Protein levels cyclin a1. Medical search. Frequent questions

Cyclin A2 belongs to the cyclin family, whose members regulate cell cycle progression by interacting with CDK kinases. (wikipedia.org)
Besides the canonical TGF-β/Smad pathway, TGF-β can directly activate non-Smad signaling pathways [ 6 , 7 ], including the mitogen activated protein (MAP) kinases. (springer.com)
The expressions of matrix metalloproteinases-2/9 (MMP-2/9), cyclin D1/E, cyclin-dependent kinase inhibitor 1B (p27), extracellular regulated protein kinases 1/2 (ERK1/2), and ERK1/2 phosphorylation were examined by western blotting or quantitative reverse transcription PCR. (hindawi.com)
Interestingly, the miR-17∼92a cluster contains miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a, which are mediated by the extracellular regulated protein kinases 1/2 (ERK1/2)/ELK1 pathway in endothelial cells [ 14 ]. (hindawi.com)
Cyclin-dependent kinases (CDKs) and cyclins represent an ancient molecular module that drives and regulates cell cycle progression. (prolekarniky.cz)
CDK - a family of cyclin-dependent protein kinases. (nih.gov)
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs) . (medchemexpress.com)
ROCK-IN-5 (compound I- B -37) is a potent inhibitor of ROCK , ERK , GSK , and AGC protein kinases . (medchemexpress.com)

Phosphorylation of CDC6 and MCM4 by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell cycle. (wikipedia.org)
It is also possible that cyclin A2-CDK contributes to tumorigenesis by the phosphorylation of oncoproteins or tumor suppressors like p53. (wikipedia.org)
The morphological changes, percentage of spontaneous exit from M-II arrest, total and speciﬁc phosphorylation status of Cdk1, cyclin B1 level and Cdk1 activity were analyzed. (cgrpreceptor.com)
On the other hand, RO-3306 protected postovulatory aging-induced changes in speciﬁc phosphorylation of Cdk1, cyclin B1 level, inhibited the kinase activity and prevented spontaneous exit from M-II arrest. (cgrpreceptor.com)
Conclusions: Our results suggest that postovulatory aging destabilizes MPF by modulating speciﬁc phosphorylation of Cdk1 and cyclin B1 level. (cgrpreceptor.com)
4. The Protein Phosphorylation Landscape of Mouse Spermatids during Spermiogenesis. (nih.gov)
10. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. (nih.gov)
controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (nih.gov)
The phosphorylation C G-protein-coupled trimers need a transporter of G-protein ovulated complexes that have the complex transcription cells and MKK7 ERCC6 isoforms( Brauner-Osborne H et al, 2007). (erik-mill.de)
The complexing of C/EBPα with Brm or HDAC1 is regulated by phosphorylation on C/EBPα-S193, which is increased by age via a cyclin D3 and GSK3β-mediated mechanism [ 27 ]. (biomedcentral.com)

Transient transfection and infection with viral vectors expressing cyclin A1 and short hairpin RNA (shRNA) targeting cyclin A1 were used to study the effects of altered cyclin A1 expression in PC3 prostate cancer cells. (medscape.com)

Overexpression of cyclin A2 in mammalian cells can result in the delayed onset of metaphase and anaphase. (wikipedia.org)
Cyclin A1 overexpression in the stem-like ALDHhigh subpopulation. (lu.se)
Cyclin A1 overexpression in the stem-like ALDHhigh subpopulation of PC3M cells, one model of PCa, enabled bone marrow integration and metastatic growth. (lu.se)
Overexpression of cyclin D1 protein, an important cell-cycle regulator, has been observed in HCL and may play a role in the molecular pathogenesis of the disease. (medscape.com)

Recent studies have shown that the cyclin A2-CDK1 complex triggers cyclin B1-CDK1 activation which results in chromatin condensation and the breakdown of the nuclear envelope. (wikipedia.org)
Present study was aimed to ﬁnd out whether RO-3306, speciﬁc cyclin dependent kinase 1 (Cdk1) inhibitor could protect against postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro. (cgrpreceptor.com)
Postovulatory aging increased Thr14/Tyr15 phosphorylated Cdk1 level, decreased Thr161 phosphorylated Cdk1 as well as cyclin B1 levels and increased Cdk1 activity in aged eggs cultured in vitro. (cgrpreceptor.com)
It is a heterodimer protein containing cyclin dependent kinase 1 (Cdk1) as a catalytic subunit and cyclin B1 as a regulatory subunit [1,5,6]. (cgrpreceptor.com)
MPF stabilization requires association of cyclin B1 with Cdk1 [3,5,7], while dissociation of cyclin B1 from MPF heterodimer and its degradation destabilizes MPF and triggers meiotic resumption from diplotene as well as metaphase-II (M-II) arrest [3-5,7-13]. (cgrpreceptor.com)
Activated Cdk1 modulates several biochemical and morphological events by triggering the speciﬁc phosphorylations of various protein substrates [16,17]. (cgrpreceptor.com)
a protein kinase that inhibits Cdk1. (nih.gov)
A30: Cdc2 (Cdk1), in association with either Cyclin B or Cyclin A, phosphorylates ORC2. (nih.gov)

Dissemination of tumor cells requires expression of metastasis-promoting genes involved in basement membrane degradation-metalloproteinases (MMPs), urokinase-type plasminogen activator (uPA), adhesion molecules, cell surface receptors, and many other proteins. (medscape.com)
The PPI network of the overlapping DEGs was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins. (nih.gov)
5. Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility. (nih.gov)
According to the TargetScan 7.2 database, the target genes of miR-17∼92a act on tissue inhibitors of metalloproteinases (TIMPs)-MMPs, p27/21 cyclins, and peroxisome-proliferator-activated receptor α (PPAR α ) ATP-binding cassette transporter (ABC) A1/G1, which are involved in the process of atherosclerosis. (hindawi.com)
In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1). (justia.com)
In specific embodiments, the modulation of expression concerns downregulation of expression of multiple genes, including in at least some cases to non-detectable levels, such as determined by any standard means in the art (at the RNA and/or protein level, for example). (justia.com)
In particular embodiments, the genes that are knocked out or knocked down are Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and Programmed cell death protein 1 (PD-1). (justia.com)
One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant neoplasms in prolonging cell survival. (biomedcentral.com)
Hallazgos recientes justifican un renovado interés en este proceso, el cual se estima que afecta más del 95% de los genes humanos. (uba.ar)
Encontramos que el cloroplasto responde a la luz generando una señal retrógrada que actúa en el núcleo en la regulación del splicing alternativo de determinados genes. (uba.ar)
The CX3 rRNA, reviewed of RAD51C and XRCC3, is D-loop genes through course with PALB2 and may regulate known in the protein of Holliday domains( Chun et al. (erik-mill.de)

also called CCNB1) cyclin B, a cell cycle inducible protein, prominent in mitosis, which activates cdks. (nih.gov)
also called CCNA1) cyclin A, a cell cycle inducible protein, prominent in S-phase, which activates cdks. (nih.gov)

Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. (medscape.com)
The progression through hormone-dependent to hormone-refractory and metastatic prostate cancer is poorly understood, but some proteins with critical roles in the process have been partially characterized. (medscape.com)
Cyclin A1, a cell cycle regulatory factor, has been demonstrated to be required for the G2/M phase transition in meiotic division of male germ cells by gene targeting, [ 14 ] and it contributes to the G1/S cell cycle progression in leukemic cell lines. (medscape.com)
The colocalization of SMYD3 and H2A.Z.1K101me2 at the promoter of cyclin A1 activated its expression and G 1 -S progression. (aacrjournals.org)
Cyclin A2 is synthesized at the onset of S phase and localizes to the nucleus, where the cyclin A2-CDK2 complex is implicated in the initiation and progression of DNA synthesis. (wikipedia.org)
The levels of cyclin A2 are tightly synchronized with the progression of the cell cycle. (wikipedia.org)
Cumulative evidence indicates that cell-cycle progression is mediated by cell-cycle regulatory proteins, such as cyclin D1, cyclin E, and cyclin-dependent kinase inhibitor 1B (p27), which are associated with G0/G1 phase cell-cycle arrest [ 5 ]. (hindawi.com)

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. (wikipedia.org)
In a second step, whole transcriptome RNA sequencing and whole-exome DNA sequencing technology followed by unbiased analysis of gene expression, gene mutation and copy number levels were performed and correlated with drug efficacy. (iiarjournals.org)
The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. (cgrpreceptor.com)
The cyclin gene family has undergone a massive expansion in angiosperm plants, but only a few cyclins were thoroughly characterized. (prolekarniky.cz)
TP53-induced gene 3 protein. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Recent studies revealed that lncRNAs are mainly involved in gene silencing, but their mechanisms are not fully understood, especially for the binding between the lncRNA and the RNA binding proteins. (biomedcentral.com)
Also immunohistochemistry (IHC) tests were perform to investigate the proteins expression of P53 gene as well as high HPV oncogenes E6 and E7 in benign and malignant laryngeal tumors. (pdfplayer.org)
Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+-CaM)-dependent protein kinase kinase-2 (CaMKK2) enzyme are linked to bipolar disorder. (edu.au)

The vertebrate Myb transcription factors comprise a small family of important regulatory proteins. (123dok.net)
The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors (MMMT) of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components. (biomedcentral.com)
The aim of this study is to evaluate the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinico-pathological data including survival outcomes. (biomedcentral.com)

The role of cyclin A1 and androgen receptor (AR) in transcription of VEGF and MMP2 was assessed by promoter mutation and chromatin immunoprecipitation. (medscape.com)
In the bone marrow, Cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted hte metastatic growth of PCa cells. (lu.se)

Cyclin A2 regulates homologous recombinational DNA repair in human breast cancer cells Loss of cyclin A2 causes high rates of double-strand breaks in DNA. (wikipedia.org)
In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. (lu.se)
Additionally, autophagy also plays a role in osteogenesis by regulating vascular calcification, which in turn regulates expression of proteins related to bone development, such as osteocalcin, osteonectin, etc. and regulated by mTOR, EphrinB2 and RhoA. (biomedcentral.com)

E2F promotes cyclin A2 transcription by de-repressing the promoter. (wikipedia.org)
In previous study, we demonstrated that TLS binds to long noncoding RNA, promoter-associated ncRNA-D (pncRNA-D), transcribed from the 5′ upstream region of cyclin D1 (CCND1), and inhibits the expression of CCND1. (biomedcentral.com)
In previous study, we demonstrated that long noncoding RNAs (lncRNAs) transcribed from the 5′ upstream region of cyclin D1 ( CCND1 ), and these lncRNA are expected to bind to TLS and inhibits the histone acetyltransferase activity of CBP/p300 at the CCND1 promoter. (biomedcentral.com)
In this study, we focused on one of the lncRNAs transcribed from the promoter region of CCND1 , pncRNA-D, since it showed the highest expression level among the pncRNAs. (biomedcentral.com)

We discuss in this review re-cent findings suggesting that B-Myb is a multifunctional protein that has, in addition to its transcriptional proper-ties, the ability to interact directly with other regulators of the cell cycle. (123dok.net)

We observed that cyclin A1 (CCNA1) protein expression was relatively higher in PCa metastatic lesions in lymph node, lung, and bone/bone marrow. (lu.se)

Your search for reliable Cyclin E1 antibodies ends here. (antibodies-online.com)
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Find available monoclonal or polyclonal Cyclin E1 Antibodies. (antibodies-online.com)
Find Cyclin E1 Antibodies with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. (antibodies-online.com)
Although protein-relevant therapeutics such as antibodies against Programmed Cell Death 1 (PD1), programmed death-ligand 1 (PDL1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) have driven a revolutionary trend in pharmacotherapy and drug development, some protein targets encoded by oncogenes are undruggable or inadequate for achieving remission, and cancer cells can acquire drug resistance [ 1 ]. (biomedcentral.com)

Moreover, a microarray analysis identified cyclin A1 as a target coregulated by SMYD3 and H2A.Z.1K101me2. (aacrjournals.org)
Cyclin A1 mRNA expression in EOC and healthy tissues was quantified by microarray analysis and quantitative real-time PCR (qRT-PCR). (biomedcentral.com)

Cyclin A1 contributes to prostate cancer invasion by modulating the expression of MMPs and VEGF and by interacting with AR. (medscape.com)
Our findings suggest that SMYD3-mediated H2A.Z.1K101 dimethylation activates cyclin A1 expression and contributes to driving the proliferation of breast cancer cells. (aacrjournals.org)

Cyclin A1 protein and mRNA expression were statistically significantly higher in prostate cancers than in adjacent benign tissues. (medscape.com)
Many of these cyclins exhibit cell-type-specific expression in vegetative tissues and distinct subcellular localization. (prolekarniky.cz)
Basic research here and elsewhere will build on current understanding at a molecular level to create an integrative biology that addresses how molecules interact to form cells, how cells interact to form tissues and organs, how organs form organisms, and how these organisms behave in the environment. (nih.gov)

Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEGF), metalloproteinase 2 (MMP2), and MMP9, in human prostate cancer. (medscape.com)
The effect of cyclin A1 expression on tumor growth and metastasis was analyzed in a mouse model of metastasis. (medscape.com)
001). PC3 cells that overexpressed cyclin A1 showed increased invasiveness, and inhibition of cyclin A1 expression via shRNA expression reduced invasiveness of these cells. (medscape.com)
001). Cyclin A1, in concert with AR, bound to and increased expression from the VEGF and MMP2 promoters. (medscape.com)
2) increased expression level of senescence-associated proteins (e.g. (degruyter.com)
and (3) increased expression level of pro-inflammation cytokines (e.g. (degruyter.com)
Enforced expression of cyclin A1 in cells containing mutant H2A.Z.1 rescued tumor formation in a mouse model. (aacrjournals.org)
Cyclin A1 expression has been reported in several epithelial malignancies, including testicular, endometrial, and epithelial ovarian cancer (EOC). (biomedcentral.com)
We analyzed Cyclin A1 expression in EOC and its correlation with clinical features to evaluate Cyclin A1 as a T-cell target in EOC. (biomedcentral.com)
Protein expression in clinical samples was assessed by immunohistochemistry (IHC) and was correlated to clinical features. (biomedcentral.com)
The mechanism behind the prolonged TTP in patients with high Cyclin A1 expression warrants further investigation. (biomedcentral.com)
The frequent, selectively high expression of Cyclin A1 in EOC makes it a promising target for T-cell therapies. (biomedcentral.com)
Increased expression of cyclin A2 has been observed in many types of cancer such as breast, cervical, liver, and lung among others. (wikipedia.org)
While it is not clear whether increased expression of cyclin A2 is a cause or result of tumorigenesis, it is indicative of prognostic values such as predictions of survival or relapse. (wikipedia.org)
In an in vitro model of stroke, inhibition of LACC1 reduced inflammation and ROS-induced oxidative stress by activating AMP-activated protein kinase (AMPK) expression and suppressing NLPR3 expression. (bvsalud.org)
The expression of cyclin D1/E was suppressed, and p27 was elevated following treatment with AD as well as ERK1/2 inhibitor. (hindawi.com)
Our phenotypic and expression data provide extensive evidence that multiplication of cyclins is in plants accompanied by functional diversification. (prolekarniky.cz)
Stress response proteins' differential expression in embryogenic and non-embryogenic callus of Vitis vinifera L. cv. (agri.gov.il)
We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. (stowers.org)
Violin plots show distribution of expression levels for Transmembrane protein (SMED30023220) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Transmembrane protein (SMED30023220) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for Transmembrane protein (SMED30023220) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
Other effects observed in vivo included increased production of tumor necrosis factor-, IL-1 macrophage inflammatory protein-2 expression, and lymphokine release, as well as activation of nuclear transcription factor activator protein-1 and lymphocyte proliferation. (nih.gov)

Cyclin A2 mediates the abundance of RAD51 protein by inhibiting proteasome degradation of this protein. (wikipedia.org)
Some proteins bind to AREs and recruit the degradation machinery to ARE-containing mRNAs. (molcells.org)
Lysosomes play vital roles in the degradation and recycling of various macromolecules, protein secretion, energy metabolism, and cell signaling. (researchsquare.com)

The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. (wikipedia.org)
6. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (nih.gov)
Myb is substantially enhanced in S phase through modi-fication by cyclin A/cdk2, and the evidence points squarely to the major role being played by B-Myb during this phase of the cell cycle. (123dok.net)
A29: Cdk2 can bind either Cyclin A or Cyclin E. For details on activation of Cdk2 (PMID: 10436023). (nih.gov)

We herein identified transmembrane protein 9 (TMEM9) as a crucial protein modulating lysosomal metabolism and lysosome-associated signaling. (researchsquare.com)
Cells of the budding yeast Saccharomyces cerevisiae are born carrying localized transmembrane landmark proteins that guide the subsequent establishment of a polarity axis and hence polarized growth to form a bud in the next cell cycle. (rupress.org)

retinoblastoma protein, a tumor suppressor that binds to the E2F family of transcription activators. (nih.gov)
Cyclin A:Cdc2 binds ORC and phosphorylates ORC2p in Xenopus (PMID: 10660590). (nih.gov)
a protein that binds to the Cdt1 component of the pre-replication complex and inactivates it, preventing assembly of the pre-replication complex at inappropriate times during the cell cycle. (nih.gov)
They include contrary activation at the thesis transcription and Subsequently, can activate taken into 19 binds( Subfamily A1-19) increased on a receptor-related checkpoint( Joost cell and Methner A, 2002). (erik-mill.de)
OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11 , which binds to CDK11 B with a K d of 40 nM. (medchemexpress.com)

Absence of cyclin A2 before the R point is due to the E2F inhibition by hypophosphorylated retinoblastoma protein (pRb). (wikipedia.org)
Dose-response matrix as heatmaps of inhibition for drug combinations in BRCA cells(A) Rapamycin and bafilomycin A1 in MDA-MB-453 cells. (researchsquare.com)

14. Evaluation of apoptotic- and autophagic-related protein expressions before and after IVM of fresh, slow-frozen and vitrified pre-pubertal mouse testicular tissue. (nih.gov)
Our study supports that a) cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b) p53 is an important immunoprognostic marker in MMMT of the uterus. (biomedcentral.com)

Compared to those less than 40 years old (y/o), people more than 65 y/o show decreased liver volume by 20-40%, reduced blood flow by 35%, decreased metabolism of LDL cholesterol by 35%, and elevated serum γ-glutamyltransferase and alkaline phosphatase levels [ 9 ]. (biomedcentral.com)

17. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. (nih.gov)
progres-sion through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. (123dok.net)

The BrdU assay, annexin V staining, and invasion chambers were used to examine cyclin A1 effects on proliferation, apoptosis, and invasion, respectively. (medscape.com)

The idea to study lipid peroxi- dation in CCl4 poisoning came to me after having observed a pro-oxidant eﬀect of CCl4 on mitochondrial proteins (Dianzani, 1961). (ac-devd-choinhibitor.com)
Substances containing thiol groups gave a partial protection against the aggregation of mitochondrial proteins seen in mitochondria isolated from CCl4-treated rats, as well as the same type of aggregation seen when mitochondria from normal liver were incubated at room temperature for 30 min. (ac-devd-choinhibitor.com)
I was only able to reply about the pro-oxidant eﬀect of CCl4 of mitochondrial proteins. (ac-devd-choinhibitor.com)

Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. (lu.se)

Moreover, ALDHhigh tumor cells expressing elevated levels of aromatase stimulated tumor/host estrogen production and acquired a growth advantage in the presence of host bone marrow cells. (lu.se)

It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in dividing somatic cells. (wikipedia.org)
In this study we performed a systematic immunolocalization screen to identify Arabidopsis thaliana A- and B-type cyclins expressed in meiosis. (prolekarniky.cz)
We found six A-type cyclins and a single B-type cyclin (CYCB3;1) to be expressed in male meiosis. (prolekarniky.cz)
Mutant analysis revealed that these cyclins contribute to distinct meiosis-related processes. (prolekarniky.cz)
We further show that cyclin SDS does not contain a D-box and is constitutively expressed throughout meiosis. (prolekarniky.cz)

Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
c-Myb is expressed at high levels in most haematopoietic precursor cells and plays a crucial role in blood cell development [1, 15, 16]. (123dok.net)
While A2 cyclins are important for chromosome segregation, CYCB3;1 prevents ectopic cell wall formation. (prolekarniky.cz)
Analysis of plants carrying cyclin SDS with an introduced D-box motif determined that, in addition to its function in recombination, SDS acts together with CYCB3;1 in suppressing unscheduled cell wall synthesis. (prolekarniky.cz)
Despite the understanding that cell cycle regulatory protein dysregulation may be involved in numerous malignant tumors [ 2 ], there is limited data that explores the role of these oncoproteins with survival data in MMMTs. (biomedcentral.com)
In haploid cells, the relevant landmark proteins are concentrated at the site of the preceding cell division, to which they recruit Cdc24, the guanine nucleotide exchange factor for the conserved polarity regulator Cdc42. (rupress.org)
Cdc7-IN-5 (compound I- B ) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I- B . Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle. (medchemexpress.com)
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase ) inhibitor with an IC 50 of 28 nM. (medchemexpress.com)

BRCA2 catalyzes L-iduronate on similar proteins, communicating to control of epithelial phosphatidic acids which are introduced by the BCDX2 synthesis( RAD51B: RAD51C: RAD51D: XRCC2). (erik-mill.de)

The increase in double-strand breaks is a consequence of defective homologous recombinational repair of the breaks resulting from reduced MRE11 and RAD51 DNA repair proteins. (wikipedia.org)
BCL2 associated x protein, highly homologous Bcl-2 family members lacking the BH4 domain. (nih.gov)

Cyclin A2 (Ccna2) is a key protein involved in the direction of mammalian cardiac myocytes to grow and divide, and has been shown to induce cardiac repair following myocardial infarction. (wikipedia.org)

Large-scale exploratory plasma protein proteomics revealed 47 proteins that signifcantly difered by diabetes status, 19 of which signifcantly correlated with pGSN levels, including adiponectin. (nih.gov)

Additionally, knockdown of PD2/Paf1 in pancreatic acinar cells resulted in the abrogation of Amylase, Elastase and Lipase (acinar marker) mRNA levels with simultaneous increase in CK19 and CAII (ductal marker) transcripts. (oncotarget.com)
Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2 . (medchemexpress.com)

TGF-β is part of a large family of polypeptide growth factors that includes activins, inhibins, and bone morphogenetic proteins (BMPs). (springer.com)
Bone morphogenetic proteins (BMPs) signal specific BMP type I and type II receptors, and stimulate the activation of R-Smad1, 5 and 8. (springer.com)

Identification of Meiotic Cyclins Reveals Fun. (prolekarniky.cz)

Therefore, the impact of the endocytosis inhibitor hydroxy-dynasore (OH-dyn), as well as bafilomycin A1 (bafA1), inhibiting the vacuolar type H + -ATPase (V-ATPase), on the cellular toxicity of nano- and microsized CuO particles, was investigated in BEAS 2 B cells. (mdpi.com)
PknB-IN-2 (Compound 10) is a Mycobacterium tuberculosis protein kinase B ( PknB ) inhibitor with an IC 50 of 12.1 μM. (medchemexpress.com)
B -Raf IN 5 (compound 3 b ) is a potent inhibitor of protein kinase B-Raf with an IC 50 of 2.0 nM. (medchemexpress.com)

Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A1(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake. (cdc.gov)

Conclusions In this cohort of racially diverse individuals with and without diabetes, we found diferences in pGSN levels with diabetes status, sex, race, and poverty. (nih.gov)

It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity. (nih.gov)

Cyclin A2 transcription is mostly regulated by the transcription factor E2F and begins in G1, after the R point. (wikipedia.org)
Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women. (cdc.gov)

Besides the so-called neoantigens, which are generated by somatic mutations in the neoplastic cells (e.g., p53) and are usually patient-specific, the targetable TAAs in EOC are usually self-antigens, which are non-mutated proteins aberrantly expressed by the tumor. (biomedcentral.com)
The results of our previous bioinformatics study demonstrated that the levels of LOC100129516 were significantly upregulated in peripheral blood mononuclear cells obtained from patients with CAD. (spandidos-publications.com)
Reverse transcription‑quantitative PCR (RT‑qPCR) was performed to detect the levels of LOC100129516 in THP‑1 macrophage‑derived foam cells. (spandidos-publications.com)
The results of the RT‑qPCR assays demonstrated that the levels of LOC100129516 were upregulated in THP‑1 macrophage‑derived foam cells. (spandidos-publications.com)
MSC‑derived exosomes were able to deliver small interfering (si)‑LOC100129516 to THP‑1 cells to reduce the levels of LOC100129516. (spandidos-publications.com)
LysoTracker staining in MDA-MB-231 cells and TMEM192-3xHA protein (A) Impact of TMEM9 depletion on vesicular acidification was examined by LysoTracker staining in control and TMEM9 knockdown cells. (researchsquare.com)
C) Rapamycin and bafilomycin A1 in MCF7 cells. (researchsquare.com)
E) Rapalink-1 and bafilomycin A1 in MDA-MB-453 cells. (researchsquare.com)
G) Rapalink-1 and bafilomycin A1 in MCF7 cells. (researchsquare.com)
MS5033 is a potent PROTAC-based AKT ( protein kinase B) degrader, with a DC 50 of 430 nM in PC3 cells. (medchemexpress.com)

Also in mice, cyclin A2 was found to be an RNA binding protein that controls the translation of Mre11 mRNA. (wikipedia.org)
In KC mice, however, PD2/Paf1 mRNA level continued to decrease with progressive dysplasia and subsequent neoplastic transformation. (oncotarget.com)

her recent study underlying mechanisms that drive diabetes and pursue reported lower levels of pGSN in women with type 2 novel therapeutic modalities to combat this prevalent dis- diabetes (n = 10) compared to women without type 2 ease. (nih.gov)

Vanicoside B targets cyclin-dependent kinase 8 ( CDK8 ) and exhibits anti-tumor activity. (medchemexpress.com)

Results pGSN levels were lower in men than women. (nih.gov)

Here, we show that the Cdc42 guanosine triphosphatase-activating protein (GAP) Rga1 establishes an exclusion zone at the division site that blocks subsequent polarization within that site. (rupress.org)

Anatomy17

Organisms9

Diseases9

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes64

Disciplines and Occupations1

Information Science3

Kinases8

Phosphorylation10

Altered cyclin A1 expression1

Overexpression4

CDK18

Genes12

CDKs2

Progression7

Gene9

Regulatory proteins3

Androgen receptor2

Regulates3

Promoter4

Transcriptional1

CCNA11

Antibodies8

Microarray analysis2

Contributes2

Tissues3

Expression23

Degradation3

Cdk24

Transmembrane2

Binds5

Inhibition2

Apoptotic2

Alkaline phosphatase1

Tumour suppressor protein2

Apoptosis1

Mitochondrial3

Metastatic1

Tumor cells1

Meiosis5

Cell8

Epithelial1

Homologous2

Mammalian1

Proteomics1

MRNA levels2

Bone2

Identification1

Inhibitor3

Interaction1

Conclusions1

Specificity1

Transcription factor2

Cells10

Mice2

Mechanisms1

Targets1

Results1

Subsequent1