Protein genes and gene. Medical search. Frequent questions

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Roundtree IA, Evans ME, Pan T, He C. Dynamic RNA modifications in gene expression regulation. (nature.com)
Budini M, Baralle FE, Buratti E. Regulation of gene expression by TDP-43 and FUS/TLS in frontotemporal lobar degeneration. (medlineplus.gov)
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. (medlineplus.gov)
Changes in gene regulation have been used to study the evolutionary chasm that exists between humans and chimpanzees despite their largely identical DNA. (sciencedaily.com)
However, scientists have discovered that mRNA expression levels, long considered a barometer for differences in gene regulation, often do not reflect differences in protein expression -- and, therefore, biological function -- between humans and chimpanzees. (sciencedaily.com)
Some of these patterns of mRNA regulation have previously been thought of as evidence of natural selection for important genes in humans, but this can no longer be assumed," Gilad said. (sciencedaily.com)
The implicated genes play important roles in migration of cells in the developing brain, communication between brain cells, regulation of gene expression, and related intracellular workings. (nih.gov)
moreover, there are different plant-specific proteins that participate in the regulation of specific targets, suggesting that not all PcG targets are regulated by the same mechanism. (europa.eu)
Regulation of post-translational protein arginine methylation during HeLa cell cycle. (semanticscholar.org)
Taken together, we proposed a novel Alu-mediated regulation network capable of stabilizing Alu-carrying mRNA levels in different cell types and restricting the activated expression levels of protein-coding, Alu-carrying mRNAs. (biomedcentral.com)
Despite the binding of two protein-coding Alu-carrying mRNAs had never been discussed previously to our knowledge, we conjectured that the resulting double stranded RNAs could trigger the post-transcriptional regulation of a large collection of protein-coding mRNAs carrying sense or antisense Alu elements, by offering potent sources of either Dicer1 -created short interfering RNA (siRNA) [ 18 - 20 ], or STAU1 -mediated mRNA decay [ 15 ]. (biomedcentral.com)

More than 70 mutations involving the SOX9 gene have been found to cause campomelic dysplasia, a disorder that affects skeletal development, sex determination, and other processes in the body and is often life-threatening in the newborn period. (medlineplus.gov)
Most cases of campomelic dysplasia are caused by mutations within the SOX9 gene. (medlineplus.gov)
These mutations prevent the production of the SOX9 protein or result in a protein with impaired ability to function as a transcription factor. (medlineplus.gov)
Individuals with milder forms of campomelic dysplasia are more likely to have chromosome abnormalities near the SOX9 gene rather than mutations within the gene. (medlineplus.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
At least 60 mutations in the TARDBP gene have been found to cause amyotrophic lateral sclerosis (ALS), a condition characterized by progressive muscle weakness, a loss of muscle mass, and an inability to control movement. (medlineplus.gov)
Most mutations change single protein building blocks (amino acids) in the TDP-43 protein. (medlineplus.gov)
Some people with ALS caused by TARDBP gene mutations also develop a condition called frontotemporal dementia (FTD), which is a progressive brain disorder that affects personality, behavior, and language. (medlineplus.gov)
It is unclear why some people with TARDBP gene mutations develop FTD and others do not. (medlineplus.gov)
Mutations in the TARDBP gene have been found to cause frontotemporal dementia (FTD) without features of amyotrophic lateral sclerosis (ALS, described above). (medlineplus.gov)
FTD caused by TARDBP gene mutations is characterized by a gradual loss of problem-solving skills and language comprehension. (medlineplus.gov)
Most TARDBP gene mutations that cause FTD change single amino acids in the TDP-43 protein. (medlineplus.gov)
These mutations are thought to affect only part of the protein, leaving other parts of the protein functional. (medlineplus.gov)
Because these TARDBP gene mutations result in a protein with some residual function, the features of the condition tend to appear later in life, in one's late sixties or early seventies. (medlineplus.gov)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Researchers have reverse-engineered the outlines of a disrupted prenatal gene network in schizophrenia , by tracing spontaneous mutations to where and when they likely cause damage in the brain. (nih.gov)
Mutations can lead to loss of integrity of a whole pathway, not just of a single gene. (nih.gov)
Earlier studies had linked spontaneous mutations to non-familial schizophrenia and traced them broadly to genes involved in brain development, but little was known about convergent effects on pathways. (nih.gov)
Seemingly disparate and scattered throughout the genome, spontaneous, or de novo, damaging mutations found in people with schizophrenia (red) clustered within genes forming a suspected disrupted network in the prefrontal cortex, thought to impair formation of new neurons during prenatal development. (nih.gov)
Yet affected siblings were modestly more likely to have mutations predicted to damage protein function. (nih.gov)
only one gene harboring damaging mutations turned up in more than one of the cases, and several patients had damaging mutations in more than one gene. (nih.gov)
The networks formed by genes harboring these damaging mutations were found to vary in connectivity, based on the extent to which their proteins are co-expressed and interact. (nih.gov)
The network formed by genes harboring damaging mutations in schizophrenia had significantly more nodes, or points of connection, than networks modeled from unaffected siblings. (nih.gov)
By contrast, the network of genes harboring non-damaging mutations in affected siblings had no more nodes than similar networks in unaffected siblings. (nih.gov)
When the researchers compared such network connectivity across different brain tissues and different periods of development, they discovered a notable difference between affected and unaffected siblings: Genes harboring damaging mutations that are expressed together in the fetal prefrontal cortex of people with schizophrenia formed a network with significantly greater connectivity than networks modeled from genes harboring similar mutations in their unaffected siblings at that time in development. (nih.gov)

Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. (cdc.gov)
Histidine-rich protein 2 (HRP2)-based RDTs are largely preferred for detecting P. falciparum malaria because of their superior sensitivity and heat-stability profile over Plasmodium lactate dehydrogenase (pLDH) or aldolase ( 6 ). (cdc.gov)
Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea. (cdc.gov)
Amoah LE , Abankwa J , Oppong A . Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana. (cdc.gov)
Plasmodium falciparum parasites with histidine-rich protein 2 ( pfhrp2 ) and pfhrp3 gene deletions in two endemic regions of Kenya. (cdc.gov)

Alankarage D, Lavery R, Svingen T, Kelly S, Ludbrook L, Bagheri-Fam S, Koopman P, Harley V. SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex development. (medlineplus.gov)
High protein expression was seen in 15.3% of cases for erb-b2, 44.1% for erb-b1, 43.2% for PIK3CA, 51.6% for p-AKT, and 28.0% for p-ERK. (medscape.com)
Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. (nih.gov)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Validated MISSION ® siRNAs have been functionally validated in Hela cells by Sigma scientists to Knockdown gene expression by 75% or greater. (sigmaaldrich.com)
Learning and memory formation are known to require dynamic CpG (de)methylation and gene expression changes. (nature.com)
To assess the influence of (variable) methylation on gene expression, RNA-seq experiments were performed as well. (nature.com)
Although numerous genomic resources are becoming available for this animal model, several in vivo experiments (e.g. knockdowns or manipulation of gene expression), are still impossible or very laborious and expensive. (nature.com)
Epigenetics is defined as the study of inheritable chromatin modifications that have an impact on gene expression without altering the underlying DNA sequence 14 . (nature.com)
This methylation mark is known to regulate gene expression and when located in the promoter region, it generally leads to transcriptional silencing of the corresponding gene 15 . (nature.com)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)
We own protein expression technology based on a series of protein expression and purification technology, including protein expression technology shown by Baculovirus outer membrane proteins (OMP), and membrane protein expression technology, etc. (cusabio.com)
Compared with traditional protein expression systems, many processes are omitted in vitro E.coli, such as the transformation of plasmids, cell culture, collection, crushing and centrifugation, etc., which greatly improves working efficiency. (cusabio.com)
NEW YORK - Researchers have uncovered thousands of gene pairs whose expression levels could account for the tissue specificity of cancer driver genes and influence patients' survival as well as drug response. (genomeweb.com)
Using a computational strategy they devised, the researchers examined gene pairs whose joint expression is linked to patient survival, which they dubbed survival-associated pairwise gene expression states, or SPAGEs. (genomeweb.com)
The pipeline first bins genes based on their activity level into low, medium, or high expression states, so that for each pair of genes there are nine possible co-activity states. (genomeweb.com)
An IFN gene expression "signature" is a candidate biomarker in patients with dermatomyositis (DM). (nih.gov)
The type I IFN gene signature in the whole blood of patients with DM was defined by determining the expression levels of 3 IFN-regulated genes (IFIT1, G1P2, and IRF7) using quantitative real-time reverse transcription-polymerase chain reaction. (nih.gov)
The level of expression of genes encoding for nine major xenobiotic metabolising Cytochrome P450s (CYPs) and the P-glycoprotein (Pgp) was determined in three different regions of the small intestine of male and female Sprague Dawley rats and the expression was compared with that in the liver. (nih.gov)
A semi-quantitative RT-PCR method, using the total RNA from the tissues, was established for the determination of the level of gene expression. (nih.gov)
The expression of the other CYP genes was remarkably different in the two organs. (nih.gov)
With the exception of the CYP2A3, none of the genes showed a clear regional distribution in their small intestinal expression. (nih.gov)
Furthermore, no obvious sex difference in the expression of the CYP and Pgp genes could be observed. (nih.gov)
The apparently strong small intestinal expression of the CYP2C genes suggests that these enzymes could play a key role in the intestinal drug metabolism in rats and therefore affect the bioavailability of those orally used drugs which are substrates of the CYP2Cs. (nih.gov)
RT-qPCR was applied to determine mRNA of m6A-associated genes and SFRP2, and western blot were used for ZEB1 and MMP9 protein expression. (nature.com)
To test this, Gilad, Jonathan Pritchard, PhD, currently at Stanford University, and their team, spearheaded by postdoctoral fellow Zia Khan, PhD, used high-resolution mass spectrometry to compare the expression levels of thousands of proteins with corresponding mRNA expression data in human and chimpanzee cell lines. (sciencedaily.com)
The team found 815 genes with differing mRNA expression levels but only 571 genes that differed in protein expression. (sciencedaily.com)
The study raises questions over why mRNA expression levels differ between species if they do not necessarily cause protein differences. (sciencedaily.com)
Although further study is needed, Gilad believes this study suggests that protein expression levels evolve under greater evolutionary constraint than mRNA levels, via a yet-uncharacterized compensation or buffering mechanism. (sciencedaily.com)
For now, research that uses mRNA expression levels as a measure of the functional importance of a gene requires reassessment, and not just in studies on evolution. (sciencedaily.com)
July 1, 2021 A new technique called sci-Space, combined with data from other technologies, could lead to four-dimensional atlases of gene expression across diverse cells during embryonic development of mammals. (sciencedaily.com)
For ParDAM6 , only a small part of the cDNA was sequenced, which was sufficient for the quantification of gene expression. (frontiersin.org)
The concomitant decrease of gene expression with endodormancy release is consistent with a role of ParDAM5 and ParDAM6 genes in dormancy induction and maintenance. (frontiersin.org)
The vector encoded the synthetic spider silk protein A2S814, which exhibits both elastic and strength motifs, along with the silkmoth Bombyx mori fibroin heavy chain (fhc) protein, to target spider silk protein production specifically to the silkworm's posterior silk gland, and an fhc enhancer to increase expression levels. (genengnews.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Unlike most other genes, expression levels of many of the 50 mutation-containing genes that form the suspected network were highest early in fetal development, tapered off by childhood, but conspicuously increased again in early adulthood - just when schizophrenia symptoms typically first develop. (nih.gov)
Post-translational histone modifications contribute to the maintenance of chromatin states associated with a defined gene expression program. (europa.eu)

SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. (senescence.info)
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. (cancerindex.org)

Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. (nih.gov)
Comparison of RNA-seq and MethylCap-seq results showed that at least 357 of the 3,457 AZA-upregulated genes are putatively regulated by methylation in the promoter region, for which a pathway analysis showed remarkable enrichment for neurological networks. (nature.com)
Antisense Alu-carrying genes were particularly enriched in neurological and developmental processes, while sense Alu-carrying genes were enriched in immunological functions. (biomedcentral.com)

NOR1 encodes a protein that plays a role in the normal self-destruction, or apoptosis, of damaged cells. (sciencenews.org)

In the present study, we identified and characterized the apricot ( Prunus armeniaca L.) homologs of three dormancy-related genes, namely the ParCBF1 ( C-repeat binding factor ), ParDAM5 ( dormancy-associated MADS-BOX ) and ParDAM6 genes. (frontiersin.org)
These results support that the newly identified apricot gene homologs have a crucial role in dormancy-associated physiological mechanisms. (frontiersin.org)
These components are homologs to animal PRC1 Ring finger proteins and are involved in H2A monoubiquitination. (europa.eu)

Activation of the erb-b signaling pathway has a very important role in human cancers, and alterations of genes in this pathway have been reported in different human cancers, including ovarian carcinoma. (medscape.com)
In the present study, we investigated the molecular mechanisms underlying the pro-apoptotic effects of quercetin (Qu) by evaluating the effect of Qu treatment on DNA methylation and posttranslational histone modifications of genes related to the apoptosis pathway. (cancerindex.org)
In summary, our results showed that enhanced apoptosis, induced by Qu, might be caused in part by its DNA demethylating activity, by HDAC inhibition, and by the enrichment of H3ac and H4ac in the promoter regions of genes involved in the apoptosis pathway, leading to their transcription activation. (cancerindex.org)
Our results implicate networked genes underlying a pathway responsible for orchestrating neurogenesis in the prefrontal cortex in schizophrenia. (nih.gov)

These gene interactions, Hannenhalli noted, could influence why some driver genes lead to tumor development in some tissue types but not others because their interacting partners could be expressed at varying levels in different tissues. (genomeweb.com)

Synaptotagmins (Syts) are a large family of membrane proteins consisted of at least 12 isoforms. (semanticscholar.org)

We tested the hypothesis that variants in genes that encode PGRPs are associated with PD risk. (nih.gov)
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Genetic differences can give individual sperm an advantage in the race for life, thus promoting the transmission of particular gene variants to the next generation. (bigthink.com)

On the basis of this action, the SOX9 protein is called a transcription factor. (medlineplus.gov)
A CA repeat polymorphism, in the IGF1 gene, which is located 969 bp upstream from the transcription start site and the rs2854744 and rs2854746 single nucleotide polymorphisms (SNPs) in the IGFBP3 gene have been associated with the serum levels of the respective proteins and colorectal cancer (CRC), but the results are inconsistent. (nih.gov)
To our knowledge, this study provides the first genome-wide DNA methylation map of the zebra finch genome as well as a comprehensive set of genes of which transcription is under putative methylation control. (nature.com)
The MYB proteins represent a large family of transcription factors and play important roles in development, senescence, and stress responses in plants. (mdpi.com)
In the current study, 233 MYB transcription factor-encoding genes were identified and analyzed in the potato genome, including 119 R1-MYB, 112 R2R3-MYB, and two R1R2R3-MYB members. (mdpi.com)
The TDP-43 protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. (medlineplus.gov)

Lab tests might be done to look for certain proteins on the cancer cells. (cancer.org)
By cutting and rearranging mRNA molecules in different ways, the TDP-43 protein controls the production of different versions of certain proteins. (medlineplus.gov)

These chromosome abnormalities disrupt regions of DNA called enhancers that normally regulate the activity of the SOX9 gene. (medlineplus.gov)
The genetic changes associated with isolated Pierre Robin sequence are thought to disrupt enhancer regions that normally regulate the activity of the SOX9 gene during development of the lower jaw, which reduces SOX9 gene activity. (medlineplus.gov)
Finally, the researchers observed that many of the genes that regulate the formation of the three germ layers also are known contributors to the growth of cancers when they are over- or underexpressed in somatic cells. (genengnews.com)

The gene deletion proportions signify a risk of false-negative HRP2-RDT results. (cdc.gov)
Parasite deletion of the genes pfhrp2 and pfhrp3 has been implicated in false-negative results using HRP2-based RDTs. (cdc.gov)
for the first time, a specific weakness in cognitive ability has been linked to deletion of a single gene. (psychologicalscience.org)
Classic WS has recently been shown to be caused by hemizygosity for at least 500 kilobases of DNA on chromosome 7 (i.e., a deletion of genes on one of the two copies of chromosome 7). (psychologicalscience.org)
Indeed, researchers have identified individuals with hemizygosity limited to the gene for elastin, a structural protein found in large arteries and other elastic connective tissue, and have established that SV AS results from this deletion. (psychologicalscience.org)
Mice with a target deletion of the GPR55 gene show no specific phenotype . (wikipedia.org)

About 5 percent of cases are caused by chromosome abnormalities that occur near the SOX9 gene. (medlineplus.gov)

Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
All of these genetic changes prevent the SOX9 protein from properly controlling the genes essential for normal development of the skeleton, reproductive organs, and other parts of the body. (medlineplus.gov)
Genetic changes that occur near the SOX9 gene cause some cases of isolated Pierre Robin sequence. (medlineplus.gov)
Our study suggests no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk. (nih.gov)
The researchers used genome-wide genetic screening to both overexpress and inactivate ("knock out") tens of thousands of genes that govern embryonic stem cell proliferation and differentiation into the three germ layers. (genengnews.com)
Instead of looking at genes one by one, we looked at thousands of genetic alterations at the same time to determine how they affect the proliferation of embryonic stem cells, and, subsequently, the development of the three germ layers that serve as the raw material for human tissues. (genengnews.com)
Our work expands the potential scope of strategies, thus far restricted to synthetic lethality, by generalizing the concept of exploiting genetic interactions to include many other yet-unexplored types of gene-pair relationships," Hannenhalli said. (genomeweb.com)
The TDP-43 protein is involved in processing molecules called messenger RNA (mRNA), which serve as the genetic blueprints for making proteins. (medlineplus.gov)
Using a combination of genetic and biochemical approaches, we will purify the putative PRC1 complexes, determine the direct targets of the PRC1 Ring finger proteins and unveil the role of H2A monoubiquitination in the mechanism. (europa.eu)
A new study of mice by researchers from the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin identifies a genetic factor called " t-haplotype ," whose tag-team act with the protein RAC1 helps a spermatozoan speed straight to the prize. (bigthink.com)

NCBI Minute Webinar: Finding Gene, Protein and Chemical Names, Aliases and Synonyms on February 8, 2017. (nih.gov)
On February 8, 2017, NCBI staff will discuss the systems in the NCBI Gene and PubChem resources that identify and correlate various names used for genes, proteins, and chemicals. (nih.gov)

If it is not clear how much HER2 protein is present, molecular testing might be done to see how many copies of the HER2 gene the cancer cells have. (cancer.org)
In some cases, doctors may test for specific gene changes in the breast cancer cells that could mean certain targeted drugs or immunotherapy drugs might help treat the cancer. (cancer.org)
The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. (nih.gov)
Gene networks in human embryonic stem cells (hESCs) have been found to serve two purposes at once. (genengnews.com)
Changes to the TDP-43 protein cause the protein to misfold and form protein clumps (aggregates), which have been found in nerve cells that control muscle movement (motor neurons) in some people with ALS. (medlineplus.gov)
To try and get around this problem recombinant spider silk proteins have been produced in hosts such as bacteria, yeast, baculovirus/insect systems, mammalian cells, and transgenic plants and animals. (genengnews.com)
In addition, Qu treatment significantly increased the mRNA levels of all these genes, when compared to cells treated with vehicle only (control cells) (*p (cancerindex.org)
The researchers then did the opposite-they created a mouse that had no Tob gene in the cells in the hippocampus but had it in the cells in the rest of the body. (scienceblog.com)
Cells normally use microRNAs to control their own gene activity, but some pathogens also release microRNAs to turn off genes involved in cellular defence in a potential target organism. (newscientist.com)
It is known to be a protein that guides cells to different places in the body. (bigthink.com)

AKT and ERK are supposed to be the 2 main downstream proteins of the erb-b receptors. (medscape.com)
All breast cancers are tested for hormone receptors (proteins). (cancer.org)

The SOX9 protein attaches (binds) to specific regions of DNA and regulates the activity of other genes, particularly those that control skeletal development and sex determination. (medlineplus.gov)
The encoded protein binds to Bcl-2 and possesses the BH3 domain. (cancerindex.org)

This gene is found in every organism from bacteria to man. (nih.gov)
Here, we aimed at establishing a genome-wide DNA methylation map of the zebra finch genome, a model organism in neuroscience, as well as identifying putatively epigenetically regulated genes. (nature.com)

Recombinant proteins are useful tools for analyzing biological interactions. (cusabio.com)
A much larger number of recombinant proteins is used in the research laboratory, including both commercial proteins and those that are generated in the course-specific research projects. (cusabio.com)
Over more than 16 years, CUSABIO has established five systems from prokaryotic to eukaryotic to express the recombinant protein. (cusabio.com)
Animal-Free Recombinant Proteins. (cusabio.com)
CUSABIO has developed the product line of recombinant proteins with no exposure to animal byproducts. (cusabio.com)
Here is the catalog of all recombinant proteins. (cusabio.com)
Recombinant protein production can be targeted to the silk gland using tissue-specific promoters, and the silk gland naturally produces silk fibers. (genengnews.com)

Inactivation of SIRT7 in HSCs results in reduced quiescence, increased mitochondrial protein folding stress and compromises their regenerative capacity. (senescence.info)

This study was performed to evaluate the capacity of IFN-dependent peripheral blood gene and chemokine signatures and levels of proinflammatory cytokines to serve as biomarkers for disease activity in adult and juvenile DM. (nih.gov)
These results suggest that serum IL-6 production and the type I IFN gene signature are candidate biomarkers for disease activity in adult and juvenile DM. (nih.gov)

An analysis of human chromosomes 21 and 22 showed that genic Alus are particularly enriched in genes of metabolism, transport and signaling processes [ 16 ]. (biomedcentral.com)

Database of human genes associated with cellular senescence. (senescence.info)
For genes to be expressed, DNA must be transcribed into messenger RNA (mRNA), which then code for proteins, the biological building blocks and engines that drive cellular function. (sciencedaily.com)

The homology modeling of protein domains and a phylogenetic analysis of ParDAM5 suggest its functional integrity. (frontiersin.org)

In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. (nih.gov)
The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (nih.gov)

Paclitaxel acts by inhibiting the proteins encoded by BCL2, TUBB1, and MAP, and the researchers noted that their analysis suggests BCL2 inhibition by paclitaxel has increased effectiveness when ITPR1 is highly expressed. (genomeweb.com)

Participants in two independent case-control studies were genotyped for 30 single-nucleotide polymorphisms (SNPs) in the four PGLYRP genes. (nih.gov)

p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)

The current study uncovers a new function of this protein as a mediator of wound healing. (nih.gov)

This suggests that the Tob gene likely has multiple direct and indirect impacts. (scienceblog.com)

p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene. (uniprot.org)
Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (nih.gov)
Identification, Structural and Functional Characterization of Dormancy Regulator Genes in Apricot (Prunus armeniaca L. (frontiersin.org)

Using an experimental drug, researchers were able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene. (nih.gov)

A subset of genes was validated using Exon Arrays, quantitative RT-PCR and CpG pyrosequencing on bisulfite-treated samples. (nature.com)

Among histone modifiers, the evolutionary conserved Polycomb Group (PcG) machinery has a key role in repressing the genes that are not required in a specific cell fate, thus, establishing cell identity. (europa.eu)

Homozygous mutation of this gene results in lethality before weaning. (jax.org)
Mice homozygous for a gene trapped allele exhibit postnatal lethality and skeletal and craniofacial defects. (jax.org)
While scientists have previously investigated interactions between pairs of genes in cancer, particularly ones that lead to synthetic lethality, a University of Maryland team has expanded on those studies to include additional types of gene pairs. (genomeweb.com)

For more information about the HER2 gene and protein see Breast Cancer HER2 Status . (cancer.org)
People with advanced or metastatic triple-negative breast cancer might have their cancer tissue tested for the PD-L1 protein, which can show if the cancer is more likely to respond to treatment with certain immunotherapy drugs along with chemotherapy. (cancer.org)
These interactions, they added, could explain why some cancer driver genes are tissue specific and could stratify breast cancer tumors into a number of survival-related subtypes. (genomeweb.com)
After further filtering, the researchers homed in on 1,704 SPAGEs - including 133 known cancer genes and 50 breast-cancer-specific driver genes - that involve neighboring genes in a protein interaction network. (genomeweb.com)

The prolonged incubation times that accompany the transmission of prions between species are due, at least in part, to differences in prion protein (PrP) sequence. (nih.gov)
To examine the species barriers between non-human primates and humans, we sequenced the open reading frames (ORF) of 25 PrP genes from apes and monkeys. (nih.gov)

These sequences are usually linked to M protein genes rather than the similar mrp or enn genes. (cdc.gov)
This helps to avoid confounding of the 180-base M protein gene segment by the similar emm- like mrp and enn sequences (see CDC Streptococcus Laboratory GAS bioinformatic pipeline for S. pyogenes external icon ). (cdc.gov)
While phylograms of primate PrP sequences revealed a novel branching pattern for the apes, the genomic organization of all the primate PrP genes was similar, with the entire ORF contained within a single exon. (nih.gov)
Prediction of the coding sequences of unidentified human genes. (nih.gov)

A directed protein interaction network for investigating intracellular signal transduction. (nih.gov)

Therefore, the CA repeat along with two SNPs in the IGF1 gene, and rs2854744 (A-202C), rs2854746 (Ala32Gly) and two additional SNPs in the IGFBP3 gene were selected to cover the whole gene regions. (nih.gov)
We did not find any association between the CA repeat length or any of the SNPs in the IGF1 and the IGFBP3 genes and the risk of CRC. (nih.gov)

The scientists identified the heat shock protein 60 gene, Hsp60, as an important player in tissue regeneration. (nih.gov)
Scientists report on the development of engineered silkworms that express a synthetic spider silk protein and stably produce chimeric silk fibers that are stronger than parental silkworm silk fibers and as tough as spider dragline silk. (genengnews.com)

G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene . (wikipedia.org)

The SOX9 gene provides instructions for making a protein that plays a critical role during embryonic development. (medlineplus.gov)

In a study led by Dr. Shawn Burgess of NIH's National Human Genome Research Institute (NHGRI), researchers screened for genes that are essential for hair cell regeneration in zebrafish. (nih.gov)
Our methods allowed us to create an 'atlas' of nearly every gene in the human genome and determine what its overexpression or loss does to the most fundamental first steps of human development," said Kamila Naxerova, PhD, a former postdoctoral fellow in the Elledge laboratory and the lead author of the Genes and Development article. (genengnews.com)

Thus, these results demonstrate that the incorporation of chimeric silkworm/spider silk proteins can significantly improve the mechanical properties of composite silk fibers produced using the transgenic silkworm platform. (genengnews.com)

Anatomy11

Organisms46

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