Protein localization protein called cyclin. Medical search. Frequent questions

It makes no sense that conserved genes would be producing alternative protein variants that are species specific. (blogspot.com)
He is firmly convinced that most human genes express a number of different protein products that are produced as the result of alternatively spliced mRNA precursors. (blogspot.com)
After wanting to knockdown five different genes whose protein have been previously proven to inhibit MDM2 turnover [19], we present. (healthandwellnesssource.org)
Like a transcription element, YAP mediates the manifestation of several growth-promoting or anti-apoptotic genes, including connective cells growth element (CTGF), cysteine-rich angiogenic inducer 61 (CYR61), cyclin E, E2F1, myc and survivin 7, 10C13. (colinsbraincancer.com)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
Despite the importance of the PAP reaction, identification of the genes responsible for encoding PAP enzymes remained elusive until 2006 when the yeast PAP was identified and was shown to be an orthologue of a family of three mammalian proteins called lipins [reviewed in 1]. (aocs.org)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
During normal conditions, cyclin C represses the transcription of stress response genes (SRG). (rowan.edu)
During growth, genes associated with protein ubiquitination/deubiquitination, cell cycle progression, and proteasomal degradation were affected, while genes linked to protein and carbohydrate catabolism were affected during early development. (frontiersin.org)
Overall, this study reveals the impact of cln5 -deficiency on gene expression in D. discoideum , provides insight on the genes and proteins that play a role in regulating Cln5-dependent processes, and sheds light on the molecular mechanisms underlying CLN5 disease. (frontiersin.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
The genes in the second group are called tumor suppressors. (cancerquest.org)
ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
The RAS gene family, responsible for signal transduction within the mitogen activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K) pathways, is frequently involved in carcinogenesis, and alterations in its member genes can be detected, with variable frequency, in a wide variety of solid and hematological cancers. (oaepublish.com)
These genes encode for closely related GTPase proteins responsible for signal transduction within two main pathways, the mitogen-activated protein kinase (MAPK) and phosphoinositide-3 kinase pathways, involved in the regulation of cell growth, survival, and differentiation. (oaepublish.com)
bimA is a member of a gene family defined by a repeated motif called the Tetratrico Peptide Repeat (TPR), which is found in genes from bacteria, yeast and insects. (rupress.org)
Cav1 has also been localized to the nucleus of ovarian carcinoma cells where it binds directly to promoter regions of the cyclin D1 and folate receptor genes. (diff.org)

Full holoenzyme activity of the cyclin D1-Cdk4 complex is induced by mitogen recruitment of CAK. (shu.edu)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (ayassbioscience.com)
These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)

Cyclins function as regulators of CDK kinases. (ayassbioscience.com)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
The cyclin D-associated kinases are essential for the proliferation of Rb-positive cells because they initiate the phosphorylation-dependent cascade that inactivates this tumor suppressor [2, 4]. (healthandwellnesssource.org)

Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)

For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
When YAP is usually phosphorylated at S127 - an activity that is usually suffering from cell denseness C it forms a far more stable complex using the 14-3-3 protein and becomes maintained in the cytoplasm 6, 25C26. (colinsbraincancer.com)
DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
In response to stress, cyclin C translocates to the cytoplasm where it facilitates mitochondrial hyperfragmentation and PCD. (rowan.edu)
Furthermore, cyclin C overexpression allows stress-independent relocalization into the cytoplasm which triggers mitochondria hyperfragmentation and increases cell sensitivity to oxidative stress. (rowan.edu)
Using a combination of genetic and biochemical approaches, I demonstrated that loss of Med13p (med13Δ) permitted cyclin C relocalization into the cytoplasm in the absence of stress. (rowan.edu)
Aberrant cyclin C localization to the cytoplasm has three consequences. (rowan.edu)

The cyclin D1-Cdk4 complex phosphorylates the pRB protein leading to sequential phosphorylation by cyclin E-Cdk2 and release of free E2F. (shu.edu)
Phosphorylation of YAP at S381 by Lats1/2 primes the proteins for following phosphorylation at multiple sites, which in turn prospects to polyubiquitination and degradation 27. (colinsbraincancer.com)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
To map the mechanisms of aggressiveness we aimed to investigate changes in protein phosphorylation across WHO grades of human meningiomas. (nature.com)
Cav1 and its phosphorylation can impact on the domain recruitment of signalling protein partners and consequently contribute to the trafficking of signalling proteins to and from the plasma membrane. (diff.org)
Ser80 phosphorylation serves to convert Cav1 to a soluble secreted protein. (diff.org)
SP lowered CVB induced phosphorylation of activating Sorafenib transcription component , but didn't alter CVB viral protein synthesis, viral progeny release, cell death, or caspase activation in contaminated cells. (mi-rna.com)

Eukaryotic RNA polymerase is a complex protein machine consisting of ten different subunits. (blogspot.com)
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)

Introduction The commitment to cell proliferation is set up when extracellular signals converge on the cell cycle and induce the expression of D-type cyclins, their association with CDK4 and/or CDK6, as well as the activation from the holoenzyme complex [1C3]. (healthandwellnesssource.org)

YAP activity could be also inhibited through the relationships with angiomotin (AMOT) family members proteins, which result in localization and sequestration from the YAP proteins to limited junction 29C31. (colinsbraincancer.com)
Whereas oskar RNP liquidity permits RNA sequestration, its strong part precludes the incorporation of RNA whereas nonetheless permitting protein sequestration. (keiseronlineuniversity.com)

Here, we showed that the cyclin-dependent protein kinase (CDK) and Dbf4-dependent Cdc7 protein kinase (DDK) regulate meiosis-specific dynamics of Mps3 on NE, particularly by mediating the resolution of Mps3 clusters and telomere clustering. (bvsalud.org)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)
p27 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclin E-CDK2, which phosphorylates pRb, thereby ushering the cell from G1 into S phase through the Restriction point (Figure 2). (shu.edu)
P15 INK4 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclind-CDK4,6, inhibiting it from hypophosphorylating Rb, thereby, rendering the cell cycle unresponsive to external proliferation signals. (shu.edu)
Med13p, together with cyclin C, cyclin dependent kinase (Cdk8p) and Med12 form a complex termed the Cdk8 module. (rowan.edu)
The Pol II activator cyclin-dependent kinase 9 (CDK9) was similarly enriched across IGSs (Extended Data Fig. 1g ). (nature.com)

However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. (medlineplus.gov)
Proteins found in the nucleus of a cell. (lookformedical.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
These data support a model that Med13p plays an important role in protecting the cell from aberrant ROS-induced apoptosis by retaining cyclin C in the nucleus. (rowan.edu)
RAC1: GTP is FEN1-processed target in program to VEGF targeting by Originally using with CYBB and NCF2, stimulating to protein of VEGF-signaling through VEGF act VEGFR2, which is a dissociation in nucleus( Ushio-Fukai et al. (erik-mill.de)

Unchecked proliferation of Rb-positive tumor cells is often connected with mutations that dysregulate this pathway: like the overexpression of D-type cyclins, the overexpression or mutation of CDK4, or mutations in the Printer ink4 category of CDK inhibitors [3, 5, 6]. (healthandwellnesssource.org)
However, like most CLN proteins, the association of CLN5 with a defined biological pathway is still under investigation. (frontiersin.org)
modern pathway proteins, highly 100 responsibilities also, showed Okazaki mitochondria are located on the RNA-DNA males other. (erik-mill.de)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)

It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)
The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)

Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. (medlineplus.gov)
This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (ayassbioscience.com)
In some invertebrate species, BOULE protein play a pivotal role in germline specification and a conserved regulatory role in meiosis. (ijbs.com)
3) Which of the following is a protein produced by a regulatory gene? (easynotecards.com)
In Drosophila, this role organelle is of at least three regulatory experience Uncertainties: direct, Groucho, and dCtBP( Drosophila C-terminal Binding Protein). (erik-mill.de)

Overexpression of BIMA, which had no deleterious affect on growth or mitosis, resulted in localization of BIMA on or throughout most nuclei. (rupress.org)

Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)

Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)

At least eight mutations in the CDKN1B gene have been found to cause a relatively rare form of multiple endocrine neoplasia called type 4. (medlineplus.gov)
Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
The main goal of the work was to analyze the characteristics of Tat protein in HIV-1 A6 variant, that is, to identify substitutions characteristic for A6 and A1 variants, as well as to compare the frequency of mutations in functionally significant domains in sub-subtype A6 and subtype B. (crie.ru)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5 disease. (frontiersin.org)

HAUSP is normally a deubiquitinase that binds to gets rid of and MDM2 ubiquitin from Posaconazole it, stabilizing the proteins and and can ubiquitinate various other substrates [20, 21]. (healthandwellnesssource.org)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
B) Allolactose binds to the repressor protein. (easynotecards.com)

The CDKN1B gene provides instructions for making a protein called p27. (medlineplus.gov)

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein that is essential in activating oncogenic transcription factors. (oncotarget.com)
The SMAD proteins are a family of transcription factors consisting of 8 members, SMAD1-8, which are further subdivided into 3 classes based on structural and functional properties. (shu.edu)

Gladfelter and her lab have extensively studied the ability of a conserved family of proteins called septins, which localize to areas of the cell that change shape or are highly curved, to sense cell curvature. (wikipedia.org)

The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)

Note that this locus is complex: it appears to produce several proteins with no sequence overlap. (blogspot.com)

Here's the figure showing the various predicted alternatively spliced transcripts and the various different proteins. (blogspot.com)
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Single-cell imaging of ATP-reduced yeast mutants revealed that ATP levels in these mutants underwent stochastic and transient depletion, which promoted the cytotoxic aggregation of endogenous proteins and pathogenic proteins, such as huntingtin and α-synuclein. (waseda.jp)

A) The repressor protein attaches to the regulator. (easynotecards.com)

A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
High ROS levels induce lipid oxidation, protein aggregation, mitochondrial hyperfragmentation, DNA damage and programmed cell death (PCD), also called apoptosis. (rowan.edu)
Our hypothesis is that cyclin C plays a role in the initiation of apoptosis. (rowan.edu)
Stress-induced cyclin C cytoplasmic translocalization and mitochondrial hyperfragmentation insures timely activation of apoptosis in stressed cells. (rowan.edu)

The most appropriate therapeutic technique may possibly in the end call for combination therapies of signal transduction modulators. (mi-rna.com)

Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)
Tat protein is a major factor of HIV (human immunodeficiency virus) transcription regulation and has other activities. (crie.ru)
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
These results indicate that cyclin C localization is critical for proper regulation of PCD. (rowan.edu)
Caveolin-1 (Cav1) is a 22 KDa multifunctional scaffolding protein with multiple binding partners that is associated with cell surface caveolae and the regulation of lipid raft domains. (diff.org)

The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)

Launch The dedication to cell proliferation is set up when extracellular indicators converge on the cell routine and stimulate the appearance of D-type cyclins, their association with CDK4 and/or CDK6, as well as the activation from the holoenzyme complicated [1C3]. (healthandwellnesssource.org)
The need for cyclin D holoenzymes for inactivation of Rb as well as the advancement of cancers in mice prompted the introduction of CDK4/6 inhibitors to take care of a number of neoplasms [7, 8]. (healthandwellnesssource.org)
This unrecognized transition previously, known as senescence after development arrest or SAGA today, is prompted in the CDK4/6 inhibitor-induced quiescent cell by the increased loss of MDM2 proteins and elevated focal localization from the chromatin-remodeling enzyme ATRX [17, 18]. (healthandwellnesssource.org)

YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)

Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (ayassbioscience.com)

Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). (embl.de)
The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
Therefore, understanding the molecular switch controlling cyclin C stress induced relocalization may provide ways to protect cells from dangerous ROS or promote the death of transformed cells. (rowan.edu)

BIMA, a TPR-containing protein required for mitosis, localizes to the spindle pole body in Aspergillus nidulans. (rupress.org)

Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
CAV -1 is an integral membrane protein found in caveolae, omega-shaped invaginations of the plasma membrane that form a subdomain of cholesterol- and sphingolipid-rich lipid rafts.Cav1 gene is localized to locus D7S522 of human chromosome 7q31.1In vivo, two isoforms of Cav1 are known to exist: α-caveolin that contains residues 1-178 and β-caveolin that contains residues 32-178. (diff.org)
while this modification is not essential for Cav1 localization to caveolae it is required for Cav1 oligomerization. (diff.org)

It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
Lipin-1 and -2 have a second function as transcriptional co-activators acting in a complex with transcriptional regulators called peroxisome proliferator-activated receptor-coactivator-1α (PGC-1α) and peroxisome proliferator-activated receptor-α (PPARα) [1,3] (Fig. 1). (aocs.org)
HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)

This protein is found in cells and tissues throughout the body. (medlineplus.gov)
Cells have a protein on their surface called PD-1 (in orange above). (shu.edu)
Hence, we attempt to Angptl2 recognize what stabilizes MDM2 proteins in quiescent cells. (healthandwellnesssource.org)
The highest levels of caveolin-1 (also called caveolin, Cav-1 and VIP2I) are found in terminally-differentiated cell types, such as adipocytes, endothelia, smooth muscle cells, and type I pneumocytes. (biomedcentral.com)
Caveolin-3 (Cav-3) has greater protein-sequence similarity to Cav-1 than to Cav-2, but it is expressed mainly in muscle cells, including smooth, skeletal, and cardiac myocytes. (biomedcentral.com)
DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
Our laboratory demonstrated that cyclin C loss increases viability of hydrogen peroxide exposed cells. (rowan.edu)
In this work, I describe the role of Med13p as the gatekeeper that maintains cyclin C nuclear localization in unstressed cells. (rowan.edu)
These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)

The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
Once active eNOS have found used into the vasoactive protein by the ubiquitin homes, the domain match recognizes. (erik-mill.de)

The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)
The present study demonstrates that cellular ATP homeostasis ensures proteostasis and revealed that suppressing the high volatility of cellular ATP levels prevented cytotoxic protein aggregation, implying that AMPK and ADK are important factors that prevent proteinopathies, such as neurodegenerative diseases. (waseda.jp)

Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
Inhibition of APE1/Ref-1 redox function significantly reduced NFĸB transcriptional activity, survivin mRNA and survivin protein levels. (oncotarget.com)

Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)

The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)

This has led to further work uncovering how liquid-liquid phase separation of RNAs and proteins can permit autonomy among syncytial nuclei and help to establish cell polarity. (wikipedia.org)

The remaining 2 mRNA variants (1 spliced, 1 unspliced) appear not to encode good proteins. (blogspot.com)

It is also called nucleotide sequence. (lookformedical.com)
The polybasic nuclear localization sequence (NLS) on the lipins as well as the oligomerization of lipins mediates membrane association. (aocs.org)

MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. (thermofisher.com)
In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)
We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Two other proteins of the same family, Cav2 and Cav3, exist and differ in their patterns of expression in different cell types. (diff.org)

Based on this function, p27 is described as a tumor suppressor protein. (medlineplus.gov)
This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (ayassbioscience.com)
Indeed, the so-called "Vogelgram", the most important model of cancer development, has been proposed in this tumor type. (oaepublish.com)

L59 substitution in the Sae3 protein disrupts complex formation with Mei5, while Y56 and N57 substitutions do not. (bvsalud.org)
During meiosis, protein ensembles in the nuclear envelope (NE) containing SUN- and KASH-domain proteins, called linker nucleocytoskeleton and cytoskeleton (LINC) complex, promote the chromosome motion. (bvsalud.org)
How could a small bit of the large RNA polymerase subunit ever be part of the RNA polymerase protein complex? (blogspot.com)
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)

As its mechanism of action remains unclear, we identified Chtop-interacting proteins using a biotinylation-proteomics approach. (embl.de)
An important mechanism by which the expression, localization, and activity of TGFβ signaling components is controlled is by post-translational modification (PTMs). (encyclopedia.pub)

Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)

skeletal regions of other and Serotonergic students are typical in download Common knowledge homologous proteins into activation component. (erik-mill.de)

proteins was connected with response, measured as both progression-free survival and general survival. (healthandwellnesssource.org)

Proteins which bind to DNA. (lookformedical.com)
D) bind to the repressor protein and inactivate it. (easynotecards.com)
D) The repressor protein and allolactose bind to RNA polymerase. (easynotecards.com)

Anatomy35

Organisms18

Diseases1

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes66

Disciplines and Occupations4

Information Science9

Genes22

Activity of the cyclin1

Highly conserved3

Kinases3

PATHWAYS2

Cytoplasm8

Phosphorylation7

Subunits3

Holoenzyme complex1

Sequestration2

Dependent6

Nucleus5

Pathway4

Tyrosine3

Regulatory5

Overexpression1

MRNAs1

Elucidate2

Mutations6

Binds3

CDKN1B1

Transcription factors2

Conserved family1

Regulate2

Several proteins1

Different proteins2

Endogenous2

Regulator1

Apoptosis4

Signal transduction1

Regulation8

Accumulation2

CDK43

Complexes2

Homeobox1

Mitotic1

Molecular4

Mitosis1

Caveolae3

Receptor3

Cells10

Ubiquitin2

Diseases3

Survivin2

Regulators1

Mitochondria1

Liquid-liquid phase separation1

Encode1

Sequence2

Cell5

Tumor3

Complex4

Mechanism2

Species2

Component1

Progression1

Bind3