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Genomic InstabilityDNA ReplicationDNA DamageProtein Kinase CProtein KinasesGenomeRad52 DNA Repair and Recombination ProteinProtein-Serine-Threonine KinasesCyclic AMP-Dependent Protein KinasesCalcium-Calmodulin-Dependent Protein KinasesPhosphorylationGenome, BacterialRad51 RecombinaseMitogen-Activated Protein KinasesProtein Kinase InhibitorsMAP Kinase Signaling SystemGenome, Viralp38 Mitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesCell Cycle ProteinsDNA RepairSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsMolecular Sequence DataEnzyme ActivationDNA Repair EnzymesMitogen-Activated Protein Kinase 1Saccharomyces cerevisiaeRecombination, GeneticProtein Kinase C-alphaAmino Acid SequenceMutationMitogen-Activated Protein Kinase KinasesCheckpoint Kinase 2Signal TransductionProtein Kinase C-deltaMitogen-Activated Protein Kinase 3JNK Mitogen-Activated Protein KinasesSchizosaccharomyces pombe ProteinsAMP-Activated Protein KinasesBase SequenceGenome, PlantGenome, HumanProtein BindingFungal ProteinsSchizosaccharomycesIsoenzymesProtein Kinase C-epsilonProtein Kinase C betaCell Linesrc-Family KinasesIntracellular Signaling Peptides and ProteinsRecombinational DNA RepairTetradecanoylphorbol AcetateCyclic GMP-Dependent Protein KinasesProtein-Tyrosine KinasesEnzyme InhibitorsNuclear ProteinsCells, CulturedCDC2 Protein KinaseDNA, FungalDNA HelicasesKineticsDNA Breaks, Double-StrandedGenome, MitochondrialCell CycleCyclic AMPCasein Kinase IICalcium-Calmodulin-Dependent Protein Kinase Type 2MAP Kinase Kinase KinasesGenome, FungalDNAGenes, cdceIF-2 KinaseTransfectionBlotting, Westernp21-Activated KinasesSequence Analysis, DNAMAP Kinase Kinase 1CalciumExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktSerinePhylogenyRibosomal Protein S6 KinasesRNA, MessengerPhosphoproteinsExonucleasesSubstrate SpecificitySequence Homology, Amino AcidCasein KinasesProto-Oncogene ProteinsBinding SitesCyclin-Dependent KinasesRecombinant ProteinsMAP Kinase Kinase 4Genome SizeCloning, MolecularTime FactorsMeiosis
EukaryoticActivationCell divisComplexFormation
Eukaryotic4
  • Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome. (wikipedia.org)
  • The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to eukaryotes, but the replication machinery in eukaryotic DNA replication is a much larger complex, coordinating many proteins at the site of replication, forming the replisome. (wikipedia.org)
  • Eukaryotic origins of replication control the formation of several protein complexes that lead to the assembly of two bidirectional DNA replication forks. (wikipedia.org)
  • eukaryotic translational initiation aspect-2 kinase 3 (Benefit), inositol-requiring enzyme 1 (IRE1) and activating transcription aspect 6 (ATF6) thus activating these protein. (cgp60474.com)
Activation2
  • Once the pre-RC is formed, activation of the complex is triggered by two kinases, cyclin-dependent kinase 2 (CDK) and Dbf4-dependent kinase (DDK) that help transition the pre-RC to the initiation complex before the initiation of DNA replication. (wikipedia.org)
  • Long term and extreme ER tension induced -cell apoptosis is certainly connected with c-jun N-terminal kinase (JNK) activation [9], [15]. (cgp60474.com)
Cell divis1
  • Association of the origin recognition complex (ORC) with a replication origin recruits the cell division cycle 6 protein (Cdc6) to form a platform for the loading of the minichromosome maintenance (Mcm 2-7) complex proteins, facilitated by the chromatin licensing and DNA replication factor 1 protein (Cdt1). (wikipedia.org)
Complex4
  • The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to eukaryotes, but the replication machinery in eukaryotic DNA replication is a much larger complex, coordinating many proteins at the site of replication, forming the replisome. (wikipedia.org)
  • The pre-RC formation involves the ordered assembly of many replication factors including the origin recognition complex (ORC), Cdc6 protein, Cdt1 protein, and minichromosome maintenance proteins (Mcm2-7). (wikipedia.org)
  • Once the pre-RC is formed, activation of the complex is triggered by two kinases, cyclin-dependent kinase 2 (CDK) and Dbf4-dependent kinase (DDK) that help transition the pre-RC to the initiation complex before the initiation of DNA replication. (wikipedia.org)
  • Meanwhile, the particles caused abnormal co-localization of the key mitotic regulatory kinase Aurora B and the centralspindlin complex by inhibiting the PI3k 110ß/Aurora B pathway. (bvsalud.org)
Formation2
  • Eukaryotic origins of replication control the formation of several protein complexes that lead to the assembly of two bidirectional DNA replication forks. (wikipedia.org)
  • ASiNPs exposure caused microfilaments aggregation and inhibited the PI3k 110ß/Aurora B pathway through excessive ROS, which then hindered the centralspindlin cluster as well as restrained the expression of centralspindlin subunits and cytokinesis-related proteins, which ultimately resulted in cytokinesis failure and the formation of multinucleation. (bvsalud.org)