Protein gene fusion. Medical search. Frequent questions

The discovery of inactivating mutations in the BRCA1-associated protein 1 gene in sporadic and hereditary mesothelioma has opened up a variety of novel molecular, clinical, and diagnostic investigations. (nih.gov)
Finally, desmoid type fibromatosis, a locally aggressive tumor that can present in the pleura, has been shown to frequently have CTNNB1 gene mutations and express β-catenin by immunohistochemistry. (nih.gov)
Genetic drivers are mutations or fusions that confer a survival advantage to "drive" malignant proliferation. (medscape.com)
[ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
Changes in your genes are also called mutations or variants . (medlineplus.gov)
Non-FA (or underlying FA) patients harboring heterozygous germline FA gene mutations may also face an increased risk of developing bone marrow failure, primary immunodeficiency disease, and hereditary cancer predisposition syndromes. (frontiersin.org)
Targeted next-generation sequencing (NGS) of a panel of 80 genes was performed on her initial bone marrow aspirate sample and identified PTPN11, NRAS , and DNMT3A somatic mutations. (frontiersin.org)
This case highlights the importance of genetic counseling in patients with hematopoietic neoplasms with high clinical suspicion for carrying cancer susceptibility gene mutations, which require timely diagnosis and personalized management. (frontiersin.org)
To date, researchers have already identified germline mutations in 22 specific genes associated with the FA pathway, each accounting for an individual FA complementation group ( 2 ). (frontiersin.org)
Here, we present the case of a 54-year-old female patient with multiple FA gene mutations. (frontiersin.org)
Comprehensive genetic testing showed that many molecular variations (including FA gene germline mutations, RAS and epigenetic pathway somatic mutations, and NUP98-HOXC11 fusion) were highly linked to her serious and complex medical history ( Figures 1A, B ). (frontiersin.org)
(B) The patient was born with four Fanconi anemia (FA) gene mutations and germline predisposition to cancers. (frontiersin.org)
She developed ovarian cancer, and then the altered FA pathway plus exposure to cytotoxic drugs promoted the emergence of acquired somatic mutations and the NUP98-HOXC11 fusion, all of which contributed to the development of secondary t-CMML. (frontiersin.org)
CRLF2 alterations are associated with the presence of activating mutations in the JAK genes JAK1 and JAK2 (Russell et al. (atlasgeneticsoncology.org)
reviewed in Roll and Reuther, 2010), as well as mutations of the lymphoid transcription factor gene IKZF1 (IKAROS) (Harvey et al. (atlasgeneticsoncology.org)
The gene view histogram is a graphical view of mutations across KRTAP5-5. (sanger.ac.uk)
These mutations are displayed at the amino acid level across the full length of the gene by default. (sanger.ac.uk)
Under this is shown the amino acid sequence and the Pfam protein structures, followed by complex mutations and insertions and deletions. (sanger.ac.uk)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
They then used DIGGIT analysis ( GitHub repo of R implementation) to identify the MR proteins and identify cellular mutations that led to them. (silvertonconsulting.com)
The types of mutations can be copy number, single point or gene fusion. (silvertonconsulting.com)
DIGGIT analysis can help identify which of the mutations are responsible for the protein being analyzed. (silvertonconsulting.com)
Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
An expanding number of degenerative disorders are associated with mutations in the genes encoding MFN2 and OPA1, including Charcot-Marie-Tooth disease type 2A and autosomal dominant optic atrophy. (centrodinoferrari.com)
Intelligent-design proponents may accept some aspects of common descent, as long as they are allowed to claim that a "designer" interfered with the genes and mutations along the way, then deferring what's not explained to "we don't know" what happened. (rationalwiki.org)
The gene view histogram is a graphical view of mutations across MUSK_ENST00000189978. (sanger.ac.uk)
Shiang R, Thompson LM, Zhu YZ: Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. (medigraphic.com)

They discovered that her tumor had a rare mutation called NTRK gene fusion - and told her about a clinical trial opening in Denver for a drug targeting that abnormality. (curetoday.com)
Patients with FA gene mutation are hypersensitive to DNA damage and unable to successfully repair damaged DNA when exposed to DNA-crosslinking agents, cytotoxic chemotherapeutics, and ionizing radiation ( 3 , 4 ). (frontiersin.org)
Throughout the lifetime of patients with an FA gene mutation, DNA damage increasing accumulates, which would lead to a complex clinically and genetically heterogeneous disorder characterized by developmental abnormalities, bone marrow failure (BMF), immune deficiency, and a high risk of developing various cancers (e.g. (frontiersin.org)
The most common mutation that causes Ewing sarcoma involves two genes, the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11 . (medlineplus.gov)
Some genes no longer code for a protein due to a mutation or error. (rationalwiki.org)

We can observe its effect if gene fusion occurs in coding sequences. (wikipedia.org)
If it happens in coding sequences, gene fusion cause the assembly of a new gene, then it allows the appearance of new functions by adding peptide modules into a multi-domain protein. (wikipedia.org)
The fact that they have identified 24 master regulatory (MR blocks) architectures (sequences of proteins that are occur) that apply to a wide set of cancer tumor sub-types implies that these could be needed to regulate the functionality of these cancers. (silvertonconsulting.com)
It encodes 1227 predicted open reading frames, of which 27% encode proteins that match known eukaryotic sequences, while over half are not recognizable. (virology.ws)
There are ample mobile genetic elements present, including self splicing proteins (called inteins) and sequences known as ribozymes that can splice themselves out of an RNA. (virology.ws)
A genome-wide survey for N-terminal signal sequences using bioinformatic tools (Psortb 2.0 and SignalP 3.0) combined with a strategy of the subtraction of lipoproteins and proteins containing multiple transmembrane domains yielded 116 secretory proteins. (cdc.gov)

A new drug can break the circuit of cancer-causing effects that develop when certain genes fuse. (curetoday.com)
Contrary to Horton's representation of our motives for doing this work, we, in fact, accidentally stumbled onto this rather startling find while carrying out experiments designed to understand the role certain genes play in Drosophila brain development. (nybooks.com)
The FLI protein controls the growth and development of some cell types by regulating the transcription of certain genes. (medlineplus.gov)

Fusion genes can contribute to tumor formation because fusion genes can produce much more active abnormal protein than non-fusion genes. (wikipedia.org)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
The quantification of protein expression for tests like PD-L1 is performed on circulating tumor cells (CTCs) and cannot be determined from circulating tumor DNA (ctDNA). (prnewswire.com)
Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from destruction. (news-medical.net)
We hope to contribute to the advance of translational cancer research and the implementation of precision medicine in the field of prostate cancer by providing a unique insight into the protein level alterations associated with tumor tissue in clinical samples," adds Flores-Morales. (sciencedaily.com)
This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
In this fashion they were able to analyze the 112 tumor subtype proteome (the total complement of all proteins active in a cell). (silvertonconsulting.com)
Then using tumor checkpoint hypothesis and Bayesian analysis/integration they further ranked the MR candidate proteins. (silvertonconsulting.com)
In the final step in their analysis, they used tumor checkpoint hypothesis and modularity with saturation & modularity analysis to identify top MR proteins and the MR blocks active in the 112 tumor subtypes. (silvertonconsulting.com)

But the abnormal BCR-ABL1 gene has instructions for an abnormal protein. (medlineplus.gov)
The BCR-ABL gene leads to the production of an abnormal protein that fuels the growth of leukemia cells. (cancercare.org)

This database is called Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. (wikipedia.org)

The approach in which the antigen was tagged by equal molecular GFP allows using the bi-function fusion protein to establish a new method for immunogical diagnosis. (virosin.org)
Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level. (news-medical.net)
FATHMM-MKL is an algorithm which predicts the functional, molecular and phenotypic consequences of protein missense variants using hidden Markov models. (sanger.ac.uk)
This review provides an overview of the basic molecular mechanisms involved in mitochondrial fusion and focuses on the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics. (centrodinoferrari.com)
Molecular cloning and viral gene delivery of fusion proteins are powerful tools to elucidate the role and regulation of proteins within the central nervous system. (gla.ac.uk)

Most fusion genes are found from hematological cancers, sarcomas, and prostate cancer.BCAM-AKT2 is a fusion gene that is specific and unique to high-grade serous ovarian cancer. (wikipedia.org)
NTRK fusions are rare: A recent sampling of more than 13,000 tumors found the abnormality in just 0.31% of adult cancers and 0.34% of pediatric tumors. (curetoday.com)
NTRK fusions appear in some common cancers, such as non-small cell lung, sarcoma and colon, as well as some rare cancers, including secretary breast carcinoma and cellular or mixed congenital mesoblastic nephroma. (curetoday.com)
Lymphocyte activation gene-3 (LAG-3) is a coinhibitory receptor associated with impaired T-cell function and is frequently coexpressed with programmed cell death protein-1 (PD-1) in the context of human cancers. (aacrjournals.org)

The present study focused on two such proteins, the transmembrane receptor PAR2 and the nuclear epigenetic regulator MeCP2. (gla.ac.uk)

The abnormal BCR-ABL1 gene is formed when pieces of chromosomes 9 and 22 break off and trade places. (medlineplus.gov)
The P2RY8 gene is located on both chromosomes X and Y. It was discovered by Cantagrel and co-workers while investigating a pericentric inversion on the X chromosome, inv(X)(p22.3 q13.2), in a family with mental retardation. (atlasgeneticsoncology.org)
An interstitial deletion of the pseudoautosomal region 1 (PAR1) of either of the sex chromosomes results in juxtaposition of the first noncoding exon of the P2RY8 gene to the first exon of CRLF2, such that CRLF2 expression from this chimeric locus is driven by the P2RY8 promoter. (atlasgeneticsoncology.org)
A rearrangement (translocation) of genetic material between chromosomes 22 and 11, written as t(11;22), fuses part of the EWSR1 gene with part of the FLI1 gene, creating the EWSR1/FLI1 fusion gene. (medlineplus.gov)
Chromosome fusion - Gene fusion or chromosome fusion is when two chromosomes are spliced together. (rationalwiki.org)
Genes Chromosomes and Cancer. (lu.se)

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)
In the case of TMPRSS2-ERG, by disrupting androgen receptor (AR) signaling and inhibiting AR expression by oncogenic ETS transcription factor, the fusion product regulates the prostate cancer. (wikipedia.org)
The EWS protein, produced from the EWSR1 gene, also regulates transcription. (medlineplus.gov)

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)

In CML, a balanced (9;22) chromosomal translocation results in a chimeric BCR-ABL fusion gene. (medscape.com)

Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia. (atlasgeneticsoncology.org)

TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
Across the whole genome, approximately 2% of the genes code for proteins, while the remaining are non-coding or still functionally unknown [ 1 ]. (biomedcentral.com)
The genome encodes proteins involved in DNA replication and repair, RNA synthesis and modification, translation proteins, and capsid proteins. (virology.ws)
A similar expansion of genes encoding an antagonist of a host innate immune protein has been observed in the genome of vaccinia virus (discussed on TWiV #198 ). (virology.ws)

The first fusion gene was described in cancer cells in the early 1980s. (wikipedia.org)
Since chromosomal translocations play such a significant role in neoplasia, a specialized database of chromosomal aberrations and gene fusions in cancer has been created. (wikipedia.org)
Presence of certain chromosomal aberrations and their resulting fusion genes is commonly used within cancer diagnostics in order to set a precise diagnosis. (wikipedia.org)
The testing that detected the NTRK gene fusion is what really made the difference between life and death," says Miller, 45, a mother of three teenagers who now travels throughout the country telling her story at cancer-related conferences. (curetoday.com)
protein composed of uncontrolled TRK enzymes, which promote cancer growth. (curetoday.com)
NTRK fusions in cancer were discovered in the 1980s, and at first, oncology researchers feared they couldn't be targeted with drugs. (curetoday.com)
This abnormal gene is involved in certain types of blood cancer . (medlineplus.gov)
This particular type of protein is very specific to prostate cancer cells and could help identify whether newly diagnosed patients require radical prostatectomy surgery or if it is safe to delay surgery. (sciencedaily.com)
Using mass spectrometry, the researchers measured concentration changes in thousands of proteins in both normal and tumour tissue from prostate cancer. (sciencedaily.com)
Among the 9000 proteins identified, one protein, the neuropeptide, pro-NPY, was demonstrated to exhibit high levels in a subgroup of prostate cancer samples. (sciencedaily.com)
Therefore, a better understanding of the protein signaling pathways deregulated in prostate cancer could lead to better preventive and therapeutic strategies for the treatment of this disease. (sciencedaily.com)
This work is the result of collaborations between the research groups of Professor Flores-Morales at IVS, Professor Matthias Mann at Novo Nordisk Foundation Center for Protein Research both from the Faculty of Health and Medical Sciences together with the Danish Cancer Society Research Center and Associate Professor Pernilla Wikström from the Umeå University, Sweden. (sciencedaily.com)
This is NOT a known cancer gene. (sanger.ac.uk)
It is not found in the Cancer Gene Census . (sanger.ac.uk)
Mouse insertional mutagenesis experiments DO NOT support the designation of KRTAP5-5 as a cancer causing gene. (sanger.ac.uk)
This gene does not have a cancer hallmark. (sanger.ac.uk)
The researchers examined the regulatory/signaling networks of proteins in 112 cancer cell lines. (silvertonconsulting.com)
According to the Economist article master regulatory proteins are proteins that regulate processes in a cancer cell that cause other proteins to be made, which cause other proteins to be made, etc. which affect the way a cancer cell lives and propagates inside a body. (silvertonconsulting.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)

The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G, Ghysdael J. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. (medlineplus.gov)
It all starts with VIPER analysis ( GitHub repo ) that measures a specific proteins transcriptional activity level. (silvertonconsulting.com)
Expression of the nir and nor genes for denitrification of Pseudomonas aeruginosa requires a novel CRP-FNR-related transcriptional regulator, DNR, in addition to ANR. (microbiologyresearch.org)

A major distinctive feature of the purine biosynthetic pathways in Bacteria is the prevalence of gene fusions where two or more purine biosynthetic enzymes are encoded by a single gene. (wikipedia.org)
Such gene fusions are almost exclusively between genes that encode enzymes that perform sequential steps in the biosynthetic pathway. (wikipedia.org)
argue that two single-domain biosynthetic enzymes appear to have evolved from gene duplication, followed by fusion, followed by a second gene duplication (Science 2000, 289:1546-1550). (the-scientist.com)
As BsV does not encode enzymes involved in this process, the virus must use host tRNAs in the process of protein synthesis. (virology.ws)

ABL1 fusion gene, composed of the 3' part of the ABL1 gene in the breakpoint on chromosome 9 and the 5' part of a gene called BCR in the breakpoint in chromosome 22. (wikipedia.org)
ABL1 protein with the capacity to induce chronic myeloid leukemia. (wikipedia.org)
A BCR-ABL1 genetic test uses a sample of blood or bone marrow to look for an abnormal gene called BCR-ABL1 . (medlineplus.gov)
The abnormal BCR-ABL1 gene is made when two separate genes merge together and become one gene. (medlineplus.gov)
The broken piece of chromosome 9 includes part of the ABL1 gene. (medlineplus.gov)
This makes the abnormal fusion gene, BCR-ABL1 . (medlineplus.gov)
An abnormal BCR-ABL1 gene is an acquired genetic change. (medlineplus.gov)
Some medicines target the protein made by the BCR-ABL1 gene. (medlineplus.gov)
If your health care provider thinks you may have a type of leukemia that involves the BCR-ABL1 gene , you may need a BCR-ABL1 genetic test to make a diagnosis. (medlineplus.gov)
See how well your treatment is working (if treatment is helping, the number of cells with BCR-ABL1 genes will decrease. (medlineplus.gov)

Biologists call these sorts of proteins transcription factors which controls the copying of DNA information into mRNA which are then taken to protein factories to create proteins from that blueprint. (silvertonconsulting.com)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
While high-throughput experimental methods like the yeast two-hybrid (Y2H) method and mass spectrometry are available to discern the function of proteins, the datasets generated by these methods tend to be incomplete and generate false positives [ 9 ]. (biomedcentral.com)
therefore, computational approaches combined with high-throughput experimental datasets are required to identify the function of proteins [ 9 , 14 ]. (biomedcentral.com)

But as researchers continued to study gene fusions, they realized those fears were unfounded. (curetoday.com)

The Food and Drug Administration approved Vitrakvi in November 2018 to treat adults and children with solid tumors of any type originating anywhere in the body if the patients have fusions in one of three NTRK (neurotrophic receptor tyrosine kinase) genes. (curetoday.com)
In the recent fifth edition of the World Health Organization classification, similar to the recent update to the International Consensus Classification, the category was renamed to "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions" and both classifications added novel subtypes with new JAK2 rearrangements (e.g. (nature.com)
Here we propose comprehensive response criteria based on the heterogenous clinical presentations of patients with MLN with eosinophilia and tyrosine kinase gene fusions. (nature.com)
Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes. (nih.gov)
This gene codes a fusion protein with high tyrosine kinase activity, resulting in growth factor-independent proliferation. (medscape.com)

Fusion gene: a 320-kb large interstitial deletion within the pseudoautosomal region 1 (PAR1) on chromosome X [del(X)(p22.33p22.33)] and chromosome Y [del(Y)(p11.32p11.32)] results in juxtaposition of the first non-encoding exon of P2RY8 to the CRLF2 coding region to form P2RY8-CRLF2 fusion which leads to over-expression of full-length CRLF2. (atlasgeneticsoncology.org)

We found that the runaway expression of a single gene, white , which we used as a "utility tool" in our experiments, induces homosexual courtship among mature males. (nybooks.com)

Endogenous retroviral insertions - Ancient retroviruses inserted inactivated viral genes into genomes . (rationalwiki.org)
Analysis of this HA gene shows that it is closely related to avian A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)

Here, we report a comprehensive secretome (600 proteins) of this species, which was identified using a multipronged strategy based on genetic/genomic, proteomic, and bioinformatic approaches. (cdc.gov)
A reporter-gene-fusion-based genomic library that was custom-generated in this study enabled the detection of 23 secretory proteins. (cdc.gov)

The latter is common in lymphomas, where oncogenes are juxtaposed to the promoters of the immunoglobulin genes. (wikipedia.org)

The EWS/FLI protein has the DNA-binding function of the FLI protein as well as the transcription regulation function of the EWS protein. (medlineplus.gov)
This basic two-step process has been confirmed in most mammalian cells, although its regulation and the repertoire of specific accessory proteins are likely to be highly context dependent. (centrodinoferrari.com)
While many proteins often interact with other proteins towards expediting their functions, there are challenges that are not just limited to their function but also to their regulation [ 7 ]. (biomedcentral.com)

That's because three NTRK genes play critical roles in the development and survival of nerve cells, raising the possibility that altering the genes could cause dangerous neurological side effects. (curetoday.com)
Fanconi anemia (FA) genes play critical roles in the repair of DNA lesions. (frontiersin.org)

This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. (cancerindex.org)
Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1. (cancerindex.org)

Genetic studies also led to the finding that WWTR1-CAMTA1 fusions are useful diagnostic markers for epithelioid hemangioendotheliomas, which can present as pleural-based masses. (nih.gov)
It is remarkable that white is one of the most studied genes in man's quest to understand genetic control and function in Drosophila (described in 1910 by Thomas Hunt Morgan as the first example of sex-linked inheritance in flies) and yet this phenomenon had not previously been reported. (nybooks.com)

CML is triggered by a chromosomal abnormality (an error during cell growth) in which the ABL gene is mistakenly joined to the BCR gene, forming a mutated BCR-ABL "fusion gene. (cancercare.org)

The detecting methods to inventory gene fusion events on a large biological scale can provide insights about the multi modular architecture of proteins. (wikipedia.org)
We confirm that the protein has biological activity in acute inflammation, causing a significant reduction in monocyte recruitment during zymosan induced peritonitis. (ox.ac.uk)
It was the first drug on the market to target NTRK fusions and the second FDA approval based on the biological characteristics of tumors rather than their location in the body. (curetoday.com)
Fusion Proteins offer an important biological assay for direct protein-to-protein interactions. (thermofisher.com)
Therefore, characterizing the uncharacterized proteins helps to understand the biological architecture of the cell [ 8 ]. (biomedcentral.com)

Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA Affinity. (utmb.edu)
This GST-fusion protein can then be purified from cells via its high affinity for glutathione. (thermofisher.com)

Oncogenic fusion genes may lead to a gene product with a new or different function from the two fusion partners. (wikipedia.org)
Alternatively, a proto-oncogene is fused to a strong promoter, and thereby the oncogenic function is set to function by an upregulation caused by the strong promoter of the upstream fusion partner. (wikipedia.org)
Oncogenic fusion transcripts may also be caused by trans-splicing or read-through events. (wikipedia.org)
Using retroviral expression screening for transforming genes in biphenotypic acute leukaemia, P2RY8 has been confirmed to have oncogenic potential (Fujiwara et al. (atlasgeneticsoncology.org)

We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)

These known-unknown regions for which no functional links are discovered, i.e. those with no biochemical properties or obvious relatives in protein and nucleic acid databases are known as orphan genes, and the end products are called HPs [ 2 ]. (biomedcentral.com)
The revelation of these species-specific orphan proteins offers a hitherto unexplored repertoire of potential targets for diagnostic, therapeutic, and vaccine research in this emerging lung pathogen. (cdc.gov)

Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles. (atlasgeneticsoncology.org)
Different computational methods have been designed for estimating protein function based on the information generated from sequence similarity, subcellular localization, phylogenetic profiles, mRNA expression profiles, homology modelling etc. [ 15 ]. (biomedcentral.com)
A homology search against the M. tuberculosis database identified nine additional secretory protein homologs that lacked a secretory signal sequence. (cdc.gov)

TLR1-GFP fusion gene was generated by fusing the green fluorescent protein (GFP) gene to the C terminus of human Toll-like receptor 1 (TLR1) gene. (invivogen.com)
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (atlasgeneticsoncology.org)

Taken as a pill once or twice daily, TKIs target the protein made by the mutated BCR-ABL fusion gene. (cancercare.org)

2010). Although P2RY8-CRLF2 fusions have been confirmed as a clear clinical risk factor in paediatric ALL, their precise role in the leukemic process remains to be elucidated with studies supporting involvement in the cellular transformation process but suggesting they function as a secondary capacity in driving the entire leukemic process (Morak et al. (atlasgeneticsoncology.org)
Proteins are key effectors of cellular functions. (sciencedaily.com)
Mitochondrial fusion and fission are fundamental processes underlying cellular dynamics [1]. (centrodinoferrari.com)

It attaches (fuses) to part of the BCR gene on chromosome 22. (medlineplus.gov)

Schmitt JM, Hwang K, Winn SR, Hollinger JO: Bone morphogenetic proteins: an update on basic biology and clinical relevance. (medigraphic.com)
Construction of hpaA gene from a clinical isolate of Helicobacter pylori and identification of fusion protein. (wjgnet.com)

Orthologous to human NAPA (NSF attachment protein alpha). (nih.gov)
Fusion genes have been found to be prevalent in all main types of human neoplasia. (wikipedia.org)
We report the in vivo pharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. (ox.ac.uk)
Why Should We Weigh Every Protein in the Human Body? (news-medical.net)
Schematic diagram of the human X chromosome indicating the location of the P2RY8 gene. (atlasgeneticsoncology.org)
GFP fusion gene was generated by fusing at the C terminus of the human TLR1 gene to a GFP variant. (invivogen.com)
These proteins are of great importance, as many of them might be associated with human diseases, thus falling into functional families. (biomedcentral.com)
Sequence Analysis of the Fusion Protein Gene of Human Respiratory Syncytial Virus Circulating in China from 2003 to 2014. (cdc.gov)

Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. (centrodinoferrari.com)

Translocations that fuse the EWSR1 gene with other genes that are related to the FLI1 gene can also cause these types of tumors, although these alternative translocations are relatively uncommon. (medlineplus.gov)

Fusion allows the exchange of contents, DNA, and metabolites between neighboring mitochondria, including damaged or senescent mitochondria, promoting their survival [2, 3]. (centrodinoferrari.com)

Purification of a histidine-tagged NnrS demonstrated that NnrS is a haem- and copper-containing membrane protein. (microbiologyresearch.org)

The identification of these fusion genes play a prominent role in being a diagnostic and prognostic marker. (wikipedia.org)

The transcribed RNA has 4198 base-pairs and encodes a 359 amino acid protein. (atlasgeneticsoncology.org)
The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)

YUE Li-Li, JI Xi-Peng, DENG Yan-Hui, LV Li-Qun, DENG Xiao-Zhao.Fusion of HBV e Gene with Green Fluorescent Protein Gene and Its Expression in E. coli Cells .VIROLOGICA SINICA, 1997, 12(4): 336. (virosin.org)
Your genes carry special instructions for making proteins that help your cells do their work. (medlineplus.gov)
The protein causes certain bone marrow cells to make large numbers of abnormal white blood cells. (medlineplus.gov)
GFP fusion gene has been fully sequenced, its fluorescence confirmed and its function tested in HEK293 cells coexpressing an NF-κB reporter plasmid ( pNiFty-SEAP ). (invivogen.com)
Ponatinib is often used to treat CML that has a specific additional alteration in the BCR-ABL gene known as T315I, which makes CML cells resistant to treatment with other TKIs. (cancercare.org)
Transcriptome comparisons of SOX9+ cells with GLT1+ cells showed that the two populations of cells exhibit largely overlapping gene expression. (jneurosci.org)
The authors believe that one copy of this gene was duplicated repeatedly as more of the encoded protein was needed to replicate in host cells. (virology.ws)
The hemagglutinin (HA) gene codes for one of the two surface glycoproteins and is central to species specificity because it is responsible for virus attachment and fusion with host cells. (cdc.gov)

We demonstrate that the in vivo efficacy of the protein can be interrogated using hydrodynamic gene delivery of a standard mammalian expression plasmid. (ox.ac.uk)
The TLR1-GFP fusion gene is cloned in the pUNO plasmid under the control of the strong and ubiquitous mammalian promoter EF1α/HTLV. (invivogen.com)

The protein produced from the EWSR1/FLI1 fusion gene, called EWS/FLI, has functions of the protein products of both genes. (medlineplus.gov)
The EWSR1/FLI1 fusion gene occurs in approximately 85 percent of Ewing sarcomas. (medlineplus.gov)
In any individual patient, t(11;22) fuses one of many observed combinations of exons from EWS and FLI1 to form the fusion message. (medscape.com)

Genes which determine animal complexity - or what makes humans so much more complex than a fruit fly or a sea urchin - have been identified for the first time. (news-medical.net)

The bifunction fusion protein of hepatitis B virus e antigen and mutant green fluorescent protein was expressed in E. coli BL21 strain. (virosin.org)

Duplication, sequence divergence, and recombination are the major contributors at work in gene evolution. (wikipedia.org)
When gene fusion happens in non-coding sequence region, it can lead to the misregulation of the expression of a gene now under the control of the cis-regulatory sequence of another gene. (wikipedia.org)

In our previous work, we developed a six-point classification scoring schema with annotation pertaining to protein family scores, orthology, protein interaction/association studies, bidirectional best BLAST hits, sorting signals, known databases and visualizers which were used to validate protein interactions. (biomedcentral.com)

Anatomy17

Organisms27

Diseases14

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes91

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Health Care2

Mutations27

Mutation5

Sequences6

Certain genes3

Tumor13

Abnormal protein2

Chromosome Aberrations1

Molecular5

Cancers4

Transmembrane1

Chromosomes6

Regulates3

Encodes a protein1

Chimeric1

Translocation partner1

Genome4

Cancer19

Transcriptional4

Enzymes4

ABL110

Transcription Factors1

Datasets3

Researchers1

Kinase5

Interstitial deletion1

Single gene1

Viral2

Genomic2

Promoters1

Regulation3

Play critical roles2

Susceptibility gene2

Genetic2

Chromosomal1

Biological5

Affinity2

Oncogenic4

Inhibitors1

Orphan2

Homology3

Receptor2

Target the protein made1

Cellular3

Attaches1

Clinical2

Human8

Metabolic1

Fuse1

Mitochondria1

Purification1

Diagnostic1

Amino2

Cells8

Mammalian2

FLI13

Humans1

Green fluores1

Sequence2

Interactions1