Protein kinase checkpoint kinase. Medical search. Frequent questions

The 3 RAF genes code for cytoplasmic serine/threonine kinases (ARAF, BRAF, and CRAF) that are activated by binding to RAS. (medscape.com)
Check point kinase 1 (Chk1) is a serine / threonine protein kinase and a key mediator in the DNA damage-induced checkpoint network. (biovendor.com)
Results prove that Nim can be characterized by intrinsic activities associated with serine-kinase, threonine-kinase and tyrosine-kinase. (readabstracts.com)
The researchers discovered that functional defects in HR were associated with PARP inhibitor sensitivity, while functional defects in replication fork protection were associated with checkpoint kinase 1 (CHK1) and serine/threonine protein kinase ATR inhibitor sensitivity. (aacr.org)
Mitotic checkpoint serine/threonine-protein kinase BUB1 is a protein in humans that is encoded by BUB1 gene. (cusabio.com)
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis. (cusabio.com)
serine threonine kinase family memb. (nig.ac.jp)
putative Serine/threonine Kinase [Or. (nig.ac.jp)
T14735 probable serine/threonine kinase (EC 2.7. (nig.ac.jp)
A86427 probable serine/threonine kinase [import. (nig.ac.jp)
serine/threonine kinase [Xenopus lae. (nig.ac.jp)
putative serine/threonine protein kin. (nig.ac.jp)
The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a "caretaker" gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. (oncotarget.com)
HIPK2, a nuclear body localized 1189-amino-acid protein, belongs to the DYRK serine/threonine homeodomain-interacting kinase family [ 16 ]. (oncotarget.com)
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. (nih.gov)
The budding yeast Mec1 is an essential serine/threonine kinase, responsible for mediating the genotoxic stress dependent induction of Rnr3 [4] . (microbialcell.com)

We examined the G2-specific checkpoint signaling response in these cells and found activation of the ATM/chk2-mediated pathway, whereas the ATR/chk1-mediated response was unaffected. (nih.gov)
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. (nih.gov)
The checkpoint kinases Chk1 and Chk2 phosphorylate the carboxy-terminal domain of hBRCA2, a protein involved in recombination-mediated DNA repair (HRR) and replication fork maintenance. (nih.gov)
Phosphorylation of the residue in hBRCA2 targeted by the Chk1 and Chk2 kinases regulates its interaction with Rad51. (nih.gov)
While depletion of Chk1 from cells leads to loss of Rad51 localization to nuclear foci in response to replication arrest, cells lacking Chk2 also show a defect in Rad51 localization, but only in presence of double strand DNA breaks, indicating that each of these kinases may contribute somewhat differently to the formation of Rad51 nucleoprotein filaments depending on the type of DNA damage incurred by the cells. (nih.gov)
ATM and ATR substrates include checkpoint kinases CHK1 and CHK2, which phosphorylate proteins that mediate cell-cycle arrest. (sdbonline.org)
The results indicate that this arrest is secondary to the activation of a CHK2-mediated DNA checkpoint in early embryos. (sdbonline.org)
Checkpoint kinase 2 (Chk2) is one of the critical kinases governing the cell cycle checkpoint, DNA damage repair, and cell apoptosis in response to DNA damaging signals. (cdc.gov)
In the present report, we demonstrate that Chk2 kinase is degraded at the protein level in response to cisplatin through ubiquitin - proteasome pathway. (cdc.gov)
Examination of Chk2 protein revealed a decreased expression of Chk2 protein in cisplatin-resistant ovarian cancer cell lines, suggesting that degradation or decreased expression of Chk2 is partially responsible for chemo-resistance. (cdc.gov)
Site-directed mutation of the putative destruction box in the Chk2 protein did not affect the Chk2 degradation induced by cisplatin. (cdc.gov)
Antisense Inhibition of Chk2/hCds1 Expression Attenuates DNA Damage Induced S and G2 Checkpoints and Enhances Apoptotic Activity in HEK-293 Cells. (nih.gov)
When triggered, ATR phosphorylates different proteins substrates, including replication element MCM2, replication proteins A (RPA), checkpoint kinases Chk2 and Chk1, and apoptotic regulator p53. (accessibletech4all.org)
thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. (utsouthwestern.edu)
Rad53 is an essential kinase that shares 24% and 30% identity with the human CHK1 and CHK2 kinases, respectively. (microbialcell.com)

Atezolizumab is a humanized monoclonal antibody to programmed death-ligand 1 (PD-L1), which acts as a checkpoint inhibitor and is used in the immunotherapy of several forms of advanced or metastatic cancer. (nih.gov)
In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. (readabstracts.com)
also known as PEBP, for phosphatidylethanolamine-binding protein) is an endogenous inhibitor of the Raf- MAPK kinase (MEK)-MAP kinase pathway. (bmj.com)
GENERAL SIGNIFICANCE: Tiliacorinine is a novel multi-kinase inhibitor and possibly a potent anti-cancer agent, in cancers with high activation of EGFR. (bvsalud.org)
Free shipping on inhibitor and protein orders over $500. (adooq.com)
CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM. (adooq.com)
TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively. (adooq.com)
BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines). (adooq.com)
GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). (adooq.com)
Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. (adooq.com)
Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM. (adooq.com)

RAS binds and activates RAF, which phosphorylates and activates MEK1 and MEK2, and these in turn phosphorylate and activate MAP kinases (also known as extracellular signal-regulated kinases ERK1 and ERK2). (medscape.com)
This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. (genetex.com)
Both kinases are shown to phosphorylate Cdc25 on the same sites. (readabstracts.com)

The BUB1B gene provides instructions for making a protein called BUBR1, which is important for proper chromosome separation during cell division. (medlineplus.gov)
A microarray analysis algorithm, EPIG, identified nine IR-responsive patterns of gene expression that were common to the three fibroblast lines, including a dominant p53-dependent G 1 checkpoint response. (nih.gov)
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. (genetex.com)
This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. (genetex.com)
Discovery of New Intronic Small Nucleolar RNAs (snoRNA) Associated with the Ribosomal Protein SA Gene in Fruit Fly, Chicken and Human. (nih.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to support multi-disciplinary projects aimed at the development of new targeted and effective therapies through systematic use and leveraging of recently identified genomic abnormalities and attendant changes in gene and/or protein expression profiles in human oral cancer samples. (nih.gov)
The function of nim1/cdr 1 gene product (Nim1) in enhancing the mitotic process by inhibting the action of mitosis inhibtor Wee1 tyrosine kinase was studied by studying the impact of direct phosphorylation. (readabstracts.com)
Collectively the human genome is composed of 30,000 genes, with each gene carrying the information needed to produce, or synthesise, different proteins. (clinuvel.com)
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) This medical feature of impaired ATR function can be a medical feature of scarcity of another DNA damage-responsive proteins also, BRIT1/microcephalin (MCPH1), the 1st gene defined as causative of major recessive autosomal microcephaly (24, 25). (accessibletech4all.org)
using a yeast two-hybrid screen designed to characterize novel molecules that bind to homeoproteins, the homeodomain-interacting protein kinases (HIPKs), have been proven to be a tumor suppressor and one of the highly conserved factors regulating signaling and gene expressions. (oncotarget.com)
The protein encoded by this gene belongs to the PI3/PI4-kinase family. (utsouthwestern.edu)
We are studying the two most prominent genetic factors in PD-the gene for alpha-synuclein ( SNCA ) and the gene for leucine-rich repeat kinase 2 ( LRRK2 ). (nih.gov)
This gene encodes a member of the never in mitosis gene A family of kinases. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. (researchandmarkets.com)

In metastatic setting, clinical strategies including angiogenesis inhibition with tyrosine kinase inhibitors, as well as immunotherapy against immune checkpoint proteins, such as PD-1/PDL-1 and CTLA-4, have revolutionized the treatment landscape. (urotoday.com)

This degradation was independent of the Thr68 phosphorylation, ATM kinase, and BRCA1 tumor suppressor. (cdc.gov)
Inhibition of the Wee1 kinase also occurred with its phosphorylation by purified Nim1 kinase. (readabstracts.com)
Through this cascade of phosphorylation occasions, ATR regulates DNA replication balance by activating the S stage checkpoint to arrest the cell routine, promoting DNA restoration, inhibiting past due replication source firing, avoiding premature mitotic admittance, and, when harm can be severe, inducing designed cell death. (accessibletech4all.org)
We further show that the deaminase ADAL preferentially catabolizes N 6 -methyl-2'-deoxyadenosine monophosphate (6mdAMP) in vitro and in vivo , and adenylate kinase 1 restricts the phosphorylation rate of 6mdAMP, together contributing to the identified checkpoint. (researchsquare.com)

The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples. (embl.de)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS , and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS , and TRANSCRIPTION FACTORS . (bvsalud.org)
These include adhesion molecules, receptor kinases/phosphatases and immune checkpoint sensors. (yale.edu)
As activation of the TCR complex is highly regulated by a number of competing kinases and phosphatases, the downstream LAT molecule offers several advantages over CD3-zeta as the signaling domain in CARs. (nih.gov)

The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes (anaphase) until each chromosome is properly attached to the spindle. (wikipedia.org)
6. Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells. (nih.gov)

2. Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus. (nih.gov)
3. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. (nih.gov)
This post-translational modification, which involves covalent linkage of one or more ubiquitin molecules to another protein, regulates many fundamental cellular processes. (sdbonline.org)
Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. (nih.gov)

Conference Report - Protein Kinase Inhibitors in Cancer Treatment: Mixing and Matching? (medscape.com)
Atezolizumab like other checkpoint inhibitors has major side effects and particularly immune related conditions, including acute hepatocellular and cholestatic liver injury that can be serious and even life threatening. (nih.gov)

Our current genetic testing protocol for 28 Finnish BRCA1/2-founder mutations and protein truncation test (PTT) of the largest exons is sensitive enough for clinical use as a primary screening tool. (nih.gov)
The current presence of phosphorylated H2AX (-H2AX) provides docking sites to recruit DNA damage-responsive detectors, such as for example MDC1 and NBS1, through their phosphoprotein-interacting BRCA1 C terminus (BRCT) domains, and 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) recruitment of the sensor protein further activates or maintains ATM kinase activity and amplifies ATM signaling (17,C19). (accessibletech4all.org)

Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals and fungi. (brookes.ac.uk)
Mec1 is an ATM/ATR protein, a family of conserved phosphatidylinositol 3-kinase like kinases (PIKKs) best understood for their roles in mediating the DNA damage response (DDR) [5] . (microbialcell.com)

In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. (yeastgenome.org)
11. Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. (nih.gov)
17. Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. (nih.gov)
When the G2 or S checkpoint is abrogated by the inhibition of Chk1, p53- deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. (biovendor.com)
Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. (nih.gov)

Here, we show that the two highly divergent FHA domains of Saccharomyces cerevisiae Rad53p, a protein kinase involved in cell cycle checkpoint control, possess phosphopeptide-binding specificity. (embl.de)
The Rad53 protein kinase of Saccharomyces cerevisiae is required for checkpoints that prevent cell division in cells with damaged or incompletely replicated DNA. (embl.de)

Numerous genes that participate in DNA metabolism were also markedly repressed in arrested fibroblasts apparently as a result of cell synchronization behind the G 1 checkpoint. (nih.gov)
To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. (embl.de)
With proteins required for almost all tasks of cellular life, preserving the integrity of our genes, and therefore DNA, is thus critical to upholding normal cell activity and survival. (clinuvel.com)

The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (phosphosite.org)
The putative mammalian homolog of Nopo was named 'TRAF-interacting protein' (TRIP) based on its ability to bind tumor necrosis factor (TNF) receptor-associated factors (TRAFs) (Lee, 1997). (sdbonline.org)

The cellular response to the introduction of double strand DNA breaks involves complexes of protein interactions that govern cell cycle checkpoint arrest and repair of the DNA lesions. (nih.gov)
This checkpoint has been reconstituted in vitro in Xenopus egg extracts, and here we use antibodies to Xenopus Bub3 (XBub3) to show that this protein is required for both the activation and the maintenance of a spindle checkpoint arrest in egg extracts. (biologists.com)
8. Expression and prognostic significance of the P53-related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA-damage-inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma. (nih.gov)
Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle. (nih.gov)

Using different types of genetic studies, it has been established that diverse kinds of defects are able to activate the SAC: spindle depolymerization, the presence of dicentric chromosomes (with two centromeres), centromeres segregating in an aberrant way, defects in the spindle pole bodies in S. cerevisiae, defects in the kinetochore proteins, mutations in the centromeric DNA or defects in the molecular motors active during mitosis. (wikipedia.org)
Malhotra's research addressed the controversy of Golgi membrane fate during mitosis and identified a new cell-cycle checkpoint. (asbmb.org)
Checkpoints block mitosis in the cell cycle in response to unreplicated or damaged DNA, usually achieved by preventing activation of the cell-division kinase Cdc2. (readabstracts.com)

Upon detection of DNA defects, the kinases ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) are recruited to sites of damage and activated. (sdbonline.org)
In the apex from the replication tension response may be the proteins kinase ataxia telangiectasia-mutated (ATM)3 and Rad3-related (ATR) (5, 6). (accessibletech4all.org)

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. (embl.de)
The Rad9 protein was phosphorylated in response to DNA damage, and phosphorylated Rad9 interacted with the COOH-terminal forkhead homology-associated (FHA) domain of Rad53. (embl.de)

CHK1 checkpoint homolog [Gallus gal. (nig.ac.jp)

We discuss the mechanism by which our α-XBub3 antibodies interfere with the checkpoint and possible roles for XBub3 in the spindle checkpoint pathway. (biologists.com)
Their precise functions in the checkpoint pathway are now the subject of intense study in many model organisms. (biologists.com)

The DNA damage/replication checkpoint plays a crucial role in preserving genomic integrity. (sdbonline.org)
Mutagenesis has shown that Chk1 functions redundantly with Cds1 kinase at the replication checkpoint. (readabstracts.com)

Mark Lemmon A major focus of the Lemmon lab has been to understand transmembrane signaling by growth factor receptor tyrosine kinases (RTKs), of which there are 58 in the human proteome that fall into 20 different families. (yale.edu)
Researchers at the NCI have developed chimeric adaptor proteins (CAPs) consisting of an extracellular targeting domain, transmembrane domain, intracellular LAT domain, and the kinase domain of ZAP70. (nih.gov)
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. (nih.gov)

Using these drugs (see the review from Rieder and Palazzo in 1992), the putative control mechanism was named Spindle Assembly Checkpoint (SAC). (wikipedia.org)
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. (yeastgenome.org)
Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). (yeastgenome.org)

Ligand binding to receptors such as the EGF receptor or HER2 binds activates receptor autophosphorylation, leading to activation of the small GTP-binding protein RAS. (medscape.com)
reported that deletion of liver kinase B1 (LKB1), the upstream kinase that phosphorylates and activates AMPK, led to a nearly complete loss of AMPK activity in the liver of adult mice. (frontiersin.org)
In response to genotoxic stress, Mec1 activates RNR via two downstream kinases Rad53 and Dun1 [11] . (microbialcell.com)

The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. (embl.de)
putative CBL-interacting protein kin. (nig.ac.jp)

Here, we used a global proteomic approach based on high-resolution mass spectrometry to compare the extracellular and intracellular roles of IL-33 in primary human endothelial cells, a major source of IL-33 protein in human tissues. (nature.com)
We found that exogenous extracellular IL-33 cytokine induced expression of a distinct set of proteins associated with inflammatory responses in endothelial cells. (nature.com)

Each of these processes require a unique combination of DNA repair proteins that interact with one another in a sequential manner to identify, remove and repair any acquired damage within our DNA. (clinuvel.com)

This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. (utsouthwestern.edu)
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. (nih.gov)

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (nih.gov)
To ensure faithful transmission of the genome upon cell division, eukaryotic cells have developed checkpoints, regulatory pathways that delay cell-cycle progression until completion of prior events. (sdbonline.org)
Phospho-kinases arrays were used to screen the affected signaling pathways after baclofen treatment, and the candidate signaling molecules were validated using the public transcriptomic data and western blot. (bvsalud.org)

FHA domains are conserved sequences of 65-100 amino acid residues found principally within eukaryotic nuclear proteins, but which also exist in certain prokaryotes. (embl.de)

Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells. (cdc.gov)
By heavy stable isotope tracing, we demonstrate that intracellular degradation of RNA m6A cannot induce any misincorporated DNA 6mA, unveiling the existence of a catabolism checkpoint that blocks DNA 6mA misincorporation. (researchsquare.com)

These mutations reduce the amount of BUBR1 protein in cells or impair the protein's ability to function. (medlineplus.gov)
We use x-ray crystallography to solve structures of these membrane proteins with the hope that the structural knowledge will shed light on their mechanism of action, explain mutations that cause human disease, and help drug development. (yale.edu)

E3s can be divided into two main classes: HECT and RING domain-containing proteins. (sdbonline.org)

Illustrative topics that we have addressed include: discovering how a Rho effector kinase is autoregulated, defining a unique kinase-substrate interaction that controls actin depolymerization, and discovering new pseudoGTPase domains in an important RhoGAP protein. (yale.edu)

The forkhead-associated (FHA) domain [ ( PUBMED:7482699 ) ] is a phosphopeptide recognition domain found in many regulatory proteins. (embl.de)

The defining biochemical feature of this checkpoint is the stimulation of the anaphase-promoting complex by M-phase cyclin-CDK complexes, which in turn causes the proteolytic destruction of cyclins and proteins that hold the sister chromatids together. (wikipedia.org)

Kathryn Ferguson We use X-ray crystallography and a wide range of biophysical techniques to understand the relationship between receptor structure and activation,with a particular focus on the receptor tyrosine kinases (RTKs). (yale.edu)

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human colon cancer by immunohistochemical analysis. (genetex.com)
ATR (phospho Thr1989) antibody detects ATR protein at nucleus in human lung cancer by immunohistochemical analysis. (genetex.com)
It has emerged as a significant metastasis suppressor in a variety of human cancers including colorectal cancer (CRC) and was recently shown to regulate the spindle checkpoint in cultured cells. (bmj.com)
Our studies primarily target proteins found onthe surface of cancer cells. (yale.edu)

Found in eukaryotic and prokaryotic proteins. (embl.de)

The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)
These findings indicate that the FHA domain is a phospho-specific protein-protein interaction motif and have important implications for mechanisms of intracellular signaling in both eukaryotes and prokaryotes. (embl.de)

Background Transmission transducers and activators of transcription (STAT) proteins are critical transcription element that are aberrantly activated in various types of malignancies including renal cell carcinoma (RCC). (biospraysehatalami.com)

The exact mechanism by which this protein contributes to the oncogenic process is not known. (nih.gov)

Viral RNA-host proteins interactions are crucial for replication of flaviviruses a genus of positive-strand RNA infections comprising main vector-borne individual pathogens including dengue infections (DENV). (biospraysehatalami.com)
The spindle checkpoint delays the onset of anaphase if there are any defects in the interactions between spindle microtubules and kinetochores. (biologists.com)
Ubiquitination may alter the fate of a protein in numerous ways, such as targeting it for destruction by the 26S proteasome, changing its subcellular location, or changing its protein-protein interactions (Merkle, 2009). (sdbonline.org)
The FHA domain is thought to mediate protein-protein interactions, but its mode of action has yet to be elucidated. (embl.de)

We examined the effect of de novo Tax expression upon the cell cycle, because appropriate activation of cell cycle checkpoints is essential to a robust damage-repair response. (nih.gov)
Taken together these data suggest that the TSS describe a unique nuclear site involved in DNA damage recognition, repair response, and cell cycle checkpoint activation. (nih.gov)
Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. (nih.gov)

Only one form of XBub3 is apparent in Xenopus tissue culture (XTC) cells,and localisation studies reveal that, unlike the Mad proteins, which are concentrated at the nuclear periphery, XBub3 is diffusely localised throughout the nucleus during interphase. (biologists.com)

Molecular docking simulations were applied to predict the binding affinity and orientation of tiliacorinine to the possible binding site(s) of the target proteins. (bvsalud.org)

Anatomy14

Organisms6

Diseases1

Chemicals and Drugs159

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes60

Information Science3

Health Care1

Serine16

Chk215

Inhibitor12

Phosphorylate3

Gene15

Tyrosine kinase1

Phosphorylation4

Phosphatases4

Mitotic checkpoint2

Regulates4

Inhibitors2

BRCA12

Family of conserved2

Inhibition5

Saccharomyces2

Genes3

Tumor2

Arrest4

Mitosis3

Ataxia2

RAD92

Homolog1

Pathway2

Replication checkpoint2

Transmembrane3

Spindle Assembly Checkpoint3

Activates3

Putative2

Extracellular2

Repair proteins1

Response to DNA damage2

Pathways3

Nuclear proteins1

Degradation2

Mutations2

Domain-containi1

Effector1

Regulatory proteins1

Cyclins1

Receptor1

Cancer4

Eukaryotic1

Interaction2

Transcription1

Oncogenic1

Interactions4

Cell cycle3

Xenopus1

Target proteins1