• Through RNA splicing mechanisms, mRNA has the ability to select different protein-coding segments (exons) of a gene, or even different parts of exons from RNA to form different mRNA sequences. (wikipedia.org)
  • this process is regulated by the alternative splicing of mRNA, though it is not clear to what extent such a process affects the diversity of the human proteome, as the abundance of mRNA transcript isoforms does not necessarily correlate with the abundance of protein isoforms. (wikipedia.org)
  • Alternative splicing is the main post-transcriptional modification process that produces mRNA transcript isoforms, and is a major molecular mechanism that may contribute to protein diversity. (wikipedia.org)
  • At both the mRNA and protein levels, most AKR isoforms were highly expressed in the upper regions of the intestine, namely, the duodenum and jejunum, and then declined toward the rectum. (aspetjournals.org)
  • Significance Statement In this study, we comprehensively determined the mRNA and protein expression profiles of AKR and SDR isoforms involved in xenobiotic metabolism in the human intestine and found that most of them are highly expressed in the upper region, where AKR1B10, AKR7A3, and CBR1 are predominantly expressed. (aspetjournals.org)
  • any "of several different forms of the same protein, arising from either single nucleotide polymorphisms, [4] differential splicing of mRNA, or post-translational modifications (e.g. sulfation, glycosylation, etc.)" [5] is called an isoform , or protein isoform . (wikidoc.org)
  • Subcellular localization analysis indicated that p35 (p35f and p35iso) expression leads to the formation of stress granules, cellular structures that package mRNA and RNA-binding proteins during cell stress. (elsevierpure.com)
  • Collectively, this study demonstrates that the 35-kDa isoforms of TDP-43 assemble in stress granules, suggesting that TDP-43 plays an important role in translation, stability, and metabolism of mRNA. (elsevierpure.com)
  • The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • The discovery of isoforms could explain the discrepancy between the small number of protein coding regions of genes revealed by the human genome project and the large diversity of proteins seen in an organism: different proteins encoded by the same gene could increase the diversity of the proteome. (wikipedia.org)
  • the ability to create catalytically different proteins from the same gene increases the diversity of the proteome. (wikidoc.org)
  • See 8 reference sequence protein isoforms for the NEIL2 gene. (nih.gov)
  • See 40 reference sequence protein isoforms for the FANCC gene. (nih.gov)
  • Our data provide support for the model of a sweet-spot of Ras dosage mediating isoform-specific contributions to cancer and development. (nature.com)
  • Characterization of the impact of alternative splicing on protein dynamics: the cases of glutathione S-transferase and ectodysplasin-A isoforms. (irbbarcelona.org)
  • In this work, we have addressed this issue using molecular dynamics simulations of the isoforms of two model proteins: glutathione S-transferase and ectodysplasin-A. We have found that AS does not have a noticeable impact on global or local structure fluctuations. (irbbarcelona.org)
  • The genes of the human low Mr phosphotyrosine protein phosphatase (PTPase) isoforms 1 (IF1) and 2 (IF2) were isolated by screening a human placenta cDNA library, cloned in pGEX and expressed in E. coli as fusion proteins with glutathione S-transferase. (unifi.it)
  • In the present study, proteins from female mouse hypothalamus that associate with PR were isolated using affinity pull-down assays with glutathione S-transferase-tagged mouse PR-A and PR-B. Using complementary proteomics approaches, reverse phase protein array (RPPA) and mass spectrometry, we identified hypothalamic proteins that interact with PR in a ligand-dependent and isoform-specific manner and were confirmed by Western blot. (utmb.edu)
  • A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. (wikipedia.org)
  • Finally, direct measurement of mutant versus wildtype KRAS protein abundance revealed a frequent imbalance that may suggest additional non-gene duplication mechanisms for optimizing oncogenic Ras dosage. (nature.com)
  • Protein A, B and C are isoforms encoded from the same gene through alternative splicing . (wikidoc.org)
  • Different forms of a protein may be produced from different but related genes , or may arise from the same gene by alternative splicing . (wikidoc.org)
  • A large number of isoforms are caused by single nucleotide polymorphisms , small genetic differences between alleles of the same gene. (wikidoc.org)
  • The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. (ehu.eus)
  • The FAM111B gene provides instructions for making a protein whose function is not well understood. (medlineplus.gov)
  • The FAM111B gene mutations that cause POIKTMP result in production of an abnormal FAM111B protein from one copy of the gene in each cell. (medlineplus.gov)
  • The version produced from the MYBPC1 gene, which is known as the slow skeletal isoform, is found primarily in skeletal muscles. (medlineplus.gov)
  • Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. (medlineplus.gov)
  • Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. (bvsalud.org)
  • With the extensive development of protein bioinformatics, the characterization and modeling of isoform features, isoform functions, and isoform-level networks have advanced notably. (umich.edu)
  • Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. (rupress.org)
  • Regulation of a truncated isoform of AMP-activated protein kinase α (AMPKα) in response to hypoxia in the muscle of Pacific oyster Crassostrea gigas. (univ-brest.fr)
  • Consistent with a role in transcriptional regulation, PR associated with transcription factors and coactivators in a ligand-specific and isoform-dependent manner. (utmb.edu)
  • We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)
  • Determining specificity becomes more complicated when a protein has multiple subunits and each subunit has multiple isoforms. (wikipedia.org)
  • Chromatin-bound cohesin is removed from chromosome arms by the prophase pathway but protected at centromeres by shugoshin 1 (Sgo1) and associated protein phosphatase 2A (PP2A) until cohesin's Scc1 subunit is proteolytically cleaved at the metaphase to anaphase transition and sister chromatids separate. (uni-bayreuth.de)
  • Premature centriole disengagement caused by Sgo1 depletion was consistently rescued by expression of a fusion protein consisting of the regulatory subunit of PP2A and the CTS. (uni-bayreuth.de)
  • In this study, we show that an isoform specific interaction between PKC epsilon and filamentous actin may serve as a necessary prelude to the enhancement of glutamate exocytosis from nerve terminals. (rupress.org)
  • Using a combination of cosedimentation, overlay, and direct binding assays, we demonstrate that filamentous actin is a principal anchoring protein for PKC epsilon within intact nerve endings. (rupress.org)
  • The binding of PKC epsilon to actin required that the kinase be activated, presumably to expose a cryptic binding site that we have identified and shown to be located between the first and second cysteine-rich regions within the regulatory domain of only this individual isoform of PKC. (rupress.org)
  • Once established, this protein-protein interaction securely anchored PKC epsilon to the cytoskeletal matrix while also serving as a chaperone that maintained the kinase in a catalytically active conformation. (rupress.org)
  • Thus, actin appears to be a bifunctional anchoring protein that is specific for the PKC epsilon isoform. (rupress.org)
  • Transcript abundance is often used as a proxy for the abundance of protein isoforms, though proteomics experiments using gel electrophoresis and mass spectrometry have demonstrated that the correlation between transcript and protein counts is often low, and that one protein isoform is usually dominant. (wikipedia.org)
  • Three-dimensional protein structure comparisons can be used to help determine which, if any, isoforms represent functional protein products, and the structure of most isoforms in the human proteome has been predicted by AlphaFold and publicly released at isoform.io. (wikipedia.org)
  • Cell surface proteins form a major fraction of the druggable proteome and can be used for tissue-specific delivery of oligonucleotide/cell-based therapeutics. (bioconductor.org)
  • The recombinant proteins were purified by a rapid one-step procedure allowing each enzyme to purify with high final yield and specific activity. (unifi.it)
  • Localization studies of various isoforms of Sgo1 identified a peptide encoded by an alternatively spliced exon, which not only directs human Sgo1 to centrosomes but at the same time also abrogates its association with centromeres. (uni-bayreuth.de)
  • Importantly, localization closely correlates with function as revealed by rescue experiments: Whereas centromere-associated isoforms of Sgo1 protect only sister chromatid cohesion, centrosomally bound variants exclusively preserve centriole engagement. (uni-bayreuth.de)
  • Cellular localization of the atypical isoforms of protein kinase C (aPKCζ/PKMζ and aPKCλ/ι) on the neuromuscular synapse. (illumina.com)
  • Alternatively spliced surface protein isoforms have been shown to differ in their subcellular localization and/or their transmembrane (TM) topology. (bioconductor.org)
  • Each unique sequence produces a specific form of a protein. (wikipedia.org)
  • View conserved domains detected in this protein sequence using CD-search. (nih.gov)
  • Recent studies have shown how alternative splicing (AS), the process by which eukaryotic genes express more than one product, affects protein sequence and structure. (irbbarcelona.org)
  • Here, we identified by sequence comparison in several mammals that c-FLIP R and not the widely studied c-FLIP S is the evolutionary ancestral short c-FLIP protein. (ashpublications.org)
  • Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. (medlineplus.gov)
  • Isoforms at the RNA level are readily characterized by cDNA transcript studies. (wikipedia.org)
  • Isoforms are readily described and discovered by microarray studies and cDNA libraries. (wikidoc.org)
  • Glucose transport can be activated in skeletal muscle in response to insulin via activation of phosphoinositide (PI) 3-kinase and in response to contractions or hypoxia, presumably via activation of 5′ AMP-activated protein kinase (AMPK). (diabetesjournals.org)
  • Isoform-specific AMPK activity was measured in skeletal muscle in response to insulin, contraction, or hypoxia. (diabetesjournals.org)
  • In conclusion, obesity-related insulin resistance is associated with an isoform-specific impairment in AMPKα1 in response to contraction. (diabetesjournals.org)
  • AMP-activated protein kinase α (AMPKα) is a key regulator of energy balance in many model species during hypoxia. (univ-brest.fr)
  • In both smooth and striated muscles, the amount of full-length AMP-activated protein kinase α (AMPKα) remained unchanged during hypoxia. (univ-brest.fr)
  • They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)
  • Although ~95% of multi-exonic genes are thought to be alternatively spliced, one study on noisy splicing observed that most of the different low-abundance transcripts are noise, and predicts that most alternative transcript and protein isoforms present in a cell are not functionally relevant. (wikipedia.org)
  • Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10 (isoform A) and LAcmvIL-10 (isoform B). The cmvIL-10 protein is the best characterized, both structurally and functionally, and has many immunosuppressive activities similar to cIL-10, while LAcmvIL-10 has more restricted biological activities. (st-andrews.ac.uk)
  • The FAM111B protein, which is found in many parts of the body, contains a functional region called a peptidase domain. (medlineplus.gov)
  • Hormone-activated PRs associate with multiple proteins to form functional complexes. (utmb.edu)
  • Annotation of Alternatively Spliced Proteins and Transcripts with Protein-Folding Algorithms and Isoform-Level Functional Networks. (umich.edu)
  • Here we present applications of the I-TASSER family of algorithms for folding and functional predictions and the IsoFunc, MIsoMine, and Hisonet data resources for isoform-level analyses of network and pathway-based functional predictions and protein-protein interactions. (umich.edu)
  • The protein products of the three Ras genes are almost identical. (nature.com)
  • There are three Ras genes that generate four almost identical proteins: HRAS, NRAS, KRAS4A and KRAS4B [ 2 ]. (nature.com)
  • While many perform the same or similar biological roles, some isoforms have unique functions. (wikipedia.org)
  • These proteins play essential roles in muscle cell structures called sarcomeres, which generate the mechanical force needed for muscles to contract. (medlineplus.gov)
  • 2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
  • Expression, purification and preliminary crystal analysis of the human low Mr phosphotyrosine protein phosphatase isoform 1. (unifi.it)
  • Great to see our new paper finally out in Genome Research describing how many cryptic promoters drive in fact the expression of alternative proteins. (pelechanolab.com)
  • Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast. (pelechanolab.com)
  • The promoters are usually tissue specific, so different tissues express different isoforms. (aao.org)
  • It was reported that an alternatively spliced isoform of Sgo1 localizes and functions at centrosomes rather than centromeres. (uni-bayreuth.de)
  • Cloning of the IL22RA2 alternatively spliced exon into an unrelated cytokine, IL-2, bestowed similar characteristics on the resulting protein. (ehu.eus)
  • Furthermore, our results showed that the three alternatively spliced isoforms lacked translational response to type I IFN stimulation. (urosario.edu.co)
  • In the cornea, high levels of an alternatively spliced isoform, soluble VEGF receptor 1 (sVEGFR-1), are expressed. (aao.org)
  • However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and RASopathies. (nature.com)
  • Importantly, HRAS, KRAS and NRAS protein abundance was never formally measured in these studies to see whether they conformed with the predicted influence of rare codons. (nature.com)
  • abstract = "TAR DNA-binding protein-43 (TDP-43) has been recently identified as a major component of the ubiquitinated inclusions found in frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis, diseases that are collectively termed TDP-43 proteinopathies. (elsevierpure.com)
  • The analyses demonstrate that the complexes between the isoforms and IL-10R1 present different types of molecular interactions and consequently different affinities and stabilities. (st-andrews.ac.uk)
  • This most likely occurs from defects in postreceptor insulin signal transduction at the level of insulin receptor substrate-1 and phosphoinositide (PI) 3-kinase ( 6 - 9 ) as well as defects in trafficking and/or function of GLUT4 ( 10 , 11 ), the major insulin-regulated GLUT isoform expressed in skeletal muscle ( 12 ). (diabetesjournals.org)
  • these proteins are found in muscles used for movement (skeletal muscles) and in heart (cardiac) muscle. (medlineplus.gov)
  • The slow isoform of myosin binding protein C is active during the development of skeletal muscles. (medlineplus.gov)
  • How does a family of Ras proteins that share a common set of activators and effectors generate isoform-specific engagement with cancer-associated signaling networks? (nature.com)
  • Moreover, it is unclear whether these protein isoforms are able to bind the cellular IL-10 receptor and induce signalling. (st-andrews.ac.uk)
  • Using computational methods, we carried out molecular modelling studies on the three-dimensional structures of the HCMV IL-10 proteins encoded by the transcripts detected in our work (cmvIL-10 (A), LAcmvIL-10 (B), E, F and H) and on their interaction with the human IL-10 receptor (IL-10R1). (st-andrews.ac.uk)
  • Furthermore, the in silico simulations (molecular dynamics simulation and normal-mode analyses) allowed us to evaluate regions that contain potential receptor binding sites in each isoform. (st-andrews.ac.uk)
  • The cellular FLICE-inhibitory protein (c-FLIP) is a modulator of death receptor-mediated apoptosis and plays a major role in T- and B-cell homeostasis. (ashpublications.org)
  • In contrast to stretch-mediated inositol phosphate accumulation, PKCε translocation is not prevented by AT 1 receptor blockade, indicating that this PKC isoform can be activated in response to mechanical deformation by an Ang II-independent mechanism in the adult myocardium. (wustl.edu)
  • Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor- Isoform Specific and Required for Adaptive Thermogenesis. (deiodinase.org)
  • Our previous studies with a thyroid hormone receptor- (TR ) isoform-selective agonist demonstrated that after TR stimulation alone, adaptive thermo- genesis was markedly impaired, although UCP-1 expression in BAT was normal. (deiodinase.org)
  • Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. (utmb.edu)
  • As this isoform is soluble, it is present in the extracellular matrix and serves as an endogenous VEGF trap or decoy receptor. (aao.org)
  • We found that the isoforms were differentially expressed within each genotype in controls and patients with and without autoantibodies. (urosario.edu.co)
  • NRAS»HRAS protein expression in cells that correlate with the rank order of Ras mutation frequencies in cancer. (nature.com)
  • We suggest that in most cases, being the most abundant Ras isoform correlates with occupying the sweet-spot and that HRAS and NRAS expression is usually insufficient to promote oncogenesis when mutated. (nature.com)
  • Among the members in the SDR superfamily, CBR1 and DHRS4 were highly expressed in the upper regions, whereas the expression levels of the other isoforms were almost uniform in all regions. (aspetjournals.org)
  • This expression profile in the human intestine was greatly different from that in the human liver, where AKR1C isoforms are predominantly expressed. (aspetjournals.org)
  • The correlation between slow fibre phenotype and strength of innervation suggests a relationship between synaptic structure and expression of troponin isoforms. (biologists.com)
  • Both the NOD mouse and human Deaf1 variant isoforms suppressed PTA expression by inhibiting the transcriptional activity of canonical Deaf1. (nih.gov)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • These results suggest that the euxanthone-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-α, -β, -δ, -λ and -ζ isoforms. (edu.hk)
  • Because the human and mouse CCR7 promoter contain Sterol Response Elements (SREs), we hypothesized that Sterol Regulatory Element Binding Proteins (SREBPs) are involved in increasing CCR7 expression and through this mechanism, statins would promote CD68+ cell emigration from plaques. (nsdfu.org)
  • The knowledge about structure and expression of specific viral IL-10 isoforms has implications for understanding of their properties and role in HCMV immune evasion and pathogenesis. (st-andrews.ac.uk)
  • The mitogenic action of VEGF , a potent hypoxia -induced angiogenic factor , was increased by 2-fold in retinal endothelial cells by the overexpression of PKC beta 1 or beta 2 isoforms and inhibited significantly by the overexpression of a dominant-negative PKC beta 2 isoform but not by the expression of PKC alpha, delta , and zeta isoforms . (bvsalud.org)
  • To examine PKC isoform expression and activation under these conditions, whole- heart extracts were examined by immunoblot analysis. (wustl.edu)
  • Heat production from BAT requires sympathetic nervous system stimulation, T3, and uncoupling protein 1 (UCP1) expression. (deiodinase.org)
  • The p48 and p44 isoforms also had impaired protein expression governed by the 3' end of the transcripts. (urosario.edu.co)
  • The specificity of translated isoforms is derived by the protein's structure/function, as well as the cell type and developmental stage during which they are produced. (wikipedia.org)
  • Here, we present the crystal structure of the catalytic domain of human SENP7 bound to SUMO2, revealing structural key elements for the SUMO2 isoform specificity of SENP7. (uab.cat)
  • In particular, we describe the specific contacts between SUMO2 and a unique insertion in SENP7 (named Loop1) that is responsible for the SUMO2 isoform specificity. (uab.cat)
  • Activation of protein kinase C (PKC) enhances the angiogenic process and is involved in the signaling of vascular endothelial growth factor ( VEGF ). (bvsalud.org)
  • Association of PKC beta 2 isoform with retinoblastoma protein was discovered in retinal endothelial cells , and PKC beta 2 isoform increased retinoblastoma phosphorylation under basal and VEGF -stimulated conditions. (bvsalud.org)
  • However, such transcripts are also produced by splicing errors in a process called "noisy splicing," and are also potentially translated into protein isoforms. (wikipedia.org)
  • Alternative splicing also results in five less studied UL111A transcripts encoding additional proteins homologous to cIL-10 (isoforms C to G). These transcripts were identified during productive HCMV infection of MRC-5 cells with the high passage laboratory adapted AD169 strain, and the structure and properties of the corresponding proteins are largely unknown. (st-andrews.ac.uk)
  • The risk allele of rs10774671 shifts splicing of OAS1 from production of the p46 isoform to multiple alternative transcripts, including p42, p48, and p44. (urosario.edu.co)
  • Tens of thousands of splice isoforms of proteins have been catalogued as predicted sequences from transcripts in humans and other species. (umich.edu)
  • The assembly of this isoform-specific signaling complex appears to play a primary role in the PKC-dependent facilitation of glutamate exocytosis. (rupress.org)
  • PKCα and PKCε activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (nebraska.edu)
  • A significant reduction of the euxanthone-induced neuritogenic effect was also observed when the PKC isoform-specific inhibitor Go6976 was included in the culture. (edu.hk)
  • The role of specific isoforms of 14-3-3 protein in regulating protein kinase activity in the brain. (ox.ac.uk)
  • We have quantified HRAS, NRAS, KRAS4A and KRAS4B protein abundance across a large panel of cell lines and healthy tissues. (nature.com)
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • In addition, differences in troponin-I isoforms correlated with TnT 1 levels between the proximal, central and distal regions. (biologists.com)
  • A protein isoform is a version of a protein with only small differences to another isoform of the same protein. (wikidoc.org)
  • The modelling predicts clear differences between the isoform structures. (st-andrews.ac.uk)
  • We identified an equivalent variant Deaf1 isoform in the PLNs of patients with type 1 diabetes. (nih.gov)
  • We describe an approach to screen large sets of MALDI-MS mass spectra for protein isoforms separated on two-dimensional electrophoresis gels. (lu.se)
  • Individual isoforms of the protein kinase C (PKC) family of kinases may have assumed distinct responsibilities for the control of complex and diverse cellular functions. (rupress.org)
  • Three different isoforms have been described on the protein level, including the long form c-FLIP L as well as 2 short forms, c-FLIP S and the recently identified c-FLIP R . The mechanisms controlling c-FLIP isoform production are largely unknown. (ashpublications.org)
  • The primary mechanisms that produce protein isoforms are alternative splicing and variable promoter usage, though modifications due to genetic changes, such as mutations and polymorphisms are sometimes also considered distinct isoforms. (wikipedia.org)
  • After applying proteasome inhibitors, aggresomes, which are aggregates of misfolded proteins, were formed in the cytoplasm of cells expressing p35. (elsevierpure.com)
  • Statins also affected the recruitment of transcriptional regulatory proteins and the organization of the chromatin at the CCR7 promoter to increase the transcriptional activity. (nsdfu.org)
  • The unusual stability and direct nature of this physical interaction indicate that actin filaments represent a new class of PKC-binding protein. (rupress.org)
  • Analysis of myofibrillar isoforms showed that levels of troponin-T 1 (TnT 1 ), a 55 kDa isoform expressed in slow-tonic (S 2 ) fibres, were correlated with synaptic properties. (biologists.com)
  • Synaptic proteins, including synapsin-I and synapsin-II, interacted with agonist-bound PR isoforms, suggesting that both isoforms function in synaptic plasticity. (utmb.edu)
  • Because many identified proteins in this PR interactome are synaptic proteins, we tested the hypothesis that progestins function in synaptic plasticity. (utmb.edu)
  • Because most of the FAM111B mutations identified in people with POIKTMP change single protein building blocks (amino acids) in the peptidase domain, researchers think that the mutations alter the protein's function, and that these changes in FAM111B function underlie the varied signs and symptoms of POIKTMP. (medlineplus.gov)