Protein fibroblast growth factors. Medical search. Frequent questions

This indicates that glucocorticoids also affect the cellular growth by mechanisms which do not involve EGF receptors. (medicaljournals.se)
Here, we report that normal adult human skin fibroblasts display two isoform-specific, cell surface glycosyl phosphatidylinositol (GPI)-anchored, TGF-beta binding proteins in addition to the type I, II, and III TGF-beta receptors. (eurekamag.com)
Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
The researchers found that levels of molecules called fibroblast growth factors (FGFs), and two of the receptors that bind to them, were significantly lower among people who had been diagnosed with severe clinical depression and had died in a depressed state. (biopsychiatry.com)

The nuclear form of FGF2 functions in mRNA export FGF2 is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. (wikipedia.org)
Despite the proposed role for nerve growth factor (NGF) in this sprouting, we observed no change in NGF mRNA or protein at several postlesion time points. (jneurosci.org)
Surprisingly, the proliferation rate of the fibroblasts was increased in the presence of dexamethasone under conditions similar to those which caused slight decrease in the EGF receptor mRNA levels. (medicaljournals.se)
Serum FGF21 ( A ) and liver Fgf21 mRNA expression ( B ) were compared in rats placed on diets that independently restricted energy vs. protein for 4 days: control (NP:NE), LP:NE, NP:LE, and LP:LE. (jci.org)
Messenger RNA levels are a measure of how active different genes are, and the researchers took care only to study brains that had no complicating factors that would have changed their mRNA levels at death. (biopsychiatry.com)
mRNA expression of genes and proteins related to disease pathology were. (lu.se)

Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. (wikipedia.org)
Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins. (wikipedia.org)
Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected. (jneurosci.org)
Fibroblast Growth Factor 2 (FGF2) is a cell survival factor mediating tumor-induced angiogenesis. (cas.cz)
As opposed to the majority of extracellularly localized proteins, FGF2 is secreted from cells by direct protein translocation across the plasma membrane. (cas.cz)
In this project, we build upon our previous work and are aiming at the determination of the precise oligomeric state of FGF2 intermediates, the analysis of a potential role of a protein ATP1A1 in initiating oligomerization of FGF2 and studying the role of heparan sulfates in facilitating the formation of FGF2 translocation intermediates. (cas.cz)

Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. (jci.org)
Here, we demonstrated that hepatic FGF21 expression is induced by dietary protein restriction, but not energy restriction. (jci.org)
Circulating FGF21 was increased 10-fold in mice and rats fed a low-protein (LP) diet. (jci.org)
In these animals, liver Fgf21 expression was increased within 24 hours of reduced protein intake. (jci.org)
LP-induced increases in FGF21 were associated with increased phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the liver, and both baseline and LP-induced serum FGF21 levels were reduced in mice lacking the eIF2α kinase general control nonderepressible 2 (GCN2). (jci.org)
Finally, while protein restriction altered food intake, energy expenditure, and body weight gain in WT mice, FGF21-deficient animals did not exhibit these changes in response to a LP diet. (jci.org)
These and other data demonstrate that reduced protein intake underlies the increase in circulating FGF21 in response to starvation and a ketogenic diet and that FGF21 is required for behavioral and metabolic responses to protein restriction. (jci.org)
FGF21 therefore represents an endocrine signal of protein restriction, which acts to coordinate metabolism and growth during periods of reduced protein intake. (jci.org)
Protein restriction underlies the increase in FGF21 during food restriction or a KD. (jci.org)
Serum BHBA ( D ) and FGF21 ( E ) were measured in mice fed control, KD, or KD supplemented with an isocaloric amount of either carbohydrate (KD + CHO) or protein (KD + P) for 4 days. (jci.org)
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Fibroblast Growth Factor 21 (FGF21) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (scalegen.com)
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Fibroblast Growth Factor 21 (FGF21) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 21 (FGF21) in samples from serum, plasma, tissue homogenates, cell lysates. (scalegen.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fibroblast Growth Factor 21 (FGF21) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (scalegen.com)

However, there is limited information on the TGF-beta receptor types, isoform specificity, and complex formation in skin fibroblasts. (eurekamag.com)

These effects of the compounds were associated with inhibition of tyrosine phosphorylation and the mitogen-activated protein kinase pathway. (nih.gov)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

The effects of 13-cis retinoic acid (RA) and dexamethasone on the levels of epidermal growth factor (EGF) receptor and fibroblast derived proteoglycan core protein (PG40) mRNAs were studied in human skin fibroblasts. (medicaljournals.se)

The FGFR2 gene produces a protein called fibroblast growth factor receptor 2. (medicalnewstoday.com)
A mutation in a specific part of the FGFR2 gene overstimulates signaling by the FGFR2 protein, which promotes the premature fusion of skull bones and affects the development of bones in the feet. (medlineplus.gov)

The identities of these proteins are confirmed on the basis of their affinity for TGF-beta isoforms, immunoprecipitation with specific antireceptor antibodies, and other biochemical analyses. (eurekamag.com)

It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. (wikipedia.org)
Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. (plos.org)
The majority of studies has investigated the function of nerve growth factor (NGF), the best-characterized member of the neurotrophin family of trophic molecules ( Korsching, 1993 ). (jneurosci.org)
PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
ANN ARBOR, MI - The brains of people with severe depression have lower levels of several related molecules that are key to the development, organization, growth and repair of the brain than the brains of people without the disease, or those with the bipolar form of depression, a new study finds. (biopsychiatry.com)
FGFs are a family of molecules that stimulate cell growth in many areas of the body, and are involved in the growth of multiple tissues and in growth that takes place at various stages of life. (biopsychiatry.com)

5% false discovery rate) between risk of MACE and eight proteins: matrix metalloproteinase (MMP)-12, IL-27 subunit α (IL-27a), kidney injury molecule (KIM)-1, fibroblast growth factor (FGF)-23, protein S100-A12, TNF receptor (TNFR)-1, TNFR-2 and TNF-related apoptosis-inducing ligand receptor (TRAIL-R)2. (springer.com)

Fibroblasts play a critical role in wound repair and in the development of fibrotic diseases, and transforming growth factor-beta (TGF-beta) has been shown to profoundly modulate fibroblast function. (eurekamag.com)

The extracellular domain of Klotho, a type-1 membrane protein, is secreted into urine and blood and may function as an endocrine or paracrine hormone. (aspetjournals.org)
Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. (bvsalud.org)

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1, RPL6, ribosomal protein S19 and API5. (wikipedia.org)

and 3) task performance in aged rats only (soluble fibroblast growth factor receptor IIIb, osteoregulin, and osteocalcin). (cdc.gov)
Cytokines are soluble proteins produced by one or more than cells. (bvsalud.org)

We have tested simultaneous inhibition of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor receptor signaling by novel indolinone derivatives using 14 myeloid, including 11 human leukemic, cell lines. (nih.gov)
Acute-onset sym- protein 1, and platelet-derived growth factor polypeptide metric polyarthritis, most often affecting the fingers, wrists, levels (data not shown), and macrophage inflammatory ankles, and knees, is the predominant clinical presentation. (cdc.gov)

The main cytokines that are founded on the health periodontal tissue are: the fibroblast growth factor, the plated-derived growth factor, the insulin-like growth factor and growth factor. (bvsalud.org)

To investigate the molecular mechanisms of cholinergic sprouting in the hippocampus after removal of entorhinal cortical inputs, we evaluated trophic factor gene expression in the denervated hippocampus. (jneurosci.org)

It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. (wikipedia.org)
The EGF receptor is involved in the regulation of cellular proliferation and the synthesis of matrix proteins, and proteoglycan 40 is important for cell attachment and interaction with collagen and fibronectin. (medicaljournals.se)
lncRNA MIR31HG Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate. (cdc.gov)

The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
Integrating transcriptomics and genomics to identify fibroblast growth factor/receptor candidate genes for non-syndromic orofacial cleft in Chinese. (cdc.gov)

bFGF), macrophage inflammatory protein 1 (MIP1), and VEGF in comparison to healthy controls. (cdc.gov)

Although much evidence supports the role of endogenous NGF in promoting neuronal survival in vivo ( Barde, 1989 ), less is known about its ability to influence axonal growth. (jneurosci.org)
These proteins were firstly discovered in 1989. (chemdiv.com)

In acute myeloid leukemia (AML), receptor tyrosine kinase ligands promote growth and survival and contribute to AML-associated marrow neoangiogenesis. (nih.gov)
FGFR 3 encodes a transmembrane tyrosine kinase receptor involved in signaling via interaction with the family of fibroblast growth factors. (aacrjournals.org)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)

Like other FGF family members, basic fibroblast growth factor possesses broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)

Autosomal dominant disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor ( FGFR) 2 and FGFR3 . (aacrjournals.org)

and vascular endothelial growth factor (VEGF). (cdc.gov)

Fibroblast growth factors (FGFs) are structurally related proteins associated with cell growth, migration, wound healing, and angiogenesis. (medscape.com)

Apert syndrome is a genetic disorder that causes abnormal head and face growth, as well as fused fingers and toes. (childrens.com)
The growth of the triradiate cartilage (endochondral growth) is abnormal, giving rise to horizontal acetabular roofs. (medscape.com)
Achondroplasia impairs the growth of bone in the limbs and causes abnormal growth in the spine and skull. (hopkinsmedicine.org)
It can be prescribed to adults with a specific abnormal change in the fibroblast growth factor receptor 1 gene. (medicalnewstoday.com)

This difference in mass cannot be explained by the difference in molecular weights alone and appears to be highly protein dependent. (genengnews.com)
By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells. (harvard.edu)

Tau is primarily known for its a role as a microtubule stabilising protein, although its multifunctional nature is becoming increasingly recognised, with roles in the nucleus andcell signalling (1-3). (researchsquare.com)

Klotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain. (aspetjournals.org)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (nih.gov)
FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. (tecomedical.com)
This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. (prosci-inc.com)

These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)
Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures. (harvard.edu)

This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. (nih.gov)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)

Somatotropin (recombinant human growth hormone [GH]) has been used to augment the height of patients with achondroplasia. (medscape.com)
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human FGF12 (NP_004104.3). (prosci-inc.com)

It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. (wikipedia.org)
This protein has many important roles in a fetus' development, including a key role in signaling bone cell development. (medicalnewstoday.com)
Among its multiple functions, this protein signals immature cells to become bone cells during embryonic development. (medlineplus.gov)
The skeletal dysplasias are a heterogeneous group of disorders characterized by intrinsic abnormalities in the growth or remodeling of cartilage and bone. (medscape.com)
Several growth factors in addition to TGF beta reside in bone matrix and can be released upon resorption to exert their biological effects, often osteoclast stimulation. (endotext.org)
In achondroplasia, this protein begins to function abnormally, slowing down the growth of bone in the cartilage of the growth plate. (hopkinsmedicine.org)
Arrested bone growth at the base of the skull and the spine can cause the spinal cord and brain stem to become compressed. (hopkinsmedicine.org)
Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)

the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. (wikipedia.org)
These cells respond to TGF-beta by markedly down-regulating all five binding proteins and by potently augmenting DNA synthesis. (eurekamag.com)
In addition, the definition of TGF-beta receptor profiles in human skin fibroblasts provides important information for studying their alterations in these cells in various skin diseases. (eurekamag.com)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. (prosci-inc.com)
This protein able to change the comportament of cells including the cells that produced it and they are secreted by residents and inflammatory cells. (bvsalud.org)
We still do not know what specific factors contribute to the success in transplantation i.e. what cells are responsible for motor recovery? (lu.se)

This study assessed 80 cardiovascular and inflammatory proteins for biomarker discovery and prediction of MACE in type 2 diabetes. (springer.com)

HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)

The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)

Simultaneous treatment of the fibroblasts with 13-cis-RA and dexamethasone resulted in similar decreases in EGF receptor and PG40 mRNAs as with 13-cis-RA alone. (medicaljournals.se)

Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)

Epidemic polyarthritis is seen for IL-1RA, IL-2, IL-5, IL-10, IL-12p70, IL-17, gran- a self-limiting febrile arthralgia syndrome that closely re- ulocyte colony-stimulating factor, monocyte chemotactic sembles chikungunya and Mayaro fever. (cdc.gov)

The Cytoskeleton Protein List reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (fgf-4.com)
The tau protein exists as multiple protein isoforms in the adult human CNS, generated by alternative splicing of the MAPT gene. (researchsquare.com)
Tau is present in the adult human CNS as multiple protein isoforms generated by alternative splicing, with either 0, 1 or 2 N-terminal inserts (0N, 1N, 2N) and either 3 or 4 C-terminal repeats (3R, 4R)(4). (researchsquare.com)

Measuring circulating proteins with presumed roles in cardiovascular pathology by targeted proteomics is a promising approach for biomarker discovery [ 15 ]. (springer.com)

This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)

and IGFs in (insulin like growth factors). (endotext.org)

2) during 24 h, with or without transforming growth factor (TGF)-β1. (lu.se)

Hyperphosphorylated, insoluble aggregates composed of the microtubule associated protein tau define a group of clinically and pathologically diverse neurodegenerative diseases collectively called the tauopathies. (researchsquare.com)

Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)

[1] [2] It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. (wikidoc.org)
The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. (tecomedical.com)

We combined data from six prospective epidemiological studies of 30-77-year-old individuals with type 2 diabetes in whom 80 circulating proteins were measured by proximity extension assay. (springer.com)

Description: A competitive ELISA for quantitative measurement of Rat Cytoskeleton associated protein 2(CKAP2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (fgf-4.com)
In samples from patients in the arthralgic conva- analyzed serum cytokine, chemokine, and growth factor lescent phase, we noted increases in IL-1, IL-4, IL-6, IL-8, levels in travelers returning to Germany from Australia. (cdc.gov)

Se- IL-9, IL-13, IL-15, GM-CSF, interferon-, tumor necrosis rum samples showed elevated concentrations in the acute factor- (TNF-), RANTES, basic fibroblast growth factor phase of the illness and, more pronounced, in the long-last- ing convalescent phase. (cdc.gov)

The purpose of this study is review and discuss the importance of the growth factors on the periodontal tissue balance and consequently its function on the periodontal health. (bvsalud.org)

Anatomy39

Organisms11

Diseases14

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes45

Disciplines and Occupations1

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Receptors5

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FGF2114

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Mitogen-activa4

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Extracellular4

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Molecular3

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