• MPZL1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (38-162) and having a molecular mass of 16.1kDa.MPZL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. (assaygenie.com)
  • Rhodanese homology domains are structural modules of about 120 amino acids, which occur in the three major evolutionary phyla [ 9 ]. (expasy.org)
  • Human recombinant protein fragment corresponding to amino acids 21-166 of human CD40(NP_001241) produced in E.coli. (origene.com)
  • Serpins are single domain proteins with an average size: 350-400 amino acids and molecular weights of 40-60 kDa [ 2 - 4 ]. (jgenomics.com)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
  • The members of the MFS are secondary active, ion-coupled transporters of sugars, amino acids, drugs, nucleosides as well as organic and inorganic cations and anions (13). (kentlandsinitiative.org)
  • In the present study, we provide quantitative proteomic data that have been obtained by mass spectrometric analysis of isolated lysosomes from Cln7 ko mouse fibroblasts by means of Stable Isotope Labelling by Amino acids in Cell culture (SILAC). (kentlandsinitiative.org)
  • Adenylate kinase [Interproscan]. (ntu.edu.sg)
  • Using a combination of ATP deuterated at the C8 position (C8D-ATP) as a molecular probe with site directed mutagenesis (SDM) of conserved amino acid residues in shikimate kinase and adenylate kinase active sites, we have elucidated a mechanism by which the ATP C8-H is induced to be labile in the broader kinase family. (biomedcentral.com)
  • We have demonstrated the mechanism by which the enzyme activities of Group 2 kinases, shikimate kinase (SK) and adenylate kinase 1 (AK1), are controlled by the C8-H of ATP. (biomedcentral.com)
  • NEPH1, a member of the immunoglobulin superfamily, is structurally related to nephrin. (nih.gov)
  • PZR: an immunoglobulin superfamily cell surface protein. (assaygenie.com)
  • Myelin Protein Zero-Like 1 (MPZL1) is a cell surface receptor, which is involved in signal transduction processes. (assaygenie.com)
  • MPZL1 is a main receptor for concanavalin-A (ConA) and it is involved in cellular signaling induced by ConA, which most likely includes Src family tyrosine-protein kinases. (assaygenie.com)
  • Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
  • Since PKB activation is PI′-3-kinase dependent, the persistent activation of certain protein tyrosine kinases, such as IGF−1 receptor, EGF receptor, PDGF receptor, pp60c-Src, and the like, leads to the persistent activation of PKB which is indeed encountered in many tumors. (justia.com)
  • The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)
  • Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. (betalifesci.com)
  • It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. (betalifesci.com)
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. (origene.com)
  • Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. (origene.com)
  • This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
  • The insulin receptor (IR) is a transmembrane receptor that belongs to a class of receptor tyrosine kinase. (picmonic.com)
  • Insulin binds to a receptor tyrosine kinase and induces downstream signaling pathways (MAPK and PI3K). (picmonic.com)
  • Mutations in bone morphogenetic protein receptor 2 ( BMPR2 ) are the cause of most heritable cases but the vast majority of other cases are genetically undefined. (biomedcentral.com)
  • For example, bone morphogenetic protein receptor type 2 ( BMPR2 ) mutations are observed in 60-80% of familial (FPAH) cases, but data from population registries indicate that penetrance of the disease phenotype ranges from 14 to 42% [ 6 ]. (biomedcentral.com)
  • In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
  • The tyrosine kinase, in turn, activates two major intracellular pathways: the phosphatidylinositol 3-kinase (PI3K) pathway, which mostly mediates the metabolic effects of insulin, and the mitogen-activated protein kinase (MAPK) pathway, which is involved in mitogenesis and growth. (picmonic.com)
  • Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. (nih.gov)
  • Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
  • Serpins are thought to have evolved through gene duplication and divergence events, giving rise to a large number of serpin genes within an organism, each encoding a protein with a unique reactive center region and physiological function(s) [ 7 ]. (jgenomics.com)
  • The candidate genes exhibit expression patterns in lung and heart similar to that of known PAH risk genes, and most variants occur in conserved protein domains. (biomedcentral.com)
  • You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. (betalifesci.com)
  • All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. (rndsystems.com)
  • The amino acid sequence of mature BDNF is identical in all mammals examined. (rndsystems.com)
  • A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
  • encodes the lysosomal polytopic CLN7 membrane protein of unknown function which contains sequence similarities with the drug: H+ antiporter family DHA1 of the major facilitator superfamily (MFS) (4,12). (kentlandsinitiative.org)
  • The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). (creativebiomart.net)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Protein kinases are involved in signal transduction pathways linking growth factors, hormones and other cell regulation molecules to cell growth, survival and metabolism under both normal and pathological conditions. (justia.com)
  • protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
  • subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)
  • PKB activation involves phosphorylation of two amino acid residues, Ser473 and Thr308. (justia.com)
  • AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
  • The RUNX1: heterodimer carrier represses thus inhibited in IL1 phosphorylation of transcription classical kinases, including GPAM, KCTD6 and AXIN1( Stender et al. (erik-mill.de)
  • The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)
  • The enzyme is activated by the second messenger PIP3 produced by PI′-3-kinase. (justia.com)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • The role of the C8-H of ATP in the binding and/or phosphoryl transfer on the enzyme activity of a number of kinase and synthetase enzymes has been elucidated. (biomedcentral.com)
  • The intrinsic catalysis rate mediated by each kinase enzyme is complex, yielding apparent K M values ranging from less than 0.4 μM to more than 1 mM for ATP in the various kinases. (biomedcentral.com)
  • The lability of the C8-H mediated by active site residues co-ordinated to the purine ring of ATP therefore plays a significant role in explaining the broad K M range associated with kinase steady state enzyme activities. (biomedcentral.com)
  • In vertebrates, rhodanese is a mitochondrial enzyme of about 300 amino-acid residues involved in forming iron-sulfur complexes and cyanide detoxification. (expasy.org)
  • Rhodanese domains, either catalytic or inactive (i.e. where the active-site Cys is replaced by another residue), are also found associated with other protein domains such as MAPK-phosphatases or thiL, an Escherichia coli enzyme involved in thiamin and thiouridine biosynthesis. (expasy.org)
  • Furthermore, HIF-1 actively limits the mitochondrial consumption of pyruvate at two levels: (i) through the enzyme PDK (PDH-kinase), which in turn inhibits PDH activity preventing the conversion of pyruvate into acetyl CoA, and thereby limiting mitochondrial metabolism of pyruvate [ 6 ] and (ii) through the direct activation of LDH [ 7 , 8 ]. (hindawi.com)
  • Expression analyses showed that the mRNA expression, biosynthesis, intracellular sorting and proteolytic processing of Cln5 were not affected, whereas the depletion of mature Cln5 protein was due to increased proteolytic degradation by cysteine proteases in Cln7 ko lysosomes. (kentlandsinitiative.org)
  • It encodes a large nuclear protein that is a component of DNA repair pathways. (lookformedical.com)
  • The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (lookformedical.com)
  • It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (lookformedical.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Rhodanese-like proteins are either composed of a single catlytic rhodanese domain, as found in glpE, or composed of two rhodanese domains, with the C-terminal domain displaying the putative catalytic Cys as observed in Rhobov and rhdA. (expasy.org)
  • The SDM clearly identified the amino acid residues involved in both the catalysis and regulation of phosphoryl transfer in SK and AK1 as mediated by C8H-ATP. (biomedcentral.com)
  • These mechanisms were developed using structurally conserved amino acid residues within hydrogen-bonding distance of a nucleotide in the active sites of crystallised kinases of a particular mechanistic class. (biomedcentral.com)
  • Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism. (tamu.edu)
  • In total, a set of 218 proteins shared by these two gametophytes were analyzed using the STRING database, and their proteome associated with metabolism, genetic information processing, and responses to abiotic stress is discussed. (bvsalud.org)
  • For example, a major regulator of metabolism is phosphoinositol 3 kinase (PI3K). (hindawi.com)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
  • functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
  • The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
  • The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)
  • Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
  • SYP7 group Qc-type SNARE protein","protein_coding" "MA_10436714g0010","No alias","Picea abies","acyl-CoA thioesterase","protein_coding" "MA_135972g0010","No alias","Picea abies","Acyl-CoA-binding domain-containing protein 3 OS=Oryza sativa subsp. (ntu.edu.sg)
  • 14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)
  • What does this gene/protein do? (cancerindex.org)
  • BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (rndsystems.com)
  • Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
  • 2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)
  • CLN7 belongs to a group of atypical solute carriers of MFS type which are located at the plasma membrane and/or in intracellular compartments (14). (kentlandsinitiative.org)
  • Thioesterase superfamily [Interproscan]. (ntu.edu.sg)
  • All AE proteins are hypothesized to share a similar topology in the cell membrane. (tcdb.org)
  • In CLN3 disease, which is caused by defects in the lysosomal membrane protein CLN3, alterations in the amounts of TPP1 (27), lysosomal acid phosphatase (28) and mannose 6-phosphate-containing glycoproteins (29) in the brain have been reported. (kentlandsinitiative.org)
  • The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
  • As noted above, the AE or solute carrier 4 (SLC4) family includes 10 members (SLC4A1-5, SLC4A7-11), which are expressed in multiple tissues in the human body. (tcdb.org)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • Pyruvate kinase [Interproscan]. (ntu.edu.sg)
  • the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
  • Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. (lookformedical.com)
  • Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (lookformedical.com)
  • Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (lookformedical.com)
  • Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. (betalifesci.com)
  • EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. (betalifesci.com)
  • Some examples include the epidermal growth factor (EGF) family, Vascular endothelial growth factors (VEGFs) family, Tumor necrosis factor (TNF) superfamily, platelet-derived growth factor (PDGF) family, and others. (picmonic.com)
  • Protein translocation in ER SUMO1 Protein targeting SUMO3 Protein targeting HSPA4 HSPA5 HSPA8 HSPA9 HSPA14 HSBP1 HIST1H2BC H1FX H2AFV H2AFX H2AFY Histone 2 Subfamily H2AFZ essential for embryogenesis There is significant overlap in function with regards to some of these proteins. (wikipedia.org)
  • CSL is an download Your Brain on Latino Comics: From Gus Arriola to Los Bros Hernandez of a possible DNA-binding histone cause that releases kinase of invalid genome interests in one decision, but hormone of the Canadian developments in another endocytosis. (evakoch.com)
  • Regulated by MITF) HMGB1 High mobility group box binds DNA ILF2 Homo sapiens interleukin enhancer binding factor 2, 45kDa (ILF2), mRNA IER2 formerly ETR101 Immediate Early Protein? (wikipedia.org)
  • These molecular properties of PKB and its central role in tumorigenesis, implies that this protein kinase may be an attractive target for novel anti-cancer agents. (justia.com)
  • Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia. (tamu.edu)
  • To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (origene.com)
  • These proteins are classified into two functional categories - inhibitory (majority) such as antithrombin III [ 5 ], while some of them are non-inhibitory, which adopt other function than inhibitory roles such as angiotensinogen, which lost inhibition during vertebrate evolution [ 6 ]. (jgenomics.com)
  • In healthy individuals, cryopyrin and apoptosis-associated speck-like protein (ASC) interact via the oligomerization of ASC to induce both apoptosis and activate nuclear factor (NF)-kappa B. (medscape.com)
  • The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. (justia.com)
  • It improves protein stability, extends storage time, and reduces shipping costs. (betalifesci.com)
  • In addition, mice lacking NEPH1 develop a nephrotic syndrome that resembles NPHS mutations, suggesting that all three proteins are essential for the integrity of glomerular podocytes. (nih.gov)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • It has been demonstrated that the adenyl moiety of ATP plays a direct role in the regulation of ATP binding and/or phosphoryl transfer within a range of kinase and synthetase enzymes. (biomedcentral.com)
  • The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
  • Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)
  • Furthermore, pyrin interacts with proline-serine-threonine phosphatase-interacting protein (PSTPIP1), also known as CD2-binding protein 1 (CD2BP1), which is a tyrosine-phosphorylated protein involved in cytoskeletal organization and thereby involved in immunologic cellular interactions. (medscape.com)
  • The interactome of this set of proteins represents a total network composed of 218 nodes and 1792 interactions, obtained mostly from databases and text mining. (bvsalud.org)
  • The interactions among the identified proteins of the ferns D. affinis and D. oreades, together with the description of their biological functions, might contribute to a better understanding of the function and development of ferns as well as fill knowledge gaps in plant evolution. (bvsalud.org)
  • Can you explain the structure of CADM3 and its interactions with other proteins or ligands in neural adhesion processes? (creativebiomart.net)
  • Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
  • to facilitate higher yields of proteins of interest, we constructed the pasop vector to express heterologous proteins in a. oryzae. (liverpool.ac.uk)
  • Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
  • Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (tcdb.org)
  • Furthermore, dysregulated expression of several soluble lysosomal proteins and impaired macroautophagy in the Cln7 ko mice suggest that loss of Cln7 results in lysosomal dysfunction in the brain (19). (kentlandsinitiative.org)
  • These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins (1, 2). (rndsystems.com)
  • protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
  • Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
  • This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
  • Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed. (justia.com)
  • Because FH1 40S strand across the replication superfamily has negatively absorbed, man can appear without the family that provides fluid of organism diseases. (erik-mill.de)
  • These diseases were reclassified based on the innate immunity mechanisms and the inflammasome, a protein complex containing caspases involved in the proteolytic cleavage of interleukin (IL)-1 precursors to produce active forms of IL-1 (explaining the pathogenesis of fevers in these individuals) (see Table 1). (medscape.com)
  • We report now that NEPH1 belongs to a family of three closely related proteins that interact with the C-terminal domain of podocin. (nih.gov)
  • Some bacterial proteins closely related to rhodanese are also thought to express a sulfotransferase activity. (expasy.org)
  • Description: A sandwich ELISA kit for detection of Zinc Finger, AN1-Type Domain Protein 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • Description: A competitive ELISA for quantitative measurement of Human AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
  • Description: A competitive ELISA for quantitative measurement of Rat AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
  • However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. (betalifesci.com)
  • mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization. (betalifesci.com)