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  • CIP1
  • Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 in human brain microvascular endothelial cells. (antibodies-online.com)
  • Among the many factors involved in these defense processes against DNA damage, p21 CDKN1A protein - known also as p21 (WAF1/CIP1/SDI1) - plays a key role in several fundamental biological processes, such as cell cycle control, DNA replication/repair, gene transcription, apoptosis, and cell motility [ 3 - 6 ]. (intechopen.com)
  • CDK1
  • JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. (adooq.com)
  • inhibits
  • This study demonstrates that cyclin G2 suppresses Wnt/beta-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. (antibodies-online.com)
  • Data (from studies using BeWo cells, a choriocarcinoma cell line, as model of placentation) suggest that miR-378a-5p (microRNA 378a) inhibits cell differentiation in syncytiotrophoblasts, in part, by down-regulating CCNG2 (cyclin G2) expression. (antibodies-online.com)
  • cdk5
  • Publications] Ando, S.: 'Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5' J.Biochem.122. (nii.ac.jp)
  • GAK is an association partner of cyclin G and CDK5. (bio-rad.com)
  • enzyme
  • Arginase I is a cytosolic enzyme that is abundantly expressed in the liver and plays a central role in the urea cycle, whereas arginase II is a mitochondrial protein that is concentrated in the kidney. (ahajournals.org)
  • Thus, the two substrates of this enzyme are ATP and a protein , whereas its two products are ADP and phosphoprotein . (wikipedia.org)
  • The systematic name of this enzyme class is ATP:protein phosphotransferase (non-specific) . (wikipedia.org)
  • This association may interfere with PCNA-dependent enzyme activities involved in DNA synthesis [ 18 , 19 ]. (intechopen.com)
  • substrates
  • These results gave useful information for developing spesific substrates and competitive inhibitors for each kinase. (nii.ac.jp)
  • To obtain substrates/inhibitors which are resistant to enzymatic proteolysis, we undertook a synthesis of cyclic or retro-inverso peptides. (nii.ac.jp)
  • Saccharomyces
  • Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae. (ebscohost.com)
  • Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor. (ebscohost.com)
  • Presents a study which examined the maturation of Saccharomyces cerevisiae a-factor and the role of prenyl protein proteases in it. (ebscohost.com)
  • substrate
  • Development and application of specific inhibitors for cyclin-dependent protein kinases on the basis of their substrate specificities. (nii.ac.jp)
  • We have examined structural features of proline which are essential for the substrate recognition by the kinase and found that the pyrrolidine ring of proline is primarily important. (nii.ac.jp)
  • Most kinases are inhibited by a pseudosubstrate that binds to the kinase like a real substrate but lacks the amino acid to be phosphorylated. (wikipedia.org)
  • In addition to having a lower affinity for Pho2 and the nuclear import protein Pse1/Kap121, phosphorylated Pho4 is a preferred substrate of the nuclear export protein Msn5, resulting in extranuclear localization. (pubmedcentralcanada.ca)
  • Peptides
  • Cyclic peptides which represent the site of histone or vimentin were effectively phosphorylated by cdc2 kinase. (nii.ac.jp)
  • synthesis
  • Furthermore, local perivascular application of the potent and selective arginase inhibitors S -(2-boronoethyl)- l -cysteine (BEC) or N G -hydroxy-nor- l -arginine (L-OHNA) immediately after injury markedly attenuated medial and neointimal DNA synthesis and neointima formation. (ahajournals.org)
  • Activity
  • Methods and Results- Balloon injury of rat carotid arteries resulted in a sustained increase in arginase activity in the vessel wall and the induction of arginase I protein in both the media and neointima of injured vessels. (ahajournals.org)
  • Substantial arginase I protein and arginase activity was also detected in rat cultured aortic VSMCs. (ahajournals.org)
  • At the molecular level, lack of FBL17 increases the stability of the CDK (CYCLIN-DEPENDENT KINASE) inhibitor KIP-RELATED PROTEIN2 known to switch off CDKA;1 kinase activity. (plantcell.org)
  • Activity of this protein is especially critical during the G1 to S phase transition. (creativebiomart.net)
  • human
  • The protein is dysregulated in several human diseases including diabetes and metabolic syndrome, cardiovascular diseases, neurodegenerative diseases and many cancer types (Steinberg and Kemp, 2009). (atlasgeneticsoncology.org)