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  • genes
  • Cairns' research focuses on chromatin remodeling complexes (CRCs), which are groups of proteins that behave like motors inside the cell's nucleus, expanding or compacting different portions of DNA to either express or silence genes. (huntsmancancer.org)
  • Assembly CRCs wind the DNA coils tight and pack the nucleosomes close together in chromosome regions that harbor silent genes. (huntsmancancer.org)
  • For many genes, the unwind-rewind cycle is repeated continuously throughout a cell's life. (huntsmancancer.org)
  • In 1911, after observing that linked traits could on occasion be inherited separately, Thomas Hunt Morgan suggested that "crossovers" can occur between linked genes, where one of the linked genes physically crosses over to a different chromosome. (wikipedia.org)
  • The sequencing of amino acids is regulated by the genes located on the chromosomes. (docplayer.net)
  • 2 GENES Genes are sections of chromosomes, each of which contains one set of instructions. (docplayer.net)
  • 4 CHROMOSOMAL THEORY A) Chromosomes carry genes, the units of heredity. (docplayer.net)
  • B) each chromosome carries many different genes. (docplayer.net)
  • Studies in several bacteria indicate that par genes, in addition to their role in chromosome segregation, contribute to other cellular processes such as chromosome replication and cell division. (nih.gov)
  • For example, in animals, the genes encoding β‐globin are condensed in cells that are not precursors to blood cells. (cliffsnotes.com)
  • The Centre aims to enhance our understanding of how genes are regulated at both the single cell and whole organism level. (wikipedia.org)
  • They process precursors to ribosomal RNA, small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) Yeast nucleases with the Class 2 RNase III domain: RNT1 (UniProtKB Q02555) - S. cerevisiae - this RNase III is involved in the transcription and processing of rDNA, the 3' end formation of U2 snRNA via cleavage of the terminal loop, cell wall stress response and degradation, and regulation of morphogenesis checkpoint genes. (wikipedia.org)
  • RNAs that are produced by Dicer act as guides for a sequence of particular silencing of cognate genes through RNAi and related pathways. (wikipedia.org)
  • TP53 is an important transcriptional activator of genes involved in the regulation of the G1 checkpoint of the cell cycle as well as certain genes responsible for programmed-cell death (apoptosis). (wikipedia.org)
  • RNAs are the direct products of genes, and these small RNAs can bind to other specific messenger RNA (mRNA) molecules and either increase or decrease their activity, for example by preventing an mRNA from being translated into a protein. (wikipedia.org)
  • RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. (wikipedia.org)
  • The initiating dsRNA can also be endogenous (originating in the cell), as in pre-microRNAs expressed from RNA-coding genes in the genome. (wikipedia.org)
  • RNA has been largely investigated within its role as an intermediary in the translation of genes into proteins. (wikipedia.org)
  • In animals, genes encoding canonical histones are typically clustered along the chromosome, lack introns and use a stem loop structure at the 3' end instead of a polyA tail. (wikipedia.org)
  • Schwann cells respond to loss of axons by extrusion of their myelin sheaths, downregulation of myelin genes, dedifferentiation and proliferation. (wikipedia.org)
  • separation
  • It is required for two microtubule-dependent processes: nuclear movement prior to anaphase, and chromosome separation. (wikipedia.org)
  • Although most injury responses include a calcium influx signaling to promote resealing of severed parts, axonal injuries initially lead to acute axonal degeneration (AAD), which is rapid separation of the proximal (the part nearer the cell body) and distal ends within 30 minutes of injury. (wikipedia.org)
  • binds
  • p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. (uniprot.org)
  • It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. (wikipedia.org)
  • CRABP1 binds to retinoid acid and helps to transport it into cells (Figure 1). (wikipedia.org)
  • Exogenous dsRNA initiates RNAi by activating the ribonuclease protein Dicer, which binds and cleaves double-stranded RNAs (dsRNAs) in plants, or short hairpin RNAs (shRNAs) in humans, to produce double-stranded fragments of 20-25 base pairs with a 2-nucleotide overhang at the 3' end. (wikipedia.org)
  • Complexed with the annexin II, p11 binds receptor and channel proteins and guides them to the cell surface, resulting in increased membrane localization and consequent magnified functional expression of these proteins. (wikipedia.org)
  • kinase
  • CRABP1 activates the extracellular signal-regulated kinase, ERK1 and ERK2 kinases, which are involved in the cell cycle. (wikipedia.org)
  • Each domain consists of six HEAT (Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A and the lipid kinase Tor) repeat units that are adjacently aligned. (wikipedia.org)
  • Because the substrate for pyruvate kinase is a simple phospho-sugar, and the product is an ATP, pyruvate kinase is a possible foundation enzyme for the evolution of the glycolysis cycle, and may be one of the most ancient enzymes in all earth-based life. (wikipedia.org)
  • In yeast cells, the interaction of yeast pyruvate kinase (YPK) with PEP and its allosteric effector Fructose 1,6-bisphosphate (FBP,) was found to be enhanced by the presence of Mg2+. (wikipedia.org)
  • Once pyruvate kinase synthesizes pyruvate, pyruvate either enters the TCA cycle for further production of ATP under aerobic conditions, or is reduced to lactate under anaerobic conditions. (wikipedia.org)
  • demonstrated that expression of endogenous miR-203 expression is under the control of protein kinase C pathway in epithelial cells. (wikipedia.org)
  • 12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). (wikipedia.org)
  • TPA induces KSHV reactivation in PEL cell cultures via stimulation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. (wikipedia.org)
  • Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters" (PDF). (wikipedia.org)
  • Phorbol Diester Receptor Copurifies with Protein Kinase C". Proceedings of the National Academy of Sciences. (wikipedia.org)
  • Shugoshin is a crucial target of Bub1 kinase that plays a central role in the cohesion of chromosomes during cell division. (wikipedia.org)
  • cytoplasm
  • The mrna leaves the nucleus of the cell and attaches to ribosomes in the cytoplasm. (docplayer.net)
  • Instead of plant cells forming a cleavage furrow such as develops between animal daughter cells, a dividing structure known as the cell plate forms in the cytoplasm and grows into a new, doubled cell wall between plant daughter cells. (wikipedia.org)
  • B-prolymphocytes are characterized by: Large size - approximately twice the size of a normal small lymphocyte Round or oval-shaped nuclei Single prominent nucleolus Moderately condensed nuclear chromatin High nuclear-cytoplasmic ratio - indicates more abundant cytoplasm This technique is used to study proteins expressed in cells using immunologic markers. (wikipedia.org)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. (wikipedia.org)
  • degradation
  • The APC/C is a large E3 ubiquitin ligase, which triggers the metaphase to anaphase transition by marking select proteins for degradation. (wikipedia.org)
  • mechanisms
  • The scientific efforts focus on discovering mechanisms of radiation injury in a search for potential drug targets and to guide medical treatment, assessing radiation injury severity, discovering and developing early preclinical radiation countermeasure candidates, and studying mechanisms and countermeasures for radiation combined with other injury. (usuhs.edu)
  • These bacteria provide a unique opportunity to probe the mechanisms involved in the maintenance of multiple chromosomes. (nih.gov)
  • In addition to the range of mechanisms proposed, which includes chromosome replication, there are clearly additional mechanisms that anchor the centromere analog to the cell pole in some bacteria, including V. cholerae . (nih.gov)
  • Multiple different mechanisms inhibit Cdks in G1: Cdk inhibitor proteins are expressed, and cyclin gene expression is down-regulated. (wikipedia.org)
  • complement
  • It thereby ensures that chromosome number and complement are maintained from one generation to the next and that, except in special cases, the daughter cells will be functional copies of the parent cell. (wikipedia.org)
  • differentiation
  • PP2A activity promotes the stem cells renewal ability during the differentiation process. (wikipedia.org)
  • MiR-203 is a microRNA that is specifically expressed in keratinocytes (the most abundant cell type in the epidermis) and in normal conditions promotes epidermal differentiation by restricting proliferative potential and inducing cell-cycle exit. (wikipedia.org)
  • Cellular differentiation - A concept in developmental biology whereby less specialized cells become a more specialized cell type in multicellular organisms. (wikipedia.org)
  • When a cell switches state from one cell type to another, it undergoes cellular differentiation. (wikipedia.org)
  • They regulate a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Adapted from Universal protein resource accession number P29762 for "RABP1_HUMAN" at UniProt. (wikipedia.org)
  • induces
  • The most well-studied outcome is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute 2 (Ago2), the catalytic component of the RISC. (wikipedia.org)
  • histone
  • It has been proposed that histone proteins are evolutionarily related to the helical part of the extended AAA+ ATPase domain, the C-domain, and to the N-terminal substrate recognition domain of Clp/Hsp100 proteins. (wikipedia.org)
  • processes
  • The processes that contribute to chromosome segregation in bacteria are still poorly understood. (nih.gov)
  • Tomo Tanaka studies the processes by which eukaryotic cells maintain their genetic integrity. (wikipedia.org)
  • By understanding the processes that occur during cell division, it is hoped that a better knowledge will be gained of human diseases such as cancer which are often characterised by chromosome instability. (wikipedia.org)
  • Cellular respiration - The metabolic reactions and processes that take place in a cell or across the cell membrane to convert biochemical energy from fuel molecules into adenosine triphosphate (ATP) and then release the cell's waste products. (wikipedia.org)
  • regulate
  • Moreover, subsequent experiments showed that TUG1 RNA could bind to PRC2 in the promotor region of CELF1 and negatively regulate CELF1 expressions in H520 cells. (biomedcentral.com)
  • structures
  • 1 PROTEINS Proteins are used by cells to build structures and are used in chemical activities. (docplayer.net)
  • They help build cell structures. (docplayer.net)
  • Higher-order structures include the 30 nm fiber (forming an irregular zigzag) and 100 nm fiber, these being the structures found in normal cells. (wikipedia.org)
  • Eukaryote - Organisms whose cells are organized into complex structures enclosed within membranes, including plants, animals, fungi, and protists. (wikipedia.org)
  • strands
  • It is most widely used by cells to accurately repair harmful breaks that occur on both strands of DNA, known as double-strand breaks (DSB). (wikipedia.org)
  • nuclei
  • The Centre is also investigating how DNA is tightly wound and compacted so that it can fit into the nuclei of eukaryotic cells, as well as the protein-DNA complexes that are involved in this packaging. (wikipedia.org)
  • progression
  • Cdc20-homologue 1 (Cdh1) plays a complementary role to Cdc20 in cell cycle progression. (wikipedia.org)
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • biology
  • The International Journal of Biochemistry & Cell Biology. (wikipedia.org)
  • Cell biology research extends to both the great diversities of single-celled organisms like bacteria and the complex specialized cells in multicellular organisms like humans. (wikipedia.org)
  • Cell biology can be described as all of the following: Branch of science - A systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. (wikipedia.org)
  • Cell biology - (formerly cytology) The study of cells. (wikipedia.org)
  • repeats
  • Near its C-terminus it contains seven WD40 repeats, which are multiple short, structural motifs of around 40 amino acids that often play a role in binding with larger protein complexes. (wikipedia.org)
  • mutations
  • Unlike other S-100 proteins, the second EF-hand of protein p11 is incapable of binding calcium due to a series of mutations caused by deletions and substitutions. (wikipedia.org)
  • Defects
  • Defects in any aspect of chromosome replication or segregation pose significant threats to genome stability, and underlie the development of many human diseases, foremost among them being cancer. (nih.gov)
  • evolutionary
  • An understanding of chromosome coordination is expected to bear on the evolutionary process of chromosome acquisition and cooption. (nih.gov)
  • Endosymbiotic theory - The evolutionary theory that certain eukaryotic organelles originated as separate prokaryotic organisms which were taken inside the cell as endosymbionts. (wikipedia.org)
  • division
  • The faithful replication of chromosomes and their segregation to incipient daughter cells before cell division are required for the stable transmission of the genome. (nih.gov)
  • When chrI replication is selectively blocked, both chrII replication and cell division are inhibited. (nih.gov)
  • However, when chrII replication is blocked, replication and segregation of chrI and cell division remain unaffected. (nih.gov)
  • Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. (uniprot.org)
  • The Centre is studying many aspects of the cell cycle, including the way in which chromosomes replicate and separate during cell division and how DNA damage is detected. (wikipedia.org)
  • Jason Swedlow is a Wellcome Trust Senior Research Fellow and investigates how chromosomes are separated during cell division. (wikipedia.org)
  • Cdc20, along with a handful of other Cdc proteins, was discovered in the early 1970s when Hartwell and colleagues made cell-division cycle mutants that failed to complete major events in the cell cycle in the yeast strain S. cerevisiae. (wikipedia.org)
  • TPA is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia. (wikipedia.org)
  • RNAi may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division. (wikipedia.org)
  • and their life cycle, division, and death. (wikipedia.org)
  • Cell division - The process of one parent cell separating into two or more daughter cells. (wikipedia.org)
  • Just as its name suggests, the Shugoshin protein guides chromosome cohesion during cell division. (wikipedia.org)
  • genome
  • One of the advantages afforded in studying a bacterium with a divided genome is to be able to ask: Do the chromosomes communicate to improve stability of their maintenance? (nih.gov)
  • Failure of these events can lead to major faults within a genome, potentially leading to the rise of cancerous cells. (wikipedia.org)
  • coiled-coil
  • The N-terminal domain of the Shugoshin protein is a coiled-coil which can be further described as a homodimeric parallel coiled-coil. (wikipedia.org)
  • suggests
  • One study suggests that in Schizosaccharomyces pombe, the protein Cdc2 regulates Dis1 through phosphorylation and dephosphorylation during metaphase and anaphase. (wikipedia.org)
  • peripheral
  • This type of leukemia is characterized by: More than 55% of circulating cells in peripheral blood (red blood cells, white blood cells and platelets collectively) are prolymphocytes. (wikipedia.org)
  • It works together with cytosolic and peripheral membrane-associated proteins such as AHNAK in the development of the intracellular membrane. (wikipedia.org)
  • study
  • CliffsNotes study guides are written by real teachers and professors, so no matter what you're studying, CliffsNotes can ease your homework headaches and help you score high on exams. (cliffsnotes.com)
  • pathway
  • demonstrated that activation of the Hedgehog signaling pathway, can lead to decreased miR-203 expression in mouse model of basal cell carcinoma. (wikipedia.org)
  • interaction
  • The biophysicists participating in QBM (Braun, Jungmann, Rädler, Schwille) bring a wealth of advanced expertise and novel methodologies, permitting the high-resolution quantitative and dynamic analysis of regulatory processes, including protein folding/conformation and the interaction of proteins with small molecules, nucleic acids, or other proteins in different settings (single molecule, purified/crude extracts). (lmu.de)
  • According to the protein interaction and topological characteristics of this multisubunit complex, the 19S regulatory particle is composed of a base and a lid subcomplex. (wikipedia.org)
  • In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy. (wikipedia.org)
  • Ion channels are among the several proteins that are transported through the interaction with p11. (wikipedia.org)
  • cellular
  • However, the mechanisms linking protein aggregation to cellular toxicity and death remain poorly understood. (lmu.de)
  • No abnormalities were observed on the cellular morphology of these cell lines both at low and high densities of cultures by microscopy according to the guideline from ATCC ( 15 ). (aacrjournals.org)
  • P11 is an integral part of cellular structural scaffolding that interacts with plasma membrane proteins through its association with annexin II. (wikipedia.org)
  • intracellular
  • 2000 ). Because GadA and GadB are intracellular enzymes, and most MSG are out of the cells, the recombinant E. coli cells have to be specially treated by sonication, ethyl acetate, toluene, and thermal activation to increase the permeability (Zhao et al. (springeropen.com)
  • It works together with cytosolic and peripheral membrane-associated proteins such as AHNAK in the development of the intracellular membrane. (wikipedia.org)
  • glutamate
  • The yield and productivity of gamma-aminobutyric acid might be significantly improved if the overexpressed GadB in E. coli cells can be excreted outside, where it can directly transforms monosodium glutamate to gamma-aminobutyric acid. (springeropen.com)
  • In neuroscience, glutamate refers to the anion of glutamic acid in its role as a neurotransmitter: a chemical that nerve cells use to send signals to other cells. (wikipedia.org)
  • Nevertheless, glutamate is formally classified as a non-essential amino acid, because it can be synthesized from alpha-Ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose starting point is citrate. (wikipedia.org)
  • Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate-glutamine cycle by the enzyme glutaminase. (wikipedia.org)
  • In brain injury or disease, they often work in reverse, and excess glutamate can accumulate outside cells. (wikipedia.org)
  • mrna
  • In addition, we also observed significantly elevated levels of SphK1 and SphK2 mrna and SphK1 protein expression in MPM cell lines such as H2691, H513 and H2461 compared to the non-malignant mesothelial Met5 cells. (docplayer.net)
  • As a result, these mRNA molecules are silenced, by one or more of the following processes: Cleavage of the mRNA strand into two pieces, Destabilization of the mRNA through shortening of its poly(A) tail, and Less efficient translation of the mRNA into proteins by ribosomes. (wikipedia.org)
  • This complementarity was proposed to inhibit the translation of the lin-14 mRNA into the LIN-14 protein. (wikipedia.org)
  • Molecular
  • In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. (wikipedia.org)
  • DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 10,000 to 1,000,000 molecular lesions per cell per day. (wikipedia.org)
  • Faithful partitioning of the genome to emerging daughter cells is ensured through the tight temporal coordination of the above individual events by molecular signaling pathways. (wikipedia.org)
  • complex
  • Key to this chromosome-wide activation is a regulatory complex containing long, non-coding RNA and three enzymes. (lmu.de)
  • Immunocytochemical staining and in vitro binding assay revealed that UBE2T interacted and colocalized with the BRCA1/BRCA1-associated RING domain protein (BARD1) complex. (aacrjournals.org)
  • Moreover, UBE2T protein was shown to bind FANCL, the Fanconi anaemia core complex, and to be necessary for the efficient DNA damage-induced monoubiquitination of FANCD2, one of Fanconi anaemia core complex subunits ( 13 , 14 ). (aacrjournals.org)
  • MKLP1, together with the Rho-family GTPase activating protein CYK-4 (also termed MgcRacGAP), forms the centralspindlin complex. (wikipedia.org)
  • The p11 protein can be found as a free monomer, a homodimer, or a heterotetramer composed of a p11 dimer complex with two molecules of annexin II. (wikipedia.org)
  • P11 and annexin II form a heterotetrameric protein complex that imitates the structure and function of S-100 proteins activated by the binding of calcium. (wikipedia.org)
  • Unlike
  • Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. (wikipedia.org)
  • Unlike other S-100 proteins, the second EF-hand of protein p11 is incapable of binding calcium due to a series of mutations caused by deletions and substitutions. (wikipedia.org)
  • HUMAN
  • Constitutive expression of IL-8 directly correlated with the metastatic potential of the human melanoma cell lines tested. (americorpshealth.biz)
  • Human mammary epithelial cells and MCF10A were purchased from Cambrex BioScience, and were used in this study for the first time after purchase. (aacrjournals.org)
  • The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals. (wikipedia.org)
  • D. melanogaster sperm cells are a more modest 1.8 mm long, although this is still about 35 times longer than a human sperm. (wikipedia.org)
  • microtubule
  • Besides being a structural component of the central spindle itself, CPC also plays a role in the phosphoregulation of other central spindle components, including PRC1 (microtubule bundling protein required for cytokinesis 1) and MKLP1 (a kinesin motor protein). (wikipedia.org)
  • inhibitor
  • Only one HDAC inhibitor, suberonylanilide hydroxamic acid (SAHA), marketed as Zolinza (vorinostat) has been approved by US Foods and Drugs Administration (FDA) for the treatment of cutaneous T-cell lymphoma (http://www.cancer.gov/cancertopics/druginfo/fdavorinostat) . (docplayer.net)
  • Transcription factor NF-kB in unstimulated cells is inactivated by IkBa inhibitor protein binding. (wikipedia.org)
  • extracellular environment
  • While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media. (wikipedia.org)
  • The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. (wikipedia.org)
  • functional
  • It thereby ensures that chromosome number and complement are maintained from one generation to the next and that, except in special cases, the daughter cells will be functional copies of the parent cell. (wikipedia.org)
  • Biological
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. (wikipedia.org)
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • Since eggs are laid with a biological clock, D. melanogaster became adaptive to their environmental cycles, which showed a major advantage. (wikipedia.org)
  • Her work has furthered understanding of the basis of stem cell function and the generation of biological diversity. (wikipedia.org)
  • fragment
  • Recent studies indicate that the structure of the N-terminal Shugoshin may be important for centromeric localisation, this is because it has been observed that the N-terminal fragment was the only part of the protein to localise at the centromere. (wikipedia.org)
  • neuronal
  • This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity. (wikipedia.org)
  • mechanism
  • The underlying mechanism involves multiple genetic mutations that results in rapid cell division. (wikipedia.org)
  • This may be a mechanism for cell to regulate the number of NF-kB available for transcriptional activation. (wikipedia.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Antibodies
  • Immunohistochemistry (IHC) is a common in vitro staining technique that uses antibodies to identify specific protein antigens within thinly sliced tissue samples. (novusbio.com)
  • dependent
  • Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. (uniprot.org)
  • extracts
  • One possible explanation would be that these complexes exist only for a short period of time, thus not obvious in cell extracts. (wikipedia.org)
  • Systems
  • important interventions will explore receptor on exchange growing, diastolic signal changes, lymphatic implantation systems Chromosome, findings determining on cysts, and acute glomerulosclerosis page. (adams-farm.com)
  • expression
  • Since protein expression in Escherichia coli represents the most facile approach (Mahalik et al. (springeropen.com)
  • Several organ-derived cytokines (produced by inflammatory cells) are known to induce expression of IL-8 in normal and transformed cells (83). (americorpshealth.biz)
  • Since IL-8 expression in melanocytes and melanoma cells can be induced by inflammatory signals, the question of whether specific organ microenvironments could influence the expression of IL-8 was analyzed. (americorpshealth.biz)
  • Knocking down of UBE2T expression with small interfering RNA drastically suppressed the growth of breast cancer cells. (aacrjournals.org)
  • Methodology/Principal Findings: In this study, we report that the expression of Sphingosine Kinase 1 (SphK1) protein was preferentially elevated in MPM tumor tissues (49 epithelioid and 13 sarcomatoid) compared to normal tissue (n = 13). (docplayer.net)
  • species
  • Other experiments show that a single miRNA species may repress the production of hundreds of proteins, but that this repression often is relatively mild (much less than 2-fold). (wikipedia.org)
  • relatively
  • Animals in the wild appear to be relatively free from eating disorders although their body composition fluctuates depending on seasonal and reproductive cycles. (wikipedia.org)
  • symptoms
  • Other late symptoms may include feeling tired due to low levels of red blood cells. (wikipedia.org)
  • Central nervous system (CNS) symptoms such cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. (wikipedia.org)
  • excessive
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • activation
  • Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. (genecards.org)
  • Stem
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)