SnRNPGene expressionPTBP1U2AFSubunitMRNAHeterogeneous nuclear ribonucleoproteinGenesRegulatesRBPsIntronsIntronRibonucleoproteinNuclearSpecificityInduces the expressionHigh affinityAffinitySplice sitesIsoformsTransmembrane proteinSnRNPsRegulatoryExtracellularCytoplasmicBiogenesisAttenuationMotifSynthesisInteractionPromoterRegulatorsReceptorIntronicRing finger proteinTissueKinaseKnockdownBiological ProcessesPolyProliferationHuman
SnRNP5
- The essential splicing signal sequences in pre-mRNA-the 5' splice site, the branch-site sequence, and the poly-pyrimidine tract (PPT) followed by the 3′ splice site-are bound by the splicing factors U1 snRNP, U2 snRNP, and U2AF 65 /U2AF 35 , respectively, which together constitute the spliceosomal A complex. (innovitaresearch.com)
- The core particles of the U1, U2, U4, and U5 snRNPs are formed by Sm proteins, whereas the LY404039 U6 snRNP contains the related Lsm2 (Like Sm2) to Lsm8 proteins (Tharun, 2009). (biomedigs.org)
- The initial step of splice site recognition comprises U1 snRNP binding to the 5splice site and U2 auxillary factor (U2AF) binding to the 3splice site. (biomedigs.org)
- Subsequently, U2 snRNP binds to the branch point, and a preformed complex of U4, U5, and U6 snRNPs is recruited to the intron. (biomedigs.org)
- The large ~280-kDa U5 snRNP protein PRPF8 is central to the dynamics of spliceosome assembly [ 11 ]. (biomedcentral.com)
Gene expression22
- 2006). Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. (nature.com)
- As a first step towards understanding the mechanism underlying the differential gene expression of the two variants of the rat proteinase-inhibitor alpha1-Inhibitor 3 (alpha1-I3) corresponding genomic clones were isolated. (eurekamag.com)
- The researchers identified a novel gene expression pathway that becomes activated following ischemia and oxygen stress. (technologynetworks.com)
- The next steps will be to test the perfusion of tissues from suboptimal human livers that were kept in extended cold storage in the presence of molecules called morpholinos that modify gene expression. (technologynetworks.com)
- Histone modification is a vital mechanism of gene expression and a promising therapy target. (thno.org)
- Our analysis revealed subsets of genes, whose expression is positively associated with H3K27me3, different to the otherwise reported negative association with gene expression in many other organisms. (uni-frankfurt.de)
- Further, we developed a Random Forests classifier to predict gene expression using genic (gene length, intron frequency, etc.) and epigenetic features. (uni-frankfurt.de)
- Upon evaluating different feature sets, we found that genic features are as predictive, of gene expression, as the epigenetic features. (uni-frankfurt.de)
- We used Shapley local feature explanation values, to suggest that high H3K4me3, high intron frequency, low gene length, high sRNA, and high GC content are the most important elements for determining gene expression status. (uni-frankfurt.de)
- We conclude that reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and that a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells. (rcsb.org)
- RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level. (encyclopedia.pub)
- INTRODUCTION With the discovery of intervening sequences in eukaryotic genes by Philip Sharp and colleagues, it became apparent that removal of introns through splicing of pre-mRNAs is a key step in eukaryotic gene expression (Berget et al. (biomedigs.org)
- The response of cells to environmental signals, as well as their differentiation, death or malignant transformation, involves changes in gene expression. (biologists.com)
- For many years, the modulation of gene expression was thought to be restricted to, or at least dominated by, the control of transcription. (biologists.com)
- The discovery of introns and the process of splicing, which eliminates them from the precursor mRNA, introduced an exciting but also perturbing factor in our simplified conceptions of the flow of gene expression in eukaryotes. (biologists.com)
- Competition for PRPF8 availability alters the transcription-coupled splicing of RNAs in which weak 5′ splice sites predominate, enabling diversification of human gene expression during biological processes like mitosis. (biomedcentral.com)
- The global gene expression and DNA copy number alterations have been shown to have profound differences in tumors of low or high stage and those with or without MYCN amplification. (biomedcentral.com)
- RNA splicing is an important regulatory mechanism of gene expression, and differential RNA splicing may be associated with the clinical behavior of a tumor. (biomedcentral.com)
- The ratio of exon-level expression to gene-level expression was used to detect alternative splicing events, while the gene-level expression was applied to characterize whole gene expression change. (biomedcentral.com)
- Pairwise comparison identified genes with splicing changes and/or whole gene expression changes in high stage tumors. (biomedcentral.com)
- In stage 4- compared with stage 1- tumors, alternatively spliced candidate genes had little overlap with genes showing whole gene expression changes, and most of them were involved in different biological processes. (biomedcentral.com)
- It is an important regulatory mechanism of gene expression for tissue-specific functions. (biomedcentral.com)
PTBP17
- The RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1), also named hnRNP I, acts as a critical mediator of insulin biosynthesis through binding to the pyrimidine-rich region in the 3'-untranslated region (UTR) of insulin mRNA. (molcells.org)
- Here, we report that glucose induces the expression of PTBP1 via the insulin receptor (IR) signaling pathway in β cells. (molcells.org)
- PTBP1 levels in immortalized β cells established from wild-type (βIRWT) mice are higher than levels in β cells established from IR-null (βIRKO) mice, and ectopic re-expression of IR-WT in βIRKO cells restored PTBP1 levels. (molcells.org)
- Thus, our results identify insulin as a pivotal mediator of glucose-induced PTBP1 expression in pancreatic β cells. (molcells.org)
- The researchers showed that as the cell senses low oxygen conditions, HIF-1 α begins regulating the RNA splicing factor, Polypyrimidine tract-binding protein 1 (Ptbp1), that in turn directs the splicing of the CEACAM1 gene, leading to the protective CEACAM1-S version that reduces the liver injury that accompanies transplantation. (technologynetworks.com)
- Two recent papers from Qian et al (4) and Zhou et al (5) demonstrate that reduced expression of the RNA binding protein PTB (encoded by Ptbp1-polypyrimidine tract-binding protein) allows the direct conversion of glial cells to neurons. (vectorbuilder.jp)
- In the work by Qian et al, conversion of mouse astrocytes to neurons was demonstrated by lentiviral-mediated shRNA knockdown (KD) of Ptbp1 (shPTB) resulting in neuronal morphology and expression of neuronal markers TUJ1 and MAP2 concomitant with suppression of astrocyte-specific genes. (vectorbuilder.jp)
U2AF5
- The essential splicing factor U2AF(65) normally recognizes a Py tract consensus sequence preceding the major class of 3' splice sites. (rcsb.org)
- Conversely, we identified a preferred binding site of U2AF(65) for purine substitutions in the 3' regions of Py tracts. (rcsb.org)
- Based on a comparison of new U2AF(65) structures bound to either A- or G-containing Py tracts with previously identified pyrimidine-containing structures, we expected to find that a D231V amino acid change in U2AF(65) would specify U over other nucleotides. (rcsb.org)
- A PPT sequence and the downstream 3′ splice site is required for binding of the known authentic splicing factor U2AF heterodimer (U2AF 65 /U2AF 35 ). (innovitaresearch.com)
- U2AF35, the small subunit of U2AF, binds to the intron/exon border, whereas the large subunit U2AF65 binds to a region rich in pyrimidines designated the polypyrimidine tract (Figure 1). (biomedigs.org)
Subunit2
- AMP-activated protein kinase α subunit (AMPKα), the central regulatory molecule of energy metabolism, plays an important role in maintaining energy homeostasis and helping cells to resist the influence of various adverse factors. (bvsalud.org)
- It specifically binds Na+/K+-ATPase -subunit to inhibit Na+/K+-ATPase, which has been explored in a number of clinical studies for cancers treatment today. (tech-strategy.org)
MRNA17
- Initiation of BAG-1 protein synthesis can occur by both cap-dependent and cap-independent mechanisms and it has been shown that synthesis of BAG-1S is dependent upon the presence of an internal ribosome entry segment (IRES) in the 5′-UTR of BAG-1 mRNA. (nature.com)
- 2002). Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). (nature.com)
- The lab also studies the dynamic mechanism of RNA splicing, the RNA-binding proteins that determine exonic specificity, and snRNAs, that are important regulators of splicing and mRNA maturation. (wikipedia.org)
- The mRNA transcripts of PyAMPKα were found to be expressed in haemocytes and all the examined tissues, including gill, mantle, gonad, adductor muscle and hepatopancreas, with the highest expression level in adductor muscle. (bvsalud.org)
- The activity of pyruvate kinase (PyPK) and the relative mRNA expression level of phosphofructokinase (PyPFK) were significantly up-regulated at 3 h after high temperature stress treatment (25 °C). Furthermore, the PyAMPKα activator AICAR could effectively upregulate the phosphorylation level of PyAMPKα, and increase activities of PyPFK and pyruvate kinase (PyPK). (bvsalud.org)
- The expression of SNRPB mRNA and protein in liver cancer cell lines were analyzed by qRT-PCR and Western blot. (bvsalud.org)
- siRNA-SNRPB had significantly inhibited the expression of SNRPB mRNA and protein in liver cancer cells. (bvsalud.org)
- The IRES directing the translation of p53 is in the 5'-untranslated region of the mRNA, whereas the IRES mediating the translation of ΔN-p53 extends further into the protein-coding region. (iisc.ac.in)
- Proteins shown in red (FDR 0.01) represent the mRNA interactome. (nature.com)
- c ) Overlap of mRNA interactome proteins in yeast and HuH-7. (nature.com)
- d ) Validation of the yeast mRNA interactome using western blotting of input samples and eluate after interactome capture with specific antibodies (ADH1, alcohol dehydrogenase 1, PUB1) or against TAP-tagged proteins (PGK1, phosphoglycerate kinase 1, TDH1, triose phosphate dehydrogenase, TRX2, thioredoxine 2, SHE2, Swi5p-dependent HO Expression 2). (nature.com)
- It binds the 3′ AG splice acceptor dinucleotide of the pre-mRNA target intron, and forms a heterodimer with U2AF2 , which binds the adjacent polypyrimidine tract. (massgenomics.org)
- In higher organisms, however, most of the coding-gene transcripts, or pre-mRNAs, are separated by non-coding sequences called "introns," which must be cut out or "spliced" to make mature mRNA that can be translated into protein. (innovitaresearch.com)
- Human pre-mRNA splicing involves dynamic stepwise reactions in a huge protein-RNA complex called "spliceosome," which includes five kinds of small nuclear ribonucleoproteins, called U snRNPs, and many protein factors. (innovitaresearch.com)
- These proteins bind specific sequences in the pre-mRNA called intronic or exonic splicing enhancer or LY404039 suppressor sequences. (biomedigs.org)
- Splice site selection will reflect the relative occupation of these sequences and LY404039 interactions among different proteins on a pre-mRNA (Witten and Ule, 2011). (biomedigs.org)
- This machinery recognizes pre-mRNA sequences at several motifs - the 5′ and 3′ splice sites, the branch point, and polypyrimidine tracts - positioned at exon-intron boundaries [ 4 ]. (biomedcentral.com)
Heterogeneous nuclear ribonucleoprotein1
- 2012). The main families of these SFs are the Ser/Arg-rich (SR) proteins and heterogeneous nuclear ribonucleoprotein particle (hnRNP) proteins. (biomedigs.org)
Genes7
- The expressions of key genes and proteins of PI3K/Akt/Beclin1 signaling pathway in brain tissue were detected by qRT-PCR and Western blot respectively. (bvsalud.org)
- The transcriptomic and epigenomic regulatory landscape of the MAC genome, which has 80% protein-coding genes and short intergenic regions, is poorly understood. (uni-frankfurt.de)
- Protein-coding genes carry the blueprint for protein production. (innovitaresearch.com)
- Subtle changes in SF levels or activity can have subtle or profound effects on the expression of downstream target genes (Figure 2). (biomedigs.org)
- Mutations in splicing elements, for example, have been found in genes such as LKB1 , KIT , CDH17 , KLF6 and BRCA1 , and changes in trans-acting regulators can affect the expression of genes such as Ron , RAC1 and CD44 . (biologists.com)
- In contrast, a larger number of genes exhibited either exon-level splicing, gene-level expression or both changes in stage 4+ versus stage 1- tumors. (biomedcentral.com)
- For 75% of genes, full-length isoform expression varies along one or more axes of phenotypic origin, underscoring the pervasiveness of isoform regulation across multiple scales. (biorxiv.org)
Regulates2
- However, the underlying mechanism that regulates its expression in β cells is unclear. (molcells.org)
- These results suggest that GAPDH exerts other functions beyond glycolysis, and that oxidatively modified GAPDH regulates its cellular functions by changing its interacting proteins, i.e. the RNA splicing by interacting with the p54nrb-PSF complex. (elsevierpure.com)
RBPs6
- RNA-binding proteins (RBPs) exert a broad range of biological functions. (nature.com)
- Only 60% of yeast and 73% of the human RBPs have functions assigned to RNA biology or structural motifs known to convey RNA binding, and many intensively studied proteins surprisingly emerge as RBPs (termed 'enigmRBPs'), including almost all glycolytic enzymes, pointing to emerging connections between gene regulation and metabolism. (nature.com)
- RNA-binding proteins (RBPs) mediate pivotal cellular functions such as RNA transport, degradation or translation and represent key effectors of post-transcriptional gene regulation. (nature.com)
- Recently developed unbiased high content techniques to identify RBPs in vivo yielded information on differences in cell type-specific expression and/or RNA-binding activity of RBPs in mammalian cells 2 , 3 . (nature.com)
- LIN28 (LIN28A and LIN28B) proteins are highly conserved small cytoplasmic RNA-binding proteins (RBPs) that function as pluripotency factors, regulating the transition from self-renewal to a differentiated cell fate [ 1 ] . (encyclopedia.pub)
- For example, in both animals and plants, many SFs/RNA binding proteins (RBPs) and some core spliceosomal components themselves undergo AS in response to signals and even control their own levels and those of other SFs via AS (Kalyna et al. (biomedigs.org)
Introns2
- The interrupted non-coding regions in pre-mRNAs, termed "introns," are excised by "splicing" to generate mature coding mRNAs that are translated into proteins. (innovitaresearch.com)
- The team began by searching for essential factors to splice out human short introns from 154 human nuclear proteins. (innovitaresearch.com)
Intron1
- Finally, biochemical analyses and splicing assays with various mutant SPF45 proteins helped establish the model of SPF45-dependent splicing on a short intron with a truncated PPT (Figure 1). (innovitaresearch.com)
Ribonucleoprotein3
- Objective: To study the expression and effect of small nuclear ribonucleoprotein-associated protein B (SNRPB) on proliferation and metastasis of liver cancer tissues and cells. (bvsalud.org)
- It consists of five small nuclear ribonucleoprotein particles (snRNPs) and over 200 additional proteins (Wahl et al. (biomedigs.org)
- This process is carried out by the human spliceosome machinery, in which over 300 proteins sequentially assemble with uridine-rich small nuclear RNA molecules (U snRNAs) to form distinct small nuclear ribonucleoprotein complexes (snRNPs). (biomedcentral.com)
Nuclear3
- We identified the interacting proteins of oxidized inactive GAPDH as p54nrb (54 kDa nuclear RNA-binding protein) and PSF (polypyrimidine tract-binding protein-associated splicing factor), both of which are known to exist as heterodimers and bind to RNA and DNA. (elsevierpure.com)
- A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
- Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
Specificity3
- Analyses of the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP. (nature.com)
- We also determined the RNA targets of an RNA-binding mitochondrial enzyme and show its specificity in RNA binding. (nature.com)
- Glial brain-region specificity in isoform expression includes strong poly(A)-site regulation, whereas neurons have stronger TSS regulation. (biorxiv.org)
Induces the expression1
- We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2). (akjournals.com)
High affinity1
- An insertion/deletion (I/D) polymorphism of the nucleotide sequence TTTCT (rs3215227) has been identified in the human RGS9 gene, which matches the consensus high affinity binding motif for the ubiquitously expressed RNA binding Polypyrimidine Tract Binding Protein (PTB). (uri.edu)
Affinity1
- Chemical shift changes upon the addition of single-stranded RNAs (ssRNAs) identified a group of residues that form a positively charged patch on the protein surface as the binding site responsible for the previously reported affinity for nucleic acids. (pdfroom.com)
Splice sites1
- The decision on which splice sites are selected under particular cellular conditions is determined by the interaction of additional proteins, globally designated as splicing factors (SFs), that guide spliceosomal components and thereby the spliceosome to the respective splice sites (Matlin et al. (biomedigs.org)
Isoforms2
- There are three major isoforms of BAG-1 in mammalian cells, termed BAG-1L (p50), BAG-1M (p46) and BAG-1S (p36) that function as pro-survival proteins and are associated with tumorigenesis and chemoresistance. (nature.com)
- They play major roles in the tissue- and stage-specific expression of protein isoforms as well as in the maintenance of protein homeostasis. (encyclopedia.pub)
Transmembrane protein2
- transmembrane protein 191C [Source:H. (gsea-msigdb.org)
- transmembrane protein 156 [Source:HG. (gsea-msigdb.org)
SnRNPs1
- A primary research goal of the lab is to elucidate the function of Survival of Motor Neuron protein, SMN, which assembles a heptameric ring of Sm proteins on U snRNAs to form snRNPs that are essential components of the splicesome. (wikipedia.org)
Regulatory4
- Moreover, extracellular PKM2 exerted regulatory control over the expression of key epithelial-mesenchymal transition (EMT) markers, including ZEB1, Snail1, vimentin, and E-cadherin. (bvsalud.org)
- Mutations in cis-acting splicing elements or changes in the activity of constitutive or alternative splicing could have a profound regulatory proteins that compromise the accuracy of either impact on human pathogenesis, in particular in tumor development and progression. (biologists.com)
- protein phosphatase 1 regulatory inh. (gsea-msigdb.org)
- Müller-McNicoll M, Rossbach O, Hui J , Medenbach J. Auto-regulatory feedback by RNA-binding proteins. (cas.cn)
Extracellular3
- Furthermore, we found that p19 INK4d modulates GATA1 protein levels through a novel pathway, the phosphatidylethanolamine-binding protein 1 (PEBP1)-phosphorylated extracellular signal-regulated kinase ( p ERK)-heat shock 70 kDa protein (HSP70)-GATA1 pathway [ 3 ]. (biomedcentral.com)
- In the tumor microenvironment (TME), communication between cancer cells and tumor-associated macrophages (TAMs) through secreted extracellular proteins promotes cancer progression. (bvsalud.org)
- The extracellular recombinant PKM2 protein not only enhanced cancer cell migration and invasion but also increased superoxide production. (bvsalud.org)
Cytoplasmic1
- ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
Biogenesis1
- The Dreyfuss Lab is interested in various projects studying the function and biogenesis of non-coding RNA and the proteins that interact with RNA. (wikipedia.org)
Attenuation2
- By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
- The mechanism of attenuation of angiogenic proteins by ibuprofen was further investigated. (akjournals.com)
Motif1
- This binding site is similar to the ssRNA-binding site of the sterile alpha motif domain of the Saccharomyces cerevisiae Vts1p protein, although the two proteins do not share a common globular fold. (pdfroom.com)
Synthesis2
- Here, we show that the BAG-1 IRES maintains synthesis of BAG-1 protein following exposure of cells to the chemotoxic drug vincristine but not to cisplatin and that this is brought about, in part, by the relocalization of PTB and PCBP1 from the nucleus to the cytoplasm. (nature.com)
- One of the important mechanisms used for protein synthesis during these conditions is internal initiation. (iisc.ac.in)
Interaction1
- Interaction between oxidized GAPDH and p54nrb was abolished upon expression of the GAPDH active site mutant C152S. (elsevierpure.com)
Promoter3
- Interestingly, p-Tyr42 RhoA translocated to the nucleus, where it bound to the ZEB1 promoter region. (bvsalud.org)
- Furthermore, because MGMT protein loss may be a result of promoter hypermethylation, it was reported that methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness to alkylating agents ( 7 ). (aacrjournals.org)
- GC-rich promoter binding protein 1 l. (gsea-msigdb.org)
Regulators1
- RGS9 is a member of the family of Regulators of G-Protein Signaling (RGS) proteins defined by the presence of an RGS domain which can accelerate the GTPase-activity of G protein Gα subunits. (uri.edu)
Receptor3
- 1996). HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. (nature.com)
- Additionally, PKM2 was found to associate with the cell surface, and its binding to integrin α5/ß1 receptor was inhibited by antibodies specifically targeting it. (bvsalud.org)
- State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)
Intronic1
- Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites. (rochester.edu)
Ring finger protein1
- ring finger protein 169 [Source:HGNC. (gsea-msigdb.org)
Tissue4
- Methods: The bioinformatics database starBase v3.0 and GEPIA were used to analyze the expression of SNRPB in liver cancer tissue and normal liver tissue, as well as the survival and prognosis of liver cancer patients. (bvsalud.org)
- Results: The expression of SNRPB was significantly higher in liver cancer tissue than normal liver tissue, and its expression level was correlated with the prognosis of liver cancer patients. (bvsalud.org)
- Results: Compared with the sham operation group, the body weight and protein expressions of p-PI3k and p-Akt in brain tissue of rats were decreased significantly in the model group, while the brain index, neurological deficit score, gene and protein expressions of Beclin1 and LC3 were increased markedly in the model group(P40.05 or P40.01). (bvsalud.org)
- Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
Kinase1
- In the present study, the results proved that the anti-CRC activity of apigenin was positively correlated with pyruvate kinase M2 (PKM2) expression, characterized by the inhibition of cell proliferation and increase of apoptotic effects induced by apigenin in LS-174T cells of knock down PKM2. (bvsalud.org)
Knockdown2
- Unexpectedly, knockdown of p19 INK4d did not affect cell cycle, and these functions caused by p19 INK4d knockdown were via decreasing levels of GATA-binding protein 1 (GATA1). (biomedcentral.com)
- This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Biological Processes1
- We now know those structures are very relevant to many critical biological processes like gene regulation, expression of telomerase and telomere maintenance, understanding of growth/oncogenes like C-myc, understanding of organismic development, comprehension of certain enigmatic diseases like ALS and possible new cancer treatments. (anti-agingfirewalls.com)
Poly2
- We have shown previously that BAG-1 IRES-meditated initiation of translation requires two trans -acting factors poly (rC) binding protein 1 (PCBP1) and polypyrimidine tract binding protein (PTB) for function. (nature.com)
- 1999). Cellular stress in Xenopus kidney cells enhances the phoshorylation of eukaryotic initiation factor eIF(4E) and the association of eIF4F with poly(A)-binding protein. (nature.com)
Proliferation2
- Polypyrimidine tract-binding protein induces p19(ink4d) expression and inhibits the proliferation of h1299 cells. (biomedcentral.com)
- Conclusion: SNRPB expression is significantly increased in liver cancer tissues and cells, and it is involved in regulating the proliferation, metastasis and EMT of liver cancer cells. (bvsalud.org)
Human2
- Purine interruptions of polypyrimidine (Py) tract splice site signals contribute to human genetic diseases. (rcsb.org)
- They downregulated these proteins' expression in a human cell line (HeLa cells) using small interfering RNAs (siRNA). (innovitaresearch.com)