turn induces the recruitment of adapter proteins (FADD, TRADD o RAIDD) to form the so-called death-inducing signal complex (DISC), which activates caspase-8. (biomedcentral.com)

We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. (oregonstate.edu)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. (nih.gov)
TERT is transcriptionally silent in most adult cells and its expression is tightly regulated during cellular and organism development (Counter et al. (uab.edu)
Conversely, the continued expression of telomerase in stem cells and cancer cells allows them to counteract this deficiency and enables their indefinite cellular growth. (uab.edu)
Our recent work demonstrated that TPM cancers are a unique subset characterized by distinct gene and protein expression profiles dominated by epithelial-mesenchymal transition (EMT) markers and elevated RAS/BRAF/MAPK signaling. (uab.edu)
35] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus. (lu.se)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)

The well-documented tumor suppressor p53, referred as 'the guardian of the genome', is activated upon exposure to a myriad of cellular stresses. (elifesciences.org)
They also demonstrated a Birt-Hogg-Dubé syndrome tumor-suppressor protein, folliculin. (medscape.com)

38, 39, 40] The formation of pulmonary cysts may be related to the dysregulation of mTOR signaling, which facilitates S6-mediated protein synthesis and HIF-1-alpha-mediated angiogenesis. (medscape.com)

Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)

VCAM1 affects the NSC fate by signaling through its intracellular domain to regulate β-catenin signaling in a context-dependent manner. (stanford.edu)

K.L. Auld, A.L. Hitchcock, H.K. Doherty, S. Frietze, L.S. Huang, and P.A. Silver (2006) The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. (umb.edu)
p97/VCP (valosin-containing protein) is a cytosolic AAA (ATPase associated with various cellular activities) essential for retrotranslocation of misfolded proteins during ERAD [ER (endoplasmic reticulum)-associated degradation]. (portlandpress.com)

The 5'- terminal ends of cellular mRNAs contain an m7GpppN cap, in which N can be any nucleotide. (biosyn.com)
The RNA helicase eIF4A and the scaffold protein eukaryotic translation initiation factor 4G (eIF4G) and the capping protein eIF4E are part of the complex that loads the mRNAs onto the 40 S ribosomal subunit, together with eIF3. (biosyn.com)
miRNAs bind to complementary sequences present in the 3′-untranslated regions (3′-UTR) of target gene mRNAs and, thus, regulate translational interference or degradation of mRNAs ( 8 ). (spandidos-publications.com)

This Special Issue, "Plant Cell Wall Proteins and Development", will cover a selection of recent research topics in the field of cell wall biology focused on cell wall proteins and their roles during development. (mdpi.com)
The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important roles in necroptosis that are closely linked to the inflammatory response. (elsevierpure.com)

Linda Huang's research focuses on how cells regulate their morphology during development. (umb.edu)

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. (nih.gov)

Polycomb group (PcG) proteins are chromatin-associated factors involved in the repression of gene transcription. (sdbonline.org)
Transcription activation is also down-regulated by NR0B2. (avivasysbio.com)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)

Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression. (nih.gov)

pii: tpc.00974.2018 Peñuelas M, Monte I, Schweizer F, Vallat A, Reymond P, García-Casado G, Franco-Zorrilla JM, Solano R. Abstract Jasmonoyl-isoleucine regulates plant immunity, growth and development in vascular plants by. (csic.es)

cellular signaling networks and leukemia progression. (thetechnoant.info)
We show that negatively regulates T\ALL cell growth and cell cycle progression but has no effect on apoptotic cell death. (thetechnoant.info)

Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)
They mainly comprise polymers like polysaccharides and lignin in lignified secondary walls and a minute amount of cell wall proteins (CWPs). (mdpi.com)
Cell wall proteomics, as well as numerous genetic or biochemical studies, have revealed the high diversity of CWPs, among which proteins acting on polysaccharides, proteases, oxido-reductases, lipid-related proteins and structural proteins. (mdpi.com)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)
Current work in the lab focuses on how these morphogenic events are regulated by specific proteins in the cell. (umb.edu)
Through genetic and biochemical experiments, they have found that SMK1 negatively regulates beta-glucan synthase activity, suggesting a direct link between Smk1 function and cell morphogenesis. (umb.edu)
The Huang lab is currently investigating how Gsc2 and other Smk1p-interacting proteins contribute to Smk1's ability to coordinate cell morphogenesis. (umb.edu)
gene rearrangementsMBDmethyl\CpG\binding site proteinMeCP2methyl CpG binding proteins\2NSGNOD.Cg\PrkdcscidIl2rgtm1Wjl/SzJqRT\PCRquantitative genuine\time PCRSOCSsuppressor of cytokine signalingT\ALLT\cell lineage severe lymphoblastic leukemiaThT\helperTSATrichostatin A 1. (thetechnoant.info)
Zinc is also an antioxidant and can directly protect cell membrane lipids and proteins and mercaptan-dependent macromolecules (tubulin and enzyme) from oxidative damage [ 6 ]. (nature.com)
If you require a native form of the protein please use the live cell version - found here . (abcam.com)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)

In addition to the catalytic domain, eukaryotic sirtuins contain variable amino- and carboxy-terminal extensions that regulate their subcellular localizations and catalytic activity. (biomedcentral.com)

Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. (nih.gov)

In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
In this review, we summarize the evidence linking cellular senescence to the pathogenesis of CKD and discuss current understanding of the mechanism and regulators controlling senescence. (frontiersin.org)
A Hang-related protein, ZNF699, is associated with alcoholism in humans (Riley, 2006), supporting the idea that a cellular stress mechanism underlying ethanol tolerance is evolutionarily conserved between humans and D. melanogaster. (sdbonline.org)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)

Alternative splicing of the primary transcript gives rise to the 2 mRNA and protein isoforms, hGR-alpha and hGR-beta. (medscape.com)
A transcript-specific dunce mutant was generated that is impaired not only in ethanol tolerance but also in the cellular stress response. (sdbonline.org)

For this, the Sfmbt protein complex was affinity purified from the nuclear extract, followed by highly specific peptide sequencing (IP/LC-MS). As a result, a number of previously uncharacterized Sfmbt interactions were discovered. (sdbonline.org)
Evidence is provided that Hangover acts as a nuclear RNA binding protein and the phosphodiesterase 4d ortholog dunce as a target RNA. (sdbonline.org)
The hang gene encodes a large, approximately 210-kDa nuclear zinc finger protein that is expressed in most, if not all, neurons in the adult brain (Scholz, 2005). (sdbonline.org)

By utilising a variety of cellular models, p62N was found to dominantly and negatively regulate p62 droplet formation. (plymouth.ac.uk)

Next, it was determined whether NOD2 regulated ODE-induced inflammatory cytokine production. (cdc.gov)

In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

RESULTS: Using microarray analysis, we confirmed four significantly up-regulated miRNAs (miR-1275, miR-6891-5p, miR-7107-5p, miR-3197) in patients with PC and BTC compared to control patients. (bvsalud.org)

FGF activity is negatively regulated by members of the sprouty family (e.g. (creativebiomart.net)

This gene has a closely related paralog that encodes a protein with similar binding activities. (nih.gov)

IL17RD has direct interactions with proteins and molecules. (creativebiomart.net)
Mass spectrometry combined with X-ray crystallography allows the characterization of cap protein interactions. (biosyn.com)

Structural complexes between proteins and their substrates can be studied in the gas-phase to determine equilibrium dissociation constants. (biosyn.com)

Much work is being done to find ways to target EMT in cancer including the application of combinatorial therapies, targeting pivotal nodes driving phenotypic switching, and reversing cellular plasticity. (uab.edu)

Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)

It could also represent the cellular receptor for hepcidin. (nih.gov)

Pathway18

Genes13

Kinase15

Apoptosis6

Phosphorylation4

Transcriptional3

Pathways3

MRNA and protein expression1

RRNA synthesis1

Messenger RNA1

Molecular4

Differentiation4

Tumorigenesis2

Interaction3

Responses3

Epithelial cells4

Positively1

Histone4

Embryonic1

Inflammation3

Induces3

Expression10

Suppressor2

Synthesis1

Replication1

Intracellular1

ATPase2

MRNAs3

Roles2

Cells regulate1

Specificity protein phosphatase1

Transcription4

FLCN1

Abstract1

Progression2

Cell14

Subcellular1

Folliculin interac1

Mechanism4

Transcript2

Nuclear3

Variety of cellular1

Cytokine1

Survival1

MiRNAs1

Activity1

Encodes1

Interactions2

Substrates1

Nodes1

Regulator1

Receptor1