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  • cytosolic
  • However, the ratio of particulate to cytosolic PKC epsilon in red muscles from fat-fed rats was increased nearly sixfold, suggesting chronic activation. (garvan.org.au)
  • Mitochondrial and cytosolic proteins from control and transgenic hearts with constitutively active or dominant negative PKCvarepsilon were analyzed using difference in-gel electrophoresis (DIGE). (cam.ac.uk)
  • Structurally, the TRP channels are tetrameric integral membrane proteins whose monomeric subunits display a domain structure characterized by six transmembrane segments (S1-S6), C- and N-cytosolic domains, and an aqueous pore region structured by S5 and S6 segments and their connecting loop. (frontiersin.org)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • PKCs
  • All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain. (ebi.ac.uk)
  • cellular functions
  • This kinase showed involvement in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. (marketresearch.com)
  • This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. (nih.gov)
  • 2016
  • According to a featured news and press release in 2016, Bryostatin (a PKC epsilon activator) produces new synapses through accumulation of the synaptic anchoring protein PSD-95 at neuronal membranes. (prnob.com)
  • insulin
  • We have tested the hypothesis that changes in the levels and cellular location of protein kinase C (PKC) isozymes might be associated with the development of insulin resistance in skeletal muscles from the high-fat-fed rat. (garvan.org.au)
  • activity
  • PKC-epsilon activity was well preserved after 16-h cryopreservation at -20 degrees C in the presence of mannose 9-N-acetylglucosamine 2 (Man9-GlcNAc2) (1 mM), an HMOS, while the activity was reduced to 15% without Man9-GlcNAc2. (biomedsearch.com)