Loading...
  • atypical
  • Thus, conventional and novel PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and ι / λ isoforms) require neither Ca2+ nor diacylglycerol for activation. (wikipedia.org)
  • Biol
  • I have started measuring in-situ Protein Kinase C activity in permeabilized cells grown in 96-well plates, based on a few references from the literature such as: Heasley L.E., J.Biol.Chem. (bio.net)
  • Substrates
  • While the catalytic domain of these kinases is highly conserved , the sequence variation that is observed in the kinome (the subset of genes in the genome that encode kinases) provides for recognition of distinct substrates. (wikipedia.org)
  • Activated Akt can then go on to activate or deactivate its myriad substrates (e.g. mTOR) via its kinase activity. (wikipedia.org)
  • 1. ROCK is a key regulator of actin organization and thus a regulator of cell migration as follows: Different substrates can be phosphorylated by ROCKs, including LIM kinase, myosin light chain (MLC) and MLC phosphatase. (wikipedia.org)
  • Inhibitor
  • Ponatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy. (drugbank.ca)
  • Tafinlar is a kinase inhibitor that was initially indicated as a single agent for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test [FDA label]. (drugbank.ca)
  • Ceritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. (drugbank.ca)
  • mediates
  • Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. (ebi.ac.uk)
  • This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. (wikipedia.org)
  • regulation
  • Protein kinase A has several functions in the cell, including regulation of glycogen , sugar , and lipid metabolism . (wikipedia.org)
  • Regulation of AMPK by CaMKK2 requires a direct interaction of these two proteins via their kinase domains. (wikipedia.org)
  • MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (wikipedia.org)
  • novel
  • Broad in its range of techniques and thoroughly detailed to help ensure experimental success, Protein Kinase Protocols offers both novice and experienced investigators powerful tools for understanding the functional roles of specific protein kinases within signaling cascades and for identification and evaluation of novel therapeutic targets. (springer.com)
  • Protein kinase C, epsilon is a novel type of protein kinase C (nPKC). (ebi.ac.uk)
  • domain
  • All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain. (ebi.ac.uk)
  • Similar to Src, it contains an SH2 domain, an SH3 domain and the tyrosine kinase domain (SH1, Src homology 1 domain). (ebi.ac.uk)
  • The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. (wikipedia.org)
  • The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and that the coiled-coil domains are required for stable dimer formation. (wikipedia.org)
  • The conserved hydrophobic motif at the C-terminal extension of the kinase domain is bound to the N-terminal lobe of the kinase domain, despite being unphosphorylated. (wikipedia.org)
  • citation needed] Akt possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. (wikipedia.org)
  • PKR contains an N-terminal dsRNA binding domain (dsRBD) and a C-terminal kinase domain, that gives it pro-apoptotic (cell-killing) functions. (wikipedia.org)
  • The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. (wikipedia.org)
  • The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. (wikipedia.org)
  • structures
  • CATH is a hierarchical classification of protein model structures. (ebi.ac.uk)
  • The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their amino acid sequences and three-dimensional structures. (ebi.ac.uk)
  • It also appears to regulate the production and function of important structures inside muscle cells by interacting with other proteins. (wikipedia.org)