• CUB and Sushi multiple domains 1 (CSMD1) is a transmembrane protein containing 15 consecutive complement control protein (CCP) domains, which are characteristic for complement inhibitors. (cf.ac.uk)
  • In all functional assays performed, well-characterized complement inhibitors were used as positive controls, whereas Coxsackie adenovirus receptor, a protein with no effect on complement, was a negative control. (cf.ac.uk)
  • This notion is supported further by the properties of mutant proteins that seem to be frozen, in either the nonmultimerized or the multimerized state, respectively. (nih.gov)
  • This unique observation highlights for the first time cross talk between a viral envelope protein and genomic RNA during morphogenesis. (asm.org)
  • Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens. (nih.gov)
  • Transcription from the BZLF1 promoter is activated by myocyte enhancer factor 2, specificity protein 1, b-Zip type transcription factors and mediating epigenetic modifications of the promoter, such as histone acetylation and H3K4me3. (fujita-hu.ac.jp)
  • Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain. (nih.gov)
  • Escudero- Esparza, A., Kalchishkova, N., Kurbasic, E., Jiang, W. G., Blom, A.M. The novel complement inhibitor human CUB and Sushi multiple domains 1 (CSMD1) protein promotes factor I-mediated degradation of C4b and C3b and inhibits the membrane attack complex assembly. (cf.ac.uk)
  • Furthermore, we investigated the highly conserved N- and C-terminal domains, which distinguish RVT proteins from other RTs. (mblwhoilibrary.org)
  • The protein is composed of two domains: the amino-terminal domain consisting of tandem repeats and the carboxyl-terminal domain containing sequences shared by other S-type carbohydrate recognition domains. (elsevier.com)
  • To investigate biochemical properties of bacterial RVTs, we conducted in vitro studies of recombinant HaRVT protein from the filamentous gliding bacterium Herpetosiphon aurantiacus (Chloroflexi). (mblwhoilibrary.org)
  • The NMR chemical shifts for backbone of the PRYSPRY domain of TRIM25 is assigned based on triple-resonance experiments using uniformly isotopic labeled protein and the secondary structure of the domain PRYSPRY domain of TRIM25 predicted based on the NMR assignments. (wikipedia.org)
  • In this study, we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating systemic glucose homeostasis. (diabetesjournals.org)
  • The unknown protein functioned by removing repression of regulatory sequences and was named Art (anti-repression transactivator). (wikipedia.org)
  • Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes. (nih.gov)
  • To investigate how this occurs in vivo, we have exploited a unique temperature-sensitive strain of B. subtilis expressing the mutant protein FtsZ(Ts1). (edu.au)
  • To determine why this is the case, we used a combination of methods to identify the specific defect of the FtsZ(Ts1) protein in vivo. (edu.au)
  • We demonstrate that mIFP correctly labels proteins in live cells, Drosophila and zebrafish. (zfin.org)
  • Within recycling endosomes, we demonstrate the compartmentalization of cargo proteins, wherein IL-6 is dynamically segregated from TNFα and from surface recycling transferrin. (rupress.org)
  • Jeff Kieft (Colorado) presented a translation initiation motif that may enable evolutionary exploration of new translated proteins. (smbe.org)
  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family grouping more than 70 TRIMs. (wikipedia.org)
  • 2019. Evolution of protein interfaces in multimers and fibrils. (asu.edu)
  • In the meeting, many themes touching on protein evolution were touched upon and several of the talks are mentioned below. (smbe.org)
  • The C-terminal domain may be capable of protein priming, which is abolished by site-directed mutagenesis of the catalytic aspartate and greatly reduced in the absence of the conserved tyrosine residues near the C-terminus. (mblwhoilibrary.org)
  • A second proinflammatory cytokine produced by activated macrophages is interleukin 6 (IL-6), which, lacking a transmembrane domain, is trafficked and secreted directly as a soluble protein. (rupress.org)
  • In recent years, the combination of high resolution microscopy and live cell imaging of fluorescently tagged proteins has largely redefined the post-Golgi trafficking and sorting of biosynthetic cargo in polarized and nonpolarized cells. (rupress.org)
  • Since ADP is unable to support multimerization, ATP hydrolysis might be followed by a return to the nonmultimerized state. (nih.gov)
  • IF proteins assemble into nanoscale biopolymers with unique strain-hardening properties that are related to their roles in regulating the mechanical integrity of cells. (mblwhoilibrary.org)
  • Between 1976 and 2008, over 55 000 experimentally determined macromolecular structures were deposited in the Protein Data Bank ( http://www.rcsb.org ), of which over 47 000 were from crystallography, over 7600 were from NMR and over 200 were from electron microscopy. (royalsocietypublishing.org)
  • The first overall views of many protein structures have been obtained by X-ray or neutron scattering. (royalsocietypublishing.org)