Protein kinase regulates. Medical search. Frequent questions

Expression levels of PER2, a clock protein, were elevated in Sik3 -knockdown cells but down-regulated in Sik3 -overexpressing cells, which could be attributed to a phosphorylation-dependent decrease in PER2 protein stability. (elifesciences.org)
PP2C38 regulates PAMP-induced BIK1 phosphorylation and impairs the phosphorylation of the NADPH oxidase RBOHD by BIK1, leading to reduced oxidative burst and stomatal immunity. (uni-koeln.de)
We also observed that ASK1DeltaN induced expression of several neuron-specific proteins and phosphorylation of neurofilament proteins, confirming that PC12 cells differentiated into mature neuronal cells by ASK1. (nih.gov)
Protein kinase C-dependent phosphorylation regulates the cel. (pubpeer.com)
Fig. 1: Serum mitogen-induced phosphorylation of PI3KC2-β induces complex formation with 14-3-3 proteins. (nature.com)
Fig. 5: mTORC2 signalling triggers PKN2 activation to control PI3KC2-β phosphorylation and sequestration with 14-3-3 proteins. (nature.com)
The A-kinase anchoring protein 79/150 (AKAP79/150) signaling scaffold regulates AMPAR phosphorylation , channel activity, and endosomal trafficking associated with LTP and LTD. AKAP79/150 is targeted to dendritic spine plasma membranes by an N-terminal polybasic domain that binds phosphoinositide lipids , F-actin , and cadherin cell adhesion molecules . (bvsalud.org)
Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)
SWCNTs induce fibrogenesis through reactive oxygen species-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK). (cdc.gov)
The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. (bvsalud.org)
Protein phosphorylation is a biological process that regulates most aspects of cellular life, and the enzymes that catalyze this reaction - protein kinases - constitute the largest family of enzymes encoded by the human genome. (lu.se)
An overall aim of our research is to study the regulation and function of protein phosphorylation cascades that are important for the maintenance of a normal energy metabolism and that might be involved in the pathophysiological changes that ultimately lead to type 2 diabetes. (lu.se)

DAPK1, located in human chromosomal locus 9q34.1, is a member of the DAPK family that belongs to the serine/threonine kinase (STK) superfamily. (frontiersin.org)
PRICKLE1 is phosphorylated by the serine/threonine kinase MINK1 and contributes to TNBC cell motility and invasiveness. (hal.science)
Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene. (wikipedia.org)
cAMP-dependent protein kinase A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cellular functions. (mdc-berlin.de)
This gene provides instructions for making a protein called calcium/calmodulin-dependent serine protein kinase (CASK). (medlineplus.gov)
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. (bvsalud.org)
In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. (bvsalud.org)

Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAPK [mitogen-activated protein kinases] and JNKs [c-Jun N-terminal kinases]) and promotes fibrosis in various tissues. (ox.ac.uk)

In this study, we compared how different signaling pathways determine extracellular nucleotide pools in control Jurkat cells versus Jurkat lines that lack the Fas-associated death domain (FADD) or receptor-interacting protein kinase 1 (RIP1) cell death regulatory proteins. (aspetjournals.org)
Thus, extracellular nucleotide accumulation during regulated tumor cell death involves interplay between ATP/AMP efflux pathways and different cell-autonomous ectonucleotidases. (aspetjournals.org)
Xiao, L, Haack, KKV & Zucker, IH 2013, ' Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling ', American Journal of Physiology - Cell Physiology , vol. 304, no. 11, pp. (nebraska.edu)
The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2. (ox.ac.uk)
Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaffolding.Here, we identify the human Na(+)/H(+) exchanger 1 (hNHE1) as a membrane scaffold protein for ERK2 and show direct hNHE1-ERK1/2 interaction in cellular contexts. (ox.ac.uk)
Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)

Furthermore to ULK1, the course III phosphatidylinositol 3-kinase Vps34 is necessary for the forming of autophagosomes during pathway initiation. (careersfromscience.org)

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. (ox.ac.uk)
We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished both serum-induced activation of ERK and proliferation of mouse (MBA-15.4) and human (MG-63) osteoblast cell lines. (ox.ac.uk)
Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube -induced fibrogenic and angiogenic responses. (cdc.gov)
Further mechanistic studies revealed that these functions were controlled by the eukaryotic initiation factor (eIF) 4E and the mitogen-activated protein kinase (MAPK) interacting protein kinase (MNK) signaling pathways, which regulate which mRNAs will be translated. (lu.se)

Using a kinase inhibitor, we demonstrate that the enzymatic activity of MINK1 is involved in PRICKLE1-LL5β complex assembly and localization, as well as in cell migration. (hal.science)
To determine whether Ca2+ regulation of P450aldo is mediated through calmodulin or calmodulin-dependent kinases (CaMK), we investigated the actions of calmidazolium (a calmodulin inhibitor) and KN93 (an inhibitor of CaMK) on expression of P450aldo in human adrenocortical H295R cell line. (unical.it)
This inhibition is reversed by cotreatment with the protein synthesis inhibitor, cycloheximide, and by the GC receptor antagonist, RU486, suggesting a classical transcriptional mechanism. (ox.ac.uk)
Phosphatase activity was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate. (ox.ac.uk)
MEN 4 is caused by an inactivating mutation of the CDKN1B gene, which codes for the cyclin dependent kinase inhibitor 1B protein, also known as p27 or p27KIP1. (msdmanuals.com)

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase signaling cascades. (nih.gov)
The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. (wikipedia.org)
RIPK1 also directly regulates caspase-8-mediated apoptosis or, if caspase-8 activity is blocked, RIPK3-MLKL-dependent necroptosis. (nih.gov)

The Arabidopsis cytoplasmic kinase BIK1 is a downstream substrate of several PRR complexes. (uni-koeln.de)
We further show that the cyclic AMP-dependent protein kinase (protein kinase A [PKA]) pathway maintains the cytoplasmic localization of Sip1 in glucose-grown cells. (elsevierpure.com)
However, other cytoplasmic RNA sensors, including the double-stranded RNA-binding protein kinase R (PKR), have been implicated in IFN-alpha/beta production, although their relative contribution and mechanism have been unclear. (ox.ac.uk)

Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
These findings establish a novel mechanism of regulation of Snf1 protein kinase by the PKA pathway. (elsevierpure.com)
This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. (wikipedia.org)
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)

Elevated CO(2) levels caused a rapid activation of AMP-activated protein kinase (AMPK) in AECs, a key regulator of metabolic homeostasis. (ilh-giessen.de)
Activation of AMPK was mediated by a CO(2)-triggered increase in intracellular Ca(2+) concentration and Ca(2+)/calmodulin-dependent kinase kinase-beta (CaMKK-beta). (ilh-giessen.de)
We are currently investigating two protein kinases, namely AMP-activated protein kinase (AMPK) and Salt-inducible kinase 2 (SIK2). (lu.se)
SIK2 is an AMPK-related kinase with abundant expression in adipose tissue. (lu.se)

The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
This evolutionarily conserved process is mediated by cell-surface activation of the downstream effector kinase Akt (also known as Akt1 - Flybase). (silverchair.com)
We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
It binds to downstream elements inseveral vertebrate ribosomal protein genes, where it apparently acts positively to stimulatetranscription and can act either negatively or positively in the context of the immunoglobulin k 3enhancer and immunoglobulin heavy-chain E1 site as well as the P5 promoter of theadeno-associated virus. (careersfromscience.org)

A further chapter discusses how surface membrane G-protein receptors in C. albicans and other fungi transmit external stimuli through 2 major protein kinase cascades. (cdc.gov)

In Saccharomyces cerevisiae, Snf1 protein kinase has three isoforms of the β subunit that confer versatility on the kinase and that exhibit distinct patterns of subcellular localization. (elsevierpure.com)
The Snf1 catalytic subunit also exhibits aberrant localization to the vacuolar membrane in PKA-deficient cells, indicating that PKA regulates the localization of Snf1-Sip1 protein kinase. (elsevierpure.com)
Syndecan-2 expression did not affect the expression of tyrosinase, a key enzyme in melanin synthesis, but instead enhanced the enzymatic activity of tyrosinase by increasing the membrane and melanosome localization of its regulator, protein kinase CβII. (ewha.ac.kr)
How the localization and activity of PI3KC2-β are regulated by mitogens is unknown. (nature.com)
Fig. 4: PKN2 regulates mTORC1 signalling by controlling PI3KC2-β activity and localization. (nature.com)
Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)

Here, we identify the protein phosphatase PP2C38 as a negative regulator of BIK1 activity and BIK1-mediated immunity. (uni-koeln.de)
Hyperactivation of IIS has been implicated in the generation of many different human tumours, which are frequently defective for the tumour-suppressor protein PTEN, a PtdIns(3,4,5)- P 3 phosphatase that directly antagonizes the effects of PI3-kinases( Goberdhan and Wilson,2003b ). (silverchair.com)
This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously . (pp1a.com)
This study adds a PPP-family protein phosphatase to the proteins involved in the control of polar growth and cell shape determination in S. coelicolor. (lu.se)

G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. (utmb.edu)

The role of specific isoforms of 14-3-3 protein in regulating protein kinase activity in the brain. (ox.ac.uk)

Ca 2+ -binding protein calmodulin (CaM) serves as a primary effector of calcium function. (frontiersin.org)
The small and highly expressed Ca 2+ -binding protein calmodulin (CaM) acts as a primary effector of calcium function ( Soderling and Stull, 2001 ). (frontiersin.org)
The precise function of PtdIns(3)P in autophagy is normally unclear, but research claim that PtdIns(3)P recruits particular effector proteins such as for example Atg18/WIPI (22, 23) and DFCP1 (dual FYVE domain-containing proteins 1) (19), both which may are likely involved in autophagosome formation. (careersfromscience.org)

It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. (wikipedia.org)
Given the versatility inherent in this intrinsically disordered region, its multisite phosphorylations, and its divergence within the family, the unique domain likely functions as a central signaling hub overseeing much of the enzymatic activities and unique functions of Src family kinases. (wikipedia.org)

RESEARCH DESIGN AND METHODS- To examine whether hypothalamic protein kinase C (PKC) mediates the ability of central nervous system lipids to activate K ATP channels and regulate glucose production in normal rodents, we first activated hypothalamic PKC in the absence or presence of K ATP channel inhibition. (diabetesjournals.org)
Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus. (ucl.ac.uk)
The chronic effects of PKCd inhibition using either rottlerin or the overexpression of a dominant negative PKCd mutant included the downregulation of eNOS gene expression that was manifested by a decrease in both eNOS promoter activity and protein expression after 24 h of treatment. (vectorbiolabs.com)
Although these effects of PKA inhibition were highly reminiscent of Notch inhibition effects, our data demonstrate that PKA and Notch independently regulate tip and stalk cell formation and behavior. (mdc-berlin.de)
These findings raise the possibility that the pattern of interneuronal activation, and thus lateral inhibition onto principal cells, is not regulated predominately by dendrodendritic synaptic inputs but instead may reflect the temporal coincidence of several types of synaptic inputs to granule cells. (jneurosci.org)

Ca 2+ /CaM binds to the death-associated protein kinase 1 (DAPK1) to regulate intracellular signaling pathways. (frontiersin.org)
Upon Ca 2+ binding, CaM is capable of interacting with hundreds of protein targets to regulate the wealth of intracellular signaling pathways. (frontiersin.org)
Early steps in this transition are complex, with at least 2 signaling pathways identified: 1 stops yeast growth and another, with a heat shock protein 70-type profile, initiates the assembly of proteins necessary for mycelial growth. (cdc.gov)
Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)
Metabolic pathways that regulate TAM phenotypes. (lu.se)

Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)
The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)
c-Src should not be confused with CSK (C-terminal Src kinase), an enzyme that phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. (wikipedia.org)

Active PKN2 phosphorylates PI3KC2-β to trigger PI3KC2-β complex formation with inhibitory 14-3-3 proteins. (nature.com)
c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. (wikipedia.org)
Streptomyces coelicolor modulates polar growth via the Ser/Thr protein kinase AfsK, which phosphorylates DivIVA. (lu.se)

Fig. 2: PKN2 facilitates mTORC1 activation by phosphorylating PI3KC2-β and triggering sequestration by 14-3-3 proteins. (nature.com)
mTORC1 suppresses autophagy and in parallel promotes cell development via the activation of eIF4E and ribosomal S6 proteins kinase (S6K) (15). (careersfromscience.org)
Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)

pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
It includes an SH2 domain, an SH3 domain and a tyrosine kinase domain. (wikipedia.org)
This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)

The Snf1/AMP-activated protein kinase family has diverse roles in cellular responses to metabolic stress. (elsevierpure.com)
The ubiquitous distributions of H 2 S-producing enzymes and potent chemical reactivities of H 2 S in biological systems make H 2 S unique in its ability to regulate cellular and organ functions in both health and disease. (hindawi.com)
The protein is involved in cellular growth and development and has an important role in regulating the cell cycle. (msdmanuals.com)

AKAP palmitoylation was regulated by seizure activity in vivo and LTP/LTD plasticity-inducing stimuli in cultured rat hippocampal neurons . (bvsalud.org)
ANG II induced a significant dose-dependent increase in ACE and decrease in ACE2 mRNA and protein expression in CATH.a neurons. (nebraska.edu)
The CASK protein is primarily found in nerve cells (neurons) in the brain, where it helps control the activity (expression) of other genes that are involved in brain development. (medlineplus.gov)

We have previously shown that GRK2 regulates mast cell functions, and thereby contributes to exacerbated inflammation during allergic reactions. (utmb.edu)
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. (ox.ac.uk)

Microtubule-associated protein/microtubule affinity-regulating kinases (MARKs)/PAR-1 are common regulators of cell polarity that are conserved from nematode to human. (elsevierpure.com)

It regulates tumor growth and various processes leading to breast cancer metastasis. (medscape.com)

Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. (elifesciences.org)
However, the mechanisms regulating lipid metabolism and the storage of lipid during development are less well characterized. (silverchair.com)
Our work therefore reveals a signalling mechanism by which the effect of insulin on lipid metabolism could be regulated independently of some of its other functions during development and adulthood. (silverchair.com)

Taken together, these data suggest that syndecan-2 regulates melanin synthesis and could be a potential therapeutic target for treating melanin-associated diseases. (ewha.ac.kr)

It also regulates the functions and activity of other intracellular proteins in many cell types. (utmb.edu)

CaM binding to the ARD triggers large conformational arrangements of DAPK1 through the disruption of the CD−ARD association, generating a constitutively active kinase. (frontiersin.org)

By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)

Mechanistic target of rapamycin (mTOR) kinase functions in two multiprotein complexes: lysosomal mTOR complex 1 (mTORC1) and mTORC2 at the plasma membrane. (nature.com)

This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
LL5β anchors microtubules at the cell cortex through its association with CLASP proteins to trigger focal adhesion disassembly. (hal.science)
Syndecan-2, a transmembrane heparan sulfate proteoglycan that is highly expressed in melanoma cells, regulates melanoma cell functions (e.g. migration). (ewha.ac.kr)
A mouse catecholaminergic neuronal cell line (CATH.a) was treated with ANG II (30, 100, and 300 nM) for 24 h, and protein expression was determined by Western blot analysis. (nebraska.edu)
Because Th2 cells are the major source of these cytokines during asthma, we determined the role of GRK2 in regulating T cell-specific responses in our HMDE mouse model. (utmb.edu)
Collectively, our studies reveal an important role for GRK2 in regulating T cell response during asthma pathogenesis and further elucidation of the mechanisms through which GRK2 modulates airway inflammation will lead to the development of new therapeutic strategies for asthma. (utmb.edu)
Nutrient restriction represents among the major ways that autophagy is turned on, and in this framework, the recycling of mobile components supplies the cell using a way to obtain ATP and proteins to maintain regular homeostatic procedures (1). (careersfromscience.org)
Microvesicle discharge provides been recommended to lead to the intercellular system of PrP diffusion and prion pass on (Mattei (2005 ) demonstrated that PrPSc stops Bax-mediated cell loss of life by suppressing the conformational adjustments of this proapoptotic proteins. (liveconscience.com)
Various other writers, examining how PrPC could regulate cell destiny, found conflicting results apparently. (liveconscience.com)
MKP-1, but not MKP-3, mRNA expression was 10-fold up-regulated in both mouse and human osteoblast cell lines within 30 min of Dex treatment and remained elevated for 24 h. (ox.ac.uk)

Analysis of the WNK1-dependent transcriptome by RNA-Seq demonstrated that WNK1 regulates the expression of 1858 genes during decidualization. (bioone.org)
Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)
These data show that K(+)-stimulated expression of P450aldo mRNA is regulated in a Ca2+ sensitive manner through mechanisms involving calmodulin and CaMK. (unical.it)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

Tissue-specific deletion of important autophagy genes (ATG) such as for example or has uncovered that autophagy has a cytoprotective function by degrading possibly dangerous aggregated proteins and broken organelles (2C9). (careersfromscience.org)

The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions. (jneurosci.org)
In this respect, we recently illuminated a new mechanism whereby selective modification of mRNA translation regulates TAM immunosuppressive functions. (lu.se)

The protein encoded by this gene belongs to the protein kinase C superfamily. (wikipedia.org)

We studied the mechanisms regulating CO(2)-induced Na,K-ATPase endocytosis in alveolar epithelial cells (AECs) and alveolar epithelial dysfunction in rats. (ilh-giessen.de)

STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)

Raw data for results from screening kinase activity towards T279 of PI3KC2-β are provided in Supplementary Table 2 . (nature.com)
ETU significantly inhibited NO production, eNOS promoter activity, and eNOS protein levels. (vectorbiolabs.com)
Here, we demonstrate that endothelial PKA activity is essential for vascular development, specifically regulating the transition from sprouting to stabilization of nascent vessels. (mdc-berlin.de)
It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix metalloproteinase-9 activity after intracerebral hemorrhage. (wikipedia.org)
and protein kinase activity. (nih.gov)

AKT , also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. (medscape.com)

Anatomy18

Organisms9

Chemicals and Drugs172

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes40

Information Science3

Phosphorylation14

Serine7

Mitogen-Activat1

Extracellular8

Affinity-regula1

Phosphatidylinositol 3-kina1

MAPK4

Inhibitor5

Apoptosis3

Cytoplasmic3

Pathway4

AMPK4

Downstream5

Cascades1

Localization6

Phosphatase4

Receptor kinase1

Isoforms1

Effector3

Family kinases2

Inhibition5

Pathways5

Regulation3

Phosphorylates3

Activation3

Tyrosine4

Cellular3

Neurons3

Contributes2

Polarity1

Tumor growth1

Metabolism3

Synthesis1

Intracellular1

Constitutively active1

Mediates1

COMPLEXES1

Cell10

Expression4

Genes1

Mechanism2

Superfamily1

Epithelial1

Ubiquitously expressed1

Activity5

Belongs1