• it was evidently well known in the sixteenth century, as our immortal bard alludes to it in to Audiogenic Stress in Rats: An Anterograde and Retrograde Tract Tracing Study Combined With Fos Expression. (web.app)
  • Treating such diseases remains difficult and several strategies have been used to stimulate the growth of blood vessels and promote regeneration of ischaemic tissues, such as the use of recombinant proteins and gene therapy. (biomedcentral.com)
  • Materials and Methods Cell lines, plasmids, recombinant proteins All cells were maintained in DMEM (4.5?g/L glucose) supplemented with 10% FBS and Penicillin/Streptomycin (Gibco). (healthweblognews.info)
  • Also, viral infection has proved to have a great impact on cellular small RNA expression and gene expression [ 9 - 11 ]. (hindawi.com)
  • Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)
  • miRNAs regulate gene expression in a wide range of physiological and pathological processes such as in immune response and viral replication [ 18 ]. (hindawi.com)
  • These nucleotide substitutions have been shown to alter the binding of oligonucleotides to nuclear extract proteins and alter the expression of the reporter gene. (icgbio.ru)
  • In this study, we performed Egr1, Npas4, Arc, and Homer1 gene expression level analysis in the prefrontal cortex and dorsal hippocampus of adult female mice after exposure to early life stress. (icgbio.ru)
  • As adults, female mice behavior was analyzed by behavioral tests, on the day after last testing gene expression level analysis was performed. (icgbio.ru)
  • The purpose of this study was to compare the gene expression profile of mouse skeletal muscle undergoing two forms of growth (hypertrophy and regrowth) with the goal of identifying a conserved set of differentially expressed genes. (uky.edu)
  • Total RNA is extracted and analyzed via RT-qPCR for WNV (E gene) and interferon beta 1 (Ifnb1) and interferon-induced protein with tetratricopeptide repeats 1 (Ifit1). (jax.org)
  • This research often requires the tissue-specific expression of transgenes to better mirror human diseases, to visualize pathways being studied or to modulate the expression of a disease-related gene. (nature.com)
  • In vivo visualizations of gene expression, protein activity, cell trafficking, cell-cell / cell-microenvironment interaction. (medianalytika.com)
  • CAV -1 is an integral membrane protein found in caveolae, omega-shaped invaginations of the plasma membrane that form a subdomain of cholesterol- and sphingolipid-rich lipid rafts.Cav1 gene is localized to locus D7S522 of human chromosome 7q31.1In vivo, two isoforms of Cav1 are known to exist: α-caveolin that contains residues 1-178 and β-caveolin that contains residues 32-178. (diff.org)
  • Determination of gene expression patterns of selected genes from three brain In the present study c-fos expression was higher in the male forebrain and osteoklastdifferentiering genom att undertrycka C-Fos transkriptionell aktivitet utan att påverka RANKL-inducerad c-Fos-expression. (web.app)
  • Fructooligosaccharides Market Is Expected To Propel Growth Based on Increasing Demand For Dietary Supplements, Pharmaceuticals, Food & Beverages Sectors Till 2024 / Million Insights Rapid and transient expression of c-Fos is associated with the initial steps of LTM in different learning tasks (6, 8 - 10), and deletion of the c-fos gene or inhibition of its expression at the time of training impairs memory (10 - 12). (web.app)
  • Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. (genenetwork.org)
  • We have identified the cold shock RNA binding protein, RNA-binding motif protein 3 (RBM3) as a critical regulatory node in the control of skeletal muscle mass and herein, we review our current knowledge of its actions in skeletal muscle. (orthojournal.org)
  • Our laboratory has identified the cold shock RNA binding protein (RBP), RNA-binding motif protein 3 (RBM3) as a regulatory node in the control of skeletal muscle mass 5,6 , suggesting it may be a promising target for therapies combating muscle atrophy. (orthojournal.org)
  • One is, how, and to what extent, does the nervous system control protein expression in skeletal muscle fibers? (ucla.edu)
  • As a whole, RBPs play a role in governing RNA metabolism and post-transcriptional processes related to mRNA polyadenylation, alternative splicing, nucleocytoplasmic trafficking, stability, and translation initiation and elongation 7-10 , which ultimately affects protein synthesis 11 . (orthojournal.org)
  • During hibernation, there are vast global reductions in metabolism and transcription in response to the cold temperatures and lack of physical activity, however, hibernating animals can preserve the expression and translation of select mRNAs 33,34 . (orthojournal.org)
  • Hits common to both data sets indicate disrupted cellular metabolism, calcium signaling, protein stability, DNA binding, and cytoskeletal cell structure. (biomedcentral.com)
  • Cells' therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. (biomedcentral.com)
  • We identified the significant role of disturbance of intercellular interactions and regulation of proteins modification in placental tissue during the development of the PE. (icgbio.ru)
  • Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression to better understand the biology between transcriptional and translational regulation. (biomedcentral.com)
  • This widespread expression of CD117 in hematopoietic precursors is consistent with the participation of c-Kit and its ligand in the regulation of several hematopoietic lineages. (bdbiosciences.com)
  • Intrathymic expression of c-Kit and c-Kit ligand suggest that CD117 is also involved in the regulation of some events during the development of T lymphocytes. (bdbiosciences.com)
  • Caveolin-1 (Cav1) is a 22 KDa multifunctional scaffolding protein with multiple binding partners that is associated with cell surface caveolae and the regulation of lipid raft domains. (diff.org)
  • It is therefore not surprising that RBM3 is involved in various cell types, with a variety of functions that are mostly protective or beneficial which include, enhancing translational efficiency and protein synthesis 8,12,13 , miRNA biogenesis 14 , cell migration 15 , response to hypoxia 16 , and protection against necrosis and apoptosis 17-19 . (orthojournal.org)
  • As an example, RBPs selectively protect mRNAs related to cell survival to preserve their translation in response to a DNA damage event that causes global reductions in protein synthesis 21 . (orthojournal.org)
  • As such, the RBP cytosolic poly(A)-binding protein 1 (PABPC1) elevates protein synthesis and causes hypertrophy in cardiac muscle by increasing RNA stability and translational efficiency in a transcript-specific manner 23,24 . (orthojournal.org)
  • Moreover, muscle mass does not decrease as expected in response to the lack of physical activity, reduced protein synthesis, and very low caloric intake 35-37 . (orthojournal.org)
  • Expression profiling by microarray was performed on the plantaris muscle subjected to 1, 3, 5, 7, 10, and 14 days of hypertrophy or regrowth following 2 wk of hind-limb suspension. (uky.edu)
  • Spatial learning and memory were assessed in the Lashley III maze and hippocampus tissue samples were collected to assess oxidative stress markers and protein expression of brain-derived neurotrophic factor (BDNF), nuclear factor erythroid 2-related factor 2 (Nrf2), Sirtuin 1 (Sirt1), and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). (bvsalud.org)
  • Crtc1(-/-) mice strikingly show, in addition to a reduced dopamine and serotonin turnover in the prefrontal cortex, a concomitant decreased expression of several susceptibility genes involved in neuroplasticity, including Bdnf, its receptor TrkB, the nuclear receptors Nr4a1-3, and several other CREB-regulated genes. (nih.gov)
  • PBM increased protein expression of Sirt1, Nrf2, and BDNF while decreasing NF-κB compared to HU mice. (bvsalud.org)
  • We found evaluation of Npas4 expression in prefrontal cortex and Nr1d1 both in prefrontal cortex and dorsal hippocampus of adult female mice of MS group, not in HD group. (icgbio.ru)
  • They found fifty percent less fat [triglycerides] in these cells in the BCAA mice, and much greater activity in the molecules that are involved in fat burning, such as the fat sensor PPAR-alpha, the enzyme COT-1 and the uncoupling proteins 2 and 3. (ironmagazine.com)
  • The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice. (ironmagazine.com)
  • Transgene expression using viral vectors provides an alternative, which allows for temporal expression of genes in mice with reduced cost and effort. (nature.com)
  • This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
  • In addition to confirming previous works regarding mRNA expression in Mecp2 -deficient animals, the current study identified hundreds of novel protein targets. (biomedcentral.com)
  • Faculty av K Aripaka · 2019 · Citerat av 8 - TRAF6 positively regulated mRNA expression of b-Catenin and subsequent activation of Wnt target genes in prostate cancer cells in vitro. (web.app)
  • Cav1 and its phosphorylation can impact on the domain recruitment of signalling protein partners and consequently contribute to the trafficking of signalling proteins to and from the plasma membrane. (diff.org)
  • Ser80 phosphorylation serves to convert Cav1 to a soluble secreted protein. (diff.org)
  • RBM3 expression is elevated in response to cellular and body temperature dropping below 37 o C and can provide a transcript-specific preservation of RNA important for cell survival and metabolic function during periods of cold stress 17,26-28 . (orthojournal.org)
  • During Adv DNA replication, host cellular proteins such as nuclear factor I and POU2F1 are used by Adv [ 13 , 14 ]. (hindawi.com)
  • Outcomes Diet-induced weight problems reduced cardiac blood sugar fat PTK787 2HCl burning capacity GLUT and AMP-activated proteins kinase (AMPK) amounts which was connected with increased degrees of macrophages toll-like receptor 4 suppressor of cytokine signaling 3 (SOCS3) and cytokines in center. (cancer-ecosystem.com)
  • Examples include finding proteins indicating cardiac problems or looking for circulating tumour cells that can indicate the spread of cancer. (50webs.com)
  • Also was evaluated expression level of stress-related genes glucocorticoid and mineralocorticoid receptors (Nr3c1 and Nr3c2) as well as Nr1d1, which encodes a transcription factor REVERBО±, which regulates sociability and anxiety-related behavior. (icgbio.ru)
  • c-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). (web.app)
  • Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. (nature.com)
  • Our approach exploits the absolute dependence of AAV transduction on the expression of its receptor 22 , AAVR (also named KIAA0319L). (nature.com)
  • By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
  • Using a recently published rat model that combines both burn and disuse components, we compare the effects of insulin treatment vs. vehicle on glucose tolerance, hypermetabolic response, muscle loss, and circadian-metabolic protein expression after burns. (elsevierpure.com)
  • Insulin treatment after burn and during disuse attenuated the hypermetabolic response, increased glucose clearance, and normalized circadian-metabolic protein expression patterns. (elsevierpure.com)
  • HSV-vektorn i PAG minskar ERK 1/2 fosforylering, blockerar Fos-expression och minskar fosforylering av CREB i råttor med utfällt morfinuttag av C Hansen · 2009 · Citerat av 75 - Moreover, inhibition of the Wnt-5a/DARPP-32/CREB pathway, by expression of the activity of CREB and c-fos are strongly attenuated in DARPP-32 knockout C-Fos Expression in Behaviorally Distinct Vole Species following Pair-Bonded Mate Reunion. (web.app)
  • Validation of expression levels of FOS and other genes involved in the amphetamine pathway in GEO datasets GSE73129, GSE92538, and GSE10784. (web.app)
  • Moreover, the M2-inducing effects of LIPUS were proved partially through the WNT pathway by upregulating FZD5 expression and enhancing β-catenin nuclear translocation in macrophages both in vitro and in vivo . (ijbs.com)
  • Two other proteins of the same family, Cav2 and Cav3, exist and differ in their patterns of expression in different cell types. (diff.org)
  • Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
  • BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue. (ironmagazine.com)
  • Other NIH-funded investigations in our lab explore epigenetic mechanisms through which an anti-aging protein called Klotho affects myogenesis and muscle regeneration in neonatal and aging muscle. (ucla.edu)
  • Two-color analysis of the expression of CD117 on mouse bone marrow cells. (bdbiosciences.com)
  • A single-cell suspension of BALB/c bone marrow was simultaneously stained with FITC Rat Anti-Mouse CD45R/B220 (Cat. (bdbiosciences.com)
  • Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
  • The transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) have been implicated in rodent models of depression. (nih.gov)
  • We previously provided evidence that Bdnf expression critically rely on a potent CREB coactivator called CREB-regulated transcription coactivator 1 (CRTC1). (nih.gov)
  • These analyses consist of enzyme activities of single muscle or neural cells, cell morphology, the kinds of proteins synthesized, the modulations of the mRNA's of specific myonuclei as well as the physiological properties of the nerve and muscle cells. (ucla.edu)
  • uncoupling proteins boost the heat production in cells. (ironmagazine.com)
  • Delivery of CS allows transplantation of cells along with matrix proteins to facilitate engraftment. (biomedcentral.com)
  • An important role of this protein was also demonstrated in different experimental studies on heart damage. (springer.com)
  • These studies have shown that although the nervous system has a significant influence on the kind and amount of specific proteins synthesized, there are factors intrinsic to individual fibers that also define these properties. (ucla.edu)
  • Among the genes involved in these key pathways, 9 hub genes and 3 master regulators were identified from the co-expression and upstream analysis networks. (icgbio.ru)
  • Microarray analysis from the conserved upregulated genes showed a set of genes related to contractile apparatus and stress response at day 1, including three genes involved in mechanotransduction and four genes encoding heat shock proteins. (uky.edu)
  • control, hindlimb unloading (HU), and HU + PBM groups. (bvsalud.org)
  • To control AAVR expression, we designed a Cre-mediated AAVR overexpression cassette (Fig. 1a ). (nature.com)
  • The expression of FOS, FOSB, JUN, PRKCA, GRIA3, and CALM3 between schizophrenia and control lymphoblast samples have Fructooligosaccharides (FOS) is responsible for stimulating the growth of bifido bacteria and lactobacilli, which are found in the human gut. (web.app)
  • Table 1 Manifestation of pyroptosis core proteins in malignancy and their effects on malignancy methylation was found to be associated with lymph node metastasis62. (colinsbraincancer.com)
  • Several selected protein targets were validated by Western blot analysis. (biomedcentral.com)
  • Functional analysis by stimulus-evoked c-Fos expression and electrophysiological recording showed that host axons formed active synapses with graft neurons at the injury site with the signal propagating by graft axons to the DCN. (jneurosci.org)
  • After surgery to fit the suspension fixing, the animals were housed either in HU cages or in their normal cage for 14 days. (bvsalud.org)
  • Animals received manual bladder expression twice daily and were inspected for weight loss, dehydration, and distress, with appropriate veterinary care when needed. (oxjournal.org)
  • The expression of stress-related genes Nr3c1 and Nr3c2 was unchanged in both groups. (icgbio.ru)
  • Identical increased expression was found in the mPOA region in the retrievers stimulated by ultrasonic vocalizations or pheromones from their mates. (web.app)
  • Pyroptosis and lung malignancy (LC) In non-small cell lung malignancy (NSCLC), higher GSDMD expression is related to invasive features, including more advanced tumor-node-metastasis stages and larger tumor sizes. (colinsbraincancer.com)
  • Expression profiles of whole blood microRNAs were altered and distinctly different in adenovirus-infected children. (hindawi.com)
  • We hypothesized that AAV transgene expression could be targeted to specific tissues or cell types by selectively overexpressing AAVR. (nature.com)
  • 2000 Neuroleptics increase c-fos expression in the forebrain: contrasting NADPH-diaphorase activity and c-fos expression in medullary neurons after fatiguing stimulation of hindlimb muscles in the rat - den 19 oktober 2003 kl 17:40. (web.app)