• In this work we describe a previously unknown role of STING in lipid metabolism in Drosophila . (elifesciences.org)
  • Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage and downregulated expression of lipid metabolism genes. (elifesciences.org)
  • Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila . (elifesciences.org)
  • Conclusions- Our comprehensive analysis of plasma proteins and lipid fractions of 3370 individuals from the general population provides new information about lipid metabolism. (lu.se)
  • 0.03) proteins included several synaptic proteins involved in energy metabolism, redox homeostasis, and cytoskeletal structure. (ku.edu)
  • Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. (scienceopen.com)
  • In the basal state, the effects of GH on protein metabolism are modest and include increased protein synthesis and decreased breakdown at the whole body level and in muscle together with decreased amino acid degradation/oxidation and decreased hepatic urea formation. (scienceopen.com)
  • Lipids are vital building blocks of living organisms, essential to cell structure and signaling, and energy metabolism. (sanbio.nl)
  • Cancerous cells undergo major changes in lipid metabolism, meaning that lipids play a major role in the proliferation of cancerous tumours. (sanbio.nl)
  • Lipids are major components of the brain, required for signaling, metabolism, trafficking and homeostasis, making lipid research fundamental to studying neurological disorders. (sanbio.nl)
  • Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease , involve lipids. (medlineplus.gov)
  • Abteilung NMR-Spektroskopie, Weinbergweg 22, DE- and differentiation and in lipid metabolism. (lu.se)
  • This allows for the interaction of proteins with cellular membranes and protein domains. (wikipedia.org)
  • Non-specific lipid-transfer proteins (nsLTPs) are involved in the movement of phospholipids, glycolipids, fatty acids, and steroids between membranes. (rcsb.org)
  • No evidence for binding to membranes or lipid vesicles by TbMORN1 either in vivo or in vitro could be obtained. (biorxiv.org)
  • Lipids are distributed in a highly heterogeneous manner between different cellular membranes. (helsinki.fi)
  • Structure, function and organization of lipids and proteins in biological membranes. (biomembranes.nl)
  • Biogenesis of membranes and the transport and sorting of lipids and proteins. (biomembranes.nl)
  • In all membranes studied, dynamics seemed to be governed by lipids around the low-temperature limit, and by proteins around the high-temperature limit of membrane functionality. (biomedcentral.com)
  • Lipids are the major constituents of all cell membranes and play dynamic roles in organelle structure and function. (centenary.org.au)
  • The ABC superfamily of genes encodes proteins that transport a number of substrates across cell membranes. (medscape.com)
  • In this project, we investigate interactions between aggregating amyloid proteins and lipid membranes, and we explore the basic principles of the amyloid-lipid coaggregation. (lu.se)
  • In this project, we study interactions between α-synuclein and lipid membranes. (lu.se)
  • We use model membranes with varying lipid compositions, and biological membranes in isolated exosomes. (lu.se)
  • In summary, the person is trying to get their head around the basic structure, formulas and meanings of carbohydrates, proteins, amino acids and lipids. (physicsforums.com)
  • I have been trying to get my head around the basics for these four (Carbohydrates, Proteins, Amino Acids and Lipids) for about a week and I just don't understand the basic structure, formulas and such. (physicsforums.com)
  • Food is made up of proteins, carbohydrates, and fats. (medlineplus.gov)
  • Carbohydrates, lipids, and proteins are the three main macronutrient categories that make up our diet. (coachingadda.com)
  • Carbohydrates provide energy, lipids are essential for long-term energy storage and cell structure, and proteins are crucial for various biological functions. (coachingadda.com)
  • We will answer key questions, including its categorization, impact on macronutrients like carbohydrates and proteins, the difference between various types of salt, and much more. (coachingadda.com)
  • Carbohydrates, lipids, and proteins are the primary biomolecules, each serving distinct functions in our bodies. (coachingadda.com)
  • Although salt doesn't belong to the category of carbohydrates, lipids, or proteins, it plays a pivotal role in human nutrition. (coachingadda.com)
  • According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00),vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)
  • These proteins insert and assume a place in the bilayer structure of the membrane alongside the similar fatty acid tails. (wikipedia.org)
  • It is shown that cholesterol segregates preferentially around the receptors in both leaflets of the lipid bilayer, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. (iucr.org)
  • Surprisingly, the protein failed to be incorporated in the lipid bilayer, pointing to a more fundamental issue. (h-its.org)
  • With the aim of finding a simple and effective solution to this problem, the researchers tried to increase the strength of the protein-lipid interactions to stabilize the proteins in the bilayer or micelle. (h-its.org)
  • Vesicles are spherical membrane structures composed of a lipid bilayer enclosing aqueous material. (biomedcentral.com)
  • The bilayer is composed of phospholipids and is typically embedded with membrane proteins. (biomedcentral.com)
  • By virtue of their partially hydrophobic nature, lipids are the physical foundation of all living systems, providing the lipid bilayer cell wall that separates living cells from their environment. (sanbio.nl)
  • find that reducing protein-water interactions by 10% in the Martini 3 coarse-grained force field enables self-assembly of transmembrane helix dimers in phospholipid micelles and bilayers in molecular dynamics simulations. (h-its.org)
  • This resolved the issue, enabling transmembrane proteins to be encapsulated into micelles and bilayers during self-assembly. (h-its.org)
  • The researchers recommend using this method for simulations of transmembrane proteins in micelles or for self-assembling bilayers with proteins using Martini 3. (h-its.org)
  • The trans-membrane protein - proteorhodopsin (pR) has been incorporated into supported lipid bilayers (SLB). (whiterose.ac.uk)
  • Although wild-type KRAS4b, a common splice variant of KRAS (hereafter referred to as RAS), does not dimerize on two-component supported lipid bilayers( 16 ), it preferentially co-localizes with anionic lipids in the liquid-disordered domains of giant unilamellar vesicles( 17 ) and the oncogenic G12V mutant clusters on the scale of tens of nanometers in extracted PM sheets( 12, 18 ). (researchsquare.com)
  • Lipid bilayers on Nanowires. (lu.se)
  • This study was undertaken to determine if two-dimensional fluorescence difference gel electrophoresis (2D DIGE) analysis of proteins in synaptic membrane lipid rafts revealed age-dependent alterations in levels of raft proteins. (ku.edu)
  • We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). (elifesciences.org)
  • S. Slathia, A. Sharma and S. Choudhary, "Influence of Exogenously Applied Epibrassinolide and Putrescine on Protein Content, Antioxidant Enzymes and Lipid Peroxidation in Lycopersicon esculentum under Salinity Stress," American Journal of Plant Sciences , Vol. 3 No. 6, 2012, pp. 714-720. (scirp.org)
  • If you have one of these disorders, you may not have enough enzymes to break down lipids. (medlineplus.gov)
  • It provides a comprehensive description of the principal constituents of milk (water, lipids, proteins, lactose, salts, vitamins, indigenous enzymes) and of the chemical aspects of cheese and fermented milks and of various dairy processing operations. (springer.com)
  • The extruded lipids are arranged into lamellae in the intercellular space with the help of concomitantly released hydrolytic enzymes. (medscape.com)
  • Furthermore, production of intracellular membrane vesicles in Escherichia coli can be triggered by expression of Acholeplasma laidlawii lipid glycosyltransferases [ 5 ]. (biomedcentral.com)
  • Together, these results and those from experiments investigating the LD targeting information in AT3G11620, and its potential protein-binding partners, provides new insights to the possible role of this protein in controlling the intracellular distribution of LDs. (uoguelph.ca)
  • for example, H-FABP makes up 3% of the plasmic intracellular LBPs from three different cytoplasmic protein content in rat heart. (lu.se)
  • The cystovirus Pseudomonas phage phi6 has an envelope that harbors five viral membrane proteins and phospholipids derived from the cytoplasmic membrane of its Gram-negative host. (biomedcentral.com)
  • MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)
  • Recent lipid research has shown that phospholipids are key bioactive constituents of high-density lipoprotein (HDL), providing new evidence in favour of the efficacy of HDL therapies in treating cardiovascular disease. (sanbio.nl)
  • The fatty acid profile in plasma lipids contributes to the increase of plasma high sensitivity C-reactive protein (hsCRP), a marker of inflammation and predictor of cardiovascular risk. (karger.com)
  • Lipids are a very large family of non-homogenous compounds that typically consist of two hydrophobic, fatty acid tails, a glycerol backbone and a hydrophilic phosphate head. (sanbio.nl)
  • Goethe-Universita¨t, DE-60439 tein (I-LBP) and intestinal fatty acid-binding protein (I-FABP). (lu.se)
  • I-LBP, ileal lipid-binding to the aqueous solubility of the fatty acid. (lu.se)
  • Furthermore, the lipid serves as a mediator of membrane associations or as a determinant for specific protein-protein interactions. (wikipedia.org)
  • Cholesterol interactions with the receptor are apparently essential for stabilizing and maintaining its physiological architecture, since the transmembrane structure contracts, involving displacements of the helices at the outer membrane surface by ∼2 Å (1-3 Å), when this lipid is extracted. (iucr.org)
  • To demonstrate the interactions of PKCgamma with caveolin (Cav)-1 and connexin(Cx)43 in lipid rafts and its regulation of gap junctions. (nih.gov)
  • Coimmunoprecipitation and Western blot analysis were used to detect protein expression and their interactions. (nih.gov)
  • Phorbol ester (TPA) and insulin-like growth factor (IGF)-1 recruited PKCgamma into Cav-1-containing lipid rafts and stimulated the interactions of PKCgamma with Cav-1 and Cx43. (nih.gov)
  • Scaling Protein-Water Interactions in the Martini 3 Coarse-Grained Force Field to Simulate Transmembrane Helix Dimers in Different Lipid Environments. (h-its.org)
  • Lipid research encompasses the large-scale profiling of cellular lipids, the quantification of specific lipids in biological samples and the documentation of the interactions between lipids and other lipids, proteins and metabolites within the body. (sanbio.nl)
  • On top of this, lipids are changing constantly in response to changes in their environment and interactions with metabolites. (sanbio.nl)
  • Internal lipids mediate crosslinking to stabilize the domain-swapped iron-sulfur protein subunit, dielectric heterogeneity within intermonomer and intramonomer electron transfer pathways, and dimer stabilization through lipid-mediated intermonomer interactions. (rcsb.org)
  • Concerning barrier properties, the dynamics of membrane lipids and lipid-protein interactions are thought to be more important. (biomedcentral.com)
  • The biological functioning is assured by the dynamics of the membrane proteins, which may depend also on lipid-protein interactions. (biomedcentral.com)
  • At the high temperature end, however, it is not clear, whether proteins or lipids, or their specific interactions are the primary actors in maintaining membrane structure and/or stress signalling. (biomedcentral.com)
  • Alkali treatment yielded superior antioxidant properties compared to those obtained using free radicals or EDC/NHS, as this method was more likely to yield CS bonds and resulted in an increased quantity of grafted GA. Spectroscopic analysis showed that alkali treatment promoted GA oxidation and thereby increased GA- protein interactions and the quenching of tryptophan fluorescence . (bvsalud.org)
  • For example, functional events in RAS dynamics may preferentially depend on local depletion or enrichment of specific lipids are extremely difficult to observe directly either in computational or biological experiments. (researchsquare.com)
  • However, these simulations showed something unexpected as well: transmembrane protein dimers were not encapsulated in lipid micelles, but rather interacted with the water in the solvent phase. (h-its.org)
  • [ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)
  • We study protein-lipid co-aggregation, membrane assoication and the consequences of protein-lipid interaction on aggregation kinetics and membrane intergrety. (lu.se)
  • These findings may have significant implications for the strength, specificity and kinetics of lipid binding. (lu.se)
  • Objective- Revealing patterns of associations between circulating protein and lipid levels could improve biological understanding of cardiovascular disease (CVD). (lu.se)
  • As lipids have such critical biological roles, any deviations from their regular function can result in a variety of diseases. (sanbio.nl)
  • Today, lipid research has started to map the lipidome of human cells and describe lipid biological pathways. (sanbio.nl)
  • Lipids play an important role in biological systems and have the potential to serve as biomarkers in medical applications. (mdpi.com)
  • Advances in lipidomics allow identification of hundreds of lipid species from biological samples. (mdpi.com)
  • Around 30% of all proteins in eukaryotic organisms have recently been shown to belong to intrinsically disordered proteins (IDPs) involved in many central biological processes and diseases. (lu.se)
  • It is becoming evident that while the bulk lipid transport occurs via vesicular transport, a major portion of lipids are trafficked by lipid transfer proteins (LTPs). (helsinki.fi)
  • Then, in these two decades, it has been elucidated that various lipids synthesized in the ER are rapidly and accurately delivered to other organelles by a variety of lipid transfer proteins (LTPs) at zones where the ER is in contact with other specific organelles. (centenary.org.au)
  • As other naturally occurring IgGs, proteins or peptides, any omalizumab that reaches water streams via eventual spills during application or after disposal of unused drug is expected to be very rapidly consumed by microbes e.g. as energy/carbon source or incorporated by them. (janusinfo.se)
  • The use of amino acids, proteins and peptides is not expected to have any environmental impact. (janusinfo.se)
  • Use of amino acids/peptides/proteins has been considered to result in insignificant environmental impact. (janusinfo.se)
  • The guidelines that cover the screening of patients for elevated serum lipid levels, and the treatment of patients with lipid abnormalities, rest on calculations of individual patients' risk for a future cardiovascular event. (medscape.com)
  • Increased risk for venous thrombosis was found among those under 50 having both lipid abnormalities. (who.int)
  • Storage lipid is a vital component of seed storage substances and valuable for rice quality. (isaaa.org)
  • 2 Lipids are major participants in the conversion of energy within cells, the transportation of substances, and cell growth, differentiation and apoptosis. (sanbio.nl)
  • Lipids are fats or fat-like substances. (medlineplus.gov)
  • Sometimes, a low serum sodium measurement is caused by an excess of certain substances (eg, glucose, lipid) in the blood (translocational hyponatremia, pseudohyponatremia) rather than by a water-sodium imbalance. (msdmanuals.com)
  • The paper compared a standard high-carbohydrate, low-fat diet (HCLF) to a very-low-carbohydrate, high-fat diet (VLCHF) in terms of blood lipid changes. (proteinpower.com)
  • although both diets had similar improvements for a number of metabolic risk markers, the HCLF diet had more favorable effects on the blood lipid profile. (proteinpower.com)
  • This suggests that the potential long-term health effects of high- and low-carbohydrate weight loss diets remain a concern, and that blood lipid levels should be monitored in obese subjects with the metabolic syndrome. (proteinpower.com)
  • So, we've got a situation here where the lipid parameters improved more on the low-carb diet as compared to the low-fat diet, yet we've got the authors of the article, the generators of this data, telling us that the HCLF diet had "more favorable effects on the blood lipid profile. (proteinpower.com)
  • Short term hempseed feeding has improved blood lipid and protein profile. (scialert.net)
  • Cav-1-containing lipid rafts and redistribution of Cav-1, PKCgamma, and Cx43 were analyzed by sucrose gradients and by consequent Western blot analysis. (nih.gov)
  • Cx43 was associated with Cav-1 in lipid rafts. (nih.gov)
  • Overexpression of a loss-of-function PKCgamma mutant did not decrease gap junction Cx43 plaques or cause redistribution in lipid rafts, even though the PKCgamma mutant still interacted with Cav-1 and Cx43. (nih.gov)
  • Activation of PKCgamma by TPA or IGF-1 stimulated the interaction of PKCgamma with Cav-1 and Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques. (nih.gov)
  • Five pairs of young and aged rat synaptic membrane rafts were subjected to DIGE separation, followed by image analysis and identification of significantly altered proteins. (ku.edu)
  • In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
  • Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)
  • IL-1β treatment also increased (within 20 min) the translocation of H-Ras into lipid rafts. (diabetesjournals.org)
  • Im Mittelpunkt der vorliegenden Promotion steht der Auswärtstransport fluoreszierender (C6-NBD-) Lipid-Analoga und endogener Lipide durch das Multidrug Resistance 1 P-Glycoprotein (MDR1 Pgp), das der ATP Binding Cassette (ABC) Transporter Superfamilie angehört. (hu-berlin.de)
  • Wie Experimente in einer BCRP überexprimierenden EPG85-257-Sublinie nahelegen, ist ausser MDR1 Pgp möglicherweise ebenfalls der ABC Halb-Transporter Breast Cancer Resistance Protein (BCRP) am Transport von C6-NBD-PS und an der verstärkten Exponierung von endogenem PS beteiligt. (hu-berlin.de)
  • This thesis focuses on outward transport of fluorescent (C6-NBD-) lipid analogs and endogenous lipids by the Multidrug Resistance 1 P-Glycoprotein (MDR1 Pgp), a member of the ATP binding cassette (ABC) transporter superfamily. (hu-berlin.de)
  • Besides MDR1 Pgp, the ABC half-size transporter Breast Cancer Resistance Protein (BCRP) is possibly also involved in transport of C6-NBD-PS and in increased exposure of endogenous PS, as found in a BCRP overexpressing EPG85-257 subline. (hu-berlin.de)
  • The results suggest that OsLTPL36, a lipid transporter, is critical for seed quality in seed development and germination in rice. (isaaa.org)
  • The underlying genetic abnormality in harlequin ichthyosis is a mutation in the lipid-transporter gene ABCA12 on chromosome 2. (medscape.com)
  • The aim is to understand how the lipid environment influences the activity of membrane proteins, using the active transporter MgtA as benchmark system, and to investigate the dynamic fluctuations between lipid and protein in solution, utilising neutron and X-ray scattering in combination with computer simulations. (lu.se)
  • As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
  • But proteins are not boring, they are the most fantastically, well, protean molecules on Earth and possibly anywhere else! (physicsforums.com)
  • The inner fluid can contain cargo molecules such as nucleic acids or soluble proteins. (biomedcentral.com)
  • Lipids are highly diverse and dynamic molecules which can make profiling an arduous task. (sanbio.nl)
  • The aim of the present study is to characterize the molecular effect of different classes of molecules on SC lipid and protein components. (lu.se)
  • EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3. (nih.gov)
  • A team led by Xin Wang of the Huazhong Agricultural University in China identified OsLTPL36, a lipid transport protein, and its specific expression in developing rice seed coat and endosperm. (isaaa.org)
  • In 2003, we showed that the ceramide transport protein CERT is the molecular machinery for the non-vesicular transport of ceramide. (centenary.org.au)
  • These results uncover a mechanism that couples mTORC2-dependent activation of PKN2 to the regulation of mTORC1-mediated nutrient signalling by local lipid signals. (nature.com)
  • We report distinctive patterns of local lipid composition that correlate with interfacially promiscuous RAS multimerization. (researchsquare.com)
  • While the broad heterogeneity in lateral diffusion observed by SPT (Fig. 1 A) is indicative of multiple RAS sub-populations that have distinct patterns of interaction with lipids and other cellular components, it provides little insights on local lipid environments and their effect on RAS behavior. (researchsquare.com)
  • The possibility to locate heterologous proteins into the P9-lipid vesicles facilitates the production of vesicular structures with novel properties. (biomedcentral.com)
  • Furthermore, its protein-lipid composition, organization and size are subject to modification by physiological events, making it an important mediator of neuronal plasticity. (iucr.org)
  • Suppression of ORP2 led to reduced cholesterol content in the PM raft domains, while increasing the PM PI(4,5)P2 content, identifying ORP2 as a novel regulator of PM lipid organization. (helsinki.fi)
  • Among only few known LTPs, ORP2 was shown to regulate PM lipid organization, and to impact vascular development. (helsinki.fi)
  • Here we show, using X-ray crystallography, molecular dynamics simulations and in vitro and in vivo functional assays, that MlaA is a monomeric α-helical OM protein that functions as a phospholipid translocation channel, forming a ~20-Å-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore. (nature.com)
  • Prenylated proteins are particularly important for eukaryotic cell growth, differentiation and morphology. (wikipedia.org)
  • More specifically, Ras is the protein that undergoes prenylation via farnesyltransferase and when it is switched on it can turn on genes involved in cell growth and differentiation. (wikipedia.org)
  • RAS proteins function as molecular switches whose active conformations, stabilized by GTP binding, interact with several protein effectors to control cell growth, proliferation, differentiation, and migration( 10 ). (researchsquare.com)
  • Cytosolic lipid droplets (LDs) are found in all eukaryotic cells, and serve primarily in lipid storage. (uoguelph.ca)
  • In eukaryotic cells, the lipid species are frequently distributed asymmetrically between the plasma membrane leaflets. (hu-berlin.de)
  • In eukaryotic cells, the endoplasmic reticulum (ER) is the main center for the synthesis of diverse types of lipids. (centenary.org.au)
  • The lipid groups play a role in protein interaction and can contribute to the function of the protein to which it is attached. (wikipedia.org)
  • This prenylation of lipid chains to proteins facilitate their interaction with the cell membrane. (wikipedia.org)
  • This dynamic interaction of prenylated proteins with the cell membrane is important for their signalling functions and is often deregulated in disease processes such as cancer. (wikipedia.org)
  • Overexpression of PKCgamma-enhanced green fluorescent protein (EGFP) increased the interaction of PKCgamma-EGFP with Cav-1 and Cx43 and decreased gap junction Cx43 plaques without exogenous growth factors. (nih.gov)
  • Preferential interaction of RAS with anionic lipids is mediated by 11 positively charged lysines in its HVR( 19 ). (researchsquare.com)
  • Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)
  • The balance between lipid- and protein-dynamics and the role of lipid-protein interaction in maintaining membrane functionality is still not fully understood. (biomedcentral.com)
  • First, they simulated different proteins to assess the generality of this behavior. (h-its.org)
  • However, peptide aggregation in vivo typically occurs in a more complex environment, surrounded by either different proteins or lipids, or both. (lu.se)
  • Amyloid protein aggregation is associated with over 30 known diseases in humans. (lu.se)
  • In amyloid plaques associated with several amyloidogenic diseases, tightly associated lipids have been identified. (lu.se)
  • For several of the amyloid disorders, protein aggregation has also been associated with membrane disruption in cells and in model lipid systems. (lu.se)
  • Together, this suggests that endogenous autostimulation of the P2X7R may oxidize lipids and impede clearance. (sens.org)
  • During fasting and other catabolic states, GH predominantly stimulates the release and oxidation of FFA, which leads to decreased glucose and protein oxidation and preservation of LBM and glycogen stores. (scienceopen.com)
  • Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. (sens.org)
  • P2X7R stimulation decreased access to the active site of cathepsin D. Interestingly, lysosomal alkalinization was accompanied by a rise in lipid oxidation that was prevented by P2X7R antagonism. (sens.org)
  • Comparison of the physical stabilities and oxidation of lipids and proteins in natural and polyphenol-modified soybean protein isolate-stabilized emulsions. (bvsalud.org)
  • Herein, we investigated the effects of alkali treatment , free radical induction, and carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS)-mediated synthetic methods on the structures and antioxidant properties of soy protein isolate (SPI)- gallic acid (GA) conjugates and the physical stabilities and protein - lipid co- oxidation properties of the resulting emulsions . (bvsalud.org)
  • Additionally, the co- oxidation of proteins and oils in emulsions remains unexplored. (bvsalud.org)
  • In particular, EDC/NHS-mediated conjugation produced an emulsion with optimal oxidative stability owing to its effective inhibition of lipid and protein oxidation . (bvsalud.org)
  • Conversely, the conjugates synthesized via alkali treatment and free radical induction displayed less inhibition of lipid oxidation and promoted protein oxidation . (bvsalud.org)
  • Methods: Eleven obese women received a 60 g/day whey protein supplement (WPS) for 4-weeks, while otherwise nourished on a spontaneous diet, IHCL concentrations, visceral body fat, total liver volume (MR), fasting total-triglyceride and cholesterol concentrations, glucose tolerance (standard 75 g OGTT), insulin sensitivity (HOMA IS index), creatinine clearance, blood pressure and body composition (bio-impedance analysis) were assessed before and after 4-week WPS. (wellnessresources.com)
  • In this study, we investigated the associations between proteins related to CVD and triglyceride (TG), total cholesterol, LDL (low-density lipoprotein), and HDL (high-density lipoprotein) cholesterol levels in individuals from the general population. (lu.se)
  • Further, 15 proteins were related to both TG and HDL cholesterol in a consistent and biologically expected manner, that is, higher TG and lower HDL cholesterol or vice versa. (lu.se)
  • Lipids are the fats in your body, such as cholesterol and triglycerides. (upmc.com)
  • Familial lipid syndrome means your body doesn't process cholesterol correctly, which can lead to severely high levels of LDL cholesterol or triglycerides. (upmc.com)
  • Doctors label lipid disorders based on the type of high cholesterol you have. (upmc.com)
  • We can assess your child early (between 6 and 12 years old) if you have familial lipid syndrome or high cholesterol. (upmc.com)
  • In the trial, we got modest lipid lowering with bempedoic acid - about a 22% reduction in low-density lipoprotein (LDL) cholesterol . (medscape.com)
  • The purpose of the present study was to localize sites of lipid peroxidation and protein nitrosylation within the septic diaphragm. (uky.edu)
  • Lipid peroxidation was determined using anti-4-hydroxynonenal (4HN) antibodies, protein nitrosylation was detected using anti-nitrotyrosine (NT) antibodies, and neutrophils were localized with a Wright's stain. (uky.edu)
  • Around the low-temperature functioning limit of the biomembranes, lipids affected protein dynamics since changes in fatty acyl chain disorders and H/D exchange exhibited certain correlation. (biomedcentral.com)
  • L'objectif de ce travail était d'étudier la composition des graines de P. vulgaris afin d'en déterminer non seulement le potentiel nutritionnel (teneur en lipides, protéines, minéraux), mais aussi la présence de métabolites spéciaux et d'en déterminer les pouvoirs antioxydant et anti-inflammatoire. (ac.be)
  • The aim of this work was to characterize the composition of these seeds to assess not only their nutritional potential (protein, lipid and minerals content), but also their antioxidant and anti-inflammatory potential as well as their specialized metabolites composition. (ac.be)
  • However, charge complementarity is insufficient to fully describe RAS nanoclustering, which is exquisitely sensitive to lipid composition( 20 ). (researchsquare.com)
  • Summarizing the literature data, it seems that there is consensus that lipid composition and dynamics have the primary role in low-temperature adaptation and cold stresses. (biomedcentral.com)
  • In the past years, several proteins were suggested to transport lipids between the leaflets of a membrane, and to potentially influence transverse lipid asymmetry and related cell properties. (hu-berlin.de)
  • Three systems are known to maintain OM lipid asymmetry: the OM phospholipase A 2 PldA 7 , the lipopolysaccharide (LPS) palmitoyl transferase PagP 8 and the Mla (maintenance of outer membrane lipid asymmetry) system. (nature.com)
  • Researchers in the Molecular and Cellular Modeling group (MCM) at HITS have recently released the first parameters of a micelle-forming lipid for the widely used coarse grained force field Martini 3. (h-its.org)
  • Lipid analysis can be challenging due to the sheer number of different cellular lipids, which can range from tens to hundreds of thousands, and their varied concentration in samples. (sanbio.nl)
  • N-myristoylation (i.e. attachment of myristic acid) is generally an irreversible protein modification that typically occurs during protein synthesis in which the myrisitc acid is attached to the α-amino group of an N-terminal glycine residue through an amide linkage. (wikipedia.org)
  • Adaptation to respiration at birth depends upon the synthesis of pulmonary surfactant, a lipid-protein complex that reduces surface tension at the air-liquid interface in the alveoli and prevents lung collapse during the ventilatory cycle. (nih.gov)
  • Conditional deletion of Emc3 in murine embryonic lung epithelial cells disrupted the synthesis and packaging of surfactant lipids and proteins, impaired the formation of lamellar bodies, and induced the unfolded protein response in alveolar type 2 (AT2) cells. (nih.gov)
  • Transcriptomic, lipidomic, and proteomic analyses demonstrated that EMC3 coordinates the assembly of lipids and proteins in AT2 cells that is necessary for surfactant synthesis and function at birth. (nih.gov)
  • We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
  • For example, lipid groups can play an important role in increasing molecular hydrophobicity. (wikipedia.org)
  • While the molecular mechanisms underlying LD biogenesis are somewhat understood, relatively few proteins involved have been identified, especially in plants. (uoguelph.ca)
  • Through recent developments, Polarization Transfer Solid-State NMR (PT ssNMR) method together with almost complete peak assignment of SC components permits the detection of small changes in the molecular dynamics of the minor fluid lipid and protein components upon the added chemicals. (lu.se)
  • Our results demonstrate that the phi6 major envelope protein P9 can trigger formation of cytoplasmic membrane structures in E. coli in the absence of any other viral protein. (biomedcentral.com)
  • LTPs are known to be of central importance in the maintenance of organelle-specific lipid compositions and thus to have a role in numerous physiological and pathological processes. (helsinki.fi)
  • Oxysterol binding protein-related protein 2 (ORP2) belongs to a ubiquitously expressed and conserved family of LTPs, the oxysterol binding protein (OSBP)-relate proteins. (helsinki.fi)
  • These lipid fingerprints are coupled to RAS dynamics, predicted to influence effector binding, and therefore may be a mechanism for regulating cell signaling cascades. (researchsquare.com)
  • Correlation of lipid disorder with membrane protein dynamics has been studied with infrared spectroscopy, by combining data characterizing lipid phase, protein structure and, via hydrogen-deuterium (H/D) exchange, protein dynamics. (biomedcentral.com)
  • Seemingly, at temperatures where protein self-dynamics allows large-scale H/D exchange, lipid-protein coupling is so weak that proteins prefer aggregating to limit the exposure of their hydrophobic surface regions to water. (biomedcentral.com)
  • We also got about the same amount, about a 22% reduction, in high-sensitivity C-reactive protein (CRP) . (medscape.com)
  • UPMC Heart and Vascular Institute has experts who diagnose and treat familial lipid syndromes. (upmc.com)
  • About one in every 250 people have the genetic mutation for a familial lipid disorder. (upmc.com)
  • From the discovery of biomarkers for rare diseases to improving our understanding of the progression of Alzheimer's disease, lipid research is showing significant potential in the field of bioscience. (sanbio.nl)
  • The rate at which our understanding of lipid behaviour is changing looks set to revolutionise the way we diagnose and treat many diseases. (sanbio.nl)
  • Lipid research plays a pinnacle role in understanding how to treat metabolic-syndrome-related diseases like diabetes. (sanbio.nl)
  • Furthermore, in the caprate complex, the ligand binds to the protein cavity in two orientations with equal occupancy. (rcsb.org)
  • Among these associations, we found KIM-1 (kidney injury molecule-1), TNFR (TNF [tumor necrosis factor] receptor) 1 and 2, TRAIL-R2 (TRAIL [TNF-related apoptosis-inducing ligand] receptor 2), and RETN (resistin) to be associated with all 4 lipid fractions. (lu.se)
  • I have minimized my lipid membrane and complex protein-ligand separately in order to have a more relaxed system, and finally I could run the first configuration file without having errors. (uiuc.edu)
  • The first generation of kinase inhibitors were intended to target single proteins. (escholarship.org)
  • Two kinase families, phosphoinositide-3-kinases (PI3Ks) and protein tyrosine kinases (PTKs), are activated by mutations and amplifications in a disproportionate number of human cancers. (escholarship.org)
  • Annular lipids are proposed to provide a connection for super-complex formation with the photosystem-I reaction center and the LHCII kinase enzyme for transmembrane signaling. (rcsb.org)
  • In functional terms, they are often assumed to be lipid-binding modules that mediate membrane targeting, but direct evidence for this role is actually lacking. (biorxiv.org)
  • Fig. 1: Serum mitogen-induced phosphorylation of PI3KC2-β induces complex formation with 14-3-3 proteins. (nature.com)
  • Hempseed significantly (p=0.004) decreased the mean fasting serum LDL level and also significantly increased the mean fasting serum HDL and total protein levels (p=0.01). (scialert.net)
  • The aim of this study was to examine the relationship between specific fatty acids (FA) of serum lipids and serum hsCRP in morbidly obese woman. (karger.com)
  • FA extracted from serum lipids were methylated and analyzed on GC-MS. Commercially available ELISA kits were used to determine the serum inflammatory markers. (karger.com)
  • We demonstrated that total saturated FA (SFA) and total monounsaturated FA (MUFA) of serum lipids were positively correlated with serum hsCRP, whereas both n-3 and n-6 total polyunsaturated FA (PUFA) were negatively correlated with serum hsCRP. (karger.com)
  • In a dynamic role[clarification needed], lipidation can sequester a protein away from its substrate to inactivate the protein and then activate it by substrate presentation. (wikipedia.org)
  • The role of lipids in the assembly, structure, and function of hetero-oligomeric membrane protein complexes is poorly understood. (rcsb.org)