Protein does inhibit. Medical search. Frequent questions

Adenine forms several biological compounds involved in a variety of cellular physiological processes such as adenosine triphosphate (ATP) in cellular respiration and deoxyribonucleic acid (DNA) in protein synthesis. (hindawi.com)
Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
A novel multiple-stage antimalarial agent that inhibits protein synthesis. (malariada.org)
its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. (malariada.org)
Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. (wikipedia.org)
In the body, these toxins inhibit protein synthesis leading to cell death. (cdc.gov)
Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
Thus, statins may inhibit the synthesis of isoprenoids and thereby suppress the activation of small G proteins (7). (cdc.gov)
they inhibit bacterial DNA-dependent RNA polymerase, suppressing RNA synthesis. (msdmanuals.com)
by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)

The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)
AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. (rcsb.org)
UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary artery smooth muscle. (aspetjournals.org)
We have studied the effects of a synthetic peptide that is based on the autoinhibitory domain of protein kinase C on tension development in detergent-permeabilized coronary artery smooth muscle. (aspetjournals.org)
This peptide inhibited two forms of protein kinase C that were isolated from the coronary artery media layer by hydroxylapatite chromatography, with apparent Ki values in the 5-8 microM range. (aspetjournals.org)
These results indicate that phorbol-12,13-dibutyrate potentiates calcium-induced contractions of permeabilized coronary arteries by activation of protein kinase C, but activated protein kinase C is not a requirement for the induction of contractions by calcium alone. (aspetjournals.org)
An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. (asahq.org)
Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)
Now, scientists at the Institute for Diabetes and Cancer (IDC) at Helmholtz Zentrum München say they have identified the adenosine monophosphate (AMP)-activated protein kinase (AMPK) as the central enzyme in cancer cachexia. (genengnews.com)
Their study ("An AMP-Activated Protein Kinase-Stabilizing Peptide Ameliorates Adipose Tissue Wasting in Cancer Cachexia in Mice") appears in Nature Medicine. (genengnews.com)
Mechanistically, we found that AMPK activation increased, whereas AMPK inhibition decreased, the levels of mitogen-activated protein kinase phosphatase-1 (MKP-1), an inducible nuclear phosphatase, by regulating proteasome-dependent degradation of MKP-1. (diabetesjournals.org)
In the early reprogramming process, fatty acid oxidation upregulated oxidative phosphorylation and downregulated protein kinase C activity. (biomedcentral.com)
Inhibition of protein kinase C also promoted reprogramming. (biomedcentral.com)
We demonstrated that fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C activity in the early stage of the reprogramming process. (biomedcentral.com)
PKC, protein kinase C. (aspetjournals.org)

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
According to a previous study, NS5A inhibits cell apoptosis in vivo and in vitro ( 4 ). (spandidos-publications.com)
Thus, the present study hypothesized that NS5A inhibits apoptosis by inducing Beclin 1-dependent autophagy. (spandidos-publications.com)
More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)

Is the Subject Area "Recombinant proteins" applicable to this article? (plos.org)
Insulin is also the first protein to be chemically synthesised and produced by DNA recombinant technology. (wikipedia.org)
Here, we identified five synthetic proteins termed Affimers from a phage display library , each capable of binding recombinant LOX-1 extracellular (oxLDL-binding) domain with high specificity . (bvsalud.org)

However, the mechanism by which adenine inhibits the proliferation of cancer cells is sketchy. (hindawi.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
In previously reports , Plasmodium vivax was found to be able to directly inhibited erythroid cell proliferation and differentiation. (biomedcentral.com)
Moreover, in vitro cultures of erythroid cells derived from haematopoietic stem cells has demonstrated that P. vivax is able to directly inhibit erythroid cell proliferation and differentiation [ 22 ]. (biomedcentral.com)
Garg, U.C. and Hassid, A. (1989) Nitric Oxide-Generating Vasodilators and 8-Bromo-cyclic Guanosine Monophosphate Inhibit Mitogenesis and Proliferation of Cultured Rat Vascular Smooth Muscle Cells. (scirp.org)
Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)

Curcumol treatment was identified to increase miR‑30a‑5p expression and to activate the Hippo signaling pathway, which in turn inhibited the invasion and migration of CRC cells. (spandidos-publications.com)
Yes-associated protein (YAP), which is a crucial downstream effector of the Hippo signaling pathway, has also been demonstrated to be involved in the EMT process ( 11 , 12 ). (spandidos-publications.com)

The short-term protein trafficking inhibition and long-term effect on plant growth and survival caused by TE1 were fully reversible upon drug washout. (portlandpress.com)
Together, these results suggested that CNPY2 promoted cell growth of PC cells by inhibition of AR protein degradation through MYLIP-mediated AR ubiquitination. (oncotarget.com)
The observed inhibition of fibronectin binding was confirmed by a reduction in the expression of genes encoding two major fibronectin-binding streptococcal surface proteins, Sof and SfbI. (microbiologyresearch.org)
Myricetin affects both surface proteins and secreted proteins which indicate that its action is unrelated to inhibition of the agr quorum sensing system. (nature.com)
Unlike antibacterials that aim to inhibit cell growth, antivirulence therapies are based on the inhibition of bacterial virulence. (nature.com)
Inhibition of TMEM16 proteins. (templarpharma.com)
In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the signal transducer and activator of transcription-1 (STAT1), while inhibition of AMPK had opposite effects. (diabetesjournals.org)

Here, we report that metformin inhibits the activity of enteropeptidase and other digestive enzymes at drug concentrations predicted to occur in the human duodenum. (simulations-plus.com)
Bactericidal effects were found in both planktonic cultures and biofilms, although higher concentrations of manuka honey were needed to inhibit biofilms. (microbiologyresearch.org)
Sublethal concentrations of manuka honey effectively prevented the binding of S. pyogenes to the human tissue protein fibronectin, but did not inhibit binding to fibrinogen. (microbiologyresearch.org)
Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. (wikipedia.org)
Based on these data and expected tissue concentrations of inhibitors, we predict that a p.o. administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa. (aspetjournals.org)
Phosgene alone caused significant increases in lavage fluid neutrophil counts and protein concentrations 24 to 25 hours after exposure. (cdc.gov)

Adenine significantly inhibited the viability of colon cancer cells, HT29 and Caco-2 cells, in a dose-dependent manner. (hindawi.com)
In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)
Lysed IE significantly inhibited gEC growth at 48 and 72 h and cell division resulting in the accumulation of cells in G0 phase. (biomedcentral.com)
ERK1/2 activation, stimulated by oxLDL binding to LOX-1, was also significantly inhibited (p (bvsalud.org)

In the journal Nature, Manuela Raffatellu, associate professor of microbiology & molecular genetics, and colleagues provide the first evidence that small protein molecules called microcins, produced by beneficial gut microbes, play a critical part in blocking certain illness-causing bacteria in inflamed intestines. (infectioncontroltoday.com)
A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a complex with both mutant and wild-type p53 protein has been characterized, purified, and identified. (nih.gov)
Molecular docking in silico and SPR assays indicated that RUT interacted with kelch-like ECH-associated protein 1 (KEAP1), and extracellular incubation studies revealed that RUT bound to the KEAP1 kelch domain with a calculated equilibrium dissociation constant K d of 19.6 μM. (nih.gov)
They also utilized quantitative proteomic methods , a technique that allows for a comprehensive analysis of proteins, to identify a molecular pathway causing the patient's condition. (medicalnewstoday.com)
TtCM was purified to homogeneity on an SDS polyacrylamide gel as a His-fusion protein with a deduced molecular mass of 15.8 kDa. (springer.com)
The human insulin protein is composed of 51 amino acids, and has a molecular mass of 5808 Da. (wikipedia.org)

2021) Transcriptional control of brain tumor stem cells by a carbohydrate binding protein. (news-medical.net)
Karla Satchell, PhD, professor in Microbiology-Immunology and her team demonstrated in a paper published in Nature Communications that a multifunctional-autoprocessing repeats-in-toxin (MARTX) protein from Vibrio vulnificus can inhibit tumor cell growth by cutting the protein Ras. (northwestern.edu)
The therapeutic manipulation took place through a specific peptide that prevents the interaction between AMPK and the lipid droplet-associated protein Cidea, and consequently can stop the increased fat breakdown found in tumor diseases. (genengnews.com)
Thus, our data establish the Ucp1 [uncoupling protein 1]-independent remodeling of adipocyte lipid homeostasis as a key event in tumor-induced WAT wasting, and we propose the ACIP-dependent preservation of Ampk integrity in the WAT as a concept in future therapies for cachexia. (genengnews.com)
Therefore, YAP-mediated EMT is considered to be a critical therapeutic target to inhibit YAP-promoted tumor invasion, and YAP may be a promising target for the treatment of CRC. (spandidos-publications.com)
Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)

Moreover, expression studies on mRNA and protein level showed upregulation of Fte-1/S3a in colon, lung and kidney carcinoma. (uni-frankfurt.de)
We conclude that AMPK activation suppresses STAT1 signaling and inhibits vascular inflammation through the upregulation of MKP-1. (diabetesjournals.org)
Wang et al ( 9 ) reported that miR-30a-5p upregulation can inhibit ovarian cancer epithelial-mesenchymal transition (EMT) and invasion. (spandidos-publications.com)

As ion channels, TMEM16 proteins facilitate the movement of ions across cellular membranes, thereby regulating important cellular functions such as electrical signaling and fluid secretion. (templarpharma.com)
TMEM16 proteins are ion channels that play a critical role in a variety of physiological processes, including neurotransmitter release, smooth muscle contraction, and mucus secretion. (templarpharma.com)
These proteins play a critical role in a variety of physiological processes, including neurotransmitter release, smooth muscle contraction, and mucus secretion. (templarpharma.com)
Beta cells are sensitive to blood sugar levels so that they secrete insulin into the blood in response to high level of glucose, and inhibit secretion of insulin when glucose levels are low. (wikipedia.org)

Researchers at the UCSD School of Medicine have identified a fibrin-derived peptide that inhibits this specific inflammation process in mouse models of Multiple Sclerosis, reducing MS symptoms. (sciencedaily.com)
A fibrous protein called fibrinogen, found in circulating blood and important in blood clotting, can promote multiple sclerosis when it leaks from the blood into the brain, triggering inflammation that leads to MS-related nerve damage. (sciencedaily.com)

It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. (wikipedia.org)
MANNHEIM, Germany - A novel drug that targets production of a liver protein involved in lipid metabolism appears to markedly reduce low-density lipoprotein (LDL) cholesterol levels for patients with homozygous familial hypercholesterolemia (HoFH), suggest results from the phase 2 GATEWAY trial. (medscape.com)
ANGPTL3 regulates lipoprotein metabolism by inhibiting lipoprotein and endothelial lipases. (medscape.com)

Levels of phosphorylation and protein expression were determined using western blotting. (hindawi.com)
Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein. (ox.ac.uk)
Brief high frequency stimulation induces long-term potentiation (LTP) and changes in the endogenous phosphorylation of a 40,000 dalton protein in the hippocampus in a calcium-dependent manner. (ox.ac.uk)
In addition, calmodulin stimulates and TFP inhibits the phosphorylation of the 40,000 dalton protein (as well as that of several other proteins) in a dose-dependent fashion. (ox.ac.uk)
These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)
The level of protein phosphorylation at specific sites varies from less than 1% to greater than 90%, depending on conditions [ 26 ]. (biomedcentral.com)

Out of 15 candidate compounds, four were able to inhibit infection by 10- to 100-fold without causing toxicity, in vitro . (frontiersin.org)
Specifically, it works by blocking proteins called "neuraminidase," which are located on the surface of flu viruses and play an important role in how these viruses cause infection. (cdc.gov)
Neuraminidase are the proteins that allow flu viruses to escape infected cells, and for that reason, antiviral drugs that block neuraminidase proteins, like oseltamivir, help to limit further infection. (cdc.gov)

Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)

Disease-linked missense mutations and multiplication of the SNCA gene encoding α-synuclein have been reported in familial forms of α-synucleinopathies, indicating that structural changes and overexpression of α-synuclein protein are involved in the development of α-synucleinopathies ( Wong and Krainc, 2017 ). (elifesciences.org)

MTT, Transwell, scratch, western blotting and reverse transcription‑quantitative PCR assays were performed to examine how curcumol inhibited CRC cell viability, invasion and migration, and to detect the role of miR‑30a‑5p and curcumol in the invasion and Hippo signaling pathways of CRC cells. (spandidos-publications.com)

The chemical modification by oxidation of these particles can trigger pathological responses, mediated by a group of membrane proteins termed scavenger receptors . (bvsalud.org)

The ACTA2 gene provides instructions for making a protein called smooth muscle alpha (α)-2 actin, which is part of the actin protein family. (medlineplus.gov)
Actin proteins are important for cell movement and the tensing (contraction) of muscles. (medlineplus.gov)
ACTA2 gene mutations that are associated with familial TAAD change single protein building blocks (amino acids) in the smooth muscle α-2 actin protein. (medlineplus.gov)

further, metformin-treated mice exhibit reduced enteropeptidase activity, reduced trypsin activity, and impaired protein digestion within the intestinal lumen. (simulations-plus.com)
CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)
1997). The screen resulted in the identification of six proteins displaying cell death-inhibiting activity in S. pombe as well as anti-apoptotic potential in mammalian cells. (uni-frankfurt.de)
In the present paper we report that 40 microM trifluoperazine (TFP), a phenothiazine that binds calmodulin and blocks its activity, inhibits LTP in the hippocampal slice. (ox.ac.uk)
In the case of cancer cachexia, however, AMPK activity is inhibited due to the illness, resulting in a pointless waste of the body's own energy store. (genengnews.com)
Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
Notably, the former α-synuclein strain inhibited proteasome activity and co-precipitated with 26S proteasome complex. (elifesciences.org)
These abnormal α-synuclein species exhibit seeding activity for prion-like conversion, being similar in this respect to the infectious forms of prion protein (PrP) causing Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy ( Goedert, 2015 ). (elifesciences.org)
Now, researchers have announced that they have created software that can design a separate protein that will stick to a target protein and potentially block its activity. (cozyappliance.com)
As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. (frontiersin.org)
Pthlh expression increases during differentiation, but inhibiting CDK1 activity reduces Pthlh expression. (lu.se)

In multicellular organisms, a variety of lipid - protein particles control the systemic flow of triacylglycerides, cholesterol , and fatty acids between cells in different tissues . (bvsalud.org)

The regulation of complex and dynamic signal transduction proteins contributes to the destination of targeting proteins and the signal transduction of cell growth, and exposure to parasites can also influence signaling pathways. (biomedcentral.com)
In cystic fibrosis, for example, the defective CFTR protein leads to an increase in TMEM16A expression, which contributes to the buildup of mucus in the lungs. (templarpharma.com)

Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)

This protein serves as a transcriptional activator of cell growth. (spandidos-publications.com)

NS5A upregulates Beclin 1 mRNA and protein expression in a HCV NS5A-transactivated protein 9 (NS5ATP9)-dependent manner ( 15 ). (spandidos-publications.com)

McGill University researchers identify proteins that drive cancer stem cells. (news-medical.net)
Our findings suggest that adenine inhibits the growth of colon cancer cells. (hindawi.com)
This report suggests that Canopy FGF signaling regulator 2 (CNPY2) controls AR protein levels in PC cells. (oncotarget.com)
Through a chemical screen, they discovered that Bestatin effectively inhibits TMEM16-mediated phosphatidylserine exposure in red blood cells. (templarpharma.com)
But there are many proteins we wish didn't function quite so well, like the proteins on the surfaces of viruses that let them latch on to new cells or the damaged proteins that cause cancer cells to grow uncontrollably. (cozyappliance.com)
Aquaporins are proteins that regulate the flow of water in and out of cells. (lu.se)

Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)

Cyt c then together with ATP or dATP induces a conformational change in the adaptator protein Apaf-1 (a homologue of the C. elegans CED4 protein) (Zou, Henzel et al. (uni-frankfurt.de)

Potentiation of calcium-induced contractions by 1 microM phorbol-12,13-dibutyrate was partially inhibited by 10 microM peptide and was completely abolished by 30 microM peptide. (aspetjournals.org)

The cell death program can be stalled at several points and we were interested in identifying new proteins inhibiting cell death downstream of Cyt c release. (uni-frankfurt.de)

Proteins are a string of amino acids, with the cell using 20 different amino acids that have some distinct chemical properties. (cozyappliance.com)
Interactions among these amino acids allow the proteins to adopt a three-dimensional configuration, which often brings key amino acids together in one location to form an "active site" that is critical for the protein's function. (cozyappliance.com)
Since each link in a protein's chain can be occupied by one of 20 different amino acids, the number of possible proteins grows enormous after the chain is just a few links long. (cozyappliance.com)
So the process started by taking each of the 20 individual amino acids and testing the strength of its interactions at billions of different sites on the surface of the target protein. (cozyappliance.com)
Separately, the researchers built up a database of about 35,000 short proteins (about 50-65 amino acids long) that formed a stable core. (cozyappliance.com)

This occurs through specific modulation of regulatory proteins during the host-pathogen interaction, especially proteins with roles in pathogenesis [ 27 ]. (biomedcentral.com)

Inhibits chloride currents in vitro. (templarpharma.com)

These changes likely affect the way the protein functions in smooth muscle contraction, interfering with the sarcomeres' ability to prevent arteries from stretching. (medlineplus.gov)

Researchers believe lubricin, a protein found in joint fluid, may serve as a novel therapeutic target for prevention and treatment of gout. (medicalnewstoday.com)
Researchers have made significant progress in identifying drugs that can effectively inhibit TMEM16 proteins, opening up new avenues for potential therapeutic applications. (templarpharma.com)
Blood proteins have been neglected as a therapeutic target, but this research shows that a blood clotting factor is an important player in MS. (sciencedaily.com)

Cell-based and in vitro assays show that Retro-2 blocks delivery of newly-synthesized TA-proteins to the ER-targeting factor ASNA1 (TRC40). (elifesciences.org)

Unlike Okadaic Acid, which only acts on protein phosphatase PP2A, Calyculin A inhibits both PP1 and PP2A. (abcam.com)

Their envelope contains the ion channel forming M2 protein and the hemagglutinin (HA), and neuraminidase (NA) glycoproteins. (frontiersin.org)
And in the lab test, if oseltamivir doesn't inhibit the function of the neuraminidase protein, we call the virus oseltamivir-resistant. (cdc.gov)

The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. (portlandpress.com)

In their study, the researchers show that a probiotic strain of E. coli called Nissle 1917 utilizes microcins to inhibit the pathogen salmonella and an invasive form of E. coli (isolated from patients with inflammatory bowel disease). (infectioncontroltoday.com)
Triptolide inhibits the inflammatory response of monocytes from rheumatoid arthritis patients by regulating miR-155]. (curehunter.com)

There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether differences in the strains of α-synuclein aggregates account for the different pathologies remained unclear. (elifesciences.org)

A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a structure that blocks ATP binding to the active site. (rcsb.org)

Affimer' synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation. (bvsalud.org)

Aiming at identifying an alternative human protein bioscavenger, we looked for an original scaffold candidate by virtual screening of the Protein Data Bank for functional similarity using the "Surfing the Molecules" software (sumo-pbil.ibcp.fr) and a search model based on the BChE active site topology. (rcsb.org)

Mechanistically, RUT potentiates NRF2 nuclear translocation to upregulate NRF2-mediated antioxidant response by directly inhibiting KEAP1-NRF2 interaction. (nih.gov)

The researchers discovered that a protein called galectin1 interacts with another protein called HOXA5 to control the genetic programs that drive cancer stem cell behavior. (news-medical.net)
It interacts with other proteins and has a crucial role in hepatocarcinogenesis ( 3 ). (spandidos-publications.com)

The findings provide evidence that targeting galectin1 protein, in combination with radiation therapy, can pave the way for future clinical trials to treat glioblastoma tumors. (news-medical.net)
Their findings centered on lubricin , a protein that lubricates joints. (medicalnewstoday.com)

Misfolding and aggregation of normally soluble proteins are common pathological features of many neurodegenerative diseases, including Alzheimer's, Parkinson's, Creutzfeldt-Jacob and Huntington's diseases ( Ross and Poirier, 2004 ). (elifesciences.org)

Norata pointed out there are at least two approaches to targeting the protein, one a monoclonal antibody, evinacumab (Evkeeza, Regeneron Pharmaceuticals), that reduces the circulating form of ANGPTL3. (medscape.com)

The researchers also analyzed patient databases and found that glioblastoma patients with low expression of galectin1 and HOXA5 proteins had the best prognosis. (news-medical.net)
While indicating a crucial role for SLTM in cellular function, these results also emphasize the need for caution when interpreting phenotypic changes associated with manipulation of protein expression levels. (bris.ac.uk)
Protein expression was measured by Western blot. (medscimonit.com)
The drug, ARO-ANG3 (Arrowhead Pharmaceuticals), is a hepatocyte-targeted small interfering ribonucleic acid (siRNA) designed to silence expression of the angiopoietin-like protein 3 (ANGPTL3) gene. (medscape.com)

TMEM16 proteins, discovered in 2008, are a group of ion channels that play a crucial role in various physiological processes. (templarpharma.com)

And we found about a dozen proteins that were markedly decreased in the patient, Terkeltaub said. (medicalnewstoday.com)

These proteins are encoded by ten different genes and are found in many tissues throughout the body. (templarpharma.com)
TMEM16 proteins, encoded by ten different genes, exhibit broad distribution across numerous tissues throughout the body, playing essential roles in diverse physiological processes. (templarpharma.com)

Additionally, studies have demonstrated its ability to inhibit platelet aggregation and reduce thrombus formation in mouse models of arterial thrombosis. (templarpharma.com)

Anatomy9

Organisms10

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes56

Information Science3

Health Care1

Synthesis11

Kinase20

Apoptosis4

Recombinant3

Proliferation6

Signaling pathway2

Inhibition7

Concentrations6

Significantly4

Molecular6

Tumor6

Upregulation3

Secretion4

Inflammation2

Metabolism3

Phosphorylation6

Infection3

Toxins1

Overexpression1

Viability1

Membrane proteins1

Actin3

Activity11

Lipid1

Contributes2

Proteases1

Cell growth1

MRNA and protein1

Cells6

Gene Expression1

Induces1

Peptide1

Downstream1

Amino acids5

Pathogenesis1

Chloride1

Smooth muscle contraction1

Therapeutic3

Vitro1

Phosphatase1

Neuraminidase2

Inhibitor1

Inflammatory2

Strain1

Blocks1

Receptor1

Molecules1

Interaction1

Interacts2

Findings2

Pathological1

Reduces1

Expression4

Crucial role1

Markedly1

Genes2

Aggregation1