The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). (wikipedia.org)
Other names in common use include: biotin-[acetyl-CoA carboxylase] synthetase, biotin-[acetyl coenzyme A carboxylase] synthetase, acetyl coenzyme A holocarboxylase synthetase, acetyl CoA holocarboxylase synthetase, biotin:apocarboxylase ligase, biotin holoenzyme synthetase, and HCS. (wikipedia.org)
Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin. (ox.ac.uk)
Enzymes can be classified and named according to their reactions: (1) oxidoreductases, (2) transferases, (3) lyases, (4) isomerases, and (6) ligases. (changingyourbusiness.com)
New research published today, in Nature , describes a new family of enzymes (ligases) which can assemble the key chemical building blocks required for pharmaceutical production. (manchester.edu.sg)
The new findings have demonstrated that the ligase enzymes can accept many substrates, but in some cases proved too unstable for practical use. (manchester.edu.sg)
We are confident that our ligase enzymes offer many advantages over the existing methods used to make amides. (manchester.edu.sg)
The ligase enzymes provide a cleaner more efficient and rapid way to construct amide bonds. (manchester.edu.sg)
They found a family of ligase enzymes that bacteria use to make amide containing toxins that kill plants. (manchester.edu.sg)
However, when they used X-ray crystallography to determine the structure of one of the ligase enzymes, they realised that the enzyme active site was relatively open and could accommodate a much wider range of substrate building blocks for production of pharmaceuticals. (manchester.edu.sg)
Bonds5
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. (wikipedia.org)
It is, as defined in biology, a class of enzyme that binds or joins two macromolecules by forming new bonds such as C-O, C-N, and C-S. Ligase enzyme catalyzes the ligase reaction, e.g. (changingyourbusiness.com)
Ligases are classified into six subclasses: (1) EC 6.1 (ligases that form carbon-oxygen bonds), (2) EC 6.2 (ligases that form carbon-sulfur bonds), (3) EC 6.3 (ligases that form carbon-nitrogen bonds), (4) EC 6.4 (ligases that form carbon-carbon bonds), (5) EC 6.5 (ligases that form phosphoric ester bonds), and ( 6) EC 6.6 (ligases that form nitrogen-metal bonds). (changingyourbusiness.com)
For example, the protein molecules that control the functions of all living organisms are held together by amide bonds, which form a link between the carbon and nitrogen atoms of amino acid building blocks. (manchester.edu.sg)
Synthetase1
Using degenerate oligonucleotide primers for highly conserved regions in these proteins, 1.4 kb, 0.75 kb, 401 bp and 171 bp fragments of the Hsp70, Hsp60, CTP synthase and alanyl-tRNA synthetase genes respectively were amplified by PCR, and these fragments were cloned and sequenced. (mcmaster.ca)
Enzyme6
What Is The Role Of Dna Ligase In Dna Replication - An enzyme is a catalyst or chemical produced by cells to speed up a biochemical reaction. (changingyourbusiness.com)
Another molecule with catalytic activity is the ribozyme, an enzyme made of RNA rather than protein. (changingyourbusiness.com)
Ligase is a type of enzyme that brings about the binding or joining of two molecules. (changingyourbusiness.com)
Biology/Biochemistry: Ligase is an enzyme that catalyzes the binding of two molecules. (changingyourbusiness.com)
Based on the molecular bond catalyzed by the ligase enzyme, ligase can be classified into six subclasses (see Table 2). (changingyourbusiness.com)
Amino2
It is usually a protein molecule with a characteristic sequence of amino acids that fold to form a three-dimensional structure, which gives the molecule its unique properties. (changingyourbusiness.com)
because, for example, amino acid-RNA ligase catalyzes, C-O bond formation between amino acid and RNA transfer. (changingyourbusiness.com)
MeSH1
Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Modification2
Lipoic Acid Ligase-Promoted Bioorthogonal Protein Modification and Immobilization. (ucdenver.edu)
Multisite clickable modification of proteins using lipoic acid ligase. (ucdenver.edu)
Molecular1
A ligase that makes the connection of two macromolecules and uses molecular energy obtained by the hydrolysis of nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), for example, the hydrolysis of -adenosine triphosphate (ATP) is adenosine. (changingyourbusiness.com)
Activity1
Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis. (ucdenver.edu)
Specific1
This protocol describes a simple and efficient way to label specific cell surface proteins with biophysical probes on mammalian cells. (ox.ac.uk)
This graph shows the total number of publications written about "Ligases" by people in this website by year, and whether "Ligases" was a major or minor topic of these publications. (ucdenver.edu)
Damage beyond the protein level activates a bigger response that includes mitochondrial biogenesis, fusion, fission and mitochondrial degradation, also known as mitophagy. (inforang.com)
This is achieved through the action of antioxidants, DNA repair, protein folding and degradation. (inforang.com)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Gene2
To facilitate an exchange of developments and advancements among participants in the PSI, the National Institute of General Medical Sciences (NIGMS) has organized annual workshops on gene cloning, protein expression, purification, protein crystallization and rapid NMR structure determination. (nih.gov)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Kinase1
Four squamous domains run shown coding with LCAD CoA suppression( Long Chain) homeostasis, found by the intestine kinase endothelium of protein, the pro-apoptotic receptor regularization of the radical cause scalar endocytosis( SCHAD), and been by the pathway transcription cis-Golgi, tumour-associated in the important Initiation exchanged natural observation. (evakoch.com)
Receptor2
In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins. (inforang.com)
ROS, nitrogen oxide, carbon monoxide, and H 2 S), and external signals (e.g. estrogen), which increase the amount of NEMP through nuclear respiration factor-1 (NRF1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and estrogen receptor. (inforang.com)
Function1
Mitochondrial quality control systems actively function, both in physiological and pathological conditions, to protect the mitochondria from stress and damage at the protein and organelle level. (inforang.com)
Fusion1
AirID-fusion proteins such as AirID-p53 or AirID-IκBα indicated biotinylation of MDM2 or RelA, respectively, in vitro and in cells, respectively. (nih.gov)
Structure2
One of the major goals of Protein Structure Initiative (PSI) is to develop, apply and disseminate methods for faster, cheaper and more reliable determination of protein structure. (nih.gov)
During the five year initial phase of this effort the PSI pilot centers have made a significant progress in establishing high throughput protein structure determination pipelines using x-ray crystallography and NMR. (nih.gov)