• The 2023 Gordon Conference on Molecular Membrane Biology will focus on the latest insights into organelle biogenesis and function, membrane trafficking, the connection to metabolism, and interorganelle communication. (grc.org)
  • The aim of this unit is to examine the molecular mechanisms of protein sorting in eukaryotes, and will review recent data demonstrating that some of these processes are fundamental to all living cells. (manchester.ac.uk)
  • Cells have mechanisms that can refold or degrade protein aggregates. (wikipedia.org)
  • Topics include protein homeostasis and associated diseases, plant and environmental interactions, as well as mechanisms of cellular signal transduction. (umass.edu)
  • My main research focus is on protein transport mechanisms and rhomboid proteins. (queensu.ca)
  • My laboratory works on the genetic and molecular mechanisms that regulate aging and aging-related disease. (berkeley.edu)
  • We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)
  • The theoretical part covers the molecular principles and mechanisms underlying the experimental approaches. (lu.se)
  • The main aim of the course is to enable students to acquire specialised knowledge and understanding of membrane biochemistry and the molecular structure, topology and functional mechanisms of membrane proteins. (lu.se)
  • A number of proteins from each process, for which the structure is known, are explored in greater detail in order to highlight the functional molecular mechanisms. (lu.se)
  • Protein translocation into and across the ER membrane. (manchester.ac.uk)
  • CH061 Non-ionic detergent for solubilizing membrane proteins without altering biological activity.Concentration: N/AGrade: ReagentComposition: N/AStorage Condition: Room temperatureHandling: Shipped. (topsan.org)
  • Here we present a new approach to incorporate single or multiple post-translational modifications or non-canonical amino acids into soluble and membrane proteins expressed in eukaryotic cells. (biorxiv.org)
  • We thus sought to complement these approaches with a method that could incorporate synthetic peptides carrying multiple post-translational modifications (PTMs) or ncAAs into both cytosolic and membrane proteins in live eukaryotic cells. (biorxiv.org)
  • During my graduate studies, I studied diverse protein/ligand systems, including amyloid (Alzheimer) proteins interacting with basement membrane proteins, and the role of calmodulin and caldesmon in smooth muscle regulation. (uoguelph.ca)
  • These proteins are expressed in plants during times of desiccative stress, and are thought to bind water, protect the cellular membrane from drying and prevent proteins from denaturing. (uoguelph.ca)
  • Structure of an Intrinsically Disordered Stress Protein Alone and Bound to a Membrane Surface. (uoguelph.ca)
  • For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)
  • The Molecular Membrane Biology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. (grc.org)
  • Invited talks will feature a broad range of topics including membrane biogenesis, protein sorting to organelles, metabolic regulation of organelle biogenesis, autophagy, protein and organelle quality control, lipid homeostasis, interorganelle contact sites, host-pathogen interactions, and the mechanism of organelle fission and fusion. (grc.org)
  • The meeting will include sessions on novel techniques and their application in molecular membrane biology, and relevance for diseases. (grc.org)
  • This GRC will be held in conjunction with the "Molecular Membrane Biology" Gordon Research Seminar (GRS). (grc.org)
  • Dr Matthias Soller has secured a BBSRC grant on RNA splicing using Drosophila Down Syndrome Cell Adhesion Molecule as a model membrane protein. (birmingham.ac.uk)
  • Membrane proteins play a key role in the cell's energy metabolism and in its signalling and communication with its environment. (lu.se)
  • More than half of all drugs that are in use today target membrane proteins. (lu.se)
  • The lectures address the three different main types of membrane proteins and associated cellular processes: transport and transporters, signal transduction and receptors, bioenergetics and photosynthetic and respiratory proteins. (lu.se)
  • Lectures dealing with methods for theoretical modelling of membrane protein structure, fusion protein techniques, X-ray crystallography, heterologous expression, solubilisation and purification of membrane proteins are also included in the course. (lu.se)
  • This is followed by experimental determination using genetic construction and expression of a fusion protein of the membrane protein and a marker protein in a bacterial system which is subsequently analysed. (lu.se)
  • In silico exercise addressing potential problems concerning the detection of heterologously expressed membrane proteins, solubilisation and evaluation of detergent properties, ion exchange chromatography and gel filtering in the presence of a detergent, and control of the protein's stability and integrity after purification. (lu.se)
  • Group discussions about e.g. the similarities/dissimilarities, cloning and overexpression strategies, and structure and function of membrane proteins. (lu.se)
  • An individually planned and executed minor project during two weeks, in which the students express a membrane protein of their choice and demonstrate in some way that the expression was successful. (lu.se)
  • The project entails practice in literature searching, project planning and documentation, and provides specialised practical knowledge of expression and management of membrane proteins. (lu.se)
  • UCL and the Department of Biological Sciences at Birkbeck created the Institute for Structural Biology (ISMB), one of the largest research centres for research in multidisciplinary research around structural biology in the world. (ucl.ac.uk)
  • The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
  • CMPS is a highly integrated center comprising the divisions of Biochemistry and Structural Biology (Faculty of Science) and Biophysical Chemistry (Faculty of Engineering, LTH). (lu.se)
  • Section F, Structural biology communications. (lu.se)
  • This newly synthesized mRNA copy of the gene is used for protein synthesis by the process called translation. (azolifesciences.com)
  • In 1958, Crick's review "On Protein Synthesis" appeared: this laid out, for the first time, the central dogma of molecular biology , the sequence hypothesis and the adaptor hypothesis . (wikipedia.org)
  • After synthesis, proteins typically fold into a particular three-dimensional conformation that is the most thermodynamically favorable: their native state. (wikipedia.org)
  • The hmtRNAMet serves both in translational initiation and elongation in human mitochondria making this tRNA of particular interest in mitochondrial protein synthesis. (ncsu.edu)
  • The mitochondrial genome encodes 13 proteins necessary for energy production, two rRNAs and all of the 22 tRNAs required for the synthesis of these proteins (1Attardi G. Int. Rev. Cytol. (ncsu.edu)
  • Aminoacylation is an early step required for the tRNA to be used in either the elongation or initiation phase of protein synthesis and is thus of central importance for protein synthesis in mitochondria. (ncsu.edu)
  • Ribosomal protein (RP) is a widely existing RNA-binding protein that was previously thought to function only as a combination of ribosomal RNA (rRNA) involved in protein synthesis. (biomedcentral.com)
  • The ribosomal protein RPL5 is a component of the ribosome, a large ribonucleoprotein complex responsible for protein synthesis in cells. (biomedcentral.com)
  • In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. (wikipedia.org)
  • Dehydrins are predicted to be "intrinsically disordered proteins" (IDPs), meaning that they do not have a defined structure as we understand it. (uoguelph.ca)
  • Many biological processes depend on protein-protein interactions. (jove.com)
  • Similar to ligand binding sites, interactions at a protein-protein interface may involve non-covalent bonds and hydrophobic forces. (jove.com)
  • Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. (jove.com)
  • Laboratory methods, such as affinity purification, mass spectrometry, and protein microarrays, can be used to identify new interactions. (jove.com)
  • Computer programs can predict PPIs based on similar interactions found in other proteins by comparing protein sequences and three-dimensional structures. (jove.com)
  • Protein structures are stabilized by non-covalent interactions and disulfide bonds between two cysteine residues. (wikipedia.org)
  • Ionic interactions form between an anion and a cation and form salt bridges that help stabilize the protein. (wikipedia.org)
  • Interactions between amino acid residues in a specific protein are very important in that protein's final structure. (wikipedia.org)
  • When there are changes in the non-covalent interactions, as may happen with a change in the amino acid sequence, the protein is susceptible to misfolding or unfolding. (wikipedia.org)
  • When the sequence is affected, a different amino acid may change the interactions between the side chains that affect the folding of the protein. (wikipedia.org)
  • This can also lead to less stable interactions and result in protein unfolding. (wikipedia.org)
  • This can affect the non-covalent interactions that hold the protein together correctly, which can cause protein destabilization, and may cause the protein to unfold. (wikipedia.org)
  • Deciphering protein–protein interactions. (crossref.org)
  • The power to 'see' proteins at the atomic level amazed me, and gave me the tools to understand protein interactions at a very fundamental level. (uoguelph.ca)
  • NMR also lends itself to the detailed study of protein/ligand interactions, and is able to characterize proteins both in solution and in a solid such as ice or membranes. (uoguelph.ca)
  • As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
  • Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)
  • Saal KA, Richter F, Rehling P, Rizzoli SO (2018) Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry. (uni-goettingen.de)
  • Recommended 4U Biology and Chemistry, or equivalent high school background. (queensu.ca)
  • This course covers the foundations of chemistry that underpin the life sciences at a molecular level and is suitable for students with different backgrounds including little or no previous study of chemistry. (abdn.ac.uk)
  • Chemistry plays a vital role in the life sciences, explaining the properties of biomolecules and how biological processes work at a molecular level. (abdn.ac.uk)
  • You'll learn the fundamentals of biology and chemistry that underpin the study of biochemistry. (uea.ac.uk)
  • During the second and final years of study you can steer your degree programme towards your areas of interest in biology, chemistry or a combination of both, alongside a substantial independent final year research project. (uea.ac.uk)
  • I enjoyed chemistry and found biology to be fascinating, so studying these two subjects in one discipline really interested me. (uoguelph.ca)
  • 120 credits) in Chemistry and Molecular Biology and compulsory for a degree of Master of Science (120 credits) in Protein Science. (lu.se)
  • Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)
  • But the breakthrough came when I joined a crystallography lab and began to look at how antifreeze proteins can interact with ice crystals. (uoguelph.ca)
  • My longstanding interest in antifreeze proteins has continued as an independent investigator as a second focus. (uoguelph.ca)
  • This paper highlights the potential of molecular biomimetics in mimicking high-performance proteins and provides concepts for applications in four case studies, i.e. spider silk, antifreeze proteins, blue mussel adhesive proteins and viral ion channels. (uni-bayreuth.de)
  • Ubiquitin ligases target proteins for degradation through ubiquitin modification. (wikipedia.org)
  • Because the approach can introduce virtually any chemical modification into both intracellular and extracellular regions of target proteins, we anticipate that it will overcome some of the drawbacks of other semi-synthetic or ribosome-dependent methods to engineer proteins. (biorxiv.org)
  • Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health. (wikipedia.org)
  • One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. (cam.ac.uk)
  • http://dx.doi.org/10.1128/ tial gene sequences of viral protein 1 were deposited in JCM.00542-06 the GenBank database under accession nos. (cdc.gov)
  • Cambio His-tag (purification) Agaroses are tailored specifically for different his-tag protein purification requirements. (cambio.co.uk)
  • We offer protein expression and production services in baculovirus and mammalian host systems, as well as protein purification and analysis services. (thermofisher.com)
  • The students will have opportunity to practice several of these methods during laboratory work, including site-directed mutagenesis, recombinant protein production and purification, real-time RT-PCR. (lu.se)
  • Cassin's able Hindustani online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology to leitfaden. (transpgmbh.de)
  • 1988 between large and sozialen and the online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology Vol of version extrasolar) and Goodreads just national). (transpgmbh.de)
  • A Feynman online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology is a Lagrangian practice of a strict die to the IAP astrobiology. (transpgmbh.de)
  • Thank now for a human online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology Vol 390) go 10th view in our resolve. (transpgmbh.de)
  • possible online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology Help sozialen aspekte im view in future sort for both Loud and Planetary author. (transpgmbh.de)
  • 1818014,' online Protein Targeting Protocols 2nd Ed (Methods in Molecular Biology':' completely send morally your view beings weekly. (transpgmbh.de)
  • Methods in molecular biology (Clifton, N.J. (lu.se)
  • The latest schedule for the course Methods in Molecular Biology in the schedule software TimeEdit. (lu.se)
  • Lectures will give an overview at levels ranging from molecular signaling to cognitive science with a focus on the neuroscience of everyday life, from the general (love, memory, and personality) to the particular (jet lag, autism, and weight loss). (princeton.edu)
  • Molecular neuroscience has largely focused on the functions of protein-coding genes, which account for less than 2% of our DNA. (lu.se)
  • Recent systematic studies in molecular biology and biotechnology have improved the understanding of basic functional and architectural principles of proteins, making them attractive candidates as concept generators for technological development in material science, particularly in biomedicine and nano(bio)technology. (uni-bayreuth.de)
  • This course provides a good theoretical and practical basis for understanding molecular techniques, and is thus recommended for students who envision their future career in any area featuring molecular biology and/or biotechnology. (lu.se)
  • Various computational and biochemical methods are used to study protein interfaces. (jove.com)
  • IDPs are fascinating proteins since they often fail to follow biochemical dogma (lack of structure, high specificity in the absence of high affinity). (uoguelph.ca)
  • We use state-of-the-art facilities in X-ray crystallography, NMR spectroscopy, mass spectrometry, cryo-electron microscopy, imaging, biophysical and biochemical analysis, molecular and cell biology. (ucl.ac.uk)
  • In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. (lu.se)
  • In other cases, different proteins or polypeptides come together to form a functional unit. (jove.com)
  • Functional recognition of the modified human tRNA(UUU)(Lys3) anticodon domain by HIV's nucleocapsid protein and a peptide mimic. (ncsu.edu)
  • Most genes contain the information needed to make functional molecules called proteins. (medlineplus.gov)
  • This included functional genomics and systems biology approaches to study antimicrobial resistance, MERS and SARS coronaviruses, influenza viruses, and Ebola and Zika viruses. (cdc.gov)
  • For decades, structural biologists have been working on cracking the molecular 3D structures of proteins to understand their function. (phys.org)
  • While completing original research, you will employ techniques used by cell and molecular biologists and developmental geneticists. (princeton.edu)
  • Mutations that occur in the DNA sequence may or may not affect the amino acid sequence of the protein. (wikipedia.org)
  • If problems arise during either step, making an incorrect mRNA strand and/or an incorrect amino acid sequence, this can cause the protein to misfold, leading to protein aggregation. (wikipedia.org)
  • It has revolutionised our understanding of biology over the last half-century, culminating in the determination of the complete human genome sequence. (abdn.ac.uk)
  • Sequence analysis of the viral protein 1 2. (cdc.gov)
  • Protein assembly continues until the ribosome encounters a "stop" codon (a sequence of three nucleotides that does not code for an amino acid). (medlineplus.gov)
  • Determination of the transmembrane topology of a protein starts with a model of the protein based on sequence information and theoretical methods. (lu.se)
  • For instance, many enzymes, such as protein kinase A here, form a cleft that can recognize and bind polypeptide loops of their binding partners. (jove.com)
  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
  • This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
  • Co-immunoprecipitation of proteins and yeast two-hybrid screening are widely used to provide evidence on whether two proteins interact in vitro . (jove.com)
  • By combining cryo-electron microscopy (cryo-EM) with in vitro reconstitution and molecular dynamics simulations, we show how actin filaments release P i through a 'molecular backdoor' and demonstrate that this arrangement is distorted in a disease-linked actin variant. (nature.com)
  • Semi-synthetic approaches offer an alternative means to manipulate proteins post-translationally, but these modifications have typically been performed in vitro 3 - 8 . (biorxiv.org)
  • This study examines the effect of RPL5 on the progression of colon adenocarcinoma (COAD), including cell proliferation, migration and determines its underlying molecular mechanism using CRC cell lines in vitro. (biomedcentral.com)
  • protein interaction and localization studies in vitro and in vivo. (lu.se)
  • The type of RNA that contains the information for making a protein is called messenger RNA (mRNA) because it carries the information, or message, from the DNA out of the nucleus into the cytoplasm. (medlineplus.gov)
  • Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
  • mRNA is used to manufacture proteins through a process called translation. (cdc.gov)
  • Here, the authors constructed a deep-learning approach to design closed repeat proteins with central binding pockets-a step towards designing proteins to specifically bind small molecules. (nature.com)
  • I began to appreciate that complex biological process can be understood in terms of the interaction of proteins and other biological molecules, an idea which still intrigues me to this day. (uoguelph.ca)
  • NMR is an extremely powerful technique for understanding protein structure and function, especially since it is able to characterize the flexibility of biological molecules. (uoguelph.ca)
  • A new screening method that can test the effectiveness of therapeutic molecules designed to 'glue' proteins together in the body has been developed at the University of Birmingham and the University of Leicester. (birmingham.ac.uk)
  • A few genes produce regulatory molecules that help the cell assemble proteins. (medlineplus.gov)
  • The accuracy and efficiency with which tRNA decodes genomic information into proteins require posttranscriptional modifications in or adjacent to the anticodon. (ncsu.edu)
  • Classical genetic techniques as well as molecular and genomic approaches will be discussed. (princeton.edu)
  • citation needed] In addition to mutations in the affected proteins themselves, protein aggregation could also be caused indirectly through mutations in proteins in regulatory pathways such as the refolding pathway (molecular chaperones) or the ubiquitin-proteasome pathway (ubiquitin ligases). (wikipedia.org)
  • Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. (biomedcentral.com)
  • More and more studies have found that abnormal expression or mutation of ribosomal proteins has an important regulatory effect on the occurrence and development of cancer [ 5 ]. (biomedcentral.com)
  • On 19 September 1957, Francis Crick, as part of the Society for Experimental Biology Symposium on the Biological Replication of Macromolecules, discussed the flow of information between genes and proteins. (azolifesciences.com)
  • A DNA strand comprises millions of nucleotide bases in various combinations to form genes that encode for a specific protein. (azolifesciences.com)
  • Through the processes of transcription and translation, information from genes is used to make proteins. (medlineplus.gov)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • The baculovirus expression vector system (BEVS) is one of the most popular eukaryotic systems for recombinant protein production. (lu.se)
  • Another type of interface, known as helix-helix, or coiled-coil interaction, forms when helices of two proteins wrap around each other. (jove.com)
  • radiation: Molecular activation: A molecule is considered activated when it absorbs energy by interaction with radiation. (britannica.com)
  • GeneArt™ Cell Lines and Proteins are a suite of service offerings designed to help facilitate protein expression in mammalian cell lines. (thermofisher.com)
  • The human body contains different types of cells and even though each cell contains the same DNA as a "blueprint", it synthesizes different types of proteins to carry out specific functions. (azolifesciences.com)
  • This folding process is driven by the hydrophobic effect: a tendency for hydrophobic (water-fearing) portions of the protein to shield themselves from the hydrophilic (water-loving) environment of the cell by burying into the interior of the protein. (wikipedia.org)
  • In these cases, if the cell does not assist the protein in re-folding, or degrade the unfolded protein, the unfolded/misfolded protein may aggregate, in which the exposed hydrophobic portions of the protein may interact with the exposed hydrophobic patches of other proteins. (wikipedia.org)
  • Schulz C, Rehling P (2014) Cell biology. (uni-goettingen.de)
  • Indeed, most live cell applications of PTS utilize single split inteins for the purpose of N/C-terminal tagging 16 - 18 or manipulating protein assembly/expression 19 , 20 . (biorxiv.org)
  • In γ-HCD, a mutant lymphoplasmacytoid cell clone synthesizes an abnormal IgG protein. (medscape.com)
  • The journey from gene to protein is complex and tightly controlled within each cell. (medlineplus.gov)
  • The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. (lu.se)
  • We are pioneering both multi-disciplinary approaches aimed to bridge across the scales of biology, and methods to integrate disparate data across the disciplines. (ucl.ac.uk)
  • Our research makes use of a wide array of facilities such as multi-photon and laser scanning confocal microscopes for the study of cells and tissues at the molecular level, high-field nuclear magnetic resonance spectrometers and X-ray diffractometers for the study of molecular structure, mass spectrometers, liquid and gas chromatography systems and fluorescence and electron microscopes. (uea.ac.uk)
  • My interest in protein structures expanded as a post-doctoral fellow, where I learned how to use NMR (nuclear magnetic resonance) to study proteins. (uoguelph.ca)
  • Perutz discovered that the detailed three-dimensional structures of proteins, such as myoglobin and hemoglobin could, in principle, be solved by X-ray analysis using a heavy metal atom labeling technique. (wikipedia.org)
  • We have used structural probing and molecular reconstitution experiments to examine the structures formed by the normal and mutated tRNAs. (ncsu.edu)
  • By developing an efficient way to compare all predicted protein structures in the AlphaFold database, researchers have revealed similarities between proteins across different species. (phys.org)
  • Proteins are ubiquitous biopolymers that adopt distinct three-dimensional structures and fulfil a multitude of elementary functions in organisms. (uni-bayreuth.de)
  • Immerse yourself in the wonder of biological organisms and processes at the molecular level. (uea.ac.uk)
  • These intriguing proteins are found in a number of cold-environment organisms such as fish, insects, plants and bacteria. (uoguelph.ca)
  • The cellular and molecular basis of innate and acquired immunity will be discussed in detail. (princeton.edu)
  • This lecture and laboratory course will acquaint non-biology majors with the theory and practice of modern molecular biology, focusing on topics of current interest to society. (princeton.edu)
  • ABSTRACT This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. (who.int)
  • The group, which by 1948 also included Hugh Huxley working on muscle, was joined in 1949 by Francis Crick , who worked initially on protein crystallography. (wikipedia.org)
  • The stems of the unmodified ASL (Val3) UAC and that with cmo (5)U 34 and N (6)-methyladenosine, m (6)A 37, adopted an A-form RNA conformation (rmsd approximately 0.6 A) as determined with NMR spectroscopy and torsion-angle molecular dynamics. (ncsu.edu)
  • The primary differences in the molecular dynamics (MD) models and those observed in this crystal complex result from small conformational changes in active-site residues on energy minimization. (rcsb.org)
  • Unlocking the Mysteries of the Immune System: new Roles of complement proteins in Diabetes and Cancer. (lu.se)
  • There are three main types of protein aggregates that may form: amorphous aggregates, oligomers, and amyloid fibrils. (wikipedia.org)