• In order to investigate any effect of truncated mutant huntingtin (tNhtt) aggregation on protein kinase C (PKC) signaling in Huntington's disease (HD), we studied a possible association of PKC isoforms with the aggregates using cellular and transgenic models of HD. (mysciencework.com)
  • In this report we describe an association of mutant tNhtt with at least three PKC isoforms (alpha, delta, zeta), as revealed by co-immunoprecipitation assays and immunocytochemistry in a cellular model of HD (Neuro2a cells expressing tNhtt-150Q-EGFP), as well as a specific association of PKC delta with intranuclear aggregates in a transgenic model (R6/2 mice). (mysciencework.com)
  • The signaling pathway for protein kinase C (PKC) activation and the role of PKC isoforms in LPS-induced nitric oxide (NO) release were studied in RAW 264.7 macrophages. (semanticscholar.org)
  • Among the differentially expressed proteins were creatine kinase, pyruvate kinase, lactate dehydrogenase, and the cytosolic isoforms of aspartate amino transferase and malate dehydrogenase, the two enzymatic components of the malate aspartate shuttle, which are required for the import of reducing equivalents from glycolysis across the inner mitochondrial membrane. (cam.ac.uk)
  • The serine/threonine-specific kinase CK1 delta a member of the CK1 (casein kinase 1) gene family is ubiquitously expressed, is p53 dependently induced in stress situations and plays an important role in various cellular processes, including cell cycle progression, cell proliferation, apoptosis, chromosome segregation, and DNA repair and recombination processes. (egms.de)
  • PKCδ is a novel class serine/threonine kinase of the PKC family, and functions in a number of cellular activities including cell proliferation, survival or apoptosis. (biomedcentral.com)
  • Multisite phosphorylation of Bcl-2 via protein kinase Cδ facilitates apoptosis of hypertrophic cardiomyocytes. (semanticscholar.org)
  • In the present study, we investigated whether the chronic effects of Ang II via AT1 receptor (AT1R) would result in endoplasmic reticulum (ER) stress/PKC-delta/p38 MAPK stimulation, and consequently podocyte apoptosis. (springer.com)
  • Together, our results indicate that Ang II-induced podocyte apoptosis is associated with AT1R/ER stress/PKC-delta/p38 MAPK axis and enhanced NHE1-mediated pHi recovery rate. (springer.com)
  • Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. (wikipedia.org)
  • Here, we overexpressed mouse DGK η in human embryonic kidney 293 cells to examine substrate specificity and signaling downstream of endogenous G protein-coupled receptors (GPCRs). (aspetjournals.org)
  • The use of different CK1 delta fragments baring specific amino acid substitutions as substrates coupled with two dimensional phosphopeptide and phosphoamino acid analyses, indicates that PKA phosphorylates predominantly serine residues within the C-terminal regulatory domain. (egms.de)
  • CK1 delta mutants with alanine substitutions at serine residues targeted by PKA exhibited a reduced kinase activity. (egms.de)
  • Alterations in the CK1 delta expression and/or activity level have been shown to contribute to the development and resistance of tumors. (egms.de)
  • 10 Several molecules, including transcription factors and their intermediates, have been found to be involved in the regulation of this process and the perturbation of the expression and activity of these proteins leads to alterations in platelet number, morphology or function. (haematologica.org)
  • We have recently demonstrated that modulation of the gap junction protein, connexin43, can affect the response of osteoblasts to fibroblast growth factor 2 in a protein kinase C-delta-dependent manner. (biomedcentral.com)
  • We establish that protein kinase C-delta physically interacts with connexin43 during fibroblast growth factor 2 signaling, and that protein kinase C delta preferentially co-precipitates phosphorylated connexin43. (biomedcentral.com)
  • Connexin43 can serve as a direct docking platform for the recruitment of protein kinase C-delta in order to affect fibroblast growth factor 2 signaling in osteoblasts. (biomedcentral.com)
  • Zhang, Keane, Zhu, Sharma, Rozengurt, Strieter, Dubinett, Huang: Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. (antibodies-online.com)
  • Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease. (mysciencework.com)
  • Immunoblot analysis of isolated nuclear fractions shows an elevation of nuclear PKC delta in transgenic brain tissue. (mysciencework.com)
  • Our results suggest that the association of PKC delta with intranuclear htt-aggregates may affect its apoptotic function in a transgenic model of HD. (mysciencework.com)
  • Mitochondrial and cytosolic proteins from control and transgenic hearts with constitutively active or dominant negative PKCvarepsilon were analyzed using difference in-gel electrophoresis (DIGE). (cam.ac.uk)
  • We demonstrate that CSC-like populations derived from multiple types of human primary tumors, from human cancer cell lines, and from transformed human cells, require PKCδ activity and are susceptible to agents which deplete PKCδ protein or activity. (biomedcentral.com)
  • Using a Neuro2a cell line expressing tNhtt with the nuclear localization signal, we demonstrate the association of PKC delta with intranuclear aggregates and present evidence that accumulation of PKC delta in cell nuclei does not depend on mutant htt nuclear translocation. (mysciencework.com)
  • PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. (ebi.ac.uk)
  • The activity of CK1 delta is modulated by several mechanisms, among them subcellular compartimentation, autophosphorylation, dephosphorylation and site-specific cleavage by proteases. (egms.de)
  • Jiao, Wang, Liu, Wang, Xue: Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. (antibodies-online.com)
  • These data suggest that PKA plays an important role as a physiological regulator of CK1 delta. (egms.de)
  • Chen, Nguyen, Shively: Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. (antibodies-online.com)
  • All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain. (ebi.ac.uk)
  • The foot processes interdigitate with the counterparts of neighboring cells to form a slit diaphragm composed of proteins, such as nephrin and p-cadherin. (springer.com)