AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
src Homology Domainssrc-Family KinasesProtein Kinase CProtein KinasesPhosphorylationProto-Oncogene Proteins pp60(c-src)Signal TransductionProtein-Tyrosine KinasesCyclic AMP-Dependent Protein KinasesEnzyme ActivationAmino Acid SequenceCalcium-Calmodulin-Dependent Protein KinasesProtein-Serine-Threonine KinasesProto-Oncogene Proteins c-yesMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesMolecular Sequence DataTyrosineProtein Kinase InhibitorsMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesCell LineFocal Adhesion Kinase 1Sequence Homology, Amino AcidMitogen-Activated Protein Kinase 1Cells, CulturedTransfectionProtein Kinase C-alphaMitogen-Activated Protein Kinase KinasesMitogen-Activated Protein Kinase 3Focal Adhesion Protein-Tyrosine KinasesProtein BindingJNK Mitogen-Activated Protein KinasesProtein Kinase C-deltaAdaptor Proteins, Signal TransducingPhosphoproteinsBase SequenceIsoenzymesIntracellular Signaling Peptides and ProteinsAMP-Activated Protein KinasesProtein Kinase C-epsilonProtein Kinase C betaBinding SitesEnzyme InhibitorsProto-Oncogene ProteinsTetradecanoylphorbol AcetatePhosphotyrosineCloning, MolecularCyclic GMP-Dependent Protein KinasesRecombinant Fusion ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Structure, TertiaryProtein Tyrosine Phosphatase, Non-Receptor Type 6KineticsMutationProtein Tyrosine PhosphatasesCDC2 Protein KinaseRecombinant ProteinsProteinsGRB2 Adaptor ProteinCyclic AMPSubstrate SpecificityMAP Kinase Kinase KinasesBlotting, WesternCasein Kinase IISequence Homology, Nucleic AcidCarrier ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2Extracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktp21-Activated KinasesCell MovementCalciumSerineeIF-2 KinasePrecipitin Tests3T3 CellsRNA, MessengerMAP Kinase Kinase 1Proto-Oncogene Proteins c-fynPhosphotransferases (Alcohol Group Acceptor)SH2 Domain-Containing Protein Tyrosine PhosphatasesRibosomal Protein S6 KinasesReceptor Protein-Tyrosine KinasesProtein Phosphatase 1Tumor Cells, CulturedPhosphoric Monoester HydrolasesSequence AlignmentCasein KinasesMAP Kinase Kinase 4DNA, ComplementaryImmunoblottingCyclin-Dependent KinasesDiglyceridesMembrane ProteinsType C PhospholipasesMutagenesis, Site-DirectedDNA-Binding ProteinsPhorbol 12,13-DibutyrateOncogene Protein pp60(v-src)
PhosphorylationSerineDomainsTarget proteinsPhosphatidylinositolBindsExtracellular signal-Pp60c-srcSignaling pathwayPhosphotyrosinePleckstrin homologyReceptorsActivation of extracellularIntracellularInteractionsInhibitorsRegulatesMetabolismCatalyticVivoPathwaysPhosphataseSpecificityStabilityComplexesInhibitionGenesCharacterizationMRNARolesDomainAntigenModulateSubstrateXenopusSubunitsMembrane proteinsSignalTyrosine phosphorylatedStructural proteinsInducibleAmino acidsMutationsPutativeSequence
Phosphorylation13
  • The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
  • To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
  • Subsequent studies have shown that, while binding of SH2 domains to their target proteins is strictly regulated by tyrosine phosphorylation, most PTB domains actually bind to their (nonphosphorylated) targets constitutively. (chemdiv.com)
  • Ang II caused a rapid tyrosine phosphorylation of Src homology and collagen (Shc), which was inhibited by quercetin. (aspetjournals.org)
  • Specifically, GSK3ß-mediated phosphorylation of ETS1 at threonine 265 and serine 269 promoted protein stability, induced the transcriptional activation of matrix metalloproteinase (MMP)-9, and increased cell migration. (bvsalud.org)
  • non-etheless there are many exceptions like the SH2 domains of SLAM-associated proteins (aka SAP SH2D1A) and cten where the binding needs Temocapril the tyrosine but irrespective of its phosphorylation position. (researchensemble.com)
  • We describe here a new model for regulation of SHP-1 involving phosphorylation of its C-terminal Ser(591) by associated protein kinase Calpha. (reading.ac.uk)
  • Phosphorylation of SHP-1 was mediated by protein kinase C and negatively regulated the activity of SHP-1 as demonstrated by a decrease in the in vitro ability of SHP-1 to dephosphorylate Vav1 on tyrosine. (reading.ac.uk)
  • Protein kinase Calpha therefore critically and negatively regulates SHP-1 function, forming part of a mechanism to retain SHP-1 in a basal active state through interaction with its SH2 domains, and phosphorylating its C-terminal Ser(591) upon cellular activation leading to inhibition of SHP-1 activity and an increase in the tyrosine phosphorylation status of its substrates. (reading.ac.uk)
  • A. Kashishian, A. Kazlauskas, J.A. Cooper, "Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo," The EMBO Journal, 11[4]:1373-82, 1992. (the-scientist.com)
  • As we mapped and mutated phosphorylation sites in the platelet-derived growth factor (PDGF) receptor, we found a dramatic difference in interactions of three tyrosines in the `kinase-insert' region. (the-scientist.com)
Serine6
  • Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. (wikipedia.org)
  • Aurora A is a member of a family of mitotic serine/threonine kinases. (wikipedia.org)
  • STP, serine/threonine protein phosphatase. (rupress.org)
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. (origene.com)
  • RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. (assaysolution.com)
  • This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. (assaysolution.com)
Domains24
  • Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
  • Several different binding motifs are known, for example: pYEEI (Src-family SH2 domains), pY [IV]. (eu.org)
  • The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)
  • SH2 domains are phosphotyrosine recognition domains, often mediating transient interactions with target proteins. (eu.org)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
  • There are 308772 RING domains in 276130 proteins in SMART's nrdb database. (embl-heidelberg.de)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • CAPN3 provides some exclusive domains including its NH2-terminal domains I which has 20C30 additional proteins not within - and m-calpains and two exclusive insertion sequences' of 62 and 77 proteins on the COOH-terminal parts of domains II (known as Is normally1) and domains III (known as IS2). (exposed-skin-care.net)
  • Crk is mainly composed of Src homology 2 (SH2) and Src homology 3 (SH3) domains, which serve as docking sites for signalling proteins, including various receptors, cytoplasmic kinases, and GTPase regulators. (rndsystems.com)
  • SH2 (Src homology region 2) and PTB (phosphotyrosine-binding) domains are small protein modules that mediate protein-protein interactions involved in many signal transduction pathways. (chemdiv.com)
  • Both domains were initially identified as modules that recognize phosphorylated tyrosines in receptor tyrosine kinases and other signaling proteins. (chemdiv.com)
  • The functions of SH2 and PTB domains include targeting of their host proteins to different cellular compartments, assembly of key components of signaling pathways in response to extracellular signals, and the control of autoinhibition, activation and dimerization of their host proteins. (chemdiv.com)
  • 1] J. Schlessinger and M. A. Lemmon, "SH2 and PTB domains in tyrosine kinase signaling. (chemdiv.com)
  • tensin4 TNS4) was defined as a faraway person in the tensin focal adhesion family members (Lo and Lo 2002 It really is a much smaller sized proteins compared to various other tensins in support of stocks the SH2 (Src homology 2) and PTB (phosphotyrosine binding) domains bought at the C-terminal ends of most various other tensins (Lo 2004 (body 1). (researchensemble.com)
  • Here, we show that insulin-induced activation of ERKs was enhanced by stable overexpression of growth factor receptor-bound protein 2 (GRB2) but not by overexpression of GRB2 proteins with point mutations in the Src homology 2 and 3 domains. (nih.gov)
  • PIP3 binds to the pleckstrin homology (PH) domains of PKB, recruits it to the membrane where it is phosphorylated and converted to its activated form. (justia.com)
  • coiled-coil domains and an SH2 (Src-homology 2) website. (healthdisparitiesks.org)
  • The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. (nih.gov)
  • In human platelets, SHP-1 was found to constitutively associate with its substrate Vav1 and, through its SH2 domains, with protein kinase Calpha. (reading.ac.uk)
  • Thesis title: The PDZ-ligand and Src-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human Src kinase activity during viral infection. (unipv.eu)
  • Phosphorylated STATs dimerize within the cytosol via their phosphotyrosines and Src-homology 2 (SH2) domains. (medscape.com)
  • Adam Kashishian (Fred Hutchinson Cancer Research Center, Seattle): "The question of the specificity of Src homology 2 (SH2) domain/phosphotyrosine interactions has been an important one since the ability of the SH2 domains to bind phosphotyrosine- containing peptides was first shown. (the-scientist.com)
  • Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src. (ox.ac.uk)
  • Signal transducing adaptor proteins that contain SRC HOMOLOGY DOMAINS and play a role in CYTOSKELETON reorganization. (bvsalud.org)
Target proteins2
  • Among these target proteins are TACC, a microtubule-associated protein that stabilizes centrosomal microtubules and Kinesin 5, a motor protein involved in the formation of the bipolar mitotic spindle. (wikipedia.org)
  • The effect of miR-126 expression on target proteins was assessed using miR-126 mimics or miR-126 inhibitors in ESCC cell lines. (spandidos-publications.com)
Phosphatidylinositol5
  • The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
  • Quercetin also inhibited Ang II-induced Shc·p85 association and subsequent activation of phosphatidylinositol 3-kinase (PI3-K)/Akt pathway in RASMC. (aspetjournals.org)
  • PF cells were found to express regulatory (p85) and catalytic (p110α and p110β) subunits of phosphatidylinositol 3′-kinase (PI3′-kinase). (jneurosci.org)
  • Purification and characterization of bovine brain type I phosphatidylinositol kinase. (wikidata.org)
  • Two types of phosphatidylinositol 3-kinase from bovine thymus. (wikidata.org)
Binds2
  • We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-70 via its Src homology 2 (SH2) domain (LckSH2) and, more recently, that Tyr319 of ZAP-70 is phosphorylated in vivo and plays a positive regulatory role. (pasteur.fr)
  • Mutants, which have a stop codon upstream of the Rabbit polyclonal to CREB.This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins.This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. (aplarcongress.org)
Extracellular signal-2
  • ERK, extracellular signal-regulated kinases. (spandidos-publications.com)
  • Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases] is mediated by Ras. (nih.gov)
Pp60c-src1
  • Since PKB activation is PI′-3-kinase dependent, the persistent activation of certain protein tyrosine kinases, such as IGF−1 receptor, EGF receptor, PDGF receptor, pp60c-Src, and the like, leads to the persistent activation of PKB which is indeed encountered in many tumors. (justia.com)
Signaling pathway1
  • This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. (nih.gov)
Phosphotyrosine1
  • 2007 The SH2 domain of cten interacts with phosphotyrosine-containing protein. (researchensemble.com)
Pleckstrin homology1
  • PAG3 encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. (novusbio.com)
Receptors4
  • Upon activation of either PAR1 or PAR4 thrombin receptors, the association between the three proteins was retained, and Vav1 became phosphorylated on tyrosine and SHP-1 became phosphorylated on Ser(591). (reading.ac.uk)
  • 8, 9] STAT3 is one of 7 human STAT (signal transducer and activator of transcription) proteins, which are critical second messengers for many cytokine, hormone, and growth factor receptors. (medscape.com)
  • In general, Janus family tyrosine kinases (JAKs) bind to the intracellular components of cytokine receptors, and are, in turn, bound by STATs upon cytokine signaling. (medscape.com)
  • Different growth factor receptors were known to bind different constellations of SH2 domain-containing proteins. (the-scientist.com)
Activation of extracellular1
  • Our findings showed that Ang II stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38 in RASMC. (aspetjournals.org)
Intracellular3
  • Fibroblast growth factor homologous factors are intracellular signaling proteins. (nih.gov)
  • Intracellular signaling pathways that involve protein tyrosine kinases (PTKs) are critical for the control of most cellular processes. (chemdiv.com)
  • This gene encodes an intracellular tyrosine kinase expressed in T-cells. (nih.gov)
Interactions2
  • They are able to bind specific motifs containing a phosphorylated tyrosine residue, propagating the signal downstream by promoting protein-protein interactions and/or modifying enzymatic activities. (eu.org)
  • Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
Inhibitors6
  • miR-126 mimics downregulated the expression of IRS-1 and GOLPH3 protein and suppressed the proliferation, migration and invasion of ESCC cells, whereas miR-126 inhibitors led to the opposite results. (spandidos-publications.com)
  • moreover, PI3′-kinase inhibitors (wortmannin and LY294002) antagonized secretion. (jneurosci.org)
  • The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
  • The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. (justia.com)
  • Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed. (justia.com)
  • The present invention relates to cell permeable, stable conjugates comprising a cell-permeability enhancement moiety and a peptide or peptidomimetic, as selective inhibitors of protein kinases, to pharmaceutical compositions containing them, as well as to processes for the preparation and use of such complex molecules. (justia.com)
Regulates2
  • The Aurora kinase A is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. (wikipedia.org)
  • The Aurora kinase B is a chromosome passenger protein and regulates chromosome segregation and cytokinesis. (wikipedia.org)
Metabolism2
  • Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. (nih.gov)
  • Protein kinases are involved in signal transduction pathways linking growth factors, hormones and other cell regulation molecules to cell growth, survival and metabolism under both normal and pathological conditions. (justia.com)
Catalytic2
Vivo1
  • The encoded protein forms a stable complex with PYK2 in vivo. (novusbio.com)
Pathways3
  • This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. (nih.gov)
  • Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
  • The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. (reliatech.de)
Phosphatase1
  • SHP-1 is a Src homology 2 (SH2) domain-containing tyrosine phosphatase that plays an essential role in negative regulation of immune cell activity. (reading.ac.uk)
Specificity2
  • E3 ubiquitin-protein ligases determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. (embl-heidelberg.de)
  • Was this a function of differences in receptor primary sequence, their locations in the cell, or, possibly, the specificity of the protein kinase domain of the receptor? (the-scientist.com)
Stability1
  • Mature microRNAs (miRNAs) are a class of small, well-conserved, non-coding RNA molecules that silence gene expression usually by interfering with mRNA stability or protein translation ( 6 , 7 ). (spandidos-publications.com)
Complexes1
  • Crk belongs to a family of adaptor molecules, which link extracellular growth and differentiation stimuli with formation of signal transduction protein complexes. (rndsystems.com)
Inhibition1
  • PKC involvement can be accounted for by PKCγ and an isoform sensitive to inhibition by pseudoZ, probably PKCζ, which is activated via PI3′-kinase. (jneurosci.org)
Genes2
  • Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
  • As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
Characterization1
  • Identification and characterization of a novel tyrosine kinase from megakaryocytes. (ox.ac.uk)
MRNA1
  • While mRNA of alfa subunits (HIFs- α) are not altered by exposure to hypoxia, alfa, but not beta, proteins are stabilized by hypoxia. (biomedcentral.com)
Roles2
Domain15
  • The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
  • Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
  • The RING domain is a protein interaction domain that has been implicated in a range of diverse biological processes. (embl-heidelberg.de)
  • Taxonomic distribution of proteins containing RING domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with RING domain is also avaliable . (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing RING domain in the selected taxonomic class. (embl-heidelberg.de)
  • lymphocyte cytosolic protein 2 (SH2 domain. (wikigenes.org)
  • Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. (pasteur.fr)
  • HGF forms a family with HGF-like protein (HLP), a unique protein with a domain structure similar to that of HGF ( 12 ). (spandidos-publications.com)
  • Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
  • With the exception of ForI and ForC all other formins conform to the domain structure GBD/FH3-FH1-FH2-DAD, where DAD is the Diaphanous autoinhibition domain and GBD/FH3 is the Rho GTPase-binding domain/formin homology 3 domain that we propose to represent a single domain. (biomedcentral.com)
  • The FH2 (formin homology 2) domain is the defining feature of all formins. (biomedcentral.com)
  • In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)
  • The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
  • In most fungal and metazoan formins the FH1-FH2 core is accompanied by a less well conserved N-terminal FH3 (formin homology 3) domain involved in targeting [ 14 ]. (biomedcentral.com)
Antigen1
Modulate1
  • Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
Substrate1
  • In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. (novusbio.com)
Xenopus3
  • The aurora kinases were first identified in 1990 during a cDNA screen of Xenopus eggs. (wikipedia.org)
  • The Xenopus, Drosophila, and Caenorhabditis elegans genomes, on the other hand, contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the centrosome during different phases of mitosis. (wikipedia.org)
  • In the case of the former, it has been suggested that Aurora A cooperates with the kinase Nek2 in Xenopus to dissolve the structure tethering the cell's centrosomes together. (wikipedia.org)
Subunits2
  • Calpain 3 provides 54 and 51% series homology towards the 80 kDa subunits of - and m-calpains, respectively, and stocks similar properties with one of these ubiquitously portrayed calpains such as for example Ca2+- reliant activation and maximal activity at natural pH (1). (exposed-skin-care.net)
  • Sirt3 can also physically interact with at HDM201 least one of the known subunits of Complex I, the 39-kDa protein NDUFA9. (aplarcongress.org)
Membrane proteins1
  • ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factorα (TNFα), the p75 TNF receptor, the β-amyloid protein precursor, and the c-kit ligand1, implying that it may participate in shedding of these membrane proteins. (reliatech.de)
Signal2
  • We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
  • The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
Tyrosine phosphorylated1
Structural proteins1
Inducible3
  • Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma. (nih.gov)
  • A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation. (nih.gov)
  • Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma. (nih.gov)
Amino acids2
  • The matk cDNA clone encodes a polypeptide of 527 amino acids and has closest sequence similarity to the csk tyrosine kinase. (ox.ac.uk)
  • The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
Mutations1
  • The mutations are predominantly missense and in-frame deletions that lead to production of proteins with dominant negative activity. (medscape.com)
Putative1
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
Sequence1