• Many antigens associated with sweat gland neoplasms, including S-100 protein, CA72.4, gross cystic disease fluid protein 15 (GCDFP-15), and carcinoembryonic antigen (CEA), are absent in sebaceous tumors. (medscape.com)
  • Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
  • Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
  • In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. (wikidoc.org)
  • Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. (wikidoc.org)
  • Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
  • this study showed that there is no relationship between pcsk9 and cd36 in subclinical hypothyroidism and pcsk9 antibodies can still be used as an effective way to treat hypercholesterolemia. (icbcongress.com)
  • 12. Sachs UJ, Wienzek-Lischka S, Duong Y, Qiu D, Hinrichs W, Cooper N, Santoso S, Bayat B, Bein G (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. (uni-giessen.de)
  • 17. Wu Y, Chen D, Xu X, Mai M, Ye X, Li C, Santoso S, Xia W, Fu Y (2020) Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. (uni-giessen.de)
  • GST group, five of eight mice in CD36 the PBS group, two of eight mice in the -fodrin 1 g/dose group, and three out of eight mice in the -fodrin 10 g/dose were positive for antinuclear antibodies. (asiatox.org)
  • Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies. (antikoerper-online.de)
  • Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor "programmed-cell-death-1" (PD1) and its ligand (PD-L1), because most cases lack the required mutational burden and neo-antigen load caused by microsatellite instability (MSI) and/or an inflamed, immune cell-infiltrated PD-L1+ tumor microenvironment. (aabioetica.org)
  • In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. (thermofisher.com)
  • By performing proximity labeling and proteomic analysis, we identified scavenger receptor CD36 as a cell surface protein interacting with Siglec-E. Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake. (biomedcentral.com)
  • Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G: Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. (exbio.cz)
  • The mouse monoclonal antibody CB38 (NL07) recognizes an extracellular epitope of CD36 (GPIIIb), a 85-113 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. (exbio.cz)
  • Alessio M, Ghigo D, Garbarino G, Geuna M, Malavasi F: Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07. (exbio.cz)
  • Alessio M, Roggero S, Bussolino F, Saitta M, Malavasi F: Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule). (exbio.cz)
  • Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
  • Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. (antikoerper-online.de)
  • Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene. (wikipedia.org)
  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. (origene.com)
  • Proprotein convertase subtilisin/kexin type 9 (pcsk9) is a serine protease and a secreted protein which increases cholesterol levels in plasma via inducing degradation of low-density lipoprotein receptor (ldlr). (icbcongress.com)
  • the 2C7 scFv inhibited the uptake of LDL(-) by macrophages in a dose-dependent manner, and internalization of LDL(-) by these cells was discovered to become mediated by the CD36 and CD14 receptor. (m-entrepreneurship.com)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • The differences in the characteristics between the murine model and humans are the host receptor and the absence of knob-like structures of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) (Table 2 ) [ 11 ]. (biomedcentral.com)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. (antikoerper-online.de)
  • Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. (exbio.cz)
  • STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
  • The presence of the extracellular matrix protein fibronectin (FN) strongly enhanced the spontaneous and SDF-1-induced migration of leukemic PB and BM cells. (johnshopkins.edu)
  • These foam cells in turn produce more inflammatory cytokines and growth factors to promote the migration of the quiescent vascular smooth muscle cells (VSMCs) in the medial layer to intima and activate VSMC proliferation and increased synthesis of extracellular matrix proteins, resulting in the thickening of intima and occlusion of the blood vessel [ 2 , 3 , 4 ]. (biomedcentral.com)
  • Compared with BBR, dhBBR and Di-MeBBR significantly reduced EMMPRIN expression, which was associated with a greater inhibition of p-p38, p-JNK, nuclear NFκB p65 and phospho-p65 induced by oxLDL in macrophages. (biomedcentral.com)
  • In addition, compared with untreated cells, lipid accumulation in macrophages was decreased, as well as the expression of Cd36, tlr-4 and Cox-2 was downregulated in macrophages treated with 2C7 scFv. (m-entrepreneurship.com)
  • Whether Siglec-E expression on macrophages impacts foam cell formation and atherosclerosis remains to be established. (biomedcentral.com)
  • This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Progress in different areas of basic research, new animal models, and the generation of specific antibody markers to target essential proteins help find and improve the treatment of patients with neuroimmunological diseases. (atlasantibodies.com)
  • CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. (exbio.cz)
  • Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. (origene.com)
  • dhBBR and Di-MeBBR reduced expression of EMMPRIN, CD68, and NFκB p65, and Di-MeBBR also reduced expression of matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic plaques. (biomedcentral.com)
  • Pilar and sebaceous neoplasms share a common expression for both high and low molecular weight cytokeratin that is not seen in most eccrine or apocrine tumors, pointing to similar cellular differentiation patterns of hair and sebaceous structures. (medscape.com)
  • cluster of differentiation 36 (cd36) is a member of a family of cell surface proteins in many cells. (icbcongress.com)
  • Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Akhtar Khan N, Montmayeur JP, Besnard P: The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. (exbio.cz)
  • CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. (exbio.cz)
  • quantification of cd36 expression on monocytes was done by flow cytometry. (icbcongress.com)
  • 8. Phuangtham R, Santoso S, Leelayuwat C, Komvilaisak P, Ding H, Romphruk AV (2020) Frequency of CD36 deficiency in Thais analyzed by quantification of CD36 on cell surfaces and in plasma. (uni-giessen.de)
  • CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on follicular B cells in vitro upon TLR and CD40 stimulation. (exbio.cz)
  • Leukemic cells expressing CD34, CD38 and HLA-DR were preferentially migrating, whereas cells expressing CD14 and CD36 showed diminished migration. (johnshopkins.edu)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • Large-scale bacterial expression and fusion protein purification A 5 ml saturated culture of pGEX-4T-2C-fodrin-transformed bacteria produced in Luria-Bertani(LB) medium supplemented with ampicillin (100. (asiatox.org)
  • Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of autoimmune diseases and cancer. (biomedcentral.com)
  • Lentiviral transduction of the full-length CXADR gene into these cells resulted in an increased expression of early erythroid antigens, including CD36, CD71, and glycophorin A. In addition, CXADR-transduction resulted in an increased migration against a serum protein gradient, whereas truncated CXADR variants did not induce expression of erythroid antigens or migration. (bvsalud.org)
  • The α-syn, encoded by the SNCA1/PARK1 gene, is a ubiquitous protein that is abundantly expressed in kidneys and blood cells, but highly enriched in the brain, particularly in the presynaptic terminals of the neocortex, hippocampus, substantia nigra (SN), thalamus, and cerebellum. (encyclopedia.pub)
  • Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)
  • it has been suggested that pcsk9 regulates cd36 in some tissues. (icbcongress.com)
  • The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • Dendritic cells (DCs), which are the most important antigen-presenting cells (APCs) that send signals to the T cells, mainly participate in the pathogenesis of many diseases with immunoregulatory mechanisms, such as AR. (frontiersin.org)
  • Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
  • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
  • In fact, as antigen-presenting cells (APC), microglia are endowed with the ability to release pro-inflammatory cytokines and chemokines into the CNS tissue microenvironment. (atlasantibodies.com)
  • Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2-domain containing protein tyrosine phosphatase SHP-1/2 upon binding to its sialoglycan ligands. (biomedcentral.com)
  • VAV, a downstream effector implicated in CD36-mediated oxidized LDL uptake, was shown to interact with SHP-1 following oxidized LDL treatment. (biomedcentral.com)
  • Mechanistically, Siglec-E interacts with CD36 to suppress downstream VAV signaling involved in modified LDL uptake. (biomedcentral.com)
  • the recombinant 2C7 scFv was created in a yield of 9.5 mg of protein/L. the specificity and affinity of purified 2C7 scFv against LDL(-) was confirmed by eLISA. (m-entrepreneurship.com)
  • The encoded protein has tyrosine kinase activity and belongs to the src family. (wikipedia.org)
  • There have been other reports of nasal and oral tolerance in SS [6,7], a phenomenon that brings about systemic immune hyporesponsiveness by Myelin Basic Protein (87-99) the exogenous administration of antigen to the peripheral immune system through the mucosal route. (asiatox.org)
  • Flow cytometry analysis (surface staining) of CD36 in human peripheral blood with anti-CD36 (CB38) purified, GAM-APC. (exbio.cz)
  • The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains TSP-1 and -2, and B, which contains TSP-3, -4 and -5 (also designated cartilage oligomeric protein or COMP). (dadamo.com)
  • Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
  • In 1997 Haneji and colleagues recognized a 120 kDa fragment of the ubiquitous cytoskeletal protein -fodrin as an autoantigen in the NFS/sld mouse model of human SS [1]. (asiatox.org)
  • We have recently conducted a first-in-human clinical trial to evaluate the safety and immunogenicity of the recombinant, full-length merozoite surface protein 1 (MSP1 FL ) formulated with GLA-SE as adjuvant. (nature.com)
  • Moniuszko M, Kowal K, Rusak M, Pietruczuk M, Dabrowska M, Bodzenta-Lukaszyk A: Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants. (exbio.cz)
  • Inhibitory peptides and fragments of TSP1 bind to CD36, leading to the expression of FAS ligand (FasL), which activates the expression of Fas. (dadamo.com)
  • Additionally, the cytoxicity of scFv is reduced as a result of their more rapidly removal in the circulation and better disposal of immune complexes which might be formed.1 For the reason that they will be fused with proteins and peptides, the production of scFvs against virtually any essential therapeutic target could supply biopharmaceuticals capable of neutralizing key soluble proteins involved in. (m-entrepreneurship.com)
  • Cell surface EMMPRIN expression was measured by flow cytometry and Western blotting, and phospho-(p)-p38, p-JNK, nuclear NFκB p65, and phospho-p65 were measured by Western blotting. (biomedcentral.com)
  • In conclusion, our data show that 2C7 scFv inhibits foam cell formation and atherosclerotic plaque development by modulating the expression of genes relevant to atherogenesis. (m-entrepreneurship.com)
  • Impacts of Siglec-E expression and cell surface sialic acid status on oxidized LDL uptake and signaling involved were examined by biochemical assays. (biomedcentral.com)
  • A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. (antikoerper-online.de)
  • But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. (antikoerper-online.de)
  • The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. (antikoerper-online.de)
  • Won WJ, Bachmann MF, Kearney JF: CD36 Is Differentially Expressed on B Cell Subsets during Development and in Responses to Antigen. (exbio.cz)
  • Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis. (dadamo.com)
  • The thrombospondins (TSP) are a family of multifunctional proteins. (dadamo.com)
  • The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. (thermofisher.com)
  • PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
  • The fluid intake of mice in the 1 g/dose -fodrin, 10 g/dose -fodrin, PBS, and GST groups was 39.2 2.1 ml, 40.4 2.5 ml, 49.3 3.1 ml and 51.6 2.8 ml, Myelin Basic Protein (87-99) respectively. (asiatox.org)
  • Our research studied the lncRNA and mRNA expression profiles of monocyte-derived DCs and demonstrated the functional networks that are involved in monocyte-derived DCs-mediated regulation in AR. (frontiersin.org)
  • cd36 involves in regulation of lipid metabolism by facilitating cellular uptake of fatty acids and participating in triglyceride storage. (icbcongress.com)
  • Molecular biology techniques thus have already been used to create monovalent antigen-binding (Fab) or single chain variable (scFv) fragments and divalent (e.g. (m-entrepreneurship.com)
  • Molecular biology methods therefore have already been employed to create monovalent antigen-binding (Fab) or single chain variable (scFv) fragments and divalent (e.g. (bcrablinhibitor.com)
  • van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ: Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. (exbio.cz)
  • Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. (rndsystems.com)
  • Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)
  • Aortic atherosclerotic lesion size, plaque matrix proteins, and EMMPRIN and other inflammatory factors were measured using Oil Red O Staining, Masson's trichromestaining and immunohistochemical staining and real-time PCR. (biomedcentral.com)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. (cusabio.com)
  • In the presence of divalent cations, the secreted protein binds to the surface of the activated platelets and is responsible for the endogenous lectin-like activity associated with activated platelets. (dadamo.com)