• Our previous studies showed that HEG drive was more difficult to achieve in Drosophila melanogaster than Anopheles gambiae and we therefore investigated ways of improving homing performance in Drosophila . (plos.org)
  • Chan Y-S, Huen DS, Glauert R, Whiteway E, Russell S (2013) Optimising Homing Endonuclease Gene Drive Performance in a Semi-Refractory Species: The Drosophila melanogaster Experience. (plos.org)
  • Studies carried out by scientists at IRIG, in collaboration with the University of Geneva, on the fruit fly model Drosophila melanogaster have revealed the role of Pcif1 in the control of gene expression, despite the fact that this protein has completely lost its RNA methyltransferase activity compared to its mammalian counterpart PCIF1. (cea.fr)
  • We have cloned the RAD6 homolog from Drosophila melanogaster and find that its encoded protein displays a very high degree of identity in amino acid sequence with the homologous RAD6 proteins from the two divergent yeasts, S. cerevisiae and Schizosaccharomyces pombe, and from human. (eur.nl)
  • One obvious possibility is to pursue the matter in Drosophila melanogaster DNA, which has sequences homologous to several vertebrate oncogenes. (embl.de)
  • One way to judge the potential influence from the gypsy infectious capability in the evolutionary background of gypsy sequences from Drosophila , is certainly to investigate the infective capability of gypsy homologous sequences from types apart from D. melanogaster . (healthyguide.info)
  • Debate and Outcomes Sequences homologous to gypsy from D. melanogaster are distributed among Drosophila types. (healthyguide.info)
  • Furthermore, in D. melanogaster perform the gypsy components have an entire useful env gene [10]. (healthyguide.info)
  • The predicted amino acid sequences had the highest degree of sequence similarity to the Drosophila melanogaster OBPs named pheromone binding protein-related proteins (PBPRPs). (elsevierpure.com)
  • Homologous GPBPRP genes were found also in D. melanogaster by database search and are shown to be expressed in Drosophila taste tissues. (elsevierpure.com)
  • By spelling out protein-coding genes in the genome and comparing the house fly sequence to that of the fruit fly, Drosophila melanogaster , the team has endeavored to unravel genetic factors coinciding with house fly features. (genomeweb.com)
  • Here, we identify two novel cGAS-like receptors (cGLRs) in the insect Drosophila melanogaster. (cnrs.fr)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • In Drosophila melanogaster , the RNase III-like enzyme Dicer cleaves the dsRNA silencing trigger into RNA species of approximately 21 to 25 nucleotides. (biomedcentral.com)
  • Burt proposed that such methods could be applied to engineer HEGs that recognise and cleave sequences within coding sequences of genes in insect genomes, with the subsequent invasion of these HEGs into a population leading to the inactivation of target genes and the subsequent decline in fitness of the targeted population [2] . (plos.org)
  • Using as hybridization probe cloned yeast YPT1 gene sequences, we have isolated from cDNA libraries prepared from RNA of mouse F9 and C3H10T1/2 cells several overlapping cDNA clones with identical sequence in the regions of overlap. (embl.de)
  • Amino acid sequences typical for guanine nucleotide-binding proteins and characteristic for ypt proteins are perfectly conserved in the mouse ypt1 protein. (embl.de)
  • These gene sequences are conservative through evolution (for example have homologous sequences in flies and in vertebrates) although they don't necessarily have the same function. (albertkharris.com)
  • The phylogenetic interactions among gypsy sequences from Drosophila types is not end up being often coincident with those of their hosts, that could end up being indicative of horizontal transfer during evolutionary background [6,7,9,10]. (healthyguide.info)
  • Gypsy sequences homologous to gypsyDm possess been discovered in a number of types of the Paleartic and Neartic subgroups, showing up being a monophyletic group that's diverged in the gypsyDm prototypic component [7 extremely,8]. (healthyguide.info)
  • The predicted amino acid sequences of the genes contain the putative signal peptide sequence at the N-terminal and most of them conserve the six cysteines common to known insect OBPs. (elsevierpure.com)
  • Using these DNA and RNA sequences, the team put together - and annotated - a 691 million base assembly that spans more than three-quarters of the fly's complete genome sequence and contains an estimated 14,810 protein-coding genes. (genomeweb.com)
  • The house fly genome contained sequences for some 771 apparent immune-related genes, for example, including 355 that are not homologous to Drosophila immune genes. (genomeweb.com)
  • The locus control region (LCR) of mammalian beta-globin genes covers at least 17 kb at the 5' end of the gene cluster and has been implicated in chromatin domain opening, enhancement, and insulation from neighboring sequences. (shengsci.com)
  • Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)
  • Thus, the PTGS degradation machinery in plants would lead to the elimination of the viral RNA, as long as the dsRNA trigger contains sequences homologous to the invading virus. (biomedcentral.com)
  • PORCN (porcupine homolog - Drosophila) is a human gene. (wikipedia.org)
  • Since discovery of teneurins in Drosophila, many other laboratories have independently described the Ten-a and Ten-m/Odz homolog proteins in different vertebrates. (wikipedia.org)
  • RePub, Erasmus University Repository: DHR6, a Drosophila homolog of the yeast DNA repair gene RAD6. (eur.nl)
  • DHR6, a Drosophila homolog of the yeast DNA repair gene RAD6. (eur.nl)
  • Genetic complementation studies indicate that the Drosophila RAD6 homolog can functionally substitute for the S. cerevisiae RAD6 gene in its DNA-repair and UV-mutagenesis functions but cannot substitute in sporulation. (eur.nl)
  • The product of the Drosophila gene decapentaplegic ( dpp) encodes a TGFβ homolog that plays multiple roles during embryogenesis and the development of imaginal discs. (biologists.com)
  • names: atonal homolog 1 (Drosophila) and atonal homolog 2 (Drosophila) respectively. (jax.org)
  • rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
  • These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. (bioone.org)
  • Researchers at IRIG, in collaboration with the University of Geneva, focused on a RNA mammalian methyltransferase, the PCIF1 protein (homologous to the Drosophila Pcif1 protein), which adds an extra methyl group to m 6 A (m 6 adenosine) to form m 6 Am when the first transcribed nucleotide is an adenosine. (cea.fr)
  • More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. (nature.com)
  • We study a median of 16,101 genes across 2 mammalian genomes (human, mouse), 12 Drosophila genomes, 5 Caenorhabditis genomes, and an outgroup yeast genome, and demonstrate that accurate inference of evolutionary relationships and events across these species must account for frequent gene-tree topology errors due to both incomplete lineage sorting and insufficient phylogenetic signal. (biorxiv.org)
  • In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
  • When a HEG is integrated into its recognition sequence in the genome, its protein product acts to cleave its cognate site on the homologous chromosome and gene conversion or homologous recombination can result in a new copy of the HEG being inserted. (plos.org)
  • In living organisms, gene expression is a complex process that results in the production of proteins from the genome in a time- and space-regulated manner. (cea.fr)
  • The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. (elifesciences.org)
  • A 50 kb DNA segment of the Drosophila genome has been cloned and characterized. (caltech.edu)
  • genome, and get away the control exerted with the flamenco gene normally, whose item represses flexibility[4]. (healthyguide.info)
  • For example, the M. domestica genome housed almost 150 cytochrome P450 enzyme-coding genes, consistent with a potentially bolstered detoxification system in the house fly. (genomeweb.com)
  • Consistent with their role as scent-based waste scavengers, the house flies had higher-than-usual representation by chemoreceptor and odorant-related genes in their genome, authors of the study noted. (genomeweb.com)
  • While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
  • We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
  • [ 7 , 8 ] Sister chromatid exchanges are considered a sensitive indicator for cell genome instability, as they are thought to be the outcome of DNA double-strand breaks resulting from homologous recombination repair. (medscape.com)
  • Mutations in this gene are associated with focal dermal hypoplasia. (wikipedia.org)
  • Mutations in the CRB1 gene are associated with variable phenotypes of severe retinal dystrophies, and retinal dystrophies resulting from CRB1 mutations may be accompanied by specific fundus features such as coat's like vasculopathy in retinitis pigmentosa patients. (biomedcentral.com)
  • CRB1 gene mutations are associated with remarkable retinal findings in patients with retinitis pigmentosa and other fundus dystrophies. (biomedcentral.com)
  • For complete details and additional special case rules, see Guidelines for Nomenclature of Genes, Genetic Markers, Alleles, and Mutations in Mouse and Rat . (jax.org)
  • By analyzing lethal mutations in the fruit fly Drosophila Hadorn accumulated evidence that genes control development to a large extent and that they determine the body plan in great detail. (balzan.org)
  • It is predicted that MCPH gene mutations may lead to the disease phenotype due to a disturbed mitotic spindle orientation, premature chromosomal condensation, signalling response as a result of damaged DNA, microtubule dynamics, transcriptional control or a few other hidden centrosomal mechanisms that can regulate the number of neurons produced by neuronal precursor cells. (biomedcentral.com)
  • Further, we review the corresponding genes and the proteins encoded by these genes, their possible role in the developing brain and reported mutations of these genes. (biomedcentral.com)
  • MCPH is inherited in an autosomal recessive pattern in which both copies of the gene in each cell have mutations. (biomedcentral.com)
  • The BLM mutations can be found in compound heterozygous forms, homozygous forms, or as single gene mutation forms. (medscape.com)
  • Over 60 mutations of the BLM gene have been found in Bloom syndrome. (medscape.com)
  • U2OS.EGFP cells caused by inactivating frameshift insertion/deletion (indel) mutations introduced by error prone non-homologous end-joining (NHEJ) repair of nuclease-induced double-stranded breaks (DSBs) (Fig. 1a and Methods ). (cdc.gov)
  • The four genes encode four of the five major third instar larval cuticle proteins. (caltech.edu)
  • Here, we present a phylogenomics-based approach for the identification of orthologous and paralogous genes in human, mouse, fly, and worm, which forms the foundation of the comparative analyses of the modENCODE and mouse ENCODE projects. (biorxiv.org)
  • Furthermore, we show that integration of two separate phylogenomic pipelines yields increased accuracy, suggesting that their sources of error are independent, and finally, we leverage the resulting annotation of homologous genes to study the functional impact of gene duplication and loss in the context of rich gene expression and functional genomic datasets of the modENCODE, mouse ENCODE, and human ENCODE projects. (biorxiv.org)
  • The very premise of using model organisms to inform human biology relies on the fact that many biological processes, and the underlying genomic elements that encode them, are frequently conserved across large evolutionary distances, especially for protein-coding genes. (biorxiv.org)
  • Thus, this clone appears to encode a portion of the mouse biliary glycoprotein gene. (shengsci.com)
  • Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
  • The primary structure, or amino acid sequence identity, of the proteins between paralogs is ~60% identical and between orthologs is ~90%, whilst between vertebrates and Drosophila or C. elegans is only 33-41% identical. (wikipedia.org)
  • The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. (embl.de)
  • The homeodomain [of a Hox protein] is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). (albertkharris.com)
  • Sequence comparisons indicate it arose by an unequal crossing over event involving two closely related and adjacent cuticle genes. (caltech.edu)
  • This family is comprised of three genes that are 55-60% homologous in DNA sequence and clustered within 8 kb of DNA. (caltech.edu)
  • For any given set of species, gene families are created by first identifying all the genes in all species and then clustering them based on their sequence similarities. (biorxiv.org)
  • Seven genes were identified with sequence similarity to insect odorant-binding protein (OBP) genes. (elsevierpure.com)
  • These genes show a high degree of sequence divergence with ∼20% amino acid identity. (elsevierpure.com)
  • The sequence data offered a peek at other fly features as well - from sex determination and sex-biased gene expression to house fly gene regulation. (genomeweb.com)
  • This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. (utsouthwestern.edu)
  • The mouse biliary glycoprotein gene (Bgp): partial nucleotide sequence, expression, and chromosomal assignment. (shengsci.com)
  • Its sequence, when compared to those of members of the human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. (shengsci.com)
  • The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. (shengsci.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • These results suggest that homologous loci approach each other to repair DSBs and AtRAD54 mediates these phenomena. (nature.com)
  • These findings suggest that homologous dsRNA could serve as protective molecules against virus infections, provided that inexpensive and effective means of production and delivery of adequate interference products onto plants surfaces were previously developed. (biomedcentral.com)
  • In particular, HEG gene drive could be particularly effective if activity was restricted to the male germline to target genes required for female fertility/viability or engineered to destroy the X-chromosome by cutting at multiple X-specific sites [5] , [6] . (plos.org)
  • Immunofluorescence analysis with anti-Pcif1 antibodies revealed the presence of the Pcif1 protein (in green) along the chromosome at transcriptionally active euchromatin sites ( i.e. excluded from DAPI dense staining, in red). (cea.fr)
  • Thus two small gene families can lie adjacent on the chromosome and exhibit different patterns of developmental expression, even though individual genes within a clustered family are coordinately expressed. (caltech.edu)
  • Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (shengsci.com)
  • Furthermore, AtRAD54, which performs an important role in the homologous recombination repair pathway, was involved in the pairing of homologous loci with γ-irradiation. (nature.com)
  • We found that AtRAD54, which performs an important role in the homologous recombination (HR) repair pathway, was involved in the approach of two homologous loci under γ-irradiation. (nature.com)
  • Our results suggest that the transient reduction in inter-allelic distance and increase in pairing frequency of homologous loci after DSB result in partial chromatin reorganisation of interphase nuclei and that AtRAD54 contributes to the subcellular movement of homologous loci in the HR repair pathway. (nature.com)
  • There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability. (embl.de)
  • The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
  • The SHH pathway should be off at most of the time, by the inhibition of specific factors such as Patched 1 (PTC1), Protein Kinase A (PKA), Casein Kinase1 (CK1), and Glycogen Synthase Kinase 3 beta (GSK3b), and only valid at precise time points [ 98 ]. (regenmedres-journal.org)
  • A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. (sdbonline.org)
  • Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila . (sdbonline.org)
  • To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)
  • This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
  • Two complexes share common components (red) and contain homologous subunits (green). (biomedcentral.com)
  • Homologous subunits are shown in green. (biomedcentral.com)
  • The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs ( Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a phosphorylation-dependent manner. (findwords.info)
  • MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
  • Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein]. (nih.gov)
  • How Gene Expression (mRNA and protein synthesis) is spatially controlled in embryos. (albertkharris.com)
  • Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. (shengsci.com)
  • Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. (embl.de)
  • In the fly, signals are regulated by a single Hh gene, while in mammals, Sonic (SHH), Indian (IHH), and Desert (DHH) hedgehog play different regulatory roles [ 37 , 148 ]. (regenmedres-journal.org)
  • In mammals, in addition to βTrCP1, a paralog protein (called βTrCP2 or FBXW11) also exists, but, so far, their functions appear redundant and indistinguishable. (findwords.info)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Double-stranded RNA (dsRNA) is a potent initiator of gene silencing in a diverse group of organisms that includes plants, Caenorhabditis elegans, Drosophila and mammals. (biomedcentral.com)
  • Shimmi, O., Umulis, D., Othmer, H. & O'Connor, M. B. Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. (nature.com)
  • The embryonic Drosophila cDNA library was screened using polymerase chain reaction (PCR) and a primer derived from the EGF-like repeats region of chicken tenascin-C protein. (wikipedia.org)
  • We show that, during embryonic devel-opment, the extramacrochaetae gene is expressed in complex patterns that comprise derivatives of the three embryonic layers. (biologists.com)
  • If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)
  • Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). (nih.gov)
  • therefore, it is also important for gene regulation and DNA replication in A. thaliana as well as other organisms. (nature.com)
  • In agreement with these observations, the Pcif1 protein is distributed all along the polytene chromosomes at the level of active transcription sites and interferes with chromatin-dependent gene expression regulation. (cea.fr)
  • The lack of catalytic activity of Pcif1 in Drosophila reveals a new mechanism of gene expression regulation. (cea.fr)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
  • The tkv receptor is therefore involved in delimiting the expression domains of homeotic genes in the visceral mesoderm. (biologists.com)
  • name: ash2 (absent, small, or homeotic)-like (Drosophila). (jax.org)
  • In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. (embl.de)
  • Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
  • Model organisms can serve the biological and medical community by enabling the study of conserved gene families and pathways in experimentally-tractable systems. (biorxiv.org)
  • In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
  • Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. (embl.de)
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
  • It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)
  • in 1999 from the original name, Ten-a, and the major site of the protein expression being in the nervous system. (wikipedia.org)
  • We show that homing in Drosophila responds to increased expression of HEGs specifically during the spermatogonia stage and this could be achieved through improved construct design. (plos.org)
  • Contrary to expectations, a fragment containing the entire region between the TBPH gene and the bgcn translational start drove strong HEG expression only during late spermatogenesis rather than in the germline stem cells and spermatogonia as expected. (plos.org)
  • This study highlights an important contribution for Pcif1 in gene expression and physiology of the organism independently of any catalytic activity. (cea.fr)
  • This expression is strictly dependent on the synthesis of messenger RNAs transcripts from the DNA molecule and their subsequent translation into proteins by the ribosomes. (cea.fr)
  • In mice, mutation of PCIF1 encoding gene causes deregulation of the expression of a set of genes and a reduced body weight. (cea.fr)
  • The work of the scientists shows that mutation of Pcif1 gene in Drosophila results in a deregulation of the expression of a set of genes, reduced body weight and a significant drop in fertility which indicates an important role for this protein in the physiology of the organism. (cea.fr)
  • Moreover, for genes that are expressed in multiple tissues or at multiple stages of development, the use of tissue-specific expression of the Cre recombinase allows gene function to be perturbed in specific cell types and/or at specific times. (elifesciences.org)
  • The three genes are expressed together in larval stages and adults but show a different pattern of developmental expression from the third instar larval cuticle protein genes. (caltech.edu)
  • The infectious capability of gypsyDm is certainly from the expression of the retroviral envelope-like proteins encoded with the env gene [2]. (healthyguide.info)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The directed expression of alpha-synuclein , a gene contributing to inherited forms of Parkinson disease (PD), in the dopaminergic neurons (DA) of flies provides a robust model of PD complete with the loss of neurons and accompanying motor defects. (sdbonline.org)
  • To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • In this sense, RNAi has become a powerful genetic tool for selectively silencing gene expression in many eukaryotes [ 12 ]. (biomedcentral.com)
  • Mutation in the TENM3/ODZ3 gene in humans has been associated with the eye condition, microphthalmia. (wikipedia.org)
  • Mutation in bam gene precludes the differentiation step resulting in accumulation of SpG cysts in the testis. (biomedcentral.com)
  • In this unique case we are reporting the incidence of coat's like vasculopathy in a patient diagnosed with Leber congenital amaurosis caused by CRB1 gene mutation, and its management. (biomedcentral.com)
  • Bloom syndrome (congenital telangiectatic erythema) is caused by a mutation in both alleles of the gene designated BLM, traced to band 15q26.1. (medscape.com)
  • However, various names were assigned to these vertebrate homologs, which complicated the nomenclature of teneurin proteins. (wikipedia.org)
  • For orthologous genes in other vertebrate species, use the same symbol as in human, rat, and mouse, whenever possible. (jax.org)
  • A major class of signalling proteins implicated in cell to cell communication is represented by members of the TGFβ superfamily. (biologists.com)
  • Rho GTPases are small (20-30 kDa) GTP-binding proteins of the Ras superfamily. (biomedcentral.com)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily. (utsouthwestern.edu)
  • Homing endonuclease gene (HEG) drive is a promising insect population control technique that employs meganucleases to impair the fitness of pest populations. (plos.org)
  • We also observed that the fraction of targets undergoing homing was temperature-sensitive, falling nearly four-fold when the temperature was lowered to 18°C. Taken together, this study demonstrates how a few simple measures can lead to substantial improvements in the HEG-based gene drive strategy and reinforce the idea that the HEG approach may be widely applicable to a variety of insect control programs. (plos.org)
  • The most striking feature was that all seven of these genes are expressed mainly in the taste tissues, such as the labellum and tarsus, unlike the known insect OBP genes expressed in olfactory tissue. (elsevierpure.com)
  • Proteins found in any species of insect. (lookformedical.com)
  • In the entire case of D. virilis and D. subobscura , it's been shown the fact that genomes of the types contain at least one duplicate of gypsy putatively encoding an entire envelope proteins [4]. (healthyguide.info)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • A molecular characterization of this strain is reported, which includes the finding of a transposable element in the promoter region of the unexpressed gene. (caltech.edu)
  • The workflow proposed can potentially enable all basic molecular biology laboratories to perform detailed targeted gene sequencing analysis in AML patients, in order to define the prognosis and the treatment. (mdpi.com)
  • This study demonstrates the importance to not restrict the function of enzymes to their sole catalytic role in the living world and the interest of thoroughly examining the evolution of proteins in eukaryotes in order to discover unsuspected or hidden mechanisms of action. (cea.fr)
  • The RAD6 gene of the yeast Saccharomyces cerevisiae is required for DNA repair, for DNA damage-induced mutagenesis, and for sporulation, and it encodes a ubiquitin-conjugating enzyme. (eur.nl)
  • The YPT1 gene of the yeast Saccharomyces cerevisiae codes for a guanine nucleotide-binding protein which is essential for cell viability. (embl.de)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • also identified Ten-m in Drosophila by screening for tyrosine phosphorylation on cDNA using monoclonal antibodies. (wikipedia.org)
  • Since Rcd-1 is a regulator of differentiation in other species, it suggests that Rcd-1r may serve a similar role during spermatogonial differentiation in Drosophila . (plos.org)
  • To inform each other and human, model organism studies require a complete map of functionally-equivalent genes and processes across species, in order to facilitate mapping of biological and experimental findings across species, but such maps are extremely difficult to obtain experimentally. (biorxiv.org)
  • The most rigorous and general method for creating a comparative genomic mapping of functionally-equivalent genes across species is through the use of phylogenetics to infer evolutionary relationships. (biorxiv.org)
  • Once gene families are established, they immediately imply a coarse mapping between the genes of different species. (biorxiv.org)
  • metabolic response, or gene or gene variant to the members of one species. (lookformedical.com)
  • Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. (cnrs.fr)
  • Formally, a gene family is defined to be a group of genes such that all genes in the family are evolutionarily derived from the same ancestral gene. (biorxiv.org)
  • Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
  • The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
  • A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w. (shengsci.com)
  • to find regulatory genes of the achaete-scute complex (AS-C). The AS-C comprises four proneural genes that confer to cells the ability to become neuroblasts or sensory organ mother cells ( Campuzano and Modolell, 1992 , review). (biologists.com)
  • The Hh gene family encodes a secreted protein that plays a critical regulatory role in the process of embryogenesis and environmental stabilization in adult tissues of invertebrates and vertebrates [ 44 ]. (regenmedres-journal.org)
  • The high degree of structural and functional conservation of RAD6 in eukaryotic evolution suggests that the various protein components involved in RAD6-dependent DNA repair and mutagenesis functions have also been conserved. (eur.nl)
  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 residue structural motif, the F-box. (findwords.info)
  • Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (shengsci.com)
  • We report here the structural organization of the human EP3 gene (PTGER3). (shengsci.com)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)
  • The team also found 146 different P450 cytochrome genes, along with genes coding for several other enzymes participating in metabolic processes that break down and detoxify drugs and other potentially dangerous compounds. (genomeweb.com)
  • Two mRNAs of 1600 and 3200 nucleotides, originating from the mouse ypt1 gene and differing in the length of their 3'-non-translated region, were identified in mouse F9 cells and in all mouse tissues examined. (embl.de)
  • The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. (wikipedia.org)
  • We also found that DNA double-strand breaks (DSBs) induce the approach of the homologous loci with γ-irradiation. (nature.com)
  • Domain commonly found in eukaryotic signalling proteins. (embl.de)
  • This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
  • The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. (shengsci.com)
  • Nuclear transport of protein TTC4 depends on the cell cycle. (nih.gov)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • BLM encodes 1417 amino acids that code for a protein in the nuclear matrix of growing cells, which is a member of the RecQ family of helicases. (medscape.com)
  • All teneurins, especially in mouse, are type II transmembrane proteins that are composed of a large extracellular C terminal domain of ~2400 amino acid residues, a single transmembrane helical domain of ~30 hydrophobic residues and an intracellular N terminal domain of ~300-375 residues. (wikipedia.org)
  • The 4 cysteine residues assist in protein folding, however, they are absent in Ten-m2 and Ten-m3. (wikipedia.org)
  • It was revealed that homologous loci kept a constant distance in nuclei of A. thaliana roots in general growth. (nature.com)
  • Here, we examined chromatin dynamics and arrangement in living roots of A. thaliana with DNA damage, focusing our attention on the distance between homologous loci using the lacO /LacI-EGFP system. (nature.com)
  • We revealed that the homologous loci kept a constant three-dimensional distance in the nucleus using live-cell imaging with a bacterial operator/repressor system. (nature.com)
  • Moreover, the distance between two homologous loci in the interphase nucleus was shortened by γ-irradiation, which induces DNA double-strand breaks (DSBs). (nature.com)
  • Together, our findings should motivate caution when interpreting conditional alleles, and suggest the exciting possibility of inter-tissue RNA or protein trafficking in modulation of reproductive biology. (elifesciences.org)
  • The protein encoded by this gene belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 repeats. (findwords.info)
  • Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. (utsouthwestern.edu)
  • Rab proteins have been primarily implicated in vesicle docking as regulators of SNARE pairing. (embl.de)
  • Drosophila spermatogenesis and the main regulators of gene activity. (biomedcentral.com)
  • The large majority of the early embryologists thought that the genes played only a minor role in development, for example by determining eye color, and that development is rather controlled by tissue interactions. (balzan.org)
  • Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family. (embl.de)
  • This approach provides a reliable and potential tool, not only for plant protection against virus diseases, but also for the study of gene silencing mechanisms in plant virus infections. (biomedcentral.com)
  • Protein A24 lyase activity in nucleoli of thioacetamide-treated rat liver releases histone 2A and ubiquitin from conjugated protein A24. (wikidata.org)
  • Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
  • To check the nomenclature of known mouse genes, search the Symbol/Name field on the Genes and Markers Query Form . (jax.org)
  • The proteins were called Ten-ms in zebrafish, teneurins in chicken, Ten-m1-4, Odz1-4, Ten-m/Odz1-4, DOC4 in mouse, neurestin in rat, and teneurin or Odz in human. (wikipedia.org)
  • During evolution, this protein naturally lost its catalytic activity in Drosophila where Pcif1 is, like its human counterpart, expressed in the nucleus and associated with the C-terminal domain of RNA polymerase (RNA Pol II). (cea.fr)
  • A monoclonal antibody specifically recognizing the 23.5-kd yeast YPT1 protein cross-reacted with a protein of identical size on protein blots of mouse, rat, pig, bovine and human cell lines. (embl.de)
  • A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product. (embl.de)
  • The human EP3 gene spanned more than 80 kb and was composed of 10 exons separated by nine introns. (shengsci.com)
  • In addition, the potential for these genes to perform various cognitive roles during human brain evolutionary processes is discussed. (biomedcentral.com)
  • By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
  • Thus, SMADs both transmit the signal into the nucleus and execute the downstream effects by directly regulating target-gene transcription. (nature.com)
  • these proteins are also important in regulating gene transcription. (biomedcentral.com)