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  • receptor
  • Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine kinases (RTKs). (duke.edu)
  • We further elucidated unique signaling downstream of a representative ITIM-containing receptor in leukemia cells. (utsouthwestern.edu)
  • 1999. HMG-1 Stimulates Estrogen Response Element Binding by Estrogen Receptor from Stably Expressed HeLa Cells. (utsouthwestern.edu)
  • 2000. Activation of the p38 Mitogen-activated Protein Kinase Pathway by Estrogen or by 4-Hydroxy Tamoxifen is Coupled to Estrogen Receptor-induced Apoptosis. (utsouthwestern.edu)
  • Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene. (wikipedia.org)
  • This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. (wikipedia.org)
  • Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the PTPRU gene. (wikipedia.org)
  • The large G proteins, for example, are involved in transduction of signaling from the G protein-coupled receptor for a variety of signaling processes like hormonal signaling, and small G proteins are involved in processes like cellular trafficking and cell cycling. (wikipedia.org)
  • GAP are heavily linked to the G-protein linked receptor family. (wikipedia.org)
  • Autocatalytic processing gives rise to an extracellular (α) and a membrane-spanning (β) subunit, which are associated non-covalently, resulting in expression of a heterodimeric receptor at the cell surface. (wikipedia.org)
  • Formal G protein-coupled signalling has been demonstrated for a number for adhesion GPCRs, however, the orphan receptor status of many of the receptors still hampers full characterisation of potential signal transduction pathways. (wikipedia.org)
  • He defined the biosynthesis and maturation of the vesicular stomatitis virus and other plasma membrane glycoproteins, identified the intracellular organelles that mediate recycling of the asialoglycoprotein and transferrin receptors, and clarified the role of pH changes in delivery of iron to cells and recycling of the transferrin receptor. (wikipedia.org)
  • His research group was the first to clone and sequence mRNAs encoding a mammalian glucose transport protein, GLUT1, and then GLUT2 and the insulin- responsive GLUT4, an anion exchange protein, a transporter for free fatty acids, the hepatic asialoglycoprotein receptors, intestinal sucrose-isomaltase, the erythropoietin receptor, two subunits of the TGFß receptor, and several adipocyte-specific proteins including adiponectin (formerly Acrp30). (wikipedia.org)
  • human
  • Dr. Atilgan Yilmaz and his team have developed a method by which they can produce haploid human embryonic stem cells from oocytes. (news-medical.net)
  • A new study in the journal Nature Cell Biology has uncovered information about a key stage that human embryonic cells must pass through just before an embryo implants. (news-medical.net)
  • In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria. (news-medical.net)
  • Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety of tumours. (wikipedia.org)
  • A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J Biol Chem. (wikipedia.org)
  • There are four human SALL proteins (SALL1, 2, 3, and 4) with structural homology and playing diverse roles in embryonic development, kidney function, and cancer. (wikipedia.org)
  • The FDA has now approved ERTs that are derived from other human cells, animal cells (i.e. (wikipedia.org)
  • vivo
  • How this is achieved is far from clear and is the subject of studies in the lab, both in vivo and in cell culture. (stanford.edu)
  • In our most recent work, we have designed cell fate tracking experiments to study stem cells in vivo. (stanford.edu)
  • hematopoiesis
  • The pioneering work of Till and McCulloch in 1961 experimentally confirmed the development of blood cells from a single precursor hematopoietic stem cell (HSC), creating the framework for the field of hematopoiesis to be studied over the following decades. (wikipedia.org)
  • Hematopoiesis is the process by which all mature blood cells are produced. (wikipedia.org)
  • endoplasmic reticulum
  • In turn, this triggers endoplasmic reticulum (ER) stress as a part of the unfolded protein response (UPR). (ijhgateway.net)
  • His group has elucidated steps in folding and oligomerization of several proteins within the endoplasmic reticulum, showed that exit of newly made proteins from this organelle requires that they be properly folded, and developed probes for measurement of the redox state within the endoplasmic reticulum. (wikipedia.org)
  • Interactions
  • Daitoku H, Sakamaki JI, Fukamizu A. Regulation of FoxO transcription factors by acetylation and protein-protein interactions. (springer.com)
  • Interactions between heparan sulfate and proteins: the concept of specificity. (springer.com)
  • Lindahl, U., Li, J.P.: Interactions between heparan sulfate and proteins-design and functional implications. (springer.com)
  • Meanwhile, scaffold proteins can also sequester the proper GAP to its G protein and enhance the proper binding interactions. (wikipedia.org)
  • These binding interactions may be specific for a particular GAP and G protein. (wikipedia.org)
  • Binding to other G proteins may not have the same favorable interactions, and they therefore do not interact. (wikipedia.org)
  • The extracellular region of adhesion GPCRs can be exceptionally long and contain a variety of structural domains that are known for the ability to facilitate cell and matrix interactions. (wikipedia.org)
  • intracellular
  • By virtue of their short-range nature and their capacity to activate both lineage-specifying and cell-polarizing intracellular signaling cascades, Wnts can polarize cells at their site of contact, orienting the axis of cell division while simultaneously programming daughter cells to adopt diverging fates in a spatially stereotyped way. (stanford.edu)
  • However, when each of the two intracellular catalytic tyrosine phosphatase domains are expressed individually as recombinant proteins and assayed in vitro using the artificial substrate ρ-nitrophenol phosphate (pNPP), both the first and second intracellular tyrosine phosphatase domain were able to dephosphorylate pNPP. (wikipedia.org)
  • Research is focused on four main areas: misfolded proteins and disease, intracellular membrane traffic, autoimmune disease and haematopoietic stem cell biology. (wikipedia.org)
  • Biology
  • 8 Area of Cell and Developmental Biology, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain. (jci.org)
  • The Wellcome Trust also funds the SCI's internationally competitive 4-Year PhD Programme in Stem Cell Biology and Medicine. (wikipedia.org)
  • Harvey F. Lodish (born November 16, 1941) is a molecular and cell biologist, professor at the Massachusetts Institute of Technology (MIT), Founding Member of the Whitehead Institute for Biomedical Research, and lead author of the textbook Molecular Cell Biology. (wikipedia.org)
  • Lodish's research focuses on cell surface proteins and other important areas at the interface between molecular cell biology and medicine. (wikipedia.org)
  • Dr. Lodish is the lead author of the textbook Molecular Cell Biology. (wikipedia.org)
  • During the 2004 calendar year Dr. Lodish served as President of the American Society for Cell Biology. (wikipedia.org)
  • embryos
  • By applying gene analysis to individual cells from early mouse embryos, researchers at Karolinska Institutet in Sweden have discovered previously unknown cellular stages of fetal development from fertilized egg to living being. (news-medical.net)
  • In mouse embryos, SALL4 expression is detectable as early as the two-cell stage. (wikipedia.org)
  • tumor cells
  • I also experimented and identified the best method for copy number variations (CNVs) analysis in the circulating tumor cells samples. (manchester.ac.uk)
  • interact
  • Researchers have made important discoveries about how stem cells move, interact with each other and respond to their environment. (news-medical.net)
  • RGS9-1, for example, is specifically expressed in the rod and cone photoreceptors in the eye retina, and is the only one to interact with G proteins involved in phototransduction in this area. (wikipedia.org)
  • specificity
  • citation needed] At the most basic level, GAP-to-G protein specificity may come simply from the timing and location of protein expression. (wikipedia.org)
  • A certain GAP and a certain G protein happen to be expressed in the same time and place, and that is how the cell ensures specificity. (wikipedia.org)
  • lineage
  • B ) Total BM cells were stained with anti-Endoglin followed sequentially by anti-rat-PE/CY5.5, a mixture of biotinylated lineage-specific antibodies, and streptavidin-APC, anti-PrP-FITC, and anti-Sca-1-PE. (nih.gov)
  • In addition, SALL4 can also activate gene expression via the recruitment of the mixed lineage leukemia (MLL) protein, which is a homolog of Drosophila Trithorax and yeast Set1 proteins and has histone 3 lysine 4 (H3K4) trimethylation activity. (wikipedia.org)
  • precursor cells
  • Other binding partners of SALL4 include promyelocytic leukemia zinc finger protein (PLZF) in sperm precursor cells, Rad50 during DNA damage repair, and b-catenin downstream of the Wnt signaling pathway. (wikipedia.org)
  • histone
  • Myb-like SWIRM and MPN domains (MYSM1) is a chromatin-interacting protein previously shown to act as a transcriptional regulator through histone H2A (H2AK119ub) deubiquitination. (bloodjournal.org)
  • SALL4 binds to retinoblastoma binding protein 4 (RBBP4), a subunit of the nucleosome remodeling and histone deacetylation (NuRD) complex, which also contains chromodomain-helicase-DNA binding proteins (CHD3/4 or Mi-2a/b), metastasis-associated proteins (MTA), methyl-CpG-binding domain proteins (MBD2 or MBD3), and histone deacetylases (HDAC1 and HDAC2). (wikipedia.org)
  • superfamily
  • The GAPs that act on small GTP-binding proteins of the Ras superfamily have conserved structures and use similar mechanisms, An example of a GTPase is the monomer Ran, which is found in the cytosol as well as the nucleus. (wikipedia.org)
  • expression
  • A ) Freshly isolated BM cells were stained with Hoechst dye 33342, and the SP fraction was gated (gates 1 and 2) to analyze the expression of PrP. (nih.gov)
  • Expression Atlas: gene and protein expression across multiple studies and organisms. (embl.de)
  • We identified Wnt-responsive stem cells by their expression of Axin2 (a common Wnt target gene) and generated a mouse strain with the CreERT2 recombination signal inserted into the Axin2 locus, Axin2-Cre. (stanford.edu)
  • Together these proteins can affect each other's expression patterns as well as their own, thus forming a mESC-specific transcriptional regulatory circuit. (wikipedia.org)
  • Its expression persists through 8- and 16-cell stages to the blastocyst, where it is found in some cells of the trophectoderm and inner cell mass (ICM), from which mouse ESCs are derived. (wikipedia.org)
  • pluripotency
  • Although we are also now able to reprogram regular cells to exhibit this pluripotency, we still have much to learn about the different cues that lead such cells towards a particular cell fate, including the cells that make up the eye. (news-medical.net)
  • In mouse ESCs, Sall4 was found to bind the essential stem cell factor, octamer-binding transcription factor 4 (Oct4), in two separate unbiased mass spectrometry (spec) screens Sall4 can also bind other important pluripotency proteins such as Nanog and sex determining region Y (SRY)-box 2 protein (Sox2). (wikipedia.org)