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  • 3'UTR
  • Using reporter assays and 3'UTR swapping experiments, we have identified the role of alternative 3'UTRs and mRNA transport in differential localization of alternative CDC42 protein isoforms. (mdc-berlin.de)
  • Moreover, we used SILAC to identify isoform-specific Cdc42 3'UTR-bound proteome with potential role in Cdc42 localization and translation. (mdc-berlin.de)
  • characterization
  • Although the characterization of each predicted isoforms is complex, since they often diverge only for few amino acids, analysis of their expression patterns in the brain might account for the different pathogenetic effects linked to PARK2 gene mutations. (hindawi.com)
  • cytoplasmic
  • This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. (abcam.com)
  • exons
  • The ALOX5 gene, which occupies 71.9 kilobase pairs (kb) on chromosome 10 (all other human lipoxygenases are clustered together on chromosome 17), is composed of 14 exons divided by 13 introns encoding the mature 78 kilodalton (kD) ALOX5 protein consisting of 673 amino acids. (wikipedia.org)
  • and isoform 3, containing 6 exons and encoding the shortest protein (392 amino acids). (wikipedia.org)
  • human
  • Here, the currently known PARK2 gene transcripts and relative predicted encoded proteins in human, rat, and mouse are reviewed. (hindawi.com)
  • Isoforms of transferrin and α 1 -antitrypsin have been implicated in several human diseases. (wiley.com)
  • Panel (a) shows an N-terminally extended isoform of the human RND3 gene which has an in-frame CUG initiating codon. (nih.gov)
  • Panel (b) shows a truncated isoform of the human CLK3 gene which was found to initiate at an AUG codon downstream of the annotated AUG start codon (Reprinted with permission from Ref 12. (nih.gov)
  • Figure 10b shows a truncated isoform of the human CLK3 gene which Lee et al.12 found to initiate at an AUG codon downstream of the annotated AUG start codon. (nih.gov)
  • Fritsch et al.13 also reported 546 N-terminal protein extensions in human (regions downstream of annotated starts were not analyzed). (nih.gov)
  • ab791 staining (1µg/ml) of Human Brain (Cerebellum) lysate (RIPA buffer, 35µg total protein per lane). (abcam.com)
  • Fluorescence-based imaging of autophagy progression by human WIPI protein detection. (nih.gov)
  • The protein is lysine rich and leucine poor compared to the content of the average Human gene and has a predicted isoelectric point of 9.305. (wikipedia.org)
  • According to the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) its approved symbol is EFS and its synonyms are "Cas scaffolding protein family member 3", CASS3, EFS1, EFS2, HEFS and SIN. (wikipedia.org)
  • There are three protein isoforms of human Efs. (wikipedia.org)
  • the other human protein that is a member of that family is Nuclear receptor co-repressor 2. (wikipedia.org)
  • RNA Folding Form TargetScan Human NCBI Protein. (wikipedia.org)
  • transcriptional
  • Little is known about the transcriptional regulation of EFS, but several transcriptional regulators for EFS have been proposed based on consensus binding sites in its promoter region for ATF (Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid receptors α and β, and p53. (wikipedia.org)
  • However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. (wikipedia.org)
  • NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. (wikipedia.org)
  • proteome
  • All these proteins are different both in structure and composition and this process is regulated by alternative splicing of mRNA and have a large impact in proteome diversity. (wikipedia.org)
  • downstream
  • As discussed in the section Ribosome Profiling of Initiating Ribosomes, initiation at alternative sites both upstream and downstream of the annotated protein coding ORFs is pervasive. (nih.gov)
  • It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. (abcam.com)
  • superfamily
  • MGI protein superfamily detail pages represent the protein classification set for a homeomorphic superfamily from the Protein Information Resource SuperFamily ( PIRSF ) site. (jax.org)
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)